Horst Thiermann

Bundeswehr Institute of Pharmacology and Toxicology

Affiliated withBundeswehr Institute of Pharmacology and Toxicology

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 9	2015
Publication title Cited by 2	2020

Other Publications

Article	Year
Simulation of cholinesterase status at different scenarios of nerve agent exposure. Toxicology\| PubMed ID: 16904807	2007
Development of antidotes: problems and strategies. Toxicology\| PubMed ID: 16949190	2007
The effect of acetylcholinesterase-inhibition on depolarization-induced GABA release from rat striatal slices. Toxicology\| PubMed ID: 12499118	2003
Human parathion poisoning. A toxicokinetic analysis. Toxicological reviews\| PubMed ID: 15181664	2003
Kinetic analysis of interactions between human acetylcholinesterase, structurally different organophosphorus compounds and oximes. Biochemical pharmacology\| PubMed ID: 15498514	2004
Ketamine reduces cholinergic modulated GABA release from rat striatal slices. Toxicology letters\| PubMed ID: 15763635	2005
Evaluation of oxime efficacy in nerve agent poisoning: development of a kinetic-based dynamic model. Toxicology and applied pharmacology\| PubMed ID: 15904945	2005
Effects of oximes on muscle force and acetylcholinesterase activity in isolated mouse hemidiaphragms exposed to paraoxon. Toxicology\| PubMed ID: 16040183	2005
Diagnostic aspects of organophosphate poisoning. Toxicology\| PubMed ID: 16051411	2005
Correlation between red blood cell acetylcholinesterase activity and neuromuscular transmission in organophosphate poisoning. Chemico-biological interactions\| PubMed ID: 16263103	2005
Estimation of oxime efficacy in nerve agent poisoning: a kinetic approach. Chemico-biological interactions\| PubMed ID: 16266695	2005
Testing of antidotes for organophosphorus compounds: experimental procedures and clinical reality. Toxicology\| PubMed ID: 17010492	2007
Anaesthesia in patients suffering from organophosphorus intoxication--interactions between general anaesthetics and acetylcholine in cortical networks in vitro. Toxicology\| PubMed ID: 17030394	2007
Lessons to be learnt from organophosphorus pesticide poisoning for the treatment of nerve agent poisoning. Toxicology\| PubMed ID: 17161895	2007
Kinetic analysis of reactivation and aging of human acetylcholinesterase inhibited by different phosphoramidates. Biochemical pharmacology\| PubMed ID: 17382909	2007
Cholinergic modulation of sevoflurane potency in cortical and spinal networks in vitro. Anesthesiology\| PubMed ID: 17525590	2007
Development and application of procedures for the highly sensitive quantification of cyclosarin enantiomers in hemolysed swine blood samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences\| PubMed ID: 17888747	2007
Red blood cell acetylcholinesterase and plasma butyrylcholinesterase status: important indicators for the treatment of patients poisoned by organophosphorus compounds. Arhiv za higijenu rada i toksikologiju\| PubMed ID: 17913691	2007
Comparison of the oxime-induced reactivation of erythrocyte and muscle acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for the real-time determination... Biochemical pharmacology\| PubMed ID: 17977518	2008
Identical kinetics of human erythrocyte and muscle acetylcholinesterase with respect to carbamate pre-treatment, residual activity upon soman challenge and spontaneous reactivation after wit... Toxicology\| PubMed ID: 18304715	2008
LC-MS-based procedures for monitoring of toxic organophosphorus compounds and verification of pesticide and nerve agent poisoning. Analytical and bioanalytical chemistry\| PubMed ID: 18330546	2008
Inhibitory potency against human acetylcholinesterase and enzymatic hydrolysis of fluorogenic nerve agent mimics by human paraoxonase 1 and squid diisopropyl fluorophosphatase. Biochemistry\| PubMed ID: 18396898	2008
Sulfur mustard research--strategies for the development of improved medical therapy. Eplasty\| PubMed ID: 18615149	2008
Are we using the right dose? - a tale of mole and gram. British journal of clinical pharmacology\| PubMed ID: 18662291	2008
Chromatographic resolution, characterisation and quantification of VX enantiomers in hemolysed swine blood samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences\| PubMed ID: 18718824	2008
Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun. The Biochemical journal\| PubMed ID: 19368529	2009
Clinical picture of sulfur mustard poisoning. Toxicology\| PubMed ID: 19386280	2009
Comparison of the oxime-induced reactivation of rhesus monkey, swine and guinea pig erythrocyte acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for th... Toxicology\| PubMed ID: 19428926	2009
Extreme variability in the formation of chlorpyrifos oxon (CPO) in patients poisoned by chlorpyrifos (CPF). Biochemical pharmacology\| PubMed ID: 19433070	2009
The chronic effects of sulfur mustard exposure. Toxicology\| PubMed ID: 19486919	2009
Plasma level of atropine after accidental ingestion of Atropa belladonna. Clinical toxicology (Philadelphia, Pa.)\| PubMed ID: 19586361	2009
Development and validation of a sensitive gas chromatography-ammonia chemical ionization mass spectrometry method for the determination of tabun enantiomers in hemolysed blood and plasma of ... Journal of chromatography. B, Analytical technologies in the biomedical and life sciences\| PubMed ID: 19766064	2010
Obidoxime in acute organophosphate poisoning: 1 - clinical effectiveness. Clinical toxicology (Philadelphia, Pa.)\| PubMed ID: 19778163	2009
Obidoxime in acute organophosphate poisoning: 2 - PK/PD relationships. Clinical toxicology (Philadelphia, Pa.)\| PubMed ID: 19778190	2009
Monitoring of neuromuscular transmission in organophosphate pesticide-poisoned patients. Toxicology letters\| PubMed ID: 19793545	2009
LC-ESI MS/MS quantification of atropine and six other antimuscarinic tropane alkaloids in plasma. Analytical and bioanalytical chemistry\| PubMed ID: 19855962	2010
Paradox findings may challenge orthodox reasoning in acute organophosphate poisoning. Chemico-biological interactions\| PubMed ID: 19883634	2010
Evaluation of medical countermeasures against organophosphorus compounds: the value of experimental data and computer simulations. Chemico-biological interactions\| PubMed ID: 19917271	2010
The toxicokinetics and toxicodynamics of organophosphonates versus the pharmacokinetics and pharmacodynamics of oxime antidotes: biological consequences. Basic & clinical pharmacology & toxicology\| PubMed ID: 19961476	2010
Atropine increases sevoflurane potency in cortical but not spinal networks during cholinergic overstimulation. Toxicology\| PubMed ID: 20004696	2010
Assessment of neuromuscular dysfunction during poisoning by organophosphorus compounds. Chemico-biological interactions\| PubMed ID: 20036651	2010
GC-MS and LC-MS analysis of nerve agents in body fluids: intra-laboratory verification test using spiked plasma and urine samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences\| PubMed ID: 20061191	2010
Kinetic analysis of interactions of different sarin and tabun analogues with human acetylcholinesterase and oximes: is there a structure-activity relationship? Chemico-biological interactions\| PubMed ID: 20105433	2010
Simultaneous quantification of the organophosphorus pesticides dimethoate and omethoate in porcine plasma and urine by LC-ESI-MS/MS and flow-injection-ESI-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences\| PubMed ID: 20106727	2010
Comparative study of oxime-induced reactivation of erythrocyte and muscle AChE from different animal species following inhibition by sarin or paraoxon. Toxicology letters\| PubMed ID: 20156534	2010
Muscle force and acetylcholinesterase activity in mouse hemidiaphragms exposed to paraoxon and treated by oximes in vitro. Toxicology\| PubMed ID: 20385200	2010
Bioanalysis of organophosphorus toxicants and corresponding antidotes. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences\| PubMed ID: 20395180	2010
Side-specific effects by cadmium exposure: apical and basolateral treatment in a coculture model of the blood-air barrier. Toxicology and applied pharmacology\| PubMed ID: 20399800	2010
Kinetic analysis of interactions between alkylene-linked bis-pyridiniumaldoximes and human acetylcholinesterases inhibited by various organophosphorus compounds. Biochemical pharmacology\| PubMed ID: 20510679	2010
Pharmacokinetics of obidoxime in patients poisoned with organophosphorus compounds. Toxicology letters\| PubMed ID: 20542100	2010
Interactions between atropine and etomidate in cortical and spinal networks during cholinergic crisis. Toxicology letters\| PubMed ID: 20696220	2010
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) for detection and identification of albumin phosphylation by organophosphorus pesticides and G- an... Analytical and bioanalytical chemistry\| PubMed ID: 20730528	2010
Kinetic prerequisites of oximes as effective reactivators of organophosphate-inhibited acetylcholinesterase: a theoretical approach. Journal of enzyme inhibition and medicinal chemistry\| PubMed ID: 20807085	2011
Effect of N-acetyl cysteine and alpha-linolenic acid on sulfur mustard caused impairment of in vitro endothelial tube formation. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 20833707	2010
Reactivation of organophosphate-inhibited human, Cynomolgus monkey, swine and guinea pig acetylcholinesterase by MMB-4: a modified kinetic approach. Toxicology and applied pharmacology\| PubMed ID: 20888357	2010
High-performance liquid-chromatographic tandem-mass spectrometric methods for atropinesterase-mediated enantioselective and chiral determination of R- and S-hyoscyamine in plasma. Analytica chimica acta\| PubMed ID: 20969988	2010
Kinetic analysis of interactions of paraoxon and oximes with human, Rhesus monkey, swine, rabbit, rat and guinea pig acetylcholinesterase. Toxicology letters\| PubMed ID: 20971170	2011
In vitro detoxification of cyclosarin (GF) by modified cyclodextrins. Toxicology letters\| PubMed ID: 21035528	2011
In vitro kinetic interactions of DEET, pyridostigmine and organophosphorus pesticides with human cholinesterases. Chemico-biological interactions\| PubMed ID: 21354413	2011
Evaluation of 6,6'-dithionicotinic acid as alternative chromogen in a modified Ellman method--comparison in various species. Toxicology mechanisms and methods\| PubMed ID: 21470076	2011
Evaluation of functional and structural alterations in muscle tissue after short-term cold storage in a new tissue preservation solution. Cells, tissues, organs\| PubMed ID: 21494014	2011
Long-term evaluation of organophosphate toxicity and antidotal therapy in co-cultures of spinal cord and muscle tissue. Toxicology letters\| PubMed ID: 21530620	2011
Thirteenth International Medical Chemical Defence Conference 2011 "New developments in the treatment of intoxications by chemical warfare agents with focus on neurotoxic agents". Toxicology letters\| PubMed ID: 21605643	2011
Anaesthetic potency of diazepam is resistant to cholinergic overstimulation. Toxicology letters\| PubMed ID: 21699965	2011
Atropine maintenance dosage in patients with severe organophosphate pesticide poisoning. Toxicology letters\| PubMed ID: 21771644	2011
Simultaneous quantification of VX and its toxic metabolite in blood and plasma samples and its application for in vivo and in vitro toxicological studies. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences\| PubMed ID: 21862421	2011
Reactivation of organophosphate-inhibited human acetylcholinesterase by isonitrosoacetone (MINA): a kinetic analysis. Chemico-biological interactions\| PubMed ID: 21930118	2011
Application of an enantioselective LC-ESI MS/MS procedure to determine R- and S-hyoscyamine following intravenous atropine administration in swine. Drug testing and analysis\| PubMed ID: 21964777	2012
Determination of acetylcholinesterase activity by the Ellman assay: a versatile tool for in vitro research on medical countermeasures against organophosphate poisoning. Drug testing and analysis\| PubMed ID: 21998030	2012
Evaluation of the Test-mate ChE (cholinesterase) field kit in acute organophosphorus poisoning. Annals of emergency medicine\| PubMed ID: 22098995	2011
Quantification of pralidoxime (2-PAM) in urine by ion pair chromatography-diode array detection: application to in vivo samples from minipig. Drug testing and analysis\| PubMed ID: 22102522	2012
In vitro and in vivo efficacy of PEGylated diisopropyl fluorophosphatase (DFPase). Drug testing and analysis\| PubMed ID: 22174192	2012
Comparative kinetics of organophosphates and oximes with erythrocyte, muscle and brain acetylcholinesterase. Toxicology letters\| PubMed ID: 22230262	2012
A role for solvents in the toxicity of agricultural organophosphorus pesticides. Toxicology\| PubMed ID: 22365945	2012
Reactivation kinetics of a homologous series of bispyridinium bis-oximes with nerve agent-inhibited human acetylcholinesterase. Archives of toxicology\| PubMed ID: 22437842	2012
Kinetic interactions of a homologous series of bispyridinium monooximes (HGG oximes) with native and phosphonylated human acetylcholinesterase. Toxicology letters\| PubMed ID: 22561105	2012
Reactivation kinetics of a series of related bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase--Structure-activity relationships. Biochemical pharmacology\| PubMed ID: 22649796	2012
Structural requirements for effective oximes--evaluation of kinetic in vitro data with phosphylated human AChE and structurally different oximes. Chemico-biological interactions\| PubMed ID: 22827894	2013
Detoxification of tabun at physiological pH mediated by substituted β-cyclodextrin and glucose derivatives containing oxime groups. Toxicology\| PubMed ID: 22982866	2012
New modified β-cyclodextrin derivatives as detoxifying agents of chemical warfare agents (II). In vitro detoxification of cyclosarin (GF): general screening and toxicokinetic aspects of OP s... Toxicology letters\| PubMed ID: 23201438	2013
New modified β-cyclodextrin derivatives as detoxifying agents of chemical warfare agents (I). Synthesis and preliminary screening: evaluation of the detoxification using a half-quantitative ... Toxicology letters\| PubMed ID: 23201439	2013
The value of novel oximes for treatment of poisoning by organophosphorus compounds. Pharmacology & therapeutics\| PubMed ID: 23603539	2013
Use of the Cultex® Radial Flow System as an in vitro exposure method to assess acute pulmonary toxicity of fine dusts and nanoparticles with special focus on the intra- and inter-laboratory ... Chemico-biological interactions\| PubMed ID: 23669118	2013
Organophosphate poisoning in the developed world - a single centre experience from here to the millennium. Chemico-biological interactions\| PubMed ID: 23685200	2013
Silibinin as a potential therapeutic for sulfur mustard injuries. Chemico-biological interactions\| PubMed ID: 23810508	2013
Sulfur mustard induced nuclear translocation of glyceraldehyde-3-phosphate-dehydrogenase (GAPDH). Chemico-biological interactions\| PubMed ID: 23827652	2013
Effects of succinylcholine in an organotypic spinal cord-skeletal muscle coculture of embryonic mice. Chemico-biological interactions\| PubMed ID: 23838346	2013
Elimination pathways of cyclosarin (GF) mediated by β-cyclodextrin in vitro: pharmacokinetic and toxicokinetic aspects. Toxicology letters\| PubMed ID: 23906718	2013
Fourteenth International Medical Chemical Defence Conference 2013 "Translation of experimental research for improved treatment of chemical warfare agents". Chemico-biological interactions\| PubMed ID: 23920049	2013
Modified immunoslotblot assay to detect hemi and sulfur mustard DNA adducts. Chemico-biological interactions\| PubMed ID: 23933409	2013
Mesenchymal stem cells are highly resistant to sulfur mustard. Chemico-biological interactions\| PubMed ID: 23933411	2013
Investigation of kinetic interactions between approved oximes and human acetylcholinesterase inhibited by pesticide carbamates. Chemico-biological interactions\| PubMed ID: 23962483	2013
Influence of organophosphate poisoning on human dendritic cells. Chemico-biological interactions\| PubMed ID: 23994500	2013
Functional expression of the transient receptor potential channel TRPA1, a sensor for toxic lung inhalants, in pulmonary epithelial cells. Chemico-biological interactions\| PubMed ID: 23994502	2013
Reactivation of plasma butyrylcholinesterase by pralidoxime chloride in patients poisoned by WHO class II toxicity organophosphorus insecticides. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 24052565	2013
In vitro kinetics of nerve agent degradation by fresh frozen plasma (FFP). Archives of toxicology\| PubMed ID: 24057572	2014
Limitations and challenges in treatment of acute chemical warfare agent poisoning. Chemico-biological interactions\| PubMed ID: 24091052	2013
Drug development for the management of organophosphorus poisoning. Expert opinion on drug discovery\| PubMed ID: 24125474	2013
Detoxification of alkyl methylphosphonofluoridates by an oxime-substituted β-cyclodextrin--an in vitro structure-activity study. Toxicology letters\| PubMed ID: 24185128	2014
Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro. Archives of toxicology\| PubMed ID: 24477626	2014
Effectiveness of a substituted β-cyclodextrin to prevent cyclosarin toxicity in vivo. Toxicology letters\| PubMed ID: 24561299	2014
In vitro toxicokinetic studies of cyclosarin: molecular mechanisms of elimination. Toxicology letters\| PubMed ID: 24641973	2014
V-type nerve agents phosphonylate ubiquitin at biologically relevant lysine residues and induce intramolecular cyclization by an isopeptide bond. Analytical and bioanalytical chemistry\| PubMed ID: 24652148	2014
Chlorambucil (nitrogen mustard) induced impairment of early vascular endothelial cell migration - effects of α-linolenic acid and N-acetylcysteine. Chemico-biological interactions\| PubMed ID: 24892517	2014
Reactivation kinetics of 31 structurally different bispyridinium oximes with organophosphate-inhibited human butyrylcholinesterase. Archives of toxicology\| PubMed ID: 24912784	2015
Spinal cord--skeletal muscle cocultures detect muscle-relaxant action of botulinum neurotoxin A. ALTEX\| PubMed ID: 25127438	2014
Post-exposure treatment of VX poisoned guinea pigs with the engineered phosphotriesterase mutant C23: a proof-of-concept study. Toxicology letters\| PubMed ID: 25195526	2014
Reactions of methylphosphonic difluoride with human acetylcholinesterase and oximes--Possible therapeutic implications. Toxicology letters\| PubMed ID: 25240274	2014
Development of a co-culture of keratinocytes and immune cells for in vitro investigation of cutaneous sulfur mustard toxicity. Chemico-biological interactions\| PubMed ID: 25256379	2014
Activation of the chemosensing transient receptor potential channel A1 (TRPA1) by alkylating agents. Archives of toxicology\| PubMed ID: 25395009	2014
In vitro and in vivo toxicological studies of V nerve agents: molecular and stereoselective aspects. Toxicology letters\| PubMed ID: 25448275	2015
Adaptation of a dynamic in vitro model with real-time determination of butyrylcholinesterase activity in the presence of cyclosarin and an oxime. Toxicology in vitro : an international journal published in association with BIBRA\| PubMed ID: 25450746	2015
Effect of reversible ligands on oxime-induced reactivation of sarin- and cyclosarin-inhibited human acetylcholinesterase. Toxicology letters\| PubMed ID: 25522658	2015
Evidence of Sulfur Mustard Exposure in Human Plasma by LC-ESI-MS-MS Detection of the Albumin-Derived Alkylated HETE-CP Dipeptide and Chromatographic Investigation of Its Cis/Trans Isomerism. Journal of analytical toxicology\| PubMed ID: 25712440	2015
Small-scale purification of butyrylcholinesterase from human plasma and implementation of a μLC-UV/ESI MS/MS method to detect its organophosphorus adducts. Drug testing and analysis\| PubMed ID: 25828536	2015
Reversed-phase ion-pair chromatography-diode array detection of the bispyridinium compound MB327: plasma analysis of a potential novel antidote for the treatment of organophosphorus poisonin... Drug testing and analysis\| PubMed ID: 26041012	2015
Impairment of hypoxia-induced HIF-1α signaling in keratinocytes and fibroblasts by sulfur mustard is counteracted by a selective PHD-2 inhibitor. Archives of toxicology\| PubMed ID: 26082309	2015
Repetitive obidoxime treatment induced increase of red blood cell acetylcholinesterase activity even in a late phase of a severe methamidophos poisoning: A case report. Toxicology letters\| PubMed ID: 26200596	2016
Catalytic bioscavengers in nerve agent poisoning: A promising approach? Toxicology letters\| PubMed ID: 26200600	2016
Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase. Toxicology letters\| PubMed ID: 26210933	2016
Kinetics of pesticide degradation by human fresh frozen plasma (FFP) in vitro. Toxicology letters\| PubMed ID: 26220518	2016
Self-regeneration of neuromuscular function following soman and VX poisoning in spinal cord-skeletal muscle cocultures. Toxicology letters\| PubMed ID: 26256036	2016
Botulinum toxin B increases intrinsic muscle activity in organotypic spinal cord-skeletal muscle co-cultures. Toxicology letters\| PubMed ID: 26260118	2016
Elimination kinetics and molecular reaction mechanisms of cyclosarin (GF) by an oxime substituted β-cyclodextrin derivative in vitro. Toxicology letters\| PubMed ID: 26272752	2015
Medical documentation, bioanalytical evidence of an accidental human exposure to sulfur mustard and general therapy recommendations. Toxicology letters\| PubMed ID: 26321678	2016
Anesthetic actions of thiopental remain largely unaffected during cholinergic overstimulation in cultured cortical networks. Toxicology letters\| PubMed ID: 26325215	2016
Optimization of the CULTEX(®) radial flow system for in vitro investigation of lung damaging agents. Toxicology letters\| PubMed ID: 26358518	2016
Protective effects of the thiol compounds GSH and NAC against sulfur mustard toxicity in a human keratinocyte cell line. Toxicology letters\| PubMed ID: 26361990	2016
Application of a dynamic in vitro model with real-time determination of acetylcholinesterase activity for the investigation of tabun analogues and oximes. Toxicology in vitro : an international journal published in association with BIBRA\| PubMed ID: 26368669	2015
Sulfur and nitrogen mustards induce characteristic poly(ADP-ribosyl)ation responses in HaCaT keratinocytes with distinctive cellular consequences. Toxicology letters\| PubMed ID: 26383629	2016
Immunochemical analysis of poly(ADP-ribosyl)ation in HaCaT keratinocytes induced by the mono-alkylating agent 2-chloroethyl ethyl sulfide (CEES): Impact of experimental conditions. Toxicology letters\| PubMed ID: 26383632	2016
Epigenetic modulations in early endothelial cells and DNA hypermethylation in human skin after sulfur mustard exposure. Toxicology letters\| PubMed ID: 26392148	2016
Optimized verification method for detection of an albumin-sulfur mustard adduct at Cys(34) using a hybrid quadrupole time-of-flight tandem mass spectrometer after direct plasma proteolysis. Toxicology letters\| PubMed ID: 26449527	2016
Characterization of sulfur mustard resistant keratinocyte cell line HaCaT/SM. Toxicology letters\| PubMed ID: 26456177	2016
Alteration of miRNA expression in early endothelial cells after exposure with sub-lethal sulfur mustard concentrations. Toxicology letters\| PubMed ID: 26456178	2016
Development of the sulfur mustard resistant keratinocyte cell line HaCaT/SM. Toxicology letters\| PubMed ID: 26463895	2016
A novel fluorogenic probe for the investigation of free thiols: Application to kinetic measurements of acetylcholinesterase activity. Toxicology letters\| PubMed ID: 26494253	2016
Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro. Archives of toxicology\| PubMed ID: 26612364	2016
Editorial. Toxicology letters\| PubMed ID: 26873068	2016
On-site analysis of acetylcholinesterase and butyrylcholinesterase activity with the ChE check mobile test kit-Determination of reference values and their relevance for diagnosis of exposure... Toxicology letters\| PubMed ID: 27033775	2016
Oximes in organophosphate poisoning: 60 years of hope and despair. Chemico-biological interactions\| PubMed ID: 27125761	2016
Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokin... Toxicology\| PubMed ID: 27153754	2016
Bispyridinium non-oximes: An evaluation of cardiac effects in isolated hearts and smooth muscle relaxing effects in jejunum. Toxicology in vitro : an international journal published in association with BIBRA\| PubMed ID: 27184650	2016
Toxicology of organophosphorus compounds in view of an increasing terrorist threat. Archives of toxicology\| PubMed ID: 27349770	2016
Pseudocatalytic scavenging of the nerve agent VX with human blood components and the oximes obidoxime and HI-6. Archives of toxicology\| PubMed ID: 27358236	2017
Single treatment of VX poisoned guinea pigs with the phosphotriesterase mutant C23AL: Intraosseous versus intravenous injection. Toxicology letters\| PubMed ID: 27397758	2016
Procedures for Analysis of Dried Plasma Using Microsampling Devices to Detect Sulfur Mustard-Albumin Adducts for Verification of Poisoning. Analytical chemistry\| PubMed ID: 27482832	2016
Modification of human serum albumin by the nerve agent VX: microbore liquid chromatography/electrospray ionization high-resolution time-of-flight tandem mass spectrometry method for detectio... Rapid communications in mass spectrometry : RCM\| PubMed ID: 27490696	2016
Blaptica dubia as sentinels for exposure to chemical warfare agents - a pilot study. Toxicology letters\| PubMed ID: 27639501	2016
N-Acetyl-L-cysteine inhibits sulfur mustard-induced and TRPA1-dependent calcium influx. Archives of toxicology\| PubMed ID: 27738742	2017
S - and N-alkylating agents diminish the fluorescence of fluorescent dye-stained DNA. Chemico-biological interactions\| PubMed ID: 27923644	2017
Identification of novel disulfide adducts between the thiol containing leaving group of the nerve agent VX and cysteine containing tripeptides derived from human serum albumin. Drug testing and analysis\| PubMed ID: 27935238	2017
Precision cut lung slices as test system for candidate therapeutics in organophosphate poisoning. Toxicology\| PubMed ID: 28743514	2017
Effects of sulfur mustard on mesenchymal stem cells. Toxicology letters\| PubMed ID: 28818580	2018
Alteration of miRNA expression in a sulfur mustard resistant cell line. Toxicology letters\| PubMed ID: 28823541	2018
Development of a sensitive, generic and easy to use organophosphate skin disclosure kit. Toxicology letters\| PubMed ID: 28851585	2017
N-Acetylcysteine as a chemical scavenger for sulfur mustard: New insights by mass spectrometry. Drug testing and analysis\| PubMed ID: 28879668	2018
Effects of anti-inflammatory compounds on sulfur mustard injured cells: Recommendations and caveats suggested by in vitro cell culture models. Toxicology letters\| PubMed ID: 28916287	2018
Anti-apoptotic and moderate anti-inflammatory effects of berberine in sulfur mustard exposed keratinocytes. Toxicology letters\| PubMed ID: 28916288	2018
Zinc chloride-induced TRPA1 activation does not contribute to toxicity in vitro. Toxicology letters\| PubMed ID: 28919489	2018
Immediate responses of the cockroach Blaptica dubia after the exposure to sulfur mustard. Archives of toxicology\| PubMed ID: 28932886	2018
Environmental exposure to organophosphorus nerve agents. Environmental toxicology and pharmacology\| PubMed ID: 28942081	2017
The oximes HI-6 and MMB-4 fail to reactivate soman-inhibited human and guinea pig AChE: A kinetic in vitro study. Toxicology letters\| PubMed ID: 28993240	2018
Searching for putative binding sites of the bispyridinium compound MB327 in the nicotinic acetylcholine receptor. Toxicology letters\| PubMed ID: 29097222	2018
Human small bowel as a useful tool to investigate smooth muscle effects of potential therapeutics in organophosphate poisoning. Toxicology letters\| PubMed ID: 29154801	2018
Sulfur mustard-induced epigenetic modifications over time - a pilot study. Toxicology letters\| PubMed ID: 29155286	2018
Sulfur mustard resistant keratinocytes obtained elevated glutathione levels and other changes in the antioxidative defense mechanism. Toxicology letters\| PubMed ID: 29183814	2018
Accidental sulfur mustard exposure: A case report. Toxicology letters\| PubMed ID: 29191789	2018
Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human α7-nicotinic acetylcholine receptor activity-An in vitro structure-activ... Toxicology letters\| PubMed ID: 29191791	2018
Counteracting desensitization of human α7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning. Toxicology letters\| PubMed ID: 29248576	2018
Glutathione as an antidote for sulfur mustard poisoning: Mass spectrometric investigations of its potency as a chemical scavenger. Toxicology letters\| PubMed ID: 29277572	2018
Bioanalytical verification of V-type nerve agent exposure: simultaneous detection of phosphonylated tyrosines and cysteine-containing disulfide-adducts derived from human albumin. Analytical and bioanalytical chemistry\| PubMed ID: 29322229	2018
Mobilization of human mesenchymal stem cells through different cytokines and growth factors after their immobilization by sulfur mustard. Toxicology letters\| PubMed ID: 29426001	2018
Cytostatic resistance profile of the sulfur mustard resistant keratinocyte cell line HaCaT/SM. Toxicology letters\| PubMed ID: 29551593	2018
A toolbox for microbore liquid chromatography tandem-high-resolution mass spectrometry analysis of albumin-adducts as novel biomarkers of organophosphorus pesticide poisoning. Toxicology letters\| PubMed ID: 29702198	2018
Novel cysteine- and albumin-adduct biomarkers to prove human poisoning with the pesticide oxydemeton-S-methyl. Toxicology letters\| PubMed ID: 29777832	2018
New Resensitizers for the Nicotinic Acetylcholine Receptor by Ligand-Based Pharmacophore Modeling. Current computer-aided drug design\| PubMed ID: 29968541	2019
Synthesis of a Series of Structurally Diverse MB327 Derivatives and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor. ChemMedChem\| PubMed ID: 29974635	2018
Simultaneous quantification of atropine and scopolamine in infusions of herbal tea and Solanaceae plant material by matrix-assisted laser desorption/ionization time-of-flight (tandem) mass s... Rapid communications in mass spectrometry : RCM\| PubMed ID: 30117208	2018
Midazolam is effective to reduce cortical network activity in organotypic cultures during severe cholinergic overstimulation with soman. Toxicology letters\| PubMed ID: 30165091	2018
Verification of organophosphorus pesticide poisoning: Detection of phosphorylated tyrosines and a cysteine-proline disulfide-adduct from human serum albumin after intoxication with dimethoat... Toxicology letters\| PubMed ID: 30165092	2018
Transient Receptor Potential Channel A1 (TRPA1) Regulates Sulfur Mustard-Induced Expression of Heat Shock 70 kDa Protein 6 () In Vitro. Cells\| PubMed ID: 30200301	2018
Effect of cholinergic crisis on the potency of different emergency anaesthesia protocols in soman-poisoned rats. Clinical toxicology (Philadelphia, Pa.)\| PubMed ID: 30307341	2019
Interactions between acetylcholinesterase, toxic organophosphorus compounds and a short series of structurally related non-oxime reactivators: Analysis of reactivation and inhibition kinetic... Toxicology letters\| PubMed ID: 30312685	2018
Synthesis of a Series of Non-Symmetric Bispyridinium and Related Compounds and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor. ChemMedChem\| PubMed ID: 30362667	2018
Necrosulfonamide - Unexpected effect in the course of a sulfur mustard intoxication. Chemico-biological interactions\| PubMed ID: 30391637	2019
Collision-induced mass spectrometric fragmentation of protonated dimethoate and omethoate generated by electrospray ionization. Rapid communications in mass spectrometry : RCM\| PubMed ID: 30402977	2019
Methionine in human serum albumin: A novel target for alkylation by sulfur mustard. Drug testing and analysis\| PubMed ID: 30468304	2019
A novel exposure system generating nebulized aerosol of sulfur mustard in comparison to the standard submerse exposure. Chemico-biological interactions\| PubMed ID: 30502332	2019
COPD and asthma therapeutics for supportive treatment in organophosphate poisoning. Clinical toxicology (Philadelphia, Pa.)\| PubMed ID: 30696282	2019
Human small bowel as model for poisoning with organophosphorus compounds. Toxicology in vitro : an international journal published in association with BIBRA\| PubMed ID: 30763608	2019
The arrhythmogenic potential of nerve agents and a cardiac safety profile of antidotes - A proof-of-concept study using human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CM)... Toxicology letters\| PubMed ID: 30858091	2019
Validation of the CULTEX® Radial Flow System for the assessment of the acute inhalation toxicity of airborne particles. Toxicology in vitro : an international journal published in association with BIBRA\| PubMed ID: 30890356	2019
Evaluation of selective and non-selective cyclooxygenase inhibitors on sulfur mustard-induced pro-inflammatory cytokine formation in normal human epidermal keratinocytes. Toxicology letters\| PubMed ID: 31048000	2019
Forensic evidence of sulfur mustard exposure in real cases of human poisoning by detection of diverse albumin-derived protein adducts. Archives of toxicology\| PubMed ID: 31069408	2019
Skin sensitizing effects of sulfur mustard and other alkylating agents in accordance to OECD guidelines. Toxicology letters\| PubMed ID: 31404593	2019
Efficacy of an organophosphorus hydrolase enzyme (OpdA) in human serum and minipig models of organophosphorus insecticide poisoning. Clinical toxicology (Philadelphia, Pa.)\| PubMed ID: 31452424	2019
Sulfur mustard alkylates steroid hormones and impacts hormone function in vitro. Archives of toxicology\| PubMed ID: 31515601	2019
[Chemical warfare agent poisoning]. Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz\| PubMed ID: 31602511	2019
Effect of sulfur mustard on melanogenesis in vitro. Toxicology letters\| PubMed ID: 31785464	2020
Screening of chiral shift reagents suitable to generically separate the enantiomers of V-agents by P-NMR spectroscopy. Toxicology letters\| PubMed ID: 31805340	2020
Validation of automated pipetting systems for cell culture seeding, exposure and bio-analytical assays in sulfur mustard toxicology. Toxicology letters\| PubMed ID: 31809884	2020
Comparison of the toxicity of sulfur mustard and its oxidation products in vitro. Toxicology letters\| PubMed ID: 31863871	2020
Impact of soman and acetylcholine on the effects of propofol in cultured cortical networks. Toxicology letters\| PubMed ID: 31954869	2020