Stephan M. Jakob

Department of Intensive Care Medicine, University and Bern University Hospital (Inselspital)

Affiliated withUniversity and Bern University Hospital (Inselspital)University of Bern

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 6	2014
Publication title Cited by 61	2017

Other Publications

Article	Year
ARDS. Monitoring tissue perfusion. Critical care clinics\| PubMed ID: 11910727	2002
Effect of dopamine-induced changes in splanchnic blood flow on MEGX production from lidocaine in septic and cardiac surgery patients. Shock (Augusta, Ga.)\| PubMed ID: 12095126	2002
Effects of dopamine on systemic and regional blood flow and metabolism in septic and cardiac surgery patients. Shock (Augusta, Ga.)\| PubMed ID: 12095139	2002
Splanchnic vasoregulation during mesenteric ischemia and reperfusion in pigs. Shock (Augusta, Ga.)\| PubMed ID: 12166777	2002
Acute normovolemic hemodilution improves oxygenation in ischemic flap tissue. Anesthesiology\| PubMed ID: 12170063	2002
Clinical review: splanchnic ischaemia. Critical care (London, England)\| PubMed ID: 12225604	2002
Splanchnic blood flow in low-flow states. Anesthesia and analgesia\| PubMed ID: 12651672	2003
Change in stroke volume in response to fluid challenge: assessment using esophageal Doppler. Intensive care medicine\| PubMed ID: 12684746	2003
Apparent heterogeneity of regional blood flow and metabolic changes within splanchnic tissues during experimental endotoxin shock. Anesthesia and analgesia\| PubMed ID: 12873953	2003
Changes in regional blood flow and pCO(2) gradients during isolated abdominal aortic blood flow reduction. Intensive care medicine\| PubMed ID: 13680116	2003
Diagnosis and management of electrolyte emergencies. Best practice & research. Clinical endocrinology & metabolism\| PubMed ID: 14687593	2003
Changes in splanchnic circulation during an alveolar recruitment maneuver in healthy porcine lungs. Anesthesia and analgesia\| PubMed ID: 15105226	2004
Measuring depth of sedation with auditory evoked potentials during controlled infusion of propofol and remifentanil in healthy volunteers. Anesthesia and analgesia\| PubMed ID: 15562062	2004
N100 auditory potential and electroencephalogram discriminate propofol-induced sedation levels. Journal of clinical monitoring and computing\| PubMed ID: 15562982	2004
Midlatency auditory-evoked potentials in the assessment of sedation in cardiac surgery patients. Journal of cardiothoracic and vascular anesthesia\| PubMed ID: 15578465	2004
Blindness in the intensive care unit. Anesthesia and analgesia\| PubMed ID: 15616076	2005
Blood pressure and vessel recanalization in the first hours after ischemic stroke. Stroke; a journal of cerebral circulation\| PubMed ID: 15637309	2005
Estimation of central venous pressure by ultrasound. Resuscitation\| PubMed ID: 15680529	2005
Hepatosplanchnic blood flow control and oxygen extraction are modified by the underlying mechanism of impaired perfusion. Critical care medicine\| PubMed ID: 15753759	2005
Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environment. Blood\| PubMed ID: 15827126	2005
Severe acute pancreatitis: case-oriented discussion of interdisciplinary management. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]\| PubMed ID: 15849485	2005
Comparison of continuous and intermittent renal replacement therapy for acute renal failure. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 15886217	2005
Preconditioning with monophosphoryl lipid A improves survival of critically ischemic tissue. Anesthesia and analgesia\| PubMed ID: 15920214	2005
Does fluid loading influence measurements of intestinal permeability? Critical care (London, England)\| PubMed ID: 15987395	2005
Reversible encephalopathy complicating post-streptococcal glomerulonephritis. The Pediatric infectious disease journal\| PubMed ID: 16395114	2006
Effects of low abdominal blood flow and dobutamine on blood flow distribution and on the hepatic arterial buffer response in anaesthetized pigs. Shock (Augusta, Ga.)\| PubMed ID: 16670644	2006
Decreasing gut wall glucose as an early marker of impaired intestinal perfusion. Critical care medicine\| PubMed ID: 16878039	2006
Effects of prolonged endotoxemia on liver, skeletal muscle and kidney mitochondrial function. Critical care (London, England)\| PubMed ID: 16895596	2006
Membrane microdialysis: Evaluation of a new method to assess splanchnic tissue metabolism. Critical care medicine\| PubMed ID: 16915109	2006
The effects of dexmedetomidine/remifentanil and midazolam/remifentanil on auditory-evoked potentials and electroencephalogram at light-to-moderate sedation levels in healthy subjects. Anesthesia and analgesia\| PubMed ID: 17056949	2006
Incidence of low central venous oxygen saturation during unplanned admissions in a multidisciplinary intensive care unit: an observational study. Critical care (London, England)\| PubMed ID: 17212816	2007
Effect of endotoxin, dobutamine and dopamine on muscle mitochondrial respiration in vitro. Journal of endotoxin research\| PubMed ID: 17254390	2006
Arterio-venous gradients of free energy change for assessment of systemic and splanchnic perfusion in cardiac surgery patients. Perfusion\| PubMed ID: 17312859	2006
Effects of vasopressin on microcirculatory blood flow in the gastrointestinal tract in anesthetized pigs in septic shock. Anesthesiology\| PubMed ID: 17525591	2007
Intraperitoneal microdialysis: critique of an editorial. Critical care medicine\| PubMed ID: 17581382	2007
Sedation and weaning from mechanical ventilation: effects of process optimization outside a clinical trial. Journal of critical care\| PubMed ID: 17869972	2007
Tonometry revisited: perfusion-related, metabolic, and respiratory components of gastric mucosal acidosis in acute cardiorespiratory failure. Shock (Augusta, Ga.)\| PubMed ID: 18004228	2008
Vasopressin in septic shock: effects on pancreatic, renal, and hepatic blood flow. Critical care (London, England)\| PubMed ID: 18078508	2007
Prevention of delayed cerebral vasospasm by continuous intrathecal infusion of glyceroltrinitrate and nimodipine in the rabbit model in vivo. Intensive care medicine\| PubMed ID: 18214428	2008
The immediate and sustained effects of volume challenge on regional blood flows in pigs. Anesthesia and analgesia\| PubMed ID: 18227321	2008
Development and simultaneous application of multiple care protocols in critical care: a multicenter feasibility study. Intensive care medicine\| PubMed ID: 18385977	2008
Orthogonal polarization spectroscopy to detect mesenteric hypoperfusion. Intensive care medicine\| PubMed ID: 18516589	2008
Thermodilution and esophageal Doppler ultrasound in the assessment of blood flow changes induced by endotoxin and dobutamine. The Journal of trauma\| PubMed ID: 18580513	2008
Norepinephrine to increase blood pressure in endotoxaemic pigs is associated with improved hepatic mitochondrial respiration. Critical care (London, England)\| PubMed ID: 18625036	2008
Dexmedetomidine versus propofol/midazolam for long-term sedation during mechanical ventilation. Intensive care medicine\| PubMed ID: 18795253	2009
Entropy and bispectral index for assessment of sedation, analgesia and the effects of unpleasant stimuli in critically ill patients: an observational study. Critical care (London, England)\| PubMed ID: 18796156	2008
Inverse thermodilution with conventional pulmonary artery catheters for the assessment of cerebral, hepatic, renal, and femoral blood flow. Shock (Augusta, Ga.)\| PubMed ID: 19033887	2009
Increased splanchnic oxygen extraction because of routine nursing procedures. Critical care medicine\| PubMed ID: 19114883	2009
Shedding light on microcirculation? Intensive care medicine\| PubMed ID: 19125231	2009
Arterial blood pressure during early sepsis and outcome. Intensive care medicine\| PubMed ID: 19189077	2009
Intra- and inter-individual variation of BIS-index and Entropy during controlled sedation with midazolam/remifentanil and dexmedetomidine/remifentanil in healthy volunteers: an interventiona... Critical care (London, England)\| PubMed ID: 19228415	2009
Assessment of splanchnic blood flow using magnetic resonance imaging. European journal of gastroenterology & hepatology\| PubMed ID: 19293721	2009
Different patterns of Siglec-9-mediated neutrophil death responses in septic shock. Shock (Augusta, Ga.)\| PubMed ID: 19295491	2009
Thromboelastometry for the assessment of coagulation abnormalities in early and established adult sepsis: a prospective cohort study. Critical care (London, England)\| PubMed ID: 19331653	2009
Norepinephrine-induced hypertension dilates vasospastic basilar artery after subarachnoid haemorrhage in rabbits. Acta neurochirurgica\| PubMed ID: 19343267	2009
Elevated level of endothelin-1 in cerebrospinal fluid and lack of nitric oxide in basilar arterial plasma associated with cerebral vasospasm after subarachnoid haemorrhage in rabbits. Acta neurochirurgica\| PubMed ID: 19415172	2009
Physical and occupational therapy during sedation stops. Lancet\| PubMed ID: 19446327	2009
Evaluation of physical and mental recovery status after elective liver resection. European journal of anaesthesiology\| PubMed ID: 19509504	2009
Septic shock resuscitation: what goals and how to achieve them? Critical care (London, England)\| PubMed ID: 19519939	2009
Peri-operative adrenocortical response to low-dose (1 microg) ACTH and relation to postoperative complications in patients undergoing elective abdominal surgery. Surgery\| PubMed ID: 19541014	2009
Effects of endotoxin and catecholamines on hepatic mitochondrial respiration. Inflammation\| PubMed ID: 19603262	2009
Treatment of acute renal failure in the intensive care unit: lower costs by intermittent dialysis than continuous venovenous hemodiafiltration. Artificial organs\| PubMed ID: 19624581	2009
Auditory event-related potentials, bispectral index, and entropy for the discrimination of different levels of sedation in intensive care unit patients. Anesthesia and analgesia\| PubMed ID: 19690250	2009
Hypoxia inducible factor-1 alpha induction by tumour necrosis factor-alpha, but not by toll-like receptor agonists, modulates cellular respiration in cultured human hepatocytes. Liver international : official journal of the International Association for the Study of the Liver\| PubMed ID: 19744167	2009
Usefulness of a clinical diagnosis of ICU-acquired paresis to predict outcome in patients with SIRS and acute respiratory failure. Intensive care medicine\| PubMed ID: 19760204	2010
Hemodynamic variables and mortality in cardiogenic shock: a retrospective cohort study. Critical care (London, England)\| PubMed ID: 19799772	2009
Effect of fluid resuscitation on mortality and organ function in experimental sepsis models. Critical care (London, England)\| PubMed ID: 19930656	2009
Perioperative metabolic changes in patients undergoing cardiac surgery. Nutrition (Burbank, Los Angeles County, Calif.)\| PubMed ID: 20053534	2010
The effects of mechanical ventilation on hepato-splanchnic perfusion. Current opinion in critical care\| PubMed ID: 20134320	2010
Effects of lung recruitment maneuvers on splanchnic organ perfusion during endotoxin-induced pulmonary arterial hypertension. Shock (Augusta, Ga.)\| PubMed ID: 20357696	2010
Splanchnic vasoregulation after major abdominal surgery in pigs. World journal of surgery\| PubMed ID: 20383500	2010
Physiologic response to changing positive end-expiratory pressure during neurally adjusted ventilatory assist in sedated, critically ill adults. Chest\| PubMed ID: 20435654	2010
500 ml of blood loss does not decrease non-invasive tissue oxygen saturation (StO2) as measured by near infrared spectroscopy - A hypothesis generating pilot study in healthy adult women. Journal of trauma management & outcomes\| PubMed ID: 20465822	2010
Effects of TLR agonists on the hypoxia-regulated transcription factor HIF-1alpha and dendritic cell maturation under normoxic conditions. PloS one\| PubMed ID: 20539755	2010
Pulse-pressure variation and hemodynamic response in patients with elevated pulmonary artery pressure: a clinical study. Critical care (London, England)\| PubMed ID: 20540730	2010
Pulse pressure variation and volume responsiveness during acutely increased pulmonary artery pressure: an experimental study. Critical care (London, England)\| PubMed ID: 20576099	2010
Increasing abdominal pressure with and without PEEP: effects on intra-peritoneal, intra-organ and intra-vascular pressures. BMC gastroenterology\| PubMed ID: 20598159	2010
Extra-intracranial blood shunt mimicking aneurysm rupture: intracranial-pressure-controlled rabbit subarachnoid hemorrhage model. Journal of neuroscience methods\| PubMed ID: 20624427	2010
Toll-like receptor-3-induced mitochondrial dysfunction in cultured human hepatocytes. Mitochondrion\| PubMed ID: 20691286	2011
Review article: improving outcome after major surgery: pathophysiological considerations. Anesthesia and analgesia\| PubMed ID: 20736438	2011
Brain herniation in a patient with apparently normal intracranial pressure: a case report. Journal of medical case reports\| PubMed ID: 20807427	2010
Does hypercapnic acidosis preserve mucosal oxygenation during hemorrhage? Shock (Augusta, Ga.)\| PubMed ID: 21079493	2010
Current approach to the haemodynamic management of septic shock patients in European intensive care units: a cross-sectional, self-reported questionnaire-based survey. European journal of anaesthesiology\| PubMed ID: 21088597	2011
Comparison of non-calibrated pulse-contour analysis with continuous thermodilution for cardiac output assessment in patients with induced hypothermia after cardiac arrest. Resuscitation\| PubMed ID: 21292380	2011
Comparison of porcine and human coagulation by thrombelastometry. Thrombosis research\| PubMed ID: 21492909	2011
CO(2)-Dependent vasomotor reactivity of cerebral arteries in patients with severe traumatic brain injury: time course and effect of augmentation of cardiac output with dobutamine. Journal of neurotrauma\| PubMed ID: 21501044	2012
Effects of catecholamines on hepatic and skeletal muscle mitochondrial respiration after prolonged exposure to faecal peritonitis in pigs. Innate immunity\| PubMed ID: 21525237	2012
Continuous intrathecal glyceryl trinitrate prevents delayed cerebral vasospasm in the single-SAH rabbit model in vivo. Acta neurochirurgica\| PubMed ID: 21671141	2011
Early non-invasive cardiac output monitoring in hemodynamically unstable intensive care patients: a multi-center randomized controlled trial. Critical care (London, England)\| PubMed ID: 21676229	2011
Dimethyloxalylglycine stabilizes HIF-1α in cultured human endothelial cells and increases random-pattern skin flap survival in vivo. Plastic and reconstructive surgery\| PubMed ID: 21788833	2011
Traumatic subarachnoid hemorrhage, basal ganglia hematoma and ischemic stroke caused by a torn lenticulostriate artery. Acta neurochirurgica\| PubMed ID: 21976234	2012
Postoperative splanchnic blood flow redistribution in response to fluid challenges in the presence and absence of endotoxemia in a porcine model. Shock (Augusta, Ga.)\| PubMed ID: 21993445	2012
Gastrointestinal function in intensive care patients: terminology, definitions and management. Recommendations of the ESICM Working Group on Abdominal Problems. Intensive care medicine\| PubMed ID: 22310869	2012
Cancer therapy modulates VEGF signaling and viability in adult rat cardiac microvascular endothelial cells and cardiomyocytes. Journal of molecular and cellular cardiology\| PubMed ID: 22326847	2012
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials. JAMA\| PubMed ID: 22436955	2012
Effects of cardiac preload reduction and dobutamine on hepatosplanchnic blood flow regulation in porcine endotoxemia. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 22556139	2012
A new rabbit model for the study of early brain injury after subarachnoid hemorrhage. Journal of neuroscience methods\| PubMed ID: 22595025	2012
The role of androgens on hypoxia-inducible factor (HIF)-1α-induced angiogenesis and on the survival of ischemically challenged skin flaps in a rat model. Microsurgery\| PubMed ID: 22707412	2012
Randomized, double-blind trial of the effect of fluid composition on electrolyte, acid-base, and fluid homeostasis in patients early after subarachnoid hemorrhage. Neurocritical care\| PubMed ID: 22872427	2013
Effect of treatment delay on disease severity and need for resuscitation in porcine fecal peritonitis. Critical care medicine\| PubMed ID: 22890256	2012
Effect of remifentanil on mitochondrial oxygen consumption of cultured human hepatocytes. PloS one\| PubMed ID: 23028840	2012
Haemodynamic variables and functional outcome in hypothermic patients following out-of-hospital cardiac arrest. Resuscitation\| PubMed ID: 23092896	2013
Mitochondrial function in sepsis. European journal of clinical investigation\| PubMed ID: 23496374	2013
Effect of sedation level on the prevalence of delirium when assessed with CAM-ICU and ICDSC. Intensive care medicine\| PubMed ID: 23921976	2013
No evidence for a local renin-angiotensin system in liver mitochondria. Scientific reports\| PubMed ID: 23959064	2013
Sedation level and prevalence of delirium: response to Brummel and Ely. Intensive care medicine\| PubMed ID: 24061632	2014
Different contribution of splanchnic organs to hyperlactatemia in fecal peritonitis and cardiac tamponade. BioMed research international\| PubMed ID: 24228242	2013
Angiotensin II in septic shock: effects on tissue perfusion, organ function, and mitochondrial respiration in a porcine model of fecal peritonitis. Critical care medicine\| PubMed ID: 24797374	2014
Interference of angiotensin II and enalapril with hepatic blood flow regulation. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 25059826	2014
Early changes of muscle membrane properties in porcine faecal peritonitis. Critical care (London, England)\| PubMed ID: 25145497	2014