Thomas H. Gillingwater

Centre for integrative Physiology, University of Edinburgh

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 50	2014
Publication title Cited by 19	2019

Other Publications

Article	Year
Age-dependent synapse withdrawal at axotomised neuromuscular junctions in Wld(s) mutant and Ube4b/Nmnat transgenic mice. The Journal of physiology\| PubMed ID: 12231635	2002
Ultrastructural correlates of synapse withdrawal at axotomized neuromuscular junctions in mutant and transgenic mice expressing the Wld gene. Journal of anatomy\| PubMed ID: 14529044	2003
Neuroprotection after transient global cerebral ischemia in Wld(s) mutant mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 14688617	2004
The relationship of neuromuscular synapse elimination to synaptic degeneration and pathology: insights from WldS and other mutant mice. Journal of neurocytology\| PubMed ID: 15034273	2003
Axotomy-dependent and -independent synapse elimination in organ cultures of Wld(s) mutant mouse skeletal muscle. Journal of neuroscience research\| PubMed ID: 15048930	2004
Myo-GDNF increases non-functional polyinnervation of reinnervated mouse muscle. Neuroreport\| PubMed ID: 15106825	2004
Progressive abnormalities in skeletal muscle and neuromuscular junctions of transgenic mice expressing the Huntington's disease mutation. The European journal of neuroscience\| PubMed ID: 15579164	2004
The slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice. Brain : a journal of neurology\| PubMed ID: 15644421	2005
A rat model of slow Wallerian degeneration (WldS) with improved preservation of neuromuscular synapses. The European journal of neuroscience\| PubMed ID: 15654865	2005
Progressive loss of motor neuron function in wasted mice: effects of a spontaneous null mutation in the gene for the eEF1 A2 translation factor. Journal of neuropathology and experimental neurology\| PubMed ID: 15835265	2005
The neuroprotective WldS gene regulates expression of PTTG1 and erythroid differentiation regulator 1-like gene in mice and human cells. Human molecular genetics\| PubMed ID: 16403805	2006
Synaptic Ras GTPase activating protein regulates pattern formation in the trigeminal system of mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16452659	2006
Involvement of protein kinase A in patterning of the mouse somatosensory cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16707791	2006
Delayed synaptic degeneration in the CNS of Wlds mice after cortical lesion. Brain : a journal of neurology\| PubMed ID: 16738060	2006
Synaptic vulnerability in neurodegenerative disease. Journal of neuropathology and experimental neurology\| PubMed ID: 16896307	2006
Differential proteomics analysis of synaptic proteins identifies potential cellular targets and protein mediators of synaptic neuroprotection conferred by the slow Wallerian degeneration (Wl... Molecular & cellular proteomics : MCP\| PubMed ID: 17470424	2007
Design of a novel quantitative PCR (QPCR)-based protocol for genotyping mice carrying the neuroprotective Wallerian degeneration slow (Wlds) gene. Molecular neurodegeneration\| PubMed ID: 17971231	2007
Selective vulnerability of motor neurons and dissociation of pre- and post-synaptic pathology at the neuromuscular junction in mouse models of spinal muscular atrophy. Human molecular genetics\| PubMed ID: 18065780	2008
Synaptic changes in the thalamocortical system of cathepsin D-deficient mice: a model of human congenital neuronal ceroid-lipofuscinosis. Journal of neuropathology and experimental neurology\| PubMed ID: 18091563	2008
A neurological phenotype in mice with DNA repair gene Ercc1 deficiency. DNA repair\| PubMed ID: 18221731	2008
VAPB interacts with and modulates the activity of ATF6. Human molecular genetics\| PubMed ID: 18263603	2008
VCP binding influences intracellular distribution of the slow Wallerian degeneration protein, Wld(S). Molecular and cellular neurosciences\| PubMed ID: 18468455	2008
Rapid loss of motor nerve terminals following hypoxia-reperfusion injury occurs via mechanisms distinct from classic Wallerian degeneration. Journal of anatomy\| PubMed ID: 18510509	2008
Modified cell cycle status in a mouse model of altered neuronal vulnerability (slow Wallerian degeneration; Wlds). Genome biology\| PubMed ID: 18570652	2008
Identity, developmental restriction and reactivity of extralaminar cells capping mammalian neuromuscular junctions. Journal of cell science\| PubMed ID: 19001504	2008
mGluR5 regulates glutamate-dependent development of the mouse somatosensory cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19052194	2008
Loss of translation elongation factor (eEF1A2) expression in vivo differentiates between Wallerian degeneration and dying-back neuronal pathology. Journal of anatomy\| PubMed ID: 19094180	2008
The importance of exposure to human material in anatomical education: a philosophical perspective. Anatomical sciences education\| PubMed ID: 19109856	2008
Protein product of CLN6 gene responsible for variant late-onset infantile neuronal ceroid lipofuscinosis interacts with CRMP-2. Journal of neuroscience research\| PubMed ID: 19235893	2009
Transcriptional regulation of the AP-1 and Nrf2 target gene sulfiredoxin. Molecules and cells\| PubMed ID: 19326073	2009
Molecular correlates of axonal and synaptic pathology in mouse models of Batten disease. Human molecular genetics\| PubMed ID: 19640925	2009
Murine cathepsin D deficiency is associated with dysmyelination/myelin disruption and accumulation of cholesteryl esters in the brain. Journal of neurochemistry\| PubMed ID: 19845830	2010
Pre-symptomatic development of lower motor neuron connectivity in a mouse model of severe spinal muscular atrophy. Human molecular genetics\| PubMed ID: 19884170	2010
Expression of the neuroprotective slow Wallerian degeneration (WldS) gene in non-neuronal tissues. BMC neuroscience\| PubMed ID: 20015399	2009
Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy. PLoS genetics\| PubMed ID: 20019802	2009
Age-related motor neuron degeneration in DNA repair-deficient Ercc1 mice. Acta neuropathologica\| PubMed ID: 20602234	2010
SMN deficiency disrupts brain development in a mouse model of severe spinal muscular atrophy. Human molecular genetics\| PubMed ID: 20705736	2010
Synaptic protection in the brain of WldS mice occurs independently of age but is sensitive to gene-dose. PloS one\| PubMed ID: 21124744	2010
The response of neuromuscular junctions to injury is developmentally regulated. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 21228222	2011
Induction of cell stress in neurons from transgenic mice expressing yellow fluorescent protein: implications for neurodegeneration research. PloS one\| PubMed ID: 21408118	2011
ApoE isoform-specific regulation of regeneration in the peripheral nervous system. Human molecular genetics\| PubMed ID: 21478199	2011
The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy. Disease models & mechanisms\| PubMed ID: 21708901	2011
Targeting synaptic pathology in multiple sclerosis: fingolimod to the rescue? British journal of pharmacology\| PubMed ID: 21806598	2012
Reversible molecular pathology of skeletal muscle in spinal muscular atrophy. Human molecular genetics\| PubMed ID: 21840928	2011
Morphologic and functional correlates of synaptic pathology in the cathepsin D knockout mouse model of congenital neuronal ceroid lipofuscinosis. Journal of neuropathology and experimental neurology\| PubMed ID: 22082660	2011
Using induced pluripotent stem cells (iPSC) to model human neuromuscular connectivity: promise or reality? Journal of anatomy\| PubMed ID: 22133357	2012
Development of a supported self-directed learning approach for anatomy education. Anatomical sciences education\| PubMed ID: 22223487	2012
Altered maturation of the primary somatosensory cortex in a mouse model of fragile X syndrome. Human molecular genetics\| PubMed ID: 22328088	2012
WldS prevents axon degeneration through increased mitochondrial flux and enhanced mitochondrial Ca2+ buffering. Current biology : CB\| PubMed ID: 22425157	2012
Combining comparative proteomics and molecular genetics uncovers regulators of synaptic and axonal stability and degeneration in vivo. PLoS genetics\| PubMed ID: 22952455	2012
Spinal muscular atrophy: going beyond the motor neuron. Trends in molecular medicine\| PubMed ID: 23228902	2013
Morphological characteristics of motor neurons do not determine their relative susceptibility to degeneration in a mouse model of severe spinal muscular atrophy. PloS one\| PubMed ID: 23285108	2012
Quantitative tractography and tract shape modeling in amyotrophic lateral sclerosis. Journal of magnetic resonance imaging : JMRI\| PubMed ID: 23450730	2013
Effect of limb lengthening on internodal length and conduction velocity of peripheral nerve. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23467369	2013
Increasing SMN levels using the histone deacetylase inhibitor SAHA ameliorates defects in skeletal muscle microvasculature in a mouse model of severe spinal muscular atrophy. Neuroscience letters\| PubMed ID: 23583590	2013
Studying synapses in human brain with array tomography and electron microscopy. Nature protocols\| PubMed ID: 23787894	2013
Total protein analysis as a reliable loading control for quantitative fluorescent Western blotting. PloS one\| PubMed ID: 24023619	2013
Executive deficits, not processing speed relates to abnormalities in distinct prefrontal tracts in amyotrophic lateral sclerosis. Brain : a journal of neurology\| PubMed ID: 24056536	2013
Label-free proteomics identifies Calreticulin and GRP75/Mortalin as peripherally accessible protein biomarkers for spinal muscular atrophy. Genome medicine\| PubMed ID: 24134804	2013
SMN-dependent intrinsic defects in Schwann cells in mouse models of spinal muscular atrophy. Human molecular genetics\| PubMed ID: 24301677	2013
Morphological analysis of neuromuscular junction development and degeneration in rodent lumbrical muscles. Journal of neuroscience methods\| PubMed ID: 24530702	2014
Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy. The Journal of clinical investigation\| PubMed ID: 24590288	2014
The armadillo as a model for peripheral neuropathy in leprosy. ILAR journal / National Research Council, Institute of Laboratory Animal Resources\| PubMed ID: 24615444	2014
A novel mouse model of Warburg Micro Syndrome reveals roles for RAB18 in eye development and organisation of the neuronal cytoskeleton. Disease models & mechanisms\| PubMed ID: 24764192	2014
Increased levels of UCHL1 are a compensatory response to disrupted ubiquitin homeostasis in spinal muscular atrophy and do not represent a viable therapeutic target. Neuropathology and applied neurobiology\| PubMed ID: 25041530	2014
The influence of storage parameters on measurement of survival motor neuron (SMN) protein levels: Implications for pre-clinical studies and clinical trials for spinal muscular atrophy. Neuromuscular disorders : NMD\| PubMed ID: 25047670	2014
Label-free quantitative proteomic profiling identifies disruption of ubiquitin homeostasis as a key driver of schwann cell defects in spinal muscular atrophy. Journal of proteome research\| PubMed ID: 25151848	2014
Loss of glial neurofascin155 delays developmental synapse elimination at the neuromuscular junction. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25232125	2014
PTEN Depletion Decreases Disease Severity and Modestly Prolongs Survival in a Mouse Model of Spinal Muscular Atrophy. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 25369768	2014