Manuel C. Peitsch

Biological Systems Research, Philip Morris Products S.A.

Affiliated withPhilip Morris Products S.A.Philip Morris International R&D

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 41	2015
Publication title Cited by 23	2016

Other Publications

Article	Year
About the use of protein models. Bioinformatics (Oxford, England)\| PubMed ID: 12117790	2002
SWISS-MODEL: An automated protein homology-modeling server. Nucleic acids research\| PubMed ID: 12824332	2003
The application of systems biology to drug discovery. Current opinion in chemical biology\| PubMed ID: 16822703	2006
From proteomics to systems biology of bacterial pathogens: approaches, tools, and applications. Proteomics\| PubMed ID: 17370256	2007
Text mining for biology--the way forward: opinions from leading scientists. Genome biology\| PubMed ID: 18834498	2008
Automated comparative protein structure modeling with SWISS-MODEL and Swiss-PdbViewer: a historical perspective. Electrophoresis\| PubMed ID: 19517507	2009
Construction of a computable cell proliferation network focused on non-diseased lung cells. BMC systems biology\| PubMed ID: 21722388	2011
Verification of systems biology research in the age of collaborative competition. Nature biotechnology\| PubMed ID: 21904331	2011
A computable cellular stress network model for non-diseased pulmonary and cardiovascular tissue. BMC systems biology\| PubMed ID: 22011616	2011
A network-based approach to quantifying the impact of biologically active substances. Drug discovery today\| PubMed ID: 22155224	2012
Industrial methodology for process verification in research (IMPROVER): toward systems biology verification. Bioinformatics (Oxford, England)\| PubMed ID: 22423044	2012
Building an R&D chemical registration system. Journal of cheminformatics\| PubMed ID: 22650418	2012
Assessment of network perturbation amplitudes by applying high-throughput data to causal biological networks. BMC systems biology\| PubMed ID: 22651900	2012
Modulation of atherogenic lipidome by cigarette smoke in apolipoprotein E-deficient mice. Atherosclerosis\| PubMed ID: 23102783	2012
Design of a tobacco exon array with application to investigate the differential cadmium accumulation property in two tobacco varieties. BMC genomics\| PubMed ID: 23190529	2012
Human bronchial epithelial cells exposed in vitro to cigarette smoke at the air-liquid interface resemble bronchial epithelium from human smokers. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 23355383	2013
Computer-assisted reading in drug discovery. Expert opinion on drug discovery\| PubMed ID: 23484641	2007
Construction of a computable network model for DNA damage, autophagy, cell death, and senescence. Bioinformatics and biology insights\| PubMed ID: 23515068	2013
Whole genome profiling physical map and ancestral annotation of tobacco Hicks Broadleaf. The Plant journal : for cell and molecular biology\| PubMed ID: 23672264	2013
A decade of Systems Biology: where are we and where are we going to? Drug discovery today\| PubMed ID: 23769977	2014
Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana tomentosiformis. Genome biology\| PubMed ID: 23773524	2013
A modular cell-type focused inflammatory process network model for non-diseased pulmonary tissue. Bioinformatics and biology insights\| PubMed ID: 23843693	2013
Confero: an integrated contrast data and gene set platform for computational analysis and biological interpretation of omics data. BMC genomics\| PubMed ID: 23895370	2013
Systematic verification of upstream regulators of a computable cellular proliferation network model on non-diseased lung cells using a dedicated dataset. Bioinformatics and biology insights\| PubMed ID: 23926424	2013
Quantitative assessment of biological impact using transcriptomic data and mechanistic network models. Toxicology and applied pharmacology\| PubMed ID: 23933166	2013
Case study: the role of mechanistic network models in systems toxicology. Drug discovery today\| PubMed ID: 23933191	2014
Cigarette smoke induces molecular responses in respiratory tissues of ApoE(-/-) mice that are progressively deactivated upon cessation. Toxicology\| PubMed ID: 24096154	2013
On Crowd-verification of Biological Networks. Bioinformatics and biology insights\| PubMed ID: 24151423	2013
Systems approaches evaluating the perturbation of xenobiotic metabolism in response to cigarette smoke exposure in nasal and bronchial tissues. BioMed research international\| PubMed ID: 24224167	2013
Systems biology approach for evaluating the biological impact of environmental toxicants in vitro. Chemical research in toxicology\| PubMed ID: 24428674	2014
Systems toxicology: from basic research to risk assessment. Chemical research in toxicology\| PubMed ID: 24446777	2014
Discovery of Emphysema Relevant Molecular Networks from an A/J Mouse Inhalation Study Using Reverse Engineering and Forward Simulation (REFS™). Gene regulation and systems biology\| PubMed ID: 24596455	2014
A 28-day rat inhalation study with an integrated molecular toxicology endpoint demonstrates reduced exposure effects for a prototypic modified risk tobacco product compared with conventional... Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association\| PubMed ID: 24632068	2014
The tobacco genome sequence and its comparison with those of tomato and potato. Nature communications\| PubMed ID: 24807620	2014
Assessment of a novel multi-array normalization method based on spike-in control probes suitable for microRNA datasets with global decreases in expression. BMC research notes\| PubMed ID: 24886675	2014
A vascular biology network model focused on inflammatory processes to investigate atherogenesis and plaque instability. Journal of translational medicine\| PubMed ID: 24965703	2014
Human aspects of the management of drug discovery knowledge. Drug discovery today. Technologies\| PubMed ID: 24981937	2005
Competitive intelligence and patent analysis in drug discovery. Drug discovery today. Technologies\| PubMed ID: 24981938	2005
Quantification of biological network perturbations for mechanistic insight and diagnostics using two-layer causal models. BMC bioinformatics\| PubMed ID: 25015298	2014
In vitro systems toxicology approach to investigate the effects of repeated cigarette smoke exposure on human buccal and gingival organotypic epithelial tissue cultures. Toxicology mechanisms and methods\| PubMed ID: 25046638	2014
CSEO - the Cigarette Smoke Exposure Ontology. Journal of biomedical semantics\| PubMed ID: 25093069	2014
Understanding the limits of animal models as predictors of human biology: lessons learned from the sbv IMPROVER Species Translation Challenge. Bioinformatics (Oxford, England)\| PubMed ID: 25236459	2014
A crowd-sourcing approach for the construction of species-specific cell signaling networks. Bioinformatics (Oxford, England)\| PubMed ID: 25294919	2014
The response of human nasal and bronchial organotypic tissue cultures to repeated whole cigarette smoke exposure. International journal of toxicology\| PubMed ID: 25297719	2014
Proteomics for systems toxicology. Computational and structural biotechnology journal\| PubMed ID: 25379146	2014
Characterization of the Vitrocell® 24/48 in vitro aerosol exposure system using mainstream cigarette smoke. Chemistry Central journal\| PubMed ID: 25411580	2014
Reputation-based collaborative network biology. Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing\| PubMed ID: 25592588	2015