Cortical Injury
Cortical Injury - Related Videos
05:30
Controlled Cortical Impact Model for Traumatic Brain Injury
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Cited by 87 •
2014
Traumatic brain injuries (TBIs) remain a serious health problem. Using the controlled cortical impact surgery model, research on the effects of TBI and possible treatment methods may be performed.
05:27
Generating A Cortical Stab Injury in a Mouse Model to Induce Reactive Astrogliosis
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2025
This video demonstrates the cortical stab injury procedure in mice, involving skull exposure and brain lesion creation. It induces reactive astrogliosis, a neuroprotective response of astrocytes, to study CNS trauma, inflammation, and repair mechanisms.
05:01
Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury
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Cited by 20 •
2019
Here we describe a protocol for the induction of murine traumatic brain injury via an open-head controlled cortical impact.
11:04
Lateral Fluid Percussion: Model of Traumatic Brain Injury in Mice
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Cited by 125 •
2011
Lateral fluid percussion (LFP), an established model of traumatic brain injury in mice, is demonstrated. LFP fulfills three major criteria for animal models: validity, reliability and clinical relevance. The procedure, consisting of surgical craniotomy, fixation of hub followed by induction of injury, resulting in focal and diffuse injuries, is described.
11:25
Isolation and Culture of Mouse Cortical Astrocytes
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Cited by 460 •
2013
Astrocytes have been recognized to be versatile cells participating in fundamental biological processes that are essential for normal brain development and function, and central nervous system repair. Here we present a rapid procedure to obtain pure mouse astrocyte cultures to study the biology of this major class of central nervous system cells.
FAQs
The initial lesion can trigger secondary processes that extend functional disruption beyond the directly damaged tissue. Inflammation alters the local neural environment, excitotoxicity overstimulates neurons, and cerebral edema increases swelling within the brain. Studying these interacting mechanisms helps neuroscientists distinguish the primary injury from later changes that may influence neurological deficits and recovery.
Cortical regions contribute to different functions, including perception, movement, language, and memory. Damage in one location can therefore disrupt a different capability than damage elsewhere, while greater severity can produce broader or more pronounced impairment. Mapping lesion characteristics against behavioral outcomes allows researchers to connect specific cortical structures with observable changes in cognition and behavior.
Neuroplasticity refers to the brain’s capacity to reorganize functional relationships after damage. Following cortical injury, researchers examine whether altered neural activity and synaptic networks accompany improvement or persistent impairment. This work helps explain why recovery may vary between individuals and provides a scientific basis for evaluating rehabilitation strategies intended to support the return of function.
Researchers combine imaging, electrophysiology, animal models, and behavioral tests to examine cortical injury from complementary perspectives. Imaging helps characterize the lesion, electrophysiology assesses related neural activity, animal models support controlled investigation, and behavioral testing measures functional consequences. Using several approaches connects tissue damage and network changes with cognition or behavior rather than relying on one measurement alone.
Functional recovery is evaluated by relating changes in behavioral performance to evidence from imaging and electrophysiology. Behavioral tests reveal whether abilities affected by the lesion improve, remain impaired, or change over time, while neural measurements provide context for those outcomes. Together, these procedures help assess neuroplasticity and determine whether a rehabilitation strategy is associated with better function.
Animal models are useful when researchers need to investigate cortical damage and recovery under controlled experimental conditions. They can be combined with imaging, electrophysiology, and behavioral testing to examine how lesions affect neural activity and behavior. This integrated design supports evaluation of rehabilitation or neuroprotective strategies before their effects are interpreted in broader neuroscience research.