Chippage Resistance
Chippage Resistance - Related Videos
02:45
Bacterial Growth on a Microfluidic Chip to Study Antibiotic Drug Resistance
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2025
Source: Liu, P. C., et al. Design and Use of a Low Cost, Automated Morbidostat for Adaptive Evolution of Bacteria Under Antibiotic Drug Selection. J. Vis. Exp. (2016)This video demonstrates the use of a microfluidic chip to visualize and compare the growth and morphology of wild-type and trimethoprim-resistant E. coli strains under trimethoprim antibiotic stress.
10:51
Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance
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Cited by 41 •
2017
This publication describes the fabrication of an organ-on-chip device with integrated electrodes for direct quantification of transendothelial electrical resistance (TEER). For validation, the blood-brain barrier was mimicked inside this microfluidic device and its barrier function was monitored. The presented methods for electrode integration and direct TEER quantification are generally applicable.
07:50
Chip-Based Digital PCR to Detect Rare Transcript Variants Using a Nanofluidic Chip
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2025
This video demonstrates chip-based digital PCR — a variation of the digital PCR technique that is useful in detecting rare transcript variants. The PCR reaction is partitioned into the chambers of a nanofluidic chip, each of which acts as an independent reaction. The detection of fluorescence signals from the chambers with amplified targets confirms the presence of rare transcript variants in the sample.
12:43
On-Chip Endothelial Inflammatory Phenotyping
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Cited by 3 •
2012
Microfluidic flow chambers etched by photolithography and fabricated from PDMS are applied to probe functional outcomes associated with EC dysfunction and inflammation. In a representative experiment, the ability of differential shear stress to modulate monocytic cell adhesion to cytokine activated EC monolayers is demonstrated.
01:35
Organ-on-Chip Models
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2026
Introduction to Organ-on-Chip Models Organ-on-chip models are advanced microphysiological systems that recreate key structural and functional features of human organs in a controlled laboratory setting. These devices integrate living human cells within microfluidic channels, allowing researchers to simulate tissue–tissue interfaces, fluid flow, and mechanical forces that are essential for normal organ function. Unlike traditional cell cultures, which often lack these dynamic physiological cues,...
FAQs
Microstructure affects how localized damage develops, while fracture toughness influences whether an initiated crack can propagate through the material. A structure that better limits crack growth can reduce the amount of material lost after impact or concentrated loading. Considering both properties helps engineers explain why materials with similar surface hardness may still show different resistance to edge or surface damage.
Hardness is one factor in chippage resistance, but it does not describe every feature governing localized fracture. Fracture toughness, microstructural characteristics, and residual stresses also affect crack initiation and propagation. For this reason, engineering comparisons should consider the combined material response rather than treating hardness as a complete measure of performance under contact or impact.
Residual stresses are internal stresses retained within a material and can influence how cracks initiate and propagate during concentrated loading. Their effect is therefore part of the material’s overall chippage response, alongside hardness, fracture toughness, and microstructure. Including residual stress in material assessment gives engineers a more complete basis for interpreting localized fracture and material loss.
Engineers evaluate chippage resistance by comparing how candidate materials respond to localized impact, contact, or concentrated loading, with attention to resulting fracture and material loss. The assessment can be applied to ceramics, coatings, cutting tools, and other components exposed to mechanical damage. Relating observed damage to microstructure, hardness, fracture toughness, and residual stresses supports meaningful material comparisons.
Ceramics, coatings, cutting tools, and other components subjected to repeated mechanical damage are important targets for improved chippage resistance. Limiting localized loss in these applications can help preserve dimensional accuracy and surface integrity. That preservation supports functional performance over longer service periods and can reduce the need for maintenance or replacement.
Testing can reveal how effectively a material withstands localized fracture and material loss under mechanically demanding conditions. Researchers can use the results to compare candidate materials and connect performance with microstructural design, hardness, fracture toughness, and residual stresses. These findings guide the development of more reliable components whose dimensions, surfaces, and functions remain usable for longer.