Shulamit Levenberg

Shulamit Levenberg

Biomedical Engineering, Technion Israel Institute of Technology

Affiliated withTechnion Israel Institute of TechnologyTechnionTechnion-Israel Institute of Technology

Research Area

Biography

Professor Shulamit Levenberg is the head of the Stem cell and Tissue engineering lab at the Technion Faculty of Biomedical Engineering and the director of the Technion Center for 3D Bioprinting. She earned her PhD at the Weizmann Institute of Science and pursued her post-doctoral research at MIT in the lab of Professor Robert Langer. She spent a sabbatical year as a visiting professor at the Wyss Institute for Biology Inspired Engineering at Harvard University and a summer sabbatical at the University of Western Australia as a winner of the Raine Visiting Professor Award. Prof. Levenberg discoveries involve in vitro vascularization of engineered tissues where, upon implantation, the engineered vessels anastomose with the host vasculature, improving survival and perfusion of engineered grafts. Prof. Levenberg was the first to engineer vascularized tissue flaps, offering novel reconstruction techniques using engineered tissue constructs. Her work demonstrated the effect of scaffold stiffness and tensile forces on early differentiation and organization of stem cells in 3D constructs, and on alignment of vessel networks in engineered tissues. She recently developed unique stem-cell engineered tissue constructs that induce the regeneration and repair of injured spinal cords.

Prof Levenberg received the Krill Prize for excellence in scientific research, awarded by the Wolf Foundation, and was named by Scientific American as a “Research Leader” in tissue engineering, for her work on vascularization of engineered tissues. She also received the Rappaport Prize for Biomedical Sciences, the Bruno prize and the Katz prize. Recently she was awarded a Medal of Distinction from the Peres center for peace and innovation. Levenberg has authored over 100 publications, and presented her work in over 100 international conferences as an invited or keynote speaker. She is founder and CSO of three start-up companies in the areas of cultured meat, spinal cord regeneration and nanoliter diagnostic arrays. She is the former President of the Israel Stem Cell Society and the former Dean of the Technion Faculty of Biomedical Engineering.

JoVE Journal Publications

ArticleTotal : 3
Year
Engineered Vascularized Muscle Flap
Publication title

Cited by 6

2016
2021
2022

Other Publications

Article
Year
Endothelial cells derived from human embryonic stem cells.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 11917100

2002
Differentiation of human embryonic stem cells on three-dimensional polymer scaffolds.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 14561891

2003
2004
2004
Advances in tissue engineering.

Current topics in developmental biology| PubMed ID: 15350399

2004
2005
Engineering vascularized skeletal muscle tissue.

Nature biotechnology| PubMed ID: 15965465

2005
Engineering blood vessels from stem cells: recent advances and applications.

Current opinion in biotechnology| PubMed ID: 16144762

2005
2006
2007
2007
2007
Engineering human embryonic stem cell differentiation.

Biotechnology & genetic engineering reviews| PubMed ID: 18059636

2007
2008
2008
2008
2009
Effect of scaffold stiffness on myoblast differentiation.

Tissue engineering. Part A| PubMed ID: 18821844

2009
Design of well and groove microchannel bioreactors for cell culture.

Biotechnology and bioengineering| PubMed ID: 18973280

2009
2009
Vascularization--the conduit to viable engineered tissues.

Tissue engineering. Part B, Reviews| PubMed ID: 19309238

2009
Cell-scaffold mechanical interplay within engineered tissue.

Seminars in cell & developmental biology| PubMed ID: 19596326

2009
2010
2010
Vascularization shaping the heart.

Annals of the New York Academy of Sciences| PubMed ID: 20201885

2010
Infantile aphakic glaucoma: a proposed etiologic role of IL-4 and VEGF.

Journal of pediatric ophthalmology and strabismus| PubMed ID: 20506964

2011
2010
2010
2010
2011
2011
Improved vascular organization enhances functional integration of engineered skeletal muscle grafts.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 21878567

2011
2011
Mechanical control of stem cell differentiation.

Regenerative medicine| PubMed ID: 22168501

2012
2012
2012
2013
2013
2013
2013
2014
An engineered muscle flap for reconstruction of large soft tissue defects.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 24711414

2014
2015
Stationary nanoliter droplet array with a substrate of choice for single adherent/nonadherent cell incubation and analysis.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 25053808

2014
Cell tri-culture for cardiac vascularization.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 25070333

2014
A method for constructing vascularized muscle flap.

Methods (San Diego, Calif.)| PubMed ID: 25843607

2015
Mechanical regulation of vascular network formation in engineered matrices.

Advanced drug delivery reviews| PubMed ID: 26212159

2016
2015
Vasculogenic dynamics in 3D engineered tissue constructs.

Scientific reports| PubMed ID: 26648270

2015
2016
Morphogenesis of 3D vascular networks is regulated by tensile forces.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 26951667

2016
2017
Spontaneous Activity Characteristics of 3D "Optonets".

Frontiers in neuroscience| PubMed ID: 28119555

2016
Elderly Patient-Derived Endothelial Cells for Vascularization of Engineered Muscle.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 28279644

2017
Engineering vascularized flaps using adipose-derived microvascular endothelial cells and mesenchymal stem cells.

Journal of tissue engineering and regenerative medicine| PubMed ID: 28382732

2018
Rapid phenotypic antimicrobial susceptibility testing using nanoliter arrays.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 28652348

2017
2017
Localization of Engineered Vasculature within 3D Tissue Constructs.

Frontiers in bioengineering and biotechnology| PubMed ID: 29404324

2018
Nanoliter Cell Culture Array with Tunable Chemical Gradients.

Analytical chemistry| PubMed ID: 29772178

2018
Innervation of an engineered muscle graft for reconstruction of muscle defects.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons| PubMed ID: 29856531

2019
2018
Oscillatory Strain Promotes Vessel Stabilization and Alignment through Fibroblast YAP-Mediated Mechanosensitivity.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)| PubMed ID: 30250793

2018
2018
2018
Mature vessel networks in engineered tissue promote graft-host anastomosis and prevent graft thrombosis.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 30718418

2019
2019
2019
2019
2020
2014
2020
2018
2020
2020
2021
Investigating lymphangiogenesis in vitro and in vivo using engineered human lymphatic vessel networks.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 34326257

2021
2021
2022
2021
2021
2021
2022
2022
The Role of Biomaterials in Peripheral Nerve and Spinal Cord Injury: A Review.

International journal of molecular sciences| PubMed ID: 35163168

2022
2022
2022