High-resolution Ultrasound
High-resolution Ultrasound - Related Videos
10:36
Ultrasound Localization Microscopy for Super-Resolution Mapping of the Rodent Brain Microvasculature
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2025
Ultrasound Localization Microscopy (ULM) is a recently developed technique that allows for an unprecedented level of resolution in imaging the microvasculature in vivo. In this work, we describe in detail how to obtain super-resolved images of the brain microvasculature in rodents using a standardized functional ultrasound imaging platform designed for preclinical research.
10:53
A Novel Application of Musculoskeletal Ultrasound Imaging
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Cited by 14 •
2013
We describe a new ultrasound-based vector tissue Doppler imaging technique to measure muscle contraction velocity, strain and strain rate with sub-millisecond temporal resolution during dynamic activities. This approach provides complementary measurements of dynamic muscle function and could lead to a better understanding of mechanisms underlying musculoskeletal disorders.
07:12
Diagnostic Ultrasound Imaging of Mouse Diaphragm Function
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Cited by 7 •
2014
Diagnostic ultrasound imaging has proven to be effective in diagnosing various respiratory diseases in human and animal subjects. We demonstrate a comprehensive ultrasound protocol utilized by Dr. Zuo's lab to analyze diaphragm kinetics specifically in mouse models. This is also a non-invasive research technique which can provide quantitative information on mouse respiratory muscle function.
08:31
Three-dimensional Optical-resolution Photoacoustic Microscopy
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Cited by 27 •
2011
Optical-resolution photoacoustic microscopy (OR-PAM) is an emerging technology capable of imaging optical absorption contrasts in vivo with cellular resolution and sensitivity. Here, we provide a visualized instruction on the experimental protocols of OR-PAM, including system configuration, system alignment, typical in vivo experimental procedures, and functional imaging schemes.
14:20
High-frequency Ultrasound Imaging of the Abdominal Aorta
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2023
Source: Amelia R. Adelsperger, Evan H. Phillips, and Craig J. Goergen, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana High-frequency ultrasound systems are used to acquire high resolution images. Here, the use of a state-of-the-art system will be demonstrated to image the morphology and hemodynamics of small pulsatile arteries and veins found in mice and rats. Ultrasound is a relatively inexpensive, portable, and versatile method for the noninvasive...
FAQs
The main trade-off is between spatial resolution and penetration. Higher-frequency sound waves distinguish smaller or more closely spaced structures, producing finer detail, but they do not reach as deeply into the body. Consequently, high-resolution ultrasound is most informative when the target lies relatively close to the surface, while deeper structures may require a different imaging approach.
The piezoelectric transducer performs both transmission and reception. It converts electrical pulses into sound waves, then detects returning echoes generated at tissue interfaces. The imaging system uses the timing and intensity of those echoes to calculate where interfaces occur and how strongly they reflect sound, creating a visual representation of tissue structure.
Doppler methods add information about blood flow to the structural detail provided by grayscale imaging. This makes it possible to assess vessels and vascular behavior alongside surrounding tissues, rather than viewing anatomy alone. In medicine, that combined information can support diagnosis, procedural guidance, treatment planning, and follow-up assessment.
This technique is particularly useful for structures that can be examined near the body surface, including superficial organs, blood vessels, muscles, tendons, nerves, skin, and small lesions. Its detailed, real-time views help clinicians evaluate these targets during clinical assessment, especially when identifying localized structural abnormalities is important.
High-resolution ultrasound can support assessment of tissue structure, small lesions, and vascular findings across several anatomical targets. Depending on the region examined, clinicians may evaluate muscles, tendons, nerves, skin, superficial organs, or blood vessels. The resulting information contributes to diagnosis and can also help determine how a condition should be managed.
Its real-time imaging supports more than diagnostic assessment. High-resolution ultrasound can guide procedures, contribute to treatment planning, and provide longitudinal monitoring, allowing findings to be evaluated over time. Because the method does not use ionizing radiation, it is valuable when clinical care requires repeated imaging to assess change or response.