Ventral Skull Incision
Ventral Skull Incision - Related Videos
08:30
A Method to Make a Craniotomy on the Ventral Skull of Neonate Rodents
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Cited by 6 •
2014
A surgical method is described to expose the ventral skull in neonate rats. Using this approach it is possible to open a craniotomy to perform acute electrophysiology and two-photon microscopy experiments in the brainstem of anesthetized pups.
05:13
Co-culturing of Ventral Hippocampal and Nucleus Accumbens
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2025
This video demonstrates the process of preparing ventral hippocampal and nucleus accumbens tissues from mouse brains for co-culture. Neurons extend projections to form synaptic connections between the ventral hippocampal and nucleus accumbens tissues. This method allows studying neuronal interactions between these two brain regions, offering insights into cognition, behavior, and neurological disorders.
05:47
Use of a Rat Model to Study Ventral Abdominal Hernia Repair
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Cited by 5 •
2017
This manuscript describes methods associated with creation and repair of a ventral abdominal wall defect (hernia). This model can be used to study repair strategies such as those that use implanted materials. In this manuscript, repair of the experimental hernia with porcine small intestinal submucosa is presented as an example.
01:22
Sutures of the Skull
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2025
The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures. Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
03:35
Cranial Ring Assembly Installation in Mouse Model: A Surgical Procedure to Implant Visualization Window Assembly on Murine Skull for High-resolution Skull Bone Marrow Imaging
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2025
In this video, we describe a surgical procedure to implant a cranial ring assembly on the exposed skull bone and further immobilize the mouse’s head for high-resolution brain imaging for a long duration.
FAQs
Controlled bone removal limits unnecessary disruption around the cranial base, where neural and vascular structures may be nearby. Maintaining this control helps preserve the anatomical relationships that researchers need to examine or manipulate. It also supports more consistent comparisons between specimens, especially when the study evaluates how localized surgical access influences anatomy, physiology, or experimental outcomes.
A ventral skull incision approaches tissues from the underside rather than the dorsal surface. This alternative becomes useful when conventional dorsal access does not adequately reach the target area or would be less suitable for the study design. The choice of approach therefore depends on the location of the tissue, the intended intervention, and the need to protect surrounding structures.
Specimen positioning, the location and extent of the incision, and consistent handling of the overlying tissue and bone all influence reproducibility. Researchers also need to maintain protection of adjacent neural and vascular structures. Standardizing these variables makes anatomical findings, sample collection, device placement, and assessments of post-manipulation effects easier to compare across experimental conditions.
The workflow begins by positioning the specimen to provide suitable access to the underside of the skull. Researchers then make a controlled incision through the overlying tissue, separate or remove the required bone, and proceed with the intended examination, collection, or intervention. Throughout the sequence, careful handling is necessary to preserve nearby neural and vascular anatomy.
Researchers may select this approach when they need localized access to tissues near the cranial base, particularly if dorsal access is unsuitable. The opening can support anatomical examination, collection of localized tissue samples, or placement of experimental devices. Its value depends on matching the access route to the target tissue while maintaining controlled surgical manipulation.
Within controlled laboratory environments, a standardized ventral skull incision provides a consistent way to study how surgical manipulation affects anatomy, physiology, and experimental outcomes. Researchers can compare specimens exposed to similar access conditions and then evaluate tissue findings, collected samples, or device-related effects. This creates a clearer link between the intervention and the observed biological response.