Steven Mennerick

Department of Psychiatry, Washington University School of Medicine

Affiliated withWashington University School of Medicine Washington University in St. Louis

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 14	2010
Publication title Cited by 14	2013

Other Publications

Article	Year
Contribution of presynaptic Na(+) channel inactivation to paired-pulse synaptic depression in cultured hippocampal neurons. Journal of neurophysiology\| PubMed ID: 11826057	2002
3beta -hydroxypregnane steroids are pregnenolone sulfate-like GABA(A) receptor antagonists. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 11978813	2002
Ethanol-induced death of postnatal hippocampal neurons. Neurobiology of disease\| PubMed ID: 12270700	2002
Feeding hungry neurons: astrocytes deliver food for thought. Neuron\| PubMed ID: 12546812	2003
Photoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain. The Journal of biological chemistry\| PubMed ID: 12560326	2003
Homeostatic effects of depolarization on Ca2+ influx, synaptic signaling, and survival. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12629186	2003
Impaired glial glutamate transport in a mouse tuberous sclerosis epilepsy model. Annals of neurology\| PubMed ID: 12891680	2003
Activation-dependent properties of pregnenolone sulfate inhibition of GABAA receptor-mediated current. The Journal of physiology\| PubMed ID: 12938673	2003
Neuroactive steroid interactions with voltage-dependent anion channels: lack of relationship to GABA(A) receptor modulation and anesthesia. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 14593090	2004
Neurosteroid analogues. 9. Conformationally constrained pregnanes: structure-activity studies of 13,24-cyclo-18,21-dinorcholane analogues of the GABA modulatory and anesthetic steroids (3alp... Journal of medicinal chemistry\| PubMed ID: 14640542	2003
Selective effects of potassium elevations on glutamate signaling and action potential conduction in hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 14715952	2004
Selective antagonism of 5alpha-reduced neurosteroid effects at GABA(A) receptors. Molecular pharmacology\| PubMed ID: 15102947	2004
Plastic elimination of functional glutamate release sites by depolarization. Neuron\| PubMed ID: 15134639	2004
Slow actions of neuroactive steroids at GABAA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15282269	2004
Calcium-stimulated adenylyl cyclases modulate ethanol-induced neurodegeneration in the neonatal brain. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15745964	2005
New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroids. Pain\| PubMed ID: 15777868	2005
Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (3alpha,5alpha)- and (3alpha,5beta)-3-hydrox... Journal of medicinal chemistry\| PubMed ID: 15828844	2005
Reluctant vesicles contribute to the total readily releasable pool in glutamatergic hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15829636	2005
Action potential fidelity during normal and epileptiform activity in paired soma-axon recordings from rat hippocampus. The Journal of physiology\| PubMed ID: 15890699	2005
Reluctant vesicles coaxed into the limelight. Neuron\| PubMed ID: 15944119	2005
An integrated functional genomics and metabolomics approach for defining poor prognosis in human neuroendocrine cancers. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15998737	2005
Neurosteroid access to the GABAA receptor. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16354918	2005
Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo. Neuron\| PubMed ID: 16364896	2005
Synaptic vesicles: turning reluctance into action. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry\| PubMed ID: 16394189	2006
Homeostatic regulation of glutamate release in response to depolarization. Molecular neurobiology\| PubMed ID: 16603793	2006
Physiological activity depresses synaptic function through an effect on vesicle priming. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16775150	2006
Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. Journal of medicinal chemistry\| PubMed ID: 16854065	2006
Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancers. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16895983	2006
A spontaneous tonic chloride conductance in solitary glutamatergic hippocampal neurons. Brain research\| PubMed ID: 16987500	2006
Action potential initiation and propagation in CA3 pyramidal axons. Journal of neurophysiology\| PubMed ID: 17314237	2007
Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light. Nature neuroscience\| PubMed ID: 17322875	2007
Neurosteroid analogues. 12. Potent enhancement of GABA-mediated chloride currents at GABAA receptors by ent-androgens. European journal of medicinal chemistry\| PubMed ID: 17434649	2008
Mechanisms of neurosteroid interactions with GABA(A) receptors. Pharmacology & therapeutics\| PubMed ID: 17524487	2007
Antagonism of neurosteroid modulation of native gamma-aminobutyric acid receptors by (3alpha,5alpha)-17-phenylandrost-16-en-3-ol. European journal of pharmacology\| PubMed ID: 17658511	2007
Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABA-A receptor potentiation. The Journal of physiology\| PubMed ID: 17761771	2007
Astrocyte membrane responses and potassium accumulation during neuronal activity. Hippocampus\| PubMed ID: 17853441	2007
Vesicle pool heterogeneity at hippocampal glutamate and GABA synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17855599	2007
Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopenta[b]phenanthrenes and cyclopenta[b]anthracenes. Journal of medicinal chemistry\| PubMed ID: 18275132	2008
Effects on membrane capacitance of steroids with antagonist properties at GABAA receptors. Biophysical journal\| PubMed ID: 18339741	2008
Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo. Neuron\| PubMed ID: 18400162	2008
A specific role for Ca2+-dependent adenylyl cyclases in recovery from adaptive presynaptic silencing. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18480272	2008
High threshold, proximal initiation, and slow conduction velocity of action potentials in dentate granule neuron mossy fibers. Journal of neurophysiology\| PubMed ID: 18480368	2008
Dimethyl sulfoxide (DMSO) produces widespread apoptosis in the developing central nervous system. Neurobiology of disease\| PubMed ID: 19100327	2009
NMDA potentiation by visible light in the presence of a fluorescent neurosteroid analogue. The Journal of physiology\| PubMed ID: 19403611	2009
Adenylyl cyclases 1 and 8 initiate a presynaptic homeostatic response to ethanol treatment. PloS one\| PubMed ID: 19479030	2009
The influence of the membrane on neurosteroid actions at GABA(A) receptors. Psychoneuroendocrinology\| PubMed ID: 19541427	2009
The influence of neuroactive steroid lipophilicity on GABAA receptor modulation: evidence for a low-affinity interaction. Journal of neurophysiology\| PubMed ID: 19553485	2009
Photodynamic effects of steroid-conjugated fluorophores on GABAA receptors. Molecular pharmacology\| PubMed ID: 19596835	2009
Axonal sodium channel distribution shapes the depolarized action potential threshold of dentate granule neurons. Hippocampus\| PubMed ID: 19603521	2010
Dynamic modulation of phasic and asynchronous glutamate release in hippocampal synapses. Journal of neurophysiology\| PubMed ID: 19889850	2010
Comparative effects of heterologous TRPV1 and TRPM8 expression in rat hippocampal neurons. PloS one\| PubMed ID: 19997638	2009
A synthetic 18-norsteroid distinguishes between two neuroactive steroid binding sites on GABAA receptors. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 20124410	2010
Diverse voltage-sensitive dyes modulate GABAA receptor function. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20181584	2010
The sticky issue of neurosteroids and GABA(A) receptors. Trends in neurosciences\| PubMed ID: 20409596	2010
Structurally diverse amphiphiles exhibit biphasic modulation of GABAA receptors: similarities and differences with neurosteroid actions. British journal of pharmacology\| PubMed ID: 20412070	2010
Rapid activation of dormant presynaptic terminals by phorbol esters. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20668189	2010
Kinetic and structural determinants for GABA-A receptor potentiation by neuroactive steroids. Current neuropharmacology\| PubMed ID: 20808543	2010
Neurosteroid analogues. 15. A comparative study of the anesthetic and GABAergic actions of alphaxalone, Î”16-alphaxalone and their corresponding 17-carbonitrile analogues. Bioorganic & medicinal chemistry letters\| PubMed ID: 20875742	2010
Differential effects of axon initial segment and somatodendritic GABAA receptors on excitability measures in rat dentate granule neurons. Journal of neurophysiology\| PubMed ID: 21068264	2011
Calcium-independent inhibitory G-protein signaling induces persistent presynaptic muting of hippocampal synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21248122	2011
Neurosteroid analogues. 16. A new explanation for the lack of anesthetic effects of Î´(16)-alphaxalone and identification of a Î´(17(20)) analogue with potent anesthetic activity. Journal of medicinal chemistry\| PubMed ID: 21504158	2011
Presynaptic silencing is an endogenous neuroprotectant during excitotoxic insults. Neurobiology of disease\| PubMed ID: 21605675	2011
Don't curse the darkness, light a candle: fluorescence studies of axon excitability. The Journal of physiology\| PubMed ID: 21885442	2011
Presynaptically Silent Synapses: Dormancy and Awakening of Presynaptic Vesicle Release. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry\| PubMed ID: 21908849	2011
Characteristics of Î±4/Î´-containing concatemeric GABA(A) receptors expressed in Xenopus oocytes. British journal of pharmacology\| PubMed ID: 21950777	2011
Excitotoxicity triggered by Neurobasal culture medium. PloS one\| PubMed ID: 21980512	2011
Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22058226	2011
Neurosteroid Analogues. 17. Inverted Binding Orientations of Androsterone Enantiomers at the Steroid Potentiation Site on Î³-Aminobutyric Acid Type A Receptors. Journal of medicinal chemistry\| PubMed ID: 22191644	2012
Crosstalk between synaptic receptors mediates NMDA-induced suppression of inhibition. Journal of neurophysiology\| PubMed ID: 22279196	2012