Christiana Ruhrberg

UCL Institute of Ophthalmology, University College London

Affiliated withUniversity College London UCL Institute of Ophthalmology

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 4	2014
Publication title Cited by 2	2018
Publication title Cited by 52	2018

Other Publications

Article	Year
Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis. Genes & development\| PubMed ID: 12381667	2002
Mutations in dynein link motor neuron degeneration to defects in retrograde transport. Science (New York, N.Y.)\| PubMed ID: 12730604	2003
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. The Journal of cell biology\| PubMed ID: 12810700	2003
Neuronal defects in the hindbrain of Hoxa1, Hoxb1 and Hoxb2 mutants reflect regulatory interactions among these Hox genes. Development (Cambridge, England)\| PubMed ID: 14522873	2003
Growing and shaping the vascular tree: multiple roles for VEGF. BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 14579246	2003
Mapping nucleolar and spliceosome localization sequences of neuregulin1-beta3. Experimental cell research\| PubMed ID: 15302578	2004
Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 15376331	2004
Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerve. Genes & development\| PubMed ID: 15545635	2004
Selective requirements for NRP1 ligands during neurovascular patterning. Development (Cambridge, England)\| PubMed ID: 17428830	2007
Role of the neuropilin ligands VEGF164 and SEMA3A in neuronal and vascular patterning in the mouse. Novartis Foundation symposium\| PubMed ID: 18300426	2007
Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells. Development (Cambridge, England)\| PubMed ID: 18356247	2008
Blood vessel maturation and response to vascular-disrupting therapy in single vascular endothelial growth factor-A isoform-producing tumors. Cancer research\| PubMed ID: 18381437	2008
Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration. Nature\| PubMed ID: 18449193	2008
Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development. Developmental biology\| PubMed ID: 18804103	2008
Neuropilin 1 signaling guides neural crest cells to coordinate pathway choice with cell specification. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19325129	2009
Neuropilin-mediated neural crest cell guidance is essential to organise sensory neurons into segmented dorsal root ganglia. Development (Cambridge, England)\| PubMed ID: 19386662	2009
Neuropilin ligands in vascular and neuronal patterning. Biochemical Society transactions\| PubMed ID: 19909252	2009
Neuropilin, you gotta let me know: should I stay or should I go? Cell adhesion & migration\| PubMed ID: 20026901	2010
Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction. Blood\| PubMed ID: 20404134	2010
A double agent in cancer: deciphering macrophage roles in human tumors. Nature medicine\| PubMed ID: 20689550	2010
VEGF receptor signaling in vertebrate development. Organogenesis\| PubMed ID: 20885856	2010
VEGF in the nervous system. Organogenesis\| PubMed ID: 20885857	2010
In the beginning: Generating neural crest cell diversity. Cell adhesion & migration\| PubMed ID: 20930541	2010
Defective gonadotropin-releasing hormone neuron migration in mice lacking SEMA3A signalling through NRP1 and NRP2: implications for the aetiology of hypogonadotropic hypogonadism. Human molecular genetics\| PubMed ID: 21059704	2011
Neural crest origin of olfactory ensheathing glia. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21078992	2010
Distinct macrophage phenotypes contribute to kidney injury and repair. Journal of the American Society of Nephrology : JASN\| PubMed ID: 21289217	2011
Robo1 regulates semaphorin signaling to guide the migration of cortical interneurons through the ventral forebrain. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21508241	2011
VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm. Neuron\| PubMed ID: 21658587	2011
VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vessels. Development (Cambridge, England)\| PubMed ID: 21828096	2011
Transcriptome analysis of embryonic mammary cells reveals insights into mammary lineage establishment. Breast cancer research : BCR\| PubMed ID: 21834968	2011
The cytoplasmic domain of neuropilin 1 is dispensable for angiogenesis, but promotes the spatial separation of retinal arteries and veins. Development (Cambridge, England)\| PubMed ID: 21852397	2011
The hormone of love attracts a partner for life. Developmental cell\| PubMed ID: 22014517	2011
Diverse roles for VEGF-A in the nervous system. Development (Cambridge, England)\| PubMed ID: 22434866	2012
Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation. Circulation research\| PubMed ID: 22723296	2012
NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system. Developmental biology\| PubMed ID: 22790009	2012
Emerging roles for semaphorins and VEGFs in synaptogenesis and synaptic plasticity. Cell adhesion & migration\| PubMed ID: 23076132	2012
NRP1 acts cell autonomously in endothelium to promote tip cell function during sprouting angiogenesis. Blood\| PubMed ID: 23315162	2013
Neuropilin signalling in vessels, neurons and tumours. Seminars in cell & developmental biology\| PubMed ID: 23319134	2013
The embryonic mouse hindbrain as a qualitative and quantitative model for studying the molecular and cellular mechanisms of angiogenesis. Nature protocols\| PubMed ID: 23424750	2013
Neurovascular development and links to disease. Cellular and molecular life sciences : CMLS\| PubMed ID: 23475065	2013
The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis. Developmental cell\| PubMed ID: 23639442	2013
The cytoplasmic domain of neuropilin-1 regulates focal adhesion turnover. FEBS letters\| PubMed ID: 24021649	2013
Vascularisation is not necessary for gut colonisation by enteric neural crest cells. Developmental biology\| PubMed ID: 24262984	2014
Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis. Development (Cambridge, England)\| PubMed ID: 24401374	2014
Neuropilin regulation of angiogenesis, arteriogenesis and vascular permeability. Microcirculation (New York, N.Y. : 1994)\| PubMed ID: 24521511	2014
Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. The Journal of experimental medicine\| PubMed ID: 24863063	2014
Neuropilin regulation of angiogenesis. Biochemical Society transactions\| PubMed ID: 25399580	2014
The mouse hindbrain: an in vivo model to analyze developmental angiogenesis. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 25468597	2015
VEGF189 binds NRP1 and is sufficient for VEGF/NRP1-dependent neuronal patterning in the developing brain. Development (Cambridge, England)\| PubMed ID: 25519242	2015
Neural crest cells in cardiovascular development. Current topics in developmental biology\| PubMed ID: 25662261	2015
Neural crest cell-derived VEGF promotes embryonic jaw extension. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25922531	2015
Altered proliferative ability of neuronal progenitors in PlexinA1 mutant mice. The Journal of comparative neurology\| PubMed ID: 25975775	2016
Dysfunctional SEMA3E signaling underlies gonadotropin-releasing hormone neuron deficiency in Kallmann syndrome. The Journal of clinical investigation\| PubMed ID: 25985275	2015
NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells. Cell reports\| PubMed ID: 26051942	2015
Neural crest-derived SEMA3C activates endothelial NRP1 for cardiac outflow tract septation. The Journal of clinical investigation\| PubMed ID: 26053665	2015
Suppression of β3-integrin in mice triggers a neuropilin-1-dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis. Disease models & mechanisms\| PubMed ID: 26159543	2015
Vascularisation of the central nervous system. Mechanisms of development\| PubMed ID: 26222953	2015
Macrophage-Induced Blood Vessels Guide Schwann Cell-Mediated Regeneration of Peripheral Nerves. Cell\| PubMed ID: 26279190	2015
The Embryonic Mouse Hindbrain and Postnatal Retina as In Vivo Models to Study Angiogenesis. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 26285754	2015
Myeloid-Derived Vascular Endothelial Growth Factor and Hypoxia-Inducible Factor Are Dispensable for Ocular Neovascularization--Brief Report. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 26603154	2016
NRP1 function and targeting in neurovascular development and eye disease. Progress in retinal and eye research\| PubMed ID: 26923176	2016
2- and 6-O-sulfated proteoglycans have distinct and complementary roles in cranial axon guidance and motor neuron migration. Development (Cambridge, England)\| PubMed ID: 27048738	2016
Neuropilin-1 mediates vascular permeability independently of vascular endothelial growth factor receptor-2 activation. Science signaling\| PubMed ID: 27117252	2016
Imatinib may be ABL to improve anti-angiogenic therapy. Molecular & cellular oncology\| PubMed ID: 27308396	2015
Regulation of embryonic neurogenesis by germinal zone vasculature. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27821771	2016
VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation. The Journal of experimental medicine\| PubMed ID: 28289053	2017
Genetic specification of left-right asymmetry in the diaphragm muscles and their motor innervation. eLife\| PubMed ID: 28639940	2017
VEGF-A and neuropilin 1 (NRP1) shape axon projections in the developing CNS via dual roles in neurons and blood vessels. Development (Cambridge, England)\| PubMed ID: 28676569	2017
Vascular-Derived Vegfa Promotes Cortical Interneuron Migration and Proximity to the Vasculature in the Developing Forebrain. Cerebral cortex (New York, N.Y. : 1991)\| PubMed ID: 29901792	2018