Aortic Stiffness
Aortic Stiffness - Related Videos
10:08
Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound
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Cited by 10 •
2014
We describe a technique for measuring aortic stiffness from its pressure-diameter relationship in vivo in mice. Aortic diameter is recorded by ultrasound and aortic pressure is measured invasively with a solid-state pressure catheter. Blood pressure is changed incrementally and the resulting diameter is measured.
12:17
Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
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Cited by 4 •
2017
Full-root aortic valve replacement by stentless aortic xenograft is a viable option in patients with small aortic roots. We describe, a technique for the full-root implantation of stentless aortic xenografts, with emphasis on the management of the proximal suture line and coronary anastomoses, and discuss its limitations and alternative options.
09:12
Aortic Ring Assay
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Cited by 42 •
2009
Angiogenesis, the sprouting of blood vessels from pre-existing vasculature, is associated with both natural and pathological processes. Here we demonstrate an aortic ring assay that allows angiogenic potentiators and inhibitors to be directly added to aortic rings in culture. Sprouting and neovessel outgrowth can be determined by inspecting the aortic rings over a period of 6-12 days.
07:45
Simple Polyacrylamide-based Multiwell Stiffness Assay for the Study of Stiffness-dependent Cell Responses
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Cited by 56 •
2015
Here, a method that enables quick, efficient, and inexpensive preparation of polyacrylamide gels in a multiwell plate format is described. The method does not require any specialized equipment and could be easily adopted by any research laboratory. It would be particularly useful in research focused on understanding stiffness-dependent cell responses.
10:35
Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy
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Cited by 26 •
2016
We present detailed protocols for isolation of aortas from mouse and measurement of their elastic modulus using atomic force microscopy.
FAQs
Elastin degradation removes elastic properties that help the aorta expand and recoil, while collagen accumulation changes the vessel wall toward a less compliant structure. Together, these remodeling processes reduce the aorta’s ability to accommodate blood ejected from the heart. The resulting mechanical change increases pulse-wave transmission and provides a structural basis for assessing vascular health and cardiovascular risk.
Persistent immune activation can promote vascular inflammation and impair endothelial function, processes that are relevant to vascular remodeling. In infection research, these changes help explain how inflammatory responses may connect infectious or immune activity with altered arterial behavior. Studying this relationship can clarify why inflammation is considered an important context when investigating cardiovascular consequences associated with infection.
Vascular inflammation and calcification represent disease-associated changes that can accompany alterations in the aortic wall. Inflammation may affect endothelial function and remodeling, whereas calcification contributes to the loss of normal arterial compliance. Considering both processes prevents aortic stiffness from being viewed as a purely age-related finding and supports investigation of multiple biological pathways affecting vascular health.
Carotid-femoral pulse wave velocity is a measurement used to assess aortic stiffness by evaluating pulse-wave transmission along a major arterial pathway. Greater transmission reflects altered arterial properties and can be examined alongside inflammatory or infection-related findings. This approach allows researchers to connect vascular measurements with cardiovascular risk and with biological changes associated with persistent immune activation.
Carotid-femoral pulse wave velocity provides a vascular measurement that can be compared with evidence of inflammation, immune activation, or infection-related changes. Its value in immunology research comes from linking arterial properties with vascular remodeling and endothelial impairment. This connection helps investigators examine whether inflammatory processes are associated with cardiovascular consequences rather than studying immune responses in isolation.
Repeated assessment of aortic stiffness can help researchers examine whether a potential intervention is associated with changes in vascular function or remodeling. In studies involving infection or inflammation, the measurement offers an outcome related to cardiovascular health, complementing investigations of immune activity. It can therefore help evaluate whether addressing disease-associated processes corresponds with improved arterial properties.