William T. Pu

Department of Cardiology, Boston Children's Hospital

Affiliated withBoston Children's Hospital Harvard University Harvard Medical School

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 16	2014
Publication title Cited by 10	2016

Other Publications

Article	Year
Structural characterization of the mouse Girk genes. Gene\| PubMed ID: 11891065	2002
NFAT transcription factors are critical survival factors that inhibit cardiomyocyte apoptosis during phenylephrine stimulation in vitro. Circulation research\| PubMed ID: 12663489	2003
Developmental changes in ventricular diastolic function correlate with changes in ventricular myoarchitecture in normal mouse embryos. Circulation research\| PubMed ID: 14551244	2003
GATA4 is a dosage-sensitive regulator of cardiac morphogenesis. Developmental biology\| PubMed ID: 15464586	2004
Morphogenesis of the right ventricle requires myocardial expression of Gata4. The Journal of clinical investigation\| PubMed ID: 15902305	2005
Transcription factor gata4 regulates cardiac BCL2 gene expression in vitro and in vivo. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 16469847	2006
Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase. Journal of cardiac failure\| PubMed ID: 16762803	2006
Overexpression of HAX-1 protects cardiac myocytes from apoptosis through caspase-9 inhibition. Circulation research\| PubMed ID: 16857965	2006
A multivariate approach for integrating genome-wide expression data and biological knowledge. Bioinformatics (Oxford, England)\| PubMed ID: 16877751	2006
Development of heart valves requires Gata4 expression in endothelial-derived cells. Development (Cambridge, England)\| PubMed ID: 16914500	2006
Gata4 is essential for the maintenance of jejunal-ileal identities in the adult mouse small intestine. Molecular and cellular biology\| PubMed ID: 16940177	2006
Gata4 is required for maintenance of postnatal cardiac function and protection from pressure overload-induced heart failure. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16983087	2006
Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects. Developmental biology\| PubMed ID: 17069789	2007
Uncoupling protein 2 modulates cell viability in adult rat cardiomyocytes. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 17468330	2007
Spectrum of heart disease associated with murine and human GATA4 mutation. Journal of molecular and cellular cardiology\| PubMed ID: 17643447	2007
Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nature medicine\| PubMed ID: 17660828	2007
Altered microRNA expression in human heart disease. Physiological genomics\| PubMed ID: 17712037	2007
Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature\| PubMed ID: 18568026	2008
GATA4 is a direct transcriptional activator of cyclin D2 and Cdk4 and is required for cardiomyocyte proliferation in anterior heart field-derived myocardium. Molecular and cellular biology\| PubMed ID: 18591257	2008
Nkx2-5- and Isl1-expressing cardiac progenitors contribute to proepicardium. Biochemical and biophysical research communications\| PubMed ID: 18722343	2008
More than a cover: epicardium as a novel source of cardiac progenitor cells. Regenerative medicine\| PubMed ID: 18729786	2008
Reassessment of Isl1 and Nkx2-5 cardiac fate maps using a Gata4-based reporter of Cre activity. Developmental biology\| PubMed ID: 18775691	2008
Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations. Circulation research\| PubMed ID: 18948621	2008
MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes. Molecular and cellular biology\| PubMed ID: 19188439	2009
Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. The Journal of clinical investigation\| PubMed ID: 19411759	2009
Identification of a cardiac disease modifier gene using forward genetics in the mouse. PLoS genetics\| PubMed ID: 19763163	2009
Inducible cardiomyocyte-specific gene disruption directed by the rat Tnnt2 promoter in the mouse. Genesis (New York, N.Y. : 2000)\| PubMed ID: 20014345	2010
Genetic fate mapping demonstrates contribution of epicardium-derived cells to the annulus fibrosis of the mammalian heart. Developmental biology\| PubMed ID: 20025864	2010
Heart failure-associated changes in RNA splicing of sarcomere genes. Circulation. Cardiovascular genetics\| PubMed ID: 20124440	2010
Expression and function of microRNAs in heart disease. Current drug targets\| PubMed ID: 20415651	2010
Dissecting spatio-temporal protein networks driving human heart development and related disorders. Molecular systems biology\| PubMed ID: 20571530	2010
Conditional Gata4 deletion in mice induces bile acid absorption in the proximal small intestine. Gut\| PubMed ID: 20581237	2010
Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death. Journal of molecular and cellular cardiology\| PubMed ID: 20708014	2010
Genome-wide location analysis by pull down of in vivo biotinylated transcription factors. Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.]\| PubMed ID: 20890903	2010
CompleteMOTIFs: DNA motif discovery platform for transcription factor binding experiments. Bioinformatics (Oxford, England)\| PubMed ID: 21183585	2011
Reprogramming fibroblasts into cardiomyocytes. The New England journal of medicine\| PubMed ID: 21226585	2011
Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology (Baltimore, Md.)\| PubMed ID: 21294146	2011
Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected] Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21330551	2011
A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. The Journal of clinical investigation\| PubMed ID: 21364285	2011
Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21415370	2011
Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. The Journal of clinical investigation\| PubMed ID: 21505261	2011
De novo cardiomyocytes from within the activated adult heart after injury. Nature\| PubMed ID: 21654746	2011
WT1 regulates epicardial epithelial to mesenchymal transition through β-catenin and retinoic acid signaling pathways. Developmental biology\| PubMed ID: 21663736	2011
Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21746915	2011
miR-155 inhibits expression of the MEF2A protein to repress skeletal muscle differentiation. The Journal of biological chemistry\| PubMed ID: 21868385	2011
Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes. Journal of molecular and cellular cardiology\| PubMed ID: 21907210	2012
Epicardial epithelial-to-mesenchymal transition in injured heart. Journal of cellular and molecular medicine\| PubMed ID: 21914126	2011
Adult cardiac-resident MSC-like stem cells with a proepicardial origin. Cell stem cell\| PubMed ID: 22136928	2011
Polycomb repressive complex 2 regulates normal development of the mouse heart. Circulation research\| PubMed ID: 22158708	2012
PRC2 directly methylates GATA4 and represses its transcriptional activity. Genes & development\| PubMed ID: 22215809	2012
Isolation and characterization of embryonic and adult epicardium and epicardium-derived cells. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22222530	2012
Transcription factor GATA4 is activated but not required for insulin-like growth factor 1 (IGF1)-induced cardiac hypertrophy. The Journal of biological chemistry\| PubMed ID: 22228770	2012
YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22308401	2012
CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy. Circulation research\| PubMed ID: 22343712	2012
Cardiac expression of ms1/STARS, a novel gene involved in cardiac development and disease, is regulated by GATA4. Molecular and cellular biology\| PubMed ID: 22431517	2012
Regulation of GATA4 transcriptional activity in cardiovascular development and disease. Current topics in developmental biology\| PubMed ID: 22449843	2012
Equal modulation of endothelial cell function by four distinct tissue-specific mesenchymal stem cells. Angiogenesis\| PubMed ID: 22527199	2012
Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo. PLoS genetics\| PubMed ID: 22589735	2012
Endocardial and epicardial epithelial to mesenchymal transitions in heart development and disease. Circulation research\| PubMed ID: 22679138	2012
Endostatin lowers blood pressure via nitric oxide and prevents hypertension associated with VEGF inhibition. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22733742	2012
Mature cardiomyocytes recall their progenitor experience via polycomb repressive complex 2. Circulation research\| PubMed ID: 22773425	2012
Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22904188	2012
Myocardial regeneration: expanding the repertoire of thymosin β4 in the ischemic heart. Annals of the New York Academy of Sciences\| PubMed ID: 23045976	2012
Genetic Cre-loxP assessment of epicardial cell fate using Wt1-driven Cre alleles. Circulation research\| PubMed ID: 23139287	2012
A dynamic H3K27ac signature identifies VEGFA-stimulated endothelial enhancers and requires EP300 activity. Genome research\| PubMed ID: 23547170	2013
Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization. Circulation\| PubMed ID: 23734001	2013
The mysterious origins of coronary vessels. Cell research\| PubMed ID: 23835479	2013
A simple method for deriving functional MSCs and applied for osteogenesis in 3D scaffolds. Scientific reports\| PubMed ID: 23873182	2013
HCN4 charges up the first heart field. Circulation research\| PubMed ID: 23908325	2013
Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24003143	2013
Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nature biotechnology\| PubMed ID: 24013197	2013
Developing insights into cardiac regeneration. Development (Cambridge, England)\| PubMed ID: 24046314	2013
WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal gland. Developmental cell\| PubMed ID: 24135228	2013
Peritruncal coronary endothelial cells contribute to proximal coronary artery stems and their aortic orifices in the mouse heart. PloS one\| PubMed ID: 24278332	2013
GATA factors promote ER integrity and β-cell survival and contribute to type 1 diabetes risk. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 24284823	2014
Hippo activation in arrhythmogenic cardiomyopathy. Circulation research\| PubMed ID: 24481838	2014
Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nature medicine\| PubMed ID: 24813252	2014
Yap1 is required for endothelial to mesenchymal transition of the atrioventricular cushion. The Journal of biological chemistry\| PubMed ID: 24831012	2014
Cardiac-Specific YAP Activation Improves Cardiac Function and Survival in an Experimental Murine MI Model. Circulation research\| PubMed ID: 24833660	2014
Notching up vascular regeneration. Cell research\| PubMed ID: 24853955	2014
Harnessing Hippo in the heart: Hippo/Yap signaling and applications to heart regeneration and rejuvenation. Stem cell research\| PubMed ID: 24881775	2014
Strategies for cardiac regeneration and repair. Science translational medicine\| PubMed ID: 24898748	2014
Vessel formation. De novo formation of a distinct coronary vascular population in neonatal heart. Science (New York, N.Y.)\| PubMed ID: 24994653	2014
Optimization of genome engineering approaches with the CRISPR/Cas9 system. PloS one\| PubMed ID: 25166277	2014
Dynamic GATA4 enhancers shape the chromatin landscape central to heart development and disease. Nature communications\| PubMed ID: 25249388	2014
Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival. Circulation research\| PubMed ID: 25249570	2015
Epicardium-to-fat transition in injured heart. Cell research\| PubMed ID: 25257468	2014
Insights into the genetic structure of congenital heart disease from human and murine studies on monogenic disorders. Cold Spring Harbor perspectives in medicine\| PubMed ID: 25274754	2014
Introduction to the special issue on heart regeneration and rejuvenation. Stem cell research\| PubMed ID: 25459518	2014
Releasing YAP from an α-catenin trap increases cardiomyocyte proliferation. Circulation research\| PubMed ID: 25552687	2015
Cellular origin and developmental program of coronary angiogenesis. Circulation research\| PubMed ID: 25634974	2015
Novel Roles of GATA4/6 in the Postnatal Heart Identified through Temporally Controlled, Cardiomyocyte-Specific Gene Inactivation by Adeno-Associated Virus Delivery of Cre Recombinase. PloS one\| PubMed ID: 26023924	2015
Trbp regulates heart function through microRNA-mediated Sox6 repression. Nature genetics\| PubMed ID: 26029872	2015
Contribution of Fetal, but Not Adult, Pulmonary Mesothelium to Mesenchymal Lineages in Lung Homeostasis and Fibrosis. American journal of respiratory cell and molecular biology\| PubMed ID: 26121126	2016
Nuclear receptor RORα regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26243880	2015
Regional differences in WT-1 and Tcf21 expression during ventricular development: implications for myocardial compaction. PloS one\| PubMed ID: 26390289	2015
SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth. Science signaling\| PubMed ID: 26396267	2015
Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. The Journal of clinical investigation\| PubMed ID: 26436652	2015
Recounting Cardiac Cellular Composition. Circulation research\| PubMed ID: 26846633	2016
Epicardium is required for cardiac seeding by yolk sac macrophages, precursors of resident macrophages of the adult heart. Developmental biology\| PubMed ID: 26988120	2016
Comprehensive analysis of promoter-proximal RNA polymerase II pausing across mammalian cell types. Genome biology\| PubMed ID: 27259512	2016
Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy. Cardiovascular research\| PubMed ID: 27557636	2016
Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth. Developmental cell\| PubMed ID: 27720608	2016
An IGF1R-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury. Circulation\| PubMed ID: 27803039	2016
Modeling Inherited Arrhythmia Disorders Using Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circulation journal : official journal of the Japanese Circulation Society\| PubMed ID: 27916777	2016
Efficient, footprint-free human iPSC genome editing by consolidation of Cas9/CRISPR and piggyBac technologies. Nature protocols\| PubMed ID: 27929521	2017