Schlenk Line
Schlenk Line - Related Videos
09:41
Schlenk Lines Transfer of Solvents
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2023
Source: Hsin-Chun Chiu and Tyler J. Morin, laboratory of Dr. Ian Tonks—University of Minnesota Twin Cities Schlenk lines and high vacuum lines are both used to exclude moisture and oxygen from reactions by running reactions under a slight overpressure of inert gas (usually N2 or Ar) or under vacuum. Vacuum transfer has been developed as a method separate solvents (other volatile reagents) from drying agents (or other nonvolatile agents) and dispense them to reaction or storage vessels while...
07:05
Handling Air- and Water-Sensitive Chemicals Using a Schlenk Line
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2023
Robert M Rioux, Ajay Sathe, Zhifeng Chen, Pennsylvania State University, University Park, PA The use of reagents sensitive to oxidation or moisture necessitates the use of air-free techniques. A Schlenk line is a routinely used glass apparatus to perform air and moisture free manipulations in a chemical laboratory1. The Schlenk line is widely utilized by many chemists since it allows them conduct air or water sensitive reactions even without the expense and restriction of a glove box. The...
06:50
Synthesis Of A Ti(III) Metallocene Using Schlenk Line Technique
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2023
Source: Tamara M. Powers, Department of Chemistry, Texas A&M University Inorganic chemists often work with highly air- and water-sensitive compounds. The two most common and practical methods for air-free synthesis utilize either Schlenk lines or gloveboxes. This experiment will demonstrate how to perform simple manipulations on a Schlenk line with a focus on solvent preparation and transfer. Through the synthesis of a reactive Ti(III) metallocene complex, we will demonstrate a new, simple...
08:18
Degassing Liquids with Freeze-Pump-Thaw Cycling
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2023
Source: Laboratory of Dr. Neil Branda — Simon Fraser University Degassing refers to the process by which dissolved gases are removed from a liquid. The presence of dissolved gases such as oxygen or carbon dioxide can impede chemical reactions that utilize sensitive reagents, interfere with spectroscopic measurements, or can induce unwanted bubble formation. A number of different techniques are available for degassing liquids; some of these include heating, ultrasonic agitation, chemical...
08:46
Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of Phosphorus(I)
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Cited by 4 •
2016
The synthesis of a triphosphenium bromide salt is described and its use as a P+ transfer agent is outlined by reactions with an N-heterocyclic carbene and an anionic bisphosphine, yielding an NHC-stabilized P(I) cation and a P(I) containing zwitterion, respectively.
FAQs
Evacuation lowers the amount of atmospheric gas and volatile material in a connected vessel, while backfilling restores an atmosphere of nitrogen or argon. Repeating these operations reduces residual oxygen and water more effectively than performing one cycle, creating cleaner conditions for air- and moisture-sensitive reagents, catalysts, and intermediates during synthesis.
Stopcocks control whether a reaction vessel connects to the vacuum side, the inert-gas side, or neither, allowing chemists to isolate and manipulate individual vessels. Flexible tubing provides the connection between the manifold and those vessels. Together, these components support controlled evacuation, backfilling, and transfers without exposing sensitive contents directly to laboratory air.
Atmospheric oxygen and water can contaminate air- and moisture-sensitive substances, while residual volatile material can interfere with controlled reaction conditions. Evacuation and inert-gas handling reduce these sources of variation. This is especially important when chemists work with reactive catalysts or intermediates, because cleaner conditions help maintain reproducibility and limit unwanted contamination.
The vacuum connection allows chemists to remove dissolved gases and volatile materials from solvents or other contents, while the inert-gas connection maintains a protected atmosphere afterward. The same controlled environment supports drying operations. These capabilities help prepare reaction media and substances for syntheses in which oxygen, moisture, or volatile contaminants could compromise the intended conditions.
A connected vessel is placed under the selected manifold connection, evacuated to remove atmospheric gases and volatile materials, and then backfilled with nitrogen or argon. Chemists may repeat this evacuation and backfilling sequence to improve exclusion of oxygen and water. Once protected, the vessel can support reagent transfer, solvent preparation, or a sensitive reaction.
Chemists use this approach when a synthesis requires controlled exclusion of air or moisture, particularly for air- and moisture-sensitive substances, reactive catalysts, or unstable intermediates. It is also useful for reagent transfer, solvent degassing, and drying. In organometallic and synthetic chemistry, the method helps preserve intended reaction conditions and improve experimental reproducibility.