Model Human-likeness Grade

Model Human-likeness Grade is an evaluative measure of how closely a computational model reproduces human behavior, cognition, or neural responses, making it useful for assessing biological plausibility in neuroscience. Researchers derive the grade by comparing model outputs with human data collected during matched tasks, often examining similarities in behavioral choices, response patterns, or brain activity. This approach helps evaluate models of perception, learning, memory, and decision-making, while identifying where artificial systems capture or depart from human information processing. Higher human-likeness can support stronger hypotheses about neural mechanisms, although similarity alone does not establish that a model uses the same underlying biological processes.

Model Human-likeness Grade - Related Videos

Research

JoVE Journal - Behavior
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Perceptual and Category Processing of the Uncanny Valley Hypothesis' Dimension of Human Likeness: Some Methodological Issues

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Cited by 25 •

2013

Investigation of the Uncanny Valley Hypothesis and affective experience requires an understanding of the hypothesis' dimension of human likeness (DHL). This protocol allows representation of the DHL and examination of categorical perception. Use of the same stimuli and fMRI to distinguish brain regions responsive to physical and category change is illustrated.

Research

JoVE Journal - Medicine
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A Novel Clinical Grade Isolation Method for Human Kidney Perivascular Stromal Cells

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Cited by 4 •

2017

Here we present a novel clinical grade isolation and culture method for kidney Perivascular Stromal Cells (kPSCs) based on whole organ perfusion with digestive enzymes and NG2-cell enrichment. With this method, it is possible to acquire sufficient cell numbers for cellular therapy.

Research

JoVE Journal - Biology
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In Vivo Modeling of the Morbid Human Genome using Danio rerio

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Cited by 66 •

2013

Here, we present a systematic approach for developing physiologically relevant, sensitive and specific in vivo assays for interpreting variation in human pathology. Transient genetic manipulation via microinjection of WT and mutant human mRNA and morpholino (MO) antisense oligonucleotides harness the tractability of the developing zebrafish embryo to rapidly assay pathogenic mutations, especially, but not exclusively, in the context of human developmental disorders.

Research

JoVE Journal - Medicine
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Optimization of High Grade Glioma Cell Culture from Surgical Specimens for Use in Clinically Relevant Animal Models and 3D Immunochemistry

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Cited by 43 •

2014

Protocol for propagation of dissociated high grade glioma surgical specimens in serum-free neurosphere medium to select for cells with cancer stem cell phenotype. For specimens that fail to grow as neurospheres, an alternative protocol is suggested. A paraffin embedding technique for maintaining the 3D neurosphere architecture for immunocytochemistry is described.

Research

JoVE Journal - Cancer Research

Development of Mouse-Derived Organoid Lines from Fallopian Tube Epithelial Cells for High Grade Serous Ovarian Carcinoma Modeling

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2025

This protocol details the development of high-grade serous ovarian carcinoma (HGSOC) mouse models in vitro and in vivo. From the derivation of murine fallopian tube organoids, their genetic modification to recapitulate human HGSOC genetics, and their introduction in the ovarian bursa of syngeneic mice for in vivo development of tumors.

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