Pdgfr-beta Perivascular
Pdgfr-beta Perivascular - Related Videos
07:05
Use of Human Perivascular Stem Cells for Bone Regeneration
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Cited by 42 •
2012
Human perivascular stem cells (PSCs) are a novel stem cell class for skeletal tissue regeneration similar to mesenchymal stem cells (MSCs). PSCs can be isolated by FACS (fluorescence activated cell sorting) from adipose tissue procured during standard liposuction procedures, then combined with an osteoinductive scaffold to achieve bone formation in vivo.
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A Novel Clinical Grade Isolation Method for Human Kidney Perivascular Stromal Cells
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Cited by 4 •
2017
Here we present a novel clinical grade isolation and culture method for kidney Perivascular Stromal Cells (kPSCs) based on whole organ perfusion with digestive enzymes and NG2-cell enrichment. With this method, it is possible to acquire sufficient cell numbers for cellular therapy.
08:15
Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue
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Cited by 7 •
2016
Human cardiac tissue harbours multipotent perivascular precursor cell populations that may be suitable for myocardial regeneration. The technique described here allows for the simultaneous isolation and purification of two multipotent stromal cell populations associated with native blood vessels, i.e. CD146+CD34- pericytes and CD34+CD146- adventitial cells, from the human myocardium.
01:25
Beta
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2024
Beta is a crucial metric in finance used to assess an investment's risk and expected return relative to the overall market. It is calculated as the slope of the line in a scatterplot that compares the returns of an individual stock to the returns of the market benchmark, typically represented by a broad market index. Beta quantifies how much a stock's price moves in response to market movements, providing insight into its volatility and systematic risk. A beta of one indicates that the stock's...
01:23
Magnetic Resonance Imaging of Perivascular Spaces in the Human Brain During a Small Vessel Stroke
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2025
Perivascular spaces (PVS) are fluid-filled spaces around the brain blood vessels involved in fluid drainage.To examine alterations in PVS during a small vessel stroke, perform magnetic resonance imaging (MRI) of the basal ganglia region in the patient’s brain.The imaging protocol includes the T2-weighted fast spin echo and fluid-attenuated inversion recovery (FLAIR) sequences.T2-weighted imaging enhances the contrast between cerebrospinal fluid (CSF)-filled PVS and surrounding tissue.FLAIR...
FAQs
Binding of PDGF ligands to PDGFR-beta activates intracellular signaling that can support cell survival, proliferation, and migration. These responses occur near endothelial cells and the extracellular matrix, so receptor activity can influence how perivascular cells are maintained, positioned, and integrated into the vessel wall environment.
Interactions with endothelial cells and the surrounding extracellular matrix connect perivascular-cell behavior to vessel organization. These contacts help explain why changes in PDGFR-beta populations may affect more than the cells themselves: altered cellular positioning or activity can be associated with changes in vascular stability, remodeling, and barrier function during tissue stress.
PDGFR-beta expression can serve as more than a positional feature: it helps distinguish a perivascular population while also pointing to a receptor-linked signaling system. This distinction matters when interpreting tissue changes, because researchers can consider both where these cells occur and how receptor-associated functions relate to vascular organization and homeostasis.
Characterization can link receptor-expressing cells to their position around vessels and to nearby endothelial and extracellular-matrix relationships. Researchers can then examine how those populations correspond with vessel stability, remodeling, barrier function, and immune-cell movement in inflamed or infected tissue. This approach connects cellular identity with vascular and immune outcomes.
Their location and interactions with vessel-associated structures provide context for studying immune-cell movement through tissues. Investigators can ask whether changes in PDGFR-beta perivascular populations coincide with altered barrier function or vascular remodeling during inflammation or infection. This analysis helps connect microvascular changes with tissue-level immune behavior.
Inflammation and infection can alter the microvasculature, making these cells useful for examining how vascular organization and homeostasis change under disease-related conditions. Studying their receptor expression, positioning, and relationships with endothelial cells may clarify mechanisms associated with instability, remodeling, or barrier disruption and may identify targets for understanding vascular dysfunction.