Lumbar Instability

Lumbar instability is excessive or poorly controlled movement between lumbar spinal segments that can impair mechanical function and contribute to low-back pain. Stability normally depends on coordinated support from the vertebrae, discs, facet joints, ligaments, and trunk muscles; degeneration, injury, or altered neuromuscular control can disrupt load sharing and permit abnormal translation or rotation during movement. In medicine, clinicians evaluate suspected instability through patient history, physical examination, movement patterns, and imaging when appropriate, using the findings to guide exercise-based rehabilitation, activity modification, or surgical consideration. Understanding this condition helps distinguish mechanical sources of pain and supports individualized management, although its clinical definition and relationship to symptoms may vary.

Lumbar Instability - Related Videos

Research

JoVE EoE - Rodent Models

Surgical Induction of Lumbar Spine Instability in Mouse Model: A Surgical Procedure for the Resection of the Lumbar Spinous Processes and Connected Ligaments in Murine Model

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2025

In this video, we describe the surgical procedure to induce lumbar spine instability in a mouse model by resecting the Lumbar L3 to L5 spinous process along with supraspinous and interspinous ligaments.

A Mouse Model of Lumbar Spine Instability

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Cited by 14 •

2021

We developed a lumbar intervertebral disc degeneration mouse model by resection of L3–L5 spinous processes along with supra- and inter-spinous ligaments and detachment of paraspinous muscles.

Multilevel Oblique Lumbar Interbody Fusion in Degenerative Lumbar Disc Disease with Instability

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2025

This protocol presents the operative technique of multilevel Oblique Lumbar Interbody Fusion (OLIF) in a step-by-step manner, elaborating on the critical steps for achieving optimal outcomes.

Education

JoVE Core - Cell Biology

Microtubule Instability

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2023

Microtubules are hollow cylindrical filaments having a diameter of approximately 25 nm and a length that varies from 200 nm to 25 μm. GTP-bound tubulin subunits form αβ-heterodimers for microtubule assembly. These core building blocks interact longitudinally, polymerizing into protofilaments. The protofilaments then interact with one another through lateral bonding forces to form stable cylindrical microtubules. These cylindrical filaments are dynamic as they undergo repeated assembly and...

Microtubule Instability

0 Views •

2021

Microtubules are hollow cylindrical filaments having a diameter of approximately 25 nm and a length that varies from 200 nm to 25 μm. GTP-bound tubulin subunits form αβ-heterodimers for microtubule assembly. These core building blocks interact longitudinally, polymerizing into protofilaments. The protofilaments then interact with one another through lateral bonding forces to form stable cylindrical microtubules. These cylindrical filaments are dynamic as they undergo repeated assembly and...

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