Implant Fixation
Implant Fixation - Related Videos
02:34
Mouse Headpost Implantation: A Method for Head Fixation in Rodents
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2023
This video shows a headpost implantation surgery in murine model. The headpost is used not only to head-fix and therefore restrain the mouse during experimentation, but also to securely attach a head device in freely moving animals.
07:51
Acrylic Resin Molding Based Head Fixation Technique in Rodents
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Cited by 4 •
2016
Traditional head fixation techniques have used metallic frames attached on the skull as an interface for head fixation apparatus. This protocol demonstrates a frameless, acrylic resin molding based head fixation technique for behavioral tasks in rodents.
08:53
Whole Animal Perfusion Fixation for Rodents
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Cited by 562 •
2012
Here we describe a low-cost, rapid, controlled and uniform fixation procedure using 4% paraformaldehyde perfused via the vascular system: through the heart of the rat to obtain the best possible preservation of the brain.
01:03
Fixation and Sectioning
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2023
Two basic types of preparation are used to visualize specimens with a light microscope: wet mounts and fixed specimens. The simplest type of preparation is the wet mount, in which the specimen is placed in a drop of liquid on the slide. A liquid specimen can be directly deposited on the slide using a dropper. Solid specimens, such as skin scraping, can be placed on the slide before adding a drop of liquid to prepare the wet mount. Sometimes the liquid is simply water, but stains are often added...
10:21
Protocol for HER2 FISH Using a Non-cross-linking, Formalin-free Tissue Fixative to Combine Advantages of Cryo-preservation and Formalin Fixation
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Cited by 3 •
2017
Fluorescence in-situ hybridization (FISH) is often required in combination with histopathology and molecular diagnostics for selection of therapy in personalized medicine. A novel non-cross-linking, formalin-free tissue fixative that allows high quality morphologic, molecular and FISH analyses from the same specimen by addition of a post-fixation step before FISH is presented.
FAQs
These approaches use distinct stabilizing strategies. Bone cement secures an implant through cement, press-fit fixation depends on the implant’s insertion, screws provide fixation for hardware, and biological integration depends on bone growing directly onto or into a textured surface. Comparing them helps guide implant design and placement for reconstruction.
Micromotion is important because excessive movement at the implant interface can contribute to loosening or failure. Adequate fixation limits this movement while helping the implant remain stable and aligned during physiological loading. This relationship explains why fixation quality is central to maintaining function in joint and skeletal reconstruction.
Textured surfaces create the setting for biological integration by allowing bone to grow directly onto or into the implant. This differs from fixation that depends primarily on cement, insertion, or screws, because the stabilizing relationship develops through the bone-implant interface. Surface design is therefore a focus of research seeking improved integration.
Physiological loads test whether fixation can preserve stability, alignment, and function after implantation. Fixation principles therefore influence both implant design and placement, especially where a device supports a reconstructed joint or skeleton. A suitable strategy must address the loads experienced by the implant while limiting micromotion associated with loosening or failure.
Implant fixation principles apply across joint replacements, fracture-fixation devices, dental implants, and other medical hardware. Depending on the device and reconstruction, fixation may involve cement, press-fit insertion, screws, or biological integration. Across these settings, the intended outcome is a stable device that supports reconstructed anatomy and permits early function.
Current research focuses on two linked goals: developing more durable materials and improving bone-implant integration. These priorities address the need for fixation to remain functional under physiological loads and to maintain a stable interface. They are relevant not only to orthopedic reconstruction but also to dental implants and other implanted medical hardware.