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JoVE Journal

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Lateral Fluid Percussion

Lateral Fluid Percussion: Model of Traumatic Brain Injury in Mice

Article DOI: 10.3791/3063
August 22nd, 2011


Summary August 22nd, 2011

Lateral fluid percussion (LFP), an established model of traumatic brain injury in mice, is demonstrated. LFP fulfills three major criteria for animal models: validity, reliability and clinical relevance. The procedure, consisting of surgical craniotomy, fixation of hub followed by induction of injury, resulting in focal and diffuse injuries, is described.

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