Autoimmune Kidney Disease
Autoimmune Kidney Disease - Related Videos
08:50
Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Cited by 25 •
2014
The degree of vascular dysfunction and contributing physiological mechanisms can be assessed in patients with chronic kidney disease by measuring brachial artery flow-mediated dilation, aortic pulse-wave velocity, and vascular endothelial cell protein expression.
09:23
Parasite Induced Genetically Driven Autoimmune Chagas Heart Disease in the Chicken Model
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Cited by 12 •
2012
The inoculation of Trypanosoma cruzi in fertile eggs prior to incubation renders the parasite kDNA minicircle integration in embryo cells genome. Crossbreeding reveals the vertical transfer of the mutations to progeny. The kDNA integrates into coding regions at several chromosomes and the chickens die with an inflammatory autoimmune heart disease.
01:25
Chronic Kidney Disease I: Introduction
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2025
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
08:47
Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
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Cited by 36 •
2016
This manuscript describes the methods for induction and scoring of the experimental autoimmune encephalomyelitis (EAE) model, together with the assessment of immune cell distribution and mRNA cytokine levels in lymph nodes, spleen, blood and spinal cord using flow cytometry and quantitative PCR, respectively, at various disease phases.
10:38
Induction of Experimental Autoimmune Hypophysitis in SJL Mice
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Cited by 4 •
2010
This video shows how to induce autoimmune hypophysitis in SJL mice and how to assess its severity by histopathology.
FAQs
These mechanisms represent distinct routes to kidney inflammation. Autoantibodies can recognize kidney-related targets, immune complexes can deposit within filtering structures, and immune cells can directly promote inflammatory injury. Although the initiating events differ, each pathway can disrupt glomerular filtration. Distinguishing these mechanisms helps immunology researchers analyze how immune tolerance fails and how tissue damage develops.
Glomeruli contain the filtration structures that separate circulating material from the urine-forming fluid. Inflammation affecting these sites can impair filtration and allow protein or blood to appear in urine. The resulting findings connect microscopic immune activity with measurable kidney dysfunction, making glomerular injury an important link between immune mechanisms, clinical assessment, and progressive renal damage.
The diseases provide models for comparing harmful immune responses directed toward self with injury associated with infection. This distinction matters because inflammation alone does not identify its cause. Studying immune tolerance, autoantibodies, immune complexes, and immune-cell activity in this context helps researchers examine why host defenses become misdirected and how protective immunity might be preserved.
Two important outcome categories are urinary abnormalities and kidney performance. Protein or blood in the urine can indicate disruption of glomerular filtration, while reduced kidney function signals a broader loss of renal performance. Considering both provides more information than either finding alone, because one reflects filtration-barrier injury and the other reflects functional consequence.
These models allow researchers to investigate failures of immune tolerance, the inflammatory processes that damage kidney tissue, and the relationship between immune targeting and organ function. They also support comparisons between autoimmune responses and infection-related injury. This combination makes the kidney a useful setting for connecting cellular immune events with measurable tissue and filtration outcomes.
Treatment aims to control the immune activity that damages renal tissue without eliminating essential host defense. This balance is central to immunology because suppressing harmful immunity may reduce inflammation and protect filtration, whereas excessive interference with protective responses could compromise the body's ability to respond to infection. The goal therefore combines renal protection with preservation of defense.