Barbara Gatto

Department of Pharmaceutical and Pharmacological Sciences, University of Padova

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 8	2015
Publication title	2023

Other Publications

Article	Year
2,6-Di(omega-aminoalkyl)-2,5,6,7-tetrahydropyrazolo[3,4,5-mn]pyrimido[5,6,1-de]acridine-5,7-diones: novel, potent, cytotoxic, and DNA-binding agents. Journal of medicinal chemistry\| PubMed ID: 11806721	2002
Sequence-specific interactions of drugs interfering with the topoisomerase-DNA cleavage complex. Biochimica et biophysica acta\| PubMed ID: 12084456	2002
New anti-human immunodeficiency virus type 1 6-aminoquinolones: mechanism of action. Antimicrobial agents and chemotherapy\| PubMed ID: 12604517	2003
Design, synthesis, and biological properties of new bis(acridine-4-carboxamides) as anticancer agents. Journal of medicinal chemistry\| PubMed ID: 12825949	2003
Involvement of p53 in specific anti-neuroectodermal tumor activity of aloe-emodin. International journal of cancer. Journal international du cancer\| PubMed ID: 12918060	2003
Clerocidin alkylates DNA through its epoxide function: evidence for a fine tuned mechanism of action. Nucleic acids research\| PubMed ID: 12930966	2003
Effects of common buffer systems on drug activity: the case of clerocidin. Chemical research in toxicology\| PubMed ID: 15089091	2004
Inhibition of human immunodeficiency virus type 1 tat-trans-activation-responsive region interaction by an antiviral quinolone derivative. Antimicrobial agents and chemotherapy\| PubMed ID: 15105155	2004
Monoclonal antibodies in cancer therapy. Current medicinal chemistry. Anti-cancer agents\| PubMed ID: 15379694	2004
Antiviral 6-amino-quinolones: molecular basis for potency and selectivity. Bioorganic & medicinal chemistry letters\| PubMed ID: 16054362	2005
Clerocidin interacts with the cleavage complex of Streptococcus pneumoniae topoisomerase IV to induce selective irreversible DNA damage. Nucleic acids research\| PubMed ID: 16614448	2006
From proteins to nucleic acid-based drugs: the role of biotech in anti-VEGF therapy. Anti-cancer agents in medicinal chemistry\| PubMed ID: 16842232	2006
Perylene side chains modulate G-quadruplex conformation in biologically relevant DNA sequences. Bioorganic & medicinal chemistry\| PubMed ID: 18819816	2008
Atacicept, a homodimeric fusion protein for the potential treatment of diseases triggered by plasma cells. Current opinion in investigational drugs (London, England : 2000)\| PubMed ID: 18951301	2008
Synthesis and biological evaluation of 2-phenylquinolones targeted at Tat/TAR recognition. Bioorganic & medicinal chemistry letters\| PubMed ID: 19109014	2009
2-Phenylquinolones as inhibitors of the HIV-1 Tat-TAR interaction. ChemMedChem\| PubMed ID: 19283692	2009
Effective DNA inhibitors of cathepsin g by in vitro selection. International journal of molecular sciences\| PubMed ID: 19325843	2008
Inhibition of subgenomic hepatitis C virus RNA replication by acridone derivatives: identification of an NS3 helicase inhibitor. Journal of medicinal chemistry\| PubMed ID: 19388645	2009
The 6-aminoquinolone WC5 inhibits human cytomegalovirus replication at an early stage by interfering with the transactivating activity of viral immediate-early 2 protein. Antimicrobial agents and chemotherapy\| PubMed ID: 20194695	2010
Rational design, synthesis, and DNA binding properties of novel sequence-selective peptidyl congeners of ametantrone. ChemMedChem\| PubMed ID: 20458714	2010
Studies of anti-HIV transcription inhibitor quinolones: identification of potent N1-vinyl derivatives. ChemMedChem\| PubMed ID: 20928882	2010
The evolving world of protein-G-quadruplex recognition: a medicinal chemist's perspective. Biochimie\| PubMed ID: 21549174	2011
Human thrombin detection through a sandwich aptamer microarray: interaction analysis in solution and in solid phase. Sensors (Basel, Switzerland)\| PubMed ID: 22163703	2011
Ellagic acid and polyhydroxylated urolithins are potent catalytic inhibitors of human topoisomerase II: an in vitro study. Journal of agricultural and food chemistry\| PubMed ID: 22924519	2012
Development of a multiplex sandwich aptamer microarray for the detection of VEGF165 and thrombin. Sensors (Basel, Switzerland)\| PubMed ID: 24097233	2013
Enzymatic formation of PEGylated oligonucleotides. Bioconjugate chemistry\| PubMed ID: 24450424	2014
Synthesis and DNA cleavage activity of Bis-3-chloropiperidines as alkylating agents. ChemMedChem\| PubMed ID: 24616300	2014
The topoisomerase II poison clerocidin alkylates non-paired guanines of DNA: implications for irreversible stimulation of DNA cleavage. Nucleic acids research\| PubMed ID: 11600711	2001
Drugs acting on the beta isoform of human topoisomerase II (p180). Current medicinal chemistry. Anti-cancer agents\| PubMed ID: 12769776	2003
Biologics targeted at TNF: design, production and challenges. Reumatismo\| PubMed ID: 16829986	2006
Bis-3-chloropiperidines containing bridging lysine linkers: Influence of side chain structure on DNA alkylating activity. Bioorganic & medicinal chemistry\| PubMed ID: 25693786	2015
Synthesis and evaluation of a bis-3-chloropiperidine derivative incorporating an anthraquinone pharmacophore. Bioorganic & medicinal chemistry letters\| PubMed ID: 26342869	2015
Development and Optimization of a Thrombin Sandwich Aptamer Microarray. Microarrays (Basel, Switzerland)\| PubMed ID: 27605338	2012
Virtual Cross-Linking of the Active Nemorubicin Metabolite PNU-159682 to Double-Stranded DNA. Chemical research in toxicology\| PubMed ID: 28068470	2017
Direct and Topoisomerase II Mediated DNA Damage by Bis-3-chloropiperidines: The Importance of Being an Earnest G. ChemMedChem\| PubMed ID: 28724198	2017
Identification of novel 2-benzoxazolinone derivatives with specific inhibitory activity against the HIV-1 nucleocapsid protein. European journal of medicinal chemistry\| PubMed ID: 29324338	2018
Behind the Mirror: Chirality Tunes the Reactivity and Cytotoxicity of Chloropiperidines as Potential Anticancer Agents. ACS medicinal chemistry letters\| PubMed ID: 30996795	2019
Multiple Inhibition of HIV-1 Proteins by 2,6-Dipeptidyl-anthraquinone Conjugates Targeting the PBS RNA. ACS medicinal chemistry letters\| PubMed ID: 32435410	2020
Aromatic Linkers Unleash the Antiproliferative Potential of 3-Chloropiperidines Against Pancreatic Cancer Cells. ChemMedChem\| PubMed ID: 32744774	2020
Appended Aromatic Moieties in Flexible Bis-3-chloropiperidines Confer Tropism against Pancreatic Cancer Cells. ChemMedChem\| PubMed ID: 33200541	2021
Bis-3-Chloropiperidines Targeting TAR RNA as A Novel Strategy to Impair the HIV-1 Nucleocapsid Protein. Molecules (Basel, Switzerland)\| PubMed ID: 33810333	2021
B-CePs as cross-linking probes for the investigation of RNA higher-order structure. Nucleic acids research\| PubMed ID: 34125908	2021
In Vitro Evaluation of Bis-3-Chloropiperidines as RNA Modulators Targeting TAR and TAR-Protein Interaction. International journal of molecular sciences\| PubMed ID: 35054766	2022
Computationally driven discovery of SARS-CoV-2 M inhibitors: from design to experimental validation. Chemical science\| PubMed ID: 35432906	2022
Decoding mechanism of action and sensitivity to drug candidates from integrated transcriptome and chromatin state. eLife\| PubMed ID: 36043458	2022
Multifaceted Aspects of HIV-1 Nucleocapsid Inhibition by TAR-Targeting Peptidyl-Anthraquinones Bearing Terminal Aromatic Moieties. Viruses\| PubMed ID: 36298688	2022