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JoVE Journal
Bioengineering
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On-Chip Endothelial Inflammatory Phenotyping
 

On-Chip Endothelial Inflammatory Phenotyping

Article DOI: 10.3791/4169
July 21st, 2012

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Summary July 21st, 2012

Microfluidic flow chambers etched by photolithography and fabricated from PDMS are applied to probe functional outcomes associated with EC dysfunction and inflammation. In a representative experiment, the ability of differential shear stress to modulate monocytic cell adhesion to cytokine activated EC monolayers is demonstrated.

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