Jian Hu

Jian Hu

Department of Cancer Biology, UT MD Anderson Cancer Center

Affiliated withUT MD Anderson Cancer CenterSanofi Pasteur LimitedThe Traditional Chinese Medicine Hospital of Beichuan Qiang Autonomous County

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Research Area

Biography

Jiancheng Hu is a Principal Investigator in the Division of Cellular and Molecular Research, National Cancer Centre Singapore, and an Asistant Professor in the Cancer and Stem Cell Program, Duke-NUS Medical School, Singapore. He received his B.S. in 1996 from the East China University of Science and Technology, M.S. in 2001 from Peking University, China , and Ph.D. in 2007 from University of Colorado, USA.

During Dr Hu’s training, he developed a keen interest on cell signaling. As a postdoctoral fellow in Andrey Shaw’s lab at Washington University in Saint Louis and Howard Hughes Medical Institute (2008~2014), USA, he studied the molecular mechanism(s) that regulates the Ras/RAF/MEK/ERK signaling and how this signaling pathway was aberrantly activated in cancer and developmental diseases. In 2014, He was recruited to National Cancer Centre Singapore as a Pricinpal Investigator and Duke-NUS Medical School as an assistant professor.

Dr Hu’s research focuses on: (1) the regulatory mechanism of RAF/MEK/ERK kinase cascade and other oncogenic protein kinases; (2) the molecular basis that underlie Intrinsic and acquired resistance of kinase inhibitors in cancer therapy; (3) the development of novel protein kinase inhibitors for cancer treatment.

JoVE Journal Publications

ArticleTotal : 4
Year
Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
Publication title

Cited by 3

2015
Differential Scanning Calorimetry — A Method for Assessing the Thermal Stability and Conformation of Protein Antigen
Publication title

Cited by 117

2017
2024
2026

Other Publications

Article
Year
Reduced ventral striatal/ventral pallidal serotonin1B receptor binding potential in major depressive disorder.

Psychopharmacology| PubMed ID: 20480149

2011
2010
2010
2010
Boundary conditions for simulating large SAW devices using ANSYS.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control| PubMed ID: 20679001

2010
2010
2010
STK39 is an independent risk factor for male hypertension in Han Chinese.

International journal of cardiology| PubMed ID: 20889219

2012
2011
Codonopsis lanceolata extract induces G0/G1 arrest and apoptosis in human colon tumor HT-29 cells--involvement of ROS generation and polyamine depletion.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association| PubMed ID: 20940027

2011
Tooth Atlas 3D, version 6.3.0.

Journal of dental education| PubMed ID: 21045233

2010
2010
2010
2011
miRNA-145 inhibits non-small cell lung cancer cell proliferation by targeting c-Myc.

Journal of experimental & clinical cancer research : CR| PubMed ID: 21092188

2010
2010
2011
2011
2011
2011
2011
2011
2011
[Clinical application of CT-guided preoperative pulmonary nodule localization technique].

Zhongguo fei ai za zhi = Chinese journal of lung cancer| PubMed ID: 21569647

2011
2011
2011
2012
2011
2011
[Effect of equol on breast tumors induced by 7, 12-dimethylbenz (α) anthracene in ovariectominzed rats].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences| PubMed ID: 21681261

2011
2011
2011
2011
2011
2011
2011
2011
2011
High-pressure magic angle spinning nuclear magnetic resonance.

Journal of magnetic resonance (San Diego, Calif. : 1997)| PubMed ID: 21862372

2011
2012
2013
An efficient, overall [4+1] cycloaddition of 1,3-dienes and nitrene precursors.

Chemistry (Weinheim an der Bergstrasse, Germany)| PubMed ID: 21887836

2011
Efficacy and safety of aliskiren, a direct renin inhibitor, compared with ramipril in Asian patients with mild to moderate hypertension.

Hypertension research : official journal of the Japanese Society of Hypertension| PubMed ID: 21900941

2012
2011
Physical aging enhanced mesomorphic structure in melt-quenched poly(L-lactic acid).

The journal of physical chemistry. B| PubMed ID: 22007760

2011
[Use of traditional Chinese medicine during the Red Army period in Chinese history].

Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine| PubMed ID: 22015198

2011
2012
Clinical predictors of familial depression in han chinese women.

Depression and anxiety| PubMed ID: 22065525

2012
2012
Subterranean termite open-air foraging and tolerance to desiccation: Comparative water relation of two sympatric Macrotermes spp. (Blattodea: Termitidae).

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology| PubMed ID: 22085890

2012
2011
Prehypertension: a meta-analysis of the epidemiology, risk factors, and predictors of progression.

Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital| PubMed ID: 22199424

2011
2012
2012
2012
2013
2012
2012
2012
2012
2012
2012
2012
2012
Intravital microscopy to study myocardial engraftment.

Interactive cardiovascular and thoracic surgery| PubMed ID: 22457185

2012
Chylous pleural effusion caused by mediastinal angiomyolipomas.

Chinese medical journal| PubMed ID: 22490602

2012
Availability and quality of emergency obstetric care, an alternative strategy to reduce maternal mortality: experience of Tongji Hospital, Wuhan, China.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban| PubMed ID: 22528213

2012
2012
[Effects of mustard seed on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University| PubMed ID: 22543145

2012
2012
2012
2012
2012
2012
2012
2012
2012
2013
2012
2012
2012
2012
[Finite element stress analysis of all-ceramic crown of the upper central incisor in differential thickness].

Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology| PubMed ID: 22934487

2012
2012
2012
2012
2012
2012
2012
The utility of a 5-in-6 double catheter technique in treating complex coronary lesions via transradial approach: the DOCA-TRI study.

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology| PubMed ID: 23171804

2012
Rotor design for high pressure magic angle spinning nuclear magnetic resonance.

Journal of magnetic resonance (San Diego, Calif. : 1997)| PubMed ID: 23220181

2013
2013
2012
2013
2013
2013
ECMO-assisted esophagectomy after left pneumonectomy.

The International journal of artificial organs| PubMed ID: 23404644

2013
2013
2013
2013
2013
2013
2013
2013
2013
2013
2013
2013
Palladium-catalyzed asymmetric intermolecular cyclization.

Angewandte Chemie (International ed. in English)| PubMed ID: 23824841

2013
2013
2013
2013
2013
Epidemiological and molecular characterization of community and hospital acquired Staphylococcus aureus strains prevailing in Shenyang, Northeastern China.

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases| PubMed ID: 23916451

2013
From the Cover: Neutralization of terminal differentiation in gliomagenesis.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 23918370

2013
2013
Highly active catalysts of bisphosphine oxides for asymmetric Heck reaction.

Chemical communications (Cambridge, England)| PubMed ID: 24005808

2013
2013
2013
2014
Effect of different coping designs on all-ceramic crown stress distribution: a finite element analysis.

Dental materials : official publication of the Academy of Dental Materials| PubMed ID: 24099644

2013
2013
Alveolar adenoma resected by thoracoscopic surgery.

Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia| PubMed ID: 24200660

2013
2013
[Research advances in molecular genetics and treatment of familial hemophagocytic lymphohistiocytosis].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics| PubMed ID: 24229589

2013
Overexpression of miR-145 increases the sensitivity of vemurafenib in drug-resistant colo205 cell line.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine| PubMed ID: 24248543

2014
2014
2014
2013
Segmentectomy or lobectomy for early stage lung cancer: a meta-analysis.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery| PubMed ID: 24321996

2014
2013
2014
2014
2013
2014
2015
[Analysis of salvianolate injection combined with usual drugs in treatment of coronary heart disease in real world].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica| PubMed ID: 24471349

2013
2014
2014
2014
2014
2014
2014
2014
2014
2014
A new strain for recovering precious metals from waste printed circuit boards.

Waste management (New York, N.Y.)| PubMed ID: 24630215

2014
Single-port video-assisted thoracoscopic right upper lobectomy using a flexible videoscope.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery| PubMed ID: 24659314

2014
2014
2014
2014
Reply to Cao et al.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery| PubMed ID: 24713890

2014
2014
2014
2014
The effect of resveratrol on surgery-induced epidural fibrosis in laminectomy rats.

Evidence-based complementary and alternative medicine : eCAM| PubMed ID: 24782910

2014
2014
2014
2014
2014
Quantitatively probing the Al distribution in zeolites.

Journal of the American Chemical Society| PubMed ID: 24815517

2014
2014
2014
2014
2013
[Mycoplasma pneumoniae-associated mucositis: a case report].

Zhonghua er ke za zhi. Chinese journal of pediatrics| PubMed ID: 24969943

2014
Reply to ng et Al.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery| PubMed ID: 25038943

2015
2014
2014
2014
2014
Diffusional motion of redox centers in carbonate electrolytes.

The Journal of chemical physics| PubMed ID: 25217939

2014
The role of the aminergic systems in the pathophysiology of bipolar disorder.

Current topics in behavioral neurosciences| PubMed ID: 25236552

2011
2014
2015
[Omental transposition to mediastinum improves the outcome of postoperative intra-thoracic infections of Ivor-Lewis surgery].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery| PubMed ID: 25273661

2014
2014
2014
2014
(1)H NMR Metabolomics Study of Metastatic Melanoma in C57BL/6J Mouse Spleen.

Metabolomics : Official journal of the Metabolomic Society| PubMed ID: 25383071

2014
2014
HLA-DRB1 and HLA-DQB1 methylation changes promote the occurrence and progression of Kazakh ESCC.

Epigenetics : official journal of the DNA Methylation Society| PubMed ID: 25437052

2014
2014
2015
[Recombinant adenovirus Ad-APN-EGFP constructing and promoting osteogenesis around implants].

Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology| PubMed ID: 25490829

2014
2014
2014
2014
2015
2015
[Effects of glucocorticoid on RAGE-NF-κB pathway in hyperoxia-induced lung tissues of neonatal rats].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics| PubMed ID: 25616300

2015
[A case of autoimmune lymphoproliferactive syndrome and literature review].

Zhonghua er ke za zhi. Chinese journal of pediatrics| PubMed ID: 25619350

2014
Periprocedural use of tirofiban in elective percutaneous coronary intervention for long coronary lesions in stable patients with overlapping drug-eluting stents-the PETITION study: A prospec...

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions| PubMed ID: 25630513

2015
2015
2015
2015
Correction to "Quantitatively probing the Al distribution in zeolites".

Journal of the American Chemical Society| PubMed ID: 25668415

2015
2015
2015
Case report of achalasia secondary to a lung carcinoma of the mediastinal type.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus / I.S.D.E| PubMed ID: 25833125

2015
Molecular signatures of major depression.

Current biology : CB| PubMed ID: 25913401

2015
Complete mitochondrial genome of the Swan Goose (Anser cygnoides L.) and its phylogenetic analysis.

Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis| PubMed ID: 25922959

2016
Complete mitochondrial genome of Paracobitis variegates and its phylogenetic analysis.

Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis| PubMed ID: 25922960

2016
5-Methoxyquinoline Derivatives as a New Class of EZH2 Inhibitors.

Molecules (Basel, Switzerland)| PubMed ID: 25923513

2015
2015
Susceptibility of glutinous rice starch to digestive enzymes.

Carbohydrate polymers| PubMed ID: 26005151

2015
Novel Targets of Drug Treatment for Pulmonary Hypertension.

American journal of cardiovascular drugs : drugs, devices, and other interventions| PubMed ID: 26016608

2015
2015
Shikonin inhibits TNF-α-induced growth and invasion of rat aortic vascular smooth muscle cells.

Canadian journal of physiology and pharmacology| PubMed ID: 26042337

2015
2015
2015
2015
Assessment of the Altitudinal Atmospheric Metal(loid) Deposition in a Mountainous City by Mosses.

Bulletin of environmental contamination and toxicology| PubMed ID: 26055166

2015
Chromosomal imbalances revealed in primary renal cell carcinomas by comparative genomic hybridization.

International journal of clinical and experimental pathology| PubMed ID: 26097545

2015
2016
2015
2015
2015
2015
Sealed rotors for in situ high temperature high pressure MAS NMR.

Chemical communications (Cambridge, England)| PubMed ID: 26171928

2015
2015
2015
2015
2015
Advances in the Development of Class I Phosphoinositide 3-Kinase (PI3K) Inhibitors.

Current topics in medicinal chemistry| PubMed ID: 26369826

2016
"Tent-Pole" for Reconstruction of Large Alveolar Defects: A Case Report.

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons| PubMed ID: 26375368

2016
Bilateral multiple intrapulmonary nodules: a puzzled and rare disease.

Journal of thoracic disease| PubMed ID: 26380748

2015
2015
2016
2015
2016
2016
2015
2016
Risk Factors for Anxiety in Major Depressive Disorder Patients.

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology| PubMed ID: 26598584

2015
2016
2015
2015
2016
2014
2016
2016
2016
Correlates and outcomes related to periprocedural myocardial injury during percutaneous coronary intervention for chronic total occlusion: Results from a prospective, single center PCI regis...

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions| PubMed ID: 26864270

2016
2016
Glioma Stem Cells: Signaling, Microenvironment, and Therapy.

Stem cells international| PubMed ID: 26880988

2016
[The cardiovascular changes in pediatric onset systemic lupus erythematosus].

Zhonghua er ke za zhi = Chinese journal of pediatrics| PubMed ID: 26887555

2015
2016
2016
2016
Folate-conjugated biodegradable core cross-linked polyphosphoester micelles for targeted and pH-triggered drug delivery.

Journal of controlled release : official journal of the Controlled Release Society| PubMed ID: 27005244

2015
Early diagnosis and management of esophageal leakage after peroral endoscopic myotomy for achalasia.

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology| PubMed ID: 27015615

2016
2016
2016
2016
Lymphadenectomy for clinical early-stage non-small-cell lung cancer: a systematic review and meta-analysis.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery| PubMed ID: 27107044

2016
2016
2016
2016
2016
2016
2016
2016
Anterior approach for right hepatectomy using the 5-steps stapling technique: A preliminary study.

International journal of surgery (London, England)| PubMed ID: 27317899

2016
2016
[Advances in Surgical Treatment of Early Stage Non-small Cell Lung Cancer].

Zhongguo fei ai za zhi = Chinese journal of lung cancer| PubMed ID: 27335305

2016
2015
2016
2016
2016
2016
2016
2016
2016
2016
2016
2016
2016
Bakkenolide A inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related signaling pathways.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie| PubMed ID: 27522258

2016
The role of entanglement concentration on the hydrodynamic properties of potato and sweet potato starches.

International journal of biological macromolecules| PubMed ID: 27586638

2016
Research and application of method of oxygen isotope of inorganic phosphate in Beijing agricultural soils.

Environmental science and pollution research international| PubMed ID: 27638796

2016
2016
2016
2016
Downregulation of RUVBL1 inhibits proliferation of lung adenocarcinoma cells by G1/S phase cell cycle arrest via multiple mechanisms.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine| PubMed ID: 27722820

2016
2016
Prescribing patterns of psychotropic medications and clinical features in patients with major depressive disorder with and without comorbid dysthymia in China.

Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists| PubMed ID: 27759189

2017
2017
[Preparation and identification of rabbit anti-AKR1B10 polyclonal antibody].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology| PubMed ID: 27774953

2016
The effects of entanglement concentration on the hydrodynamic properties of cereal starches.

Journal of the science of food and agriculture| PubMed ID: 27781270

2016
2017
2017
2017
2017
2016
2016
2016
2016
2016
2017
2016
Magic Angle Spinning NMR Metabolomics.

Metabolomics : open access| PubMed ID: 28042496

2016
2016
2017
2017
2016
Multiple functional self-association interfaces in plant TIR domains.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 28159890

2017
2017
2017
2017
2017
2017