C. Elegans Genome
C. Elegans Genome - Related Videos
11:34
Basic Caenorhabditis elegans Methods: Synchronization and Observation
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Cited by 452 •
2012
The easiness of maintaining and propagating the nematode C. elegans make it a nice model organism to work with. The possibility of synchronizing worms allows the work with a significant amount of subjects at the same developmental stage, what facilitates the study of one particular process in many animals.
09:51
RNAi in C. elegans
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2023
RNA interference (RNAi) is a widely used technique in which double stranded RNA is exogenously introduced into an organism, causing knockdown of a target gene. In the nematode, C. elegans, RNAi is particularly easy and effective because it can be delivered simply by feeding the worms bacteria that express double stranded RNA (dsRNA) that is complementary to a gene of interest. First, this video will introduce the concept of RNA interference and explain how it causes targeted gene knockdown.
10:54
C. elegans Maintenance
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2023
Ceanorhabditis elegans has been, and is still, used to great success as a model organism for studying a variety of developmental, genetic, molecular and even physical phenomena. In order to use C. elegans to its full potential, proper care and attention to the basic maintenance of this powerful organism is essential. In this video you will learn the basic housing and feeding requirements of C. elegans, how to correctly handle and manipulate worms using a worm pick and how to freeze and recover...
09:13
An Introduction to Caenorhabditis elegans
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2023
Caenorhabditis elegans is a microscopic, soil-dwelling roundworm that has been powerfully used as a model organism since the early 1970’s. It was initially proposed as a model for developmental biology because of its invariant body plan, ease of genetic manipulation and low cost of maintenance. Since then C. elegans has rapidly grown in popularity and is now utilized in numerous research endeavors, from studying the forces at work during locomotion to studies of neural circuitry. This video...
06:40
Small-Scale Extraction of Caenorhabditis elegans Genomic DNA
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Cited by 3 •
2022
Presented here is a description of the straightforward and relatively rapid isolation of Caenorhabditis elegans genomic DNA from one or a few animals using a commercially available tissue kit. The resulting gDNA preparation is a suitable template for PCR.
FAQs
Its nuclear DNA is arranged primarily across six chromosomes, alongside a mitochondrial genome. This organization gives researchers distinct genomic units to examine when relating sequence differences to biological traits. Considering both chromosome-based and mitochondrial DNA helps frame experiments that investigate heredity, gene function, and the genetic basis of development, physiology, or reproduction.
Mutations provide evidence by creating a DNA change that can be associated with an observable trait. If the altered organism differs in development, physiology, or reproduction, researchers can use that relationship to infer a gene’s contribution to the phenotype. Manipulating gene activity offers a complementary way to test whether changing that gene produces corresponding biological effects.
Linking a mutation or altered gene activity to an observable trait can reveal more than the role of one gene. The result may show how that gene participates in a conserved biological pathway, interacts genetically with other genes, or contributes to regulation of gene activity. These relationships help explain coordinated effects on development, physiology, reproduction, or other studied processes.
Researchers can begin with a genetic difference, such as a mutation, or with altered gene activity, then examine the resulting observable traits. The central analysis relates the genomic change to outcomes in development, physiology, or reproduction. This workflow turns phenotype patterns into evidence for gene function, genetic interactions, and regulatory mechanisms.
Its well-annotated sequence and experimental accessibility make it useful for investigating disease-related genes. Researchers can connect gene activity or mutations to observable outcomes and place those findings within conserved biological pathways. The approach helps clarify gene function and pathway behavior in an experimentally accessible genetic system, rather than relying on sequence information alone.
The system is particularly useful for questions involving development, aging, neurobiology, and reproduction, as well as disease-related genes. Its compact, well-annotated sequence supports focused analysis of gene function, while observable traits help connect genetic changes with biological outcomes. These features also support studies of conserved pathways and interactions across several areas of genetics.