Assessment of Endothelial Cell Migration After Exposure to Toxic Chemicals

Dirk Steinritz; Annette Schmidt; Frank Balszuweit; Horst Thiermann; Marwa Ibrahim; Birgit B&#246;lck; Wilhelm Bloch

doi:10.3791/52768

Journal

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Developmental Biology

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Assessment of Endothelial Cell Migration After Exposure to Toxic Chemicals

JoVE Journal
Developmental Biology

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JoVE Journal Developmental Biology

Assessment of Endothelial Cell Migration After Exposure to Toxic Chemicals

8,662 Views

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07:07 min

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July 10, 2015

DOI:

10.3791/52768-v

DOI:

10.3791/52768-v

•

07:07 min

July 10, 2015

•

8649 Views

Dirk Steinritz^1,2, Annette Schmidt^1,3, Frank Balszuweit¹, Horst Thiermann¹, Marwa Ibrahim³, Birgit Bölck³, Wilhelm Bloch³

¹Bundeswehr Institute of Pharmacology and Toxicology ²Walther Straub Institute of Pharmacology and Toxicology,Ludwig-Maximilians-Universität München ³Department of Molecular and Cellular Sports Medicine,German Sports University Cologne

Summary

Investigation of early endothelial cell (EEC) migration is important to understand the pathophysiology of certain illnesses and to potentially identify novel strategies for therapeutic intervention. The following protocol describes techniques to assess cell migration that have been adapted for the investigation of EEC.