Snare Resection
Snare Resection - Related Videos
09:19
Analysis of SNARE-mediated Membrane Fusion Using an Enzymatic Cell Fusion Assay
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2012
We have developed a cell fusion assay that quantifies SNARE-mediated membrane fusion events by activated expression of β-galactosidase.
01:43
SNAREs and Membrane Fusion
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2023
Once a transport vesicle has recognized its target organelle, the vesicular membrane needs to fuse with the target membrane to unload the cargo. Transmembrane proteins called SNAREs present on organelle membranes and their vesicles, mediate vesicle fusion. SNAREs exist in pairs that symmetrically interact and catalyze the fusion of the lipid bilayers in vesicle and target organelle. v-SNARE in the vesicle membrane are single polypeptide chains that bind to a complementary t-SNARE, composed of 2...
03:58
Brain Tumor Resection in a Mouse Using a Minimally Invasive Resection System
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2025
Source: Alomari, S., et al. Implementation of Minimally Invasive Brain Tumor Resection in Rodents for High Viability Tissue Collection. J. Vis. Exp. (2022)This video demonstrates the use of a minimally invasive resection system (MIRS) to excise tumor tissue from an anesthetized mouse implanted with a tumor. The procedure involves securing the mouse onto a stereotactic frame, reopening the previous surgical site to access the brain, and inserting a specialized cannula that utilizes suction and a...
10:58
SNARE-mediated Fusion of Single Proteoliposomes with Tethered Supported Bilayers in a Microfluidic Flow Cell Monitored by Polarized TIRF Microscopy
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Cited by 8 •
2016
Here, we present a protocol to detect single, SNARE-mediated fusion events between liposomes and supported bilayers in microfluidic channels using polarized TIRFM, with single molecule sensitivity and ~15 msec time resolution. Lipid and soluble cargo release can be detected simultaneously. Liposome size, lipid diffusivity, and fusion pore properties are measured.
07:25
Open Surgical Resection of Cerebral Arteriovenous Malformations
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2025
Source: Rennert, R. C., et al. Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations. J. Vis. Exp. (2017).This video demonstrates the open surgical resection of a cerebral arteriovenous malformation (AVM) in a human brain. The procedure involves creating a bone flap, accessing the subarachnoid space, identifying and occluding feeding arteries and draining veins, and carefully removing the AVM. Intraoperative angiography confirms complete resection,...
FAQs
Cold snare resection cuts tissue without electrical energy, whereas hot snare resection combines mechanical cutting with electrocautery. The choice depends on lesion characteristics and bleeding risk. This distinction allows clinicians to tailor removal to the target lesion and the procedural circumstances rather than applying one approach universally.
Lesion characteristics help determine how the snare should be used and whether electrical energy is appropriate. A clinician selects the technique according to features of the targeted tissue and the anticipated bleeding risk. Careful matching of method to lesion supports effective removal while addressing safety considerations during gastrointestinal endoscopy.
In hot snare resection, electrocautery supplies electrical energy as the tightened wire loop severs the lesion. Its use distinguishes this approach from cold snare removal and is considered in relation to lesion characteristics and bleeding risk. The resulting specimen can still be retrieved for histopathological examination after excision.
The technique can remove a targeted superficial lesion while preserving the excised tissue for histopathological examination. Pathology can therefore contribute to diagnosis after the procedure, while the resection itself provides treatment by eliminating the lesion. This combined therapeutic and diagnostic role is important when evaluating polyps and other gastrointestinal lesions.
During gastrointestinal endoscopy, the clinician positions the wire loop around the lesion, encircles the target, and tightens the snare to sever the tissue. Depending on lesion characteristics and bleeding risk, the cut is made without electrical energy or with electrocautery. The removed tissue may then be retrieved for examination.
Snare resection is used for polyps and other superficial lesions that can be targeted endoscopically. Because it is minimally invasive, it can reduce the need for open surgery and support earlier intervention. Its clinical relevance is especially evident in managing lesions associated with colorectal neoplasia, where removal and tissue examination can occur together.