Xavier Saelens

Inflammation Research Center, VIB

Affiliated withVIB Ghent University Ghent University (UGent)

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 15	2015
Publication title Cited by 154	2017

Other Publications

Article	Year
Proteolysis of enteric cell villin by Entamoeba histolytica cysteine proteinases. The Journal of biological chemistry\| PubMed ID: 12690119	2003
Mitochondrial intermembrane proteins in cell death. Biochemical and biophysical research communications\| PubMed ID: 12729583	2003
A Bcl-2 transgene expressed in hepatocytes does not protect mice from fulminant liver destruction induced by Fas ligand. Cytokine\| PubMed ID: 12849704	2003
Bcl-2 family members as sentinels of cellular integrity and role of mitochondrial intermembrane space proteins in apoptotic cell death. Acta haematologica\| PubMed ID: 14646342	2004
Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD. The Journal of biological chemistry\| PubMed ID: 14668343	2004
Phagocytosis of necrotic cells by macrophages is phosphatidylserine dependent and does not induce inflammatory cytokine production. Molecular biology of the cell\| PubMed ID: 14668480	2004
Caspase-1 activates nuclear factor of the kappa-enhancer in B cells independently of its enzymatic activity. The Journal of biological chemistry\| PubMed ID: 15039421	2004
Toxic proteins released from mitochondria in cell death. Oncogene\| PubMed ID: 15077149	2004
Doxorubicin-induced activation of protein kinase D1 through caspase-mediated proteolytic cleavage: identification of two cleavage sites by microsequencing. Cellular signalling\| PubMed ID: 15093611	2004
INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation. The Journal of biological chemistry\| PubMed ID: 15383541	2004
A novel caspase-2 complex containing TRAF2 and RIP1. The Journal of biological chemistry\| PubMed ID: 15590671	2005
Apoptosis of hematopoietic cells induced by growth factor withdrawal is associated with caspase-9 mediated cleavage of Raf-1. Oncogene\| PubMed ID: 15674327	2005
Protein synthesis persists during necrotic cell death. The Journal of cell biology\| PubMed ID: 15699214	2005
Necrosis is associated with IL-6 production but apoptosis is not. Cellular signalling\| PubMed ID: 16023831	2006
The universal influenza vaccine M2e-HBc administered intranasally in combination with the adjuvant CTA1-DD provides complete protection. Vaccine\| PubMed ID: 16169634	2006
Improved design and intranasal delivery of an M2e-based human influenza A vaccine. Vaccine\| PubMed ID: 16814430	2006
Proteome-wide Identification of HtrA2/Omi Substrates. Journal of proteome research\| PubMed ID: 17266347	2007
Caspase-mediated cleavage of the exosome subunit PM/Scl-75 during apoptosis. Arthritis research & therapy\| PubMed ID: 17280603	2007
CTA1-M2e-DD: a novel mucosal adjuvant targeted influenza vaccine. Vaccine\| PubMed ID: 18243429	2008
An influenza A vaccine based on tetrameric ectodomain of matrix protein 2. The Journal of biological chemistry\| PubMed ID: 18252707	2008
Universal influenza A M2e-HBc vaccine protects against disease even in the presence of pre-existing anti-HBc antibodies. Vaccine\| PubMed ID: 18835315	2008
Pandemic preparedness: toward a universal influenza vaccine. Drug news & perspectives\| PubMed ID: 19330167	2009
Universal M2 ectodomain-based influenza A vaccines: preclinical and clinical developments. Expert review of vaccines\| PubMed ID: 19348565	2009
Role of IFN-alpha during the acute stage of a swine influenza virus infection. Research in veterinary science\| PubMed ID: 19647281	2010
M2e-based universal influenza A vaccine. Vaccine\| PubMed ID: 19840661	2009
The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal. Cell research\| PubMed ID: 20125124	2010
Controlling influenza by cytotoxic T-cells: calling for help from destroyers. Journal of biomedicine & biotechnology\| PubMed ID: 20508820	2010
Antiserum against the conserved nine amino acid N-terminal peptide of influenza A virus matrix protein 2 is not immunoprotective. The Journal of general virology\| PubMed ID: 20965983	2011
Universal vaccine based on ectodomain of matrix protein 2 of influenza A: Fc receptors and alveolar macrophages mediate protection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21169548	2011
The proton translocation domain of cellular vacuolar ATPase provides a target for the treatment of influenza A virus infections. British journal of pharmacology\| PubMed ID: 21418188	2011
Nanobodies with in vitro neutralizing activity protect mice against H5N1 influenza virus infection. The Journal of infectious diseases\| PubMed ID: 21450996	2011
A novel non-toxic combined CTA1-DD and ISCOMS adjuvant vector for effective mucosal immunization against influenza virus. Vaccine\| PubMed ID: 21481325	2011
Llama-derived single domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules. PloS one\| PubMed ID: 21483777	2011
Assessment of the antiviral properties of recombinant porcine SP-D against various influenza A viruses in vitro. PloS one\| PubMed ID: 21935489	2011
Nanobodies®: new ammunition to battle viruses. Antiviral research\| PubMed ID: 21939690	2011
Nanobodies® specific for respiratory syncytial virus fusion protein protect against infection by inhibition of fusion. The Journal of infectious diseases\| PubMed ID: 21998474	2011
Polymeric multilayer capsule-mediated vaccination induces protective immunity against cancer and viral infection. ACS nano\| PubMed ID: 22303914	2012
Tailor-made cleavage site attenuates influenza B. Expert review of vaccines\| PubMed ID: 22309664	2012
A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection. PLoS pathogens\| PubMed ID: 22396652	2012
The Sin3a repressor complex is a master regulator of STAT transcriptional activity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22783022	2012
Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza a virus infection. The Journal of biological chemistry\| PubMed ID: 22910914	2012
Influenza vaccines: T-cell responses deserve more attention. Expert review of vaccines\| PubMed ID: 23002976	2012
Interferon-inducible protein Mx1 inhibits influenza virus by interfering with functional viral ribonucleoprotein complex assembly. Journal of virology\| PubMed ID: 23015724	2012
Immunization with M2e-displaying T7 bacteriophage nanoparticles protects against influenza A virus challenge. PloS one\| PubMed ID: 23029232	2012
Recombinant influenza virus carrying the respiratory syncytial virus (RSV) F85-93 CTL epitope reduces RSV replication in mice. Journal of virology\| PubMed ID: 23302879	2013
Hepatitis B core-based virus-like particles to present heterologous epitopes. Expert review of vaccines\| PubMed ID: 23414409	2013
M2e-displaying virus-like particles with associated RNA promote T helper 1 type adaptive immunity against influenza A. PloS one\| PubMed ID: 23527091	2013
Immunogenicity of live attenuated B. pertussis BPZE1 producing the universal influenza vaccine candidate M2e. PloS one\| PubMed ID: 23555631	2013
Insight into structural diversity of influenza virus haemagglutinin. The Journal of general virology\| PubMed ID: 23636824	2013
Challenges and advances towards the rational design of mRNA vaccines. Trends in molecular medicine\| PubMed ID: 24138818	2013
Metabolic profiling of insect cell lines: Unveiling cell line determinants behind system's productivity. Biotechnology and bioengineering\| PubMed ID: 24258249	2014
Mx proteins: antiviral gatekeepers that restrain the uninvited. Microbiology and molecular biology reviews : MMBR\| PubMed ID: 24296571	2013
Insight into highly conserved H1 subtype-specific epitopes in influenza virus hemagglutinin. PloS one\| PubMed ID: 24587046	2014
Akt inhibitor MK2206 prevents influenza pH1N1 virus infection in vitro. Antimicrobial agents and chemotherapy\| PubMed ID: 24752266	2014
Single-domain antibodies targeting neuraminidase protect against an H5N1 influenza virus challenge. Journal of virology\| PubMed ID: 24829341	2014
Influenza vaccines to control influenza-associated bacterial infection: where do we stand? Expert review of vaccines\| PubMed ID: 25209381	2015
CD⁸ T cell immunity against human respiratory syncytial virus. Vaccine\| PubMed ID: 25223272	2014
Protection and mechanism of action of a novel human respiratory syncytial virus vaccine candidate based on the extracellular domain of small hydrophobic protein. EMBO molecular medicine\| PubMed ID: 25298406	2014
Sequence-dependent internalization of aggregating peptides. The Journal of biological chemistry\| PubMed ID: 25391649	2015
Structure of the extracellular domain of matrix protein 2 of influenza a virus in complex with a protective monoclonal antibody. Journal of virology\| PubMed ID: 25609808	2015
Scop3D: Three-dimensional visualization of sequence conservation. Proteomics\| PubMed ID: 25641949	2015
Analysis of the genetic diversity of influenza A viruses using next-generation DNA sequencing. BMC genomics\| PubMed ID: 25758772	2015
Small hydrophobic protein of respiratory syncytial virus as a novel vaccine antigen. Immunotherapy\| PubMed ID: 25804473	2015
A GFP Expressing Influenza A Virus to Report In Vivo Tropism and Protection by a Matrix Protein 2 Ectodomain-Specific Monoclonal Antibody. PloS one\| PubMed ID: 25816132	2015
The C terminus of NS1 protein of influenza A/WSN/1933(H1N1) virus modulates antiviral responses in infected human macrophages and mice. The Journal of general virology\| PubMed ID: 25934792	2015
Protection against Influenza A Virus Challenge with M2e-Displaying Filamentous Escherichia coli Phages. PloS one\| PubMed ID: 25973787	2015
Functional Comparison of Mx1 from Two Different Mouse Species Reveals the Involvement of Loop L4 in the Antiviral Activity against Influenza A Viruses. Journal of virology\| PubMed ID: 26292322	2015
M2e-Based Universal Influenza A Vaccines. Vaccines\| PubMed ID: 26344949	2015
Crystal Structure of the Conserved Amino Terminus of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus Gripped by an Antibody. Journal of virology\| PubMed ID: 26468526	2015
GM-CSF treatment prevents respiratory syncytial virus-induced pulmonary exacerbation responses in postallergic mice by stimulating alveolar macrophage maturation. The Journal of allergy and clinical immunology\| PubMed ID: 26560044	2016
Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling. European journal of immunology\| PubMed ID: 26677802	2016
Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine. Antiviral research\| PubMed ID: 26738783	2016
A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection. PLoS pathogens\| PubMed ID: 26815999	2016
Long-Lasting Cross-Protection Against Influenza A by Neuraminidase and M2e-based immunization strategies. Scientific reports\| PubMed ID: 27072615	2016
Production and Purification of Recombinant Filamentous Bacteriophages Displaying Immunogenic Heterologous Epitopes. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 27076317	2016
One Against All: A Broadly Influenza Neutralizing Man-made Monoclonal Antibody Passes Phase I. EBioMedicine\| PubMed ID: 27077102	2016
Illumina MiSeq sequencing disfavours a sequence motif in the GFP reporter gene. Scientific reports\| PubMed ID: 27193250	2016
Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages. Molecular & cellular proteomics : MCP\| PubMed ID: 27486199	2016
Type I Interferons Interfere with the Capacity of mRNA Lipoplex Vaccines to Elicit Cytolytic T Cell Responses. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 27506450	2016
Increased Protein Degradation Improves Influenza Virus Nucleoprotein-Specific CD8+ T Cell Activation In Vitro but Not in C57BL/6 Mice. Journal of virology\| PubMed ID: 27581985	2016
M2-based influenza vaccines: recent advances and clinical potential. Expert review of vaccines\| PubMed ID: 27653543	2017
Inﬂuenza and Memory T Cells: How to Awake the Force. Vaccines\| PubMed ID: 27754364	2016
Regulation of kynurenine biosynthesis during influenza virus infection. The FEBS journal\| PubMed ID: 27860276	2017
Chemical-controlled Activation of Antiviral Myxovirus Resistance Protein 1. The Journal of biological chemistry\| PubMed ID: 28011636	2017
Hierarchical and Redundant Roles of Activating FcγRs in Protection against Influenza Disease by M2e-Specific IgG1 and IgG2a Antibodies. Journal of virology\| PubMed ID: 28077656	2017
IgG3 Snitcher of RSV Infections in the Very Young. EBioMedicine\| PubMed ID: 28159571	2017
Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state. Nature communications\| PubMed ID: 28194013	2017
Bispecific T cell engaging antibody constructs targeting a universally conserved part of the viral M2 ectodomain cure and prevent influenza A virus infection. Antiviral research\| PubMed ID: 28257797	2017
Effect of serial pig passages on the adaptation of an avian H9N2 influenza virus to swine. PloS one\| PubMed ID: 28384328	2017