Dieter Egli

Department of Molecular and Cell Biology, Harvard

Affiliated withHarvard Columbia University Columbia College

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 7	2006
Publication title Cited by 3	2024

Other Publications

Article	Year
Breaking ground on translational stem cell research. Annals of the New York Academy of Sciences\| PubMed ID: 20233361	2010
Recipient cell nuclear factors are required for reprogramming by nuclear transfer. Development (Cambridge, England)\| PubMed ID: 20463036	2010
The New York Stem Cell Foundation: Fifth Annual Translational Stem Cell Research Conference. Annals of the New York Academy of Sciences\| PubMed ID: 21615750	2011
Reprogramming within hours following nuclear transfer into mouse but not human zygotes. Nature communications\| PubMed ID: 21971503	2011
Human oocytes reprogram somatic cells to a pluripotent state. Nature\| PubMed ID: 21979046	2011
Impracticality of egg donor recruitment in the absence of compensation. Cell stem cell\| PubMed ID: 21982228	2011
BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity. Science (New York, N.Y.)\| PubMed ID: 22034435	2011
Long-term safety and efficacy of human induced pluripotent stem cell (iPS) grafts in a preclinical model of retinitis pigmentosa. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 22895806	2012
Mouse ooplasm confers context-specific reprogramming capacity. Nature genetics\| PubMed ID: 22902786	2012
Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants. Nature\| PubMed ID: 23254936	2013
Improved methods for reprogramming human dermal fibroblasts using fluorescence activated cell sorting. PloS one\| PubMed ID: 23555815	2013
Tying replication to cell identity. Nature reviews. Molecular cell biology\| PubMed ID: 23698578	2013
iPSC-derived β cells model diabetes due to glucokinase deficiency. The Journal of clinical investigation\| PubMed ID: 23778137	2013
Connecting the cell cycle with cellular identity. Cellular reprogramming\| PubMed ID: 24073943	2013
β-cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome. Diabetes\| PubMed ID: 24227685	2014
Mouse BAZ1A (ACF1) is dispensable for double-strand break repair but is essential for averting improper gene expression during spermatogenesis. PLoS genetics\| PubMed ID: 24244200	2013
Harnessing the stem cell potential: the path to prevent mitochondrial disease. Nature medicine\| PubMed ID: 24309656	2013
Validation of genome-wide association study (GWAS)-identified disease risk alleles with patient-specific stem cell lines. Human molecular genetics\| PubMed ID: 24497574	2014
Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia. Obesity (Silver Spring, Md.)\| PubMed ID: 24574081	2014
Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells. Nature\| PubMed ID: 24776804	2014
Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice. Cell metabolism\| PubMed ID: 24807221	2014
Gene therapy in patient-specific stem cell lines and a preclinical model of retinitis pigmentosa with membrane frizzled-related protein defects. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 24895994	2014
FOXO1 inhibition yields functional insulin-producing cells in human gut organoid cultures. Nature communications\| PubMed ID: 24979718	2014
Comparable frequencies of coding mutations and loss of imprinting in human pluripotent cells derived by nuclear transfer and defined factors. Cell stem cell\| PubMed ID: 25517467	2014
Differentiation of hypothalamic-like neurons from human pluripotent stem cells. The Journal of clinical investigation\| PubMed ID: 25555215	2015
Toward beta cell replacement for diabetes. The EMBO journal\| PubMed ID: 25733347	2015
Knockout of 'metal-responsive transcription factor' MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis. The EMBO journal\| PubMed ID: 12505988	2003
Physical and functional interaction between the Bloom's syndrome gene product and the largest subunit of chromatin assembly factor 1. Molecular and cellular biology\| PubMed ID: 15143166	2004
An efficient method to generate chromosomal rearrangements by targeted DNA double-strand breaks in Drosophila melanogaster. Genome research\| PubMed ID: 15197166	2004
Metal-responsive transcription factor (MTF-1) and heavy metal stress response in Drosophila and mammalian cells: a functional comparison. Biological chemistry\| PubMed ID: 15318808	2004
Metal-responsive transcription factor (MTF-1) handles both extremes, copper load and copper starvation, by activating different genes. Genes & development\| PubMed ID: 15833915	2005
A family knockout of all four Drosophila metallothioneins reveals a central role in copper homeostasis and detoxification. Molecular and cellular biology\| PubMed ID: 16508004	2006
The four members of the Drosophila metallothionein family exhibit distinct yet overlapping roles in heavy metal homeostasis and detoxification. Genes to cells : devoted to molecular & cellular mechanisms\| PubMed ID: 16716195	2006
Transcriptome response to heavy metal stress in Drosophila reveals a new zinc transporter that confers resistance to zinc. Nucleic acids research\| PubMed ID: 16973896	2006
In vivo construction of transgenes in Drosophila. Genetics\| PubMed ID: 17179096	2007
Copper homeostasis in Drosophila by complex interplay of import, storage and behavioral avoidance. The EMBO journal\| PubMed ID: 17290228	2007
Developmental reprogramming after chromosome transfer into mitotic mouse zygotes. Nature\| PubMed ID: 17554301	2007
CAF-1 is essential for Drosophila development and involved in the maintenance of epigenetic memory. Developmental biology\| PubMed ID: 17916346	2007
Mediators of reprogramming: transcription factors and transitions through mitosis. Nature reviews. Molecular cell biology\| PubMed ID: 18568039	2008
Dumpy-30 family members as determinants of male fertility and interaction partners of metal-responsive transcription factor 1 (MTF-1) in Drosophila. BMC developmental biology\| PubMed ID: 18588663	2008
Overexpression of metal-responsive transcription factor (MTF-1) in Drosophila melanogaster ameliorates life-span reductions associated with oxidative stress and metal toxicity. Neurobiology of aging\| PubMed ID: 18775584	2010
Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines. Cell stem cell\| PubMed ID: 19200798	2009
Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming. Nature biotechnology\| PubMed ID: 19330000	2009
Digital RNA allelotyping reveals tissue-specific and allele-specific gene expression in human. Nature methods\| PubMed ID: 19620972	2009
Reprogramming after chromosome transfer into mouse blastomeres. Current biology : CB\| PubMed ID: 19682906	2009
A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell stem cell\| PubMed ID: 19818703	2009
Stem Cell-Derived Beta Cells for Treatment of Type 1 Diabetes? EBioMedicine\| PubMed ID: 26137512	2014
From cloned frogs to patient matched stem cells: induced pluripotency or somatic cell nuclear transfer? Current opinion in genetics & development\| PubMed ID: 26282611	2015
Human embryos commonly form abnormal nuclei during development: a mechanism of DNA damage, embryonic aneuploidy, and developmental arrest. Human reproduction (Oxford, England)\| PubMed ID: 26621855	2016
Attitudes toward prevention of mtDNA-related diseases through oocyte mitochondrial replacement therapy. Human reproduction (Oxford, England)\| PubMed ID: 26936885	2016
Derivation and differentiation of haploid human embryonic stem cells. Nature\| PubMed ID: 26982723	2016
Hypomorphism of Fto and Rpgrip1l causes obesity in mice. The Journal of clinical investigation\| PubMed ID: 27064284	2016
Genetic Drift Can Compromise Mitochondrial Replacement by Nuclear Transfer in Human Oocytes. Cell stem cell\| PubMed ID: 27212703	2016
Efficient Generation of Hypothalamic Neurons from Human Pluripotent Stem Cells. Current protocols in human genetics\| PubMed ID: 27367166	2016
Analysis of chromosomal aberrations and recombination by allelic bias in RNA-Seq. Nature communications\| PubMed ID: 27385103	2016
Identification and propagation of haploid human pluripotent stem cells. Nature protocols\| PubMed ID: 27763625	2016
Induced pluripotent stem cells (iPSC) created from skin fibroblasts of patients with Prader-Willi syndrome (PWS) retain the molecular signature of PWS. Stem cell research\| PubMed ID: 27789403	2016
Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome. The Journal of clinical investigation\| PubMed ID: 27941249	2017
Inconsistency in 'three-parent' IVF study. Reproductive biomedicine online\| PubMed ID: 28038847	2017
PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons. Stem cell reports\| PubMed ID: 28132887	2017
Genome Transfer Prevents Fragmentation and Restores Developmental Potential of Developmentally Compromised Postovulatory Aged Mouse Oocytes. Stem cell reports\| PubMed ID: 28242217	2017
Genomic instability during reprogramming by nuclear transfer is DNA replication dependent. Nature cell biology\| PubMed ID: 28263958	2017
Tying genetic stability to cell identity. Cell cycle (Georgetown, Tex.)\| PubMed ID: 28548589	2017
β-Cell Replacement in Mice Using Human Type 1 Diabetes Nuclear Transfer Embryonic Stem Cells. Diabetes\| PubMed ID: 28931519	2018
Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells. Transplantation\| PubMed ID: 29781950	2018
ILDR2 has a negligible role in hepatic steatosis. PloS one\| PubMed ID: 29847571	2018
Compensating human subjects providing oocytes for stem cell research: 9-year experience and outcomes. Journal of assisted reproduction and genetics\| PubMed ID: 29872942	2018
Identification and Analysis of Islet Antigen-Specific CD8 T Cells with T Cell Libraries. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 30082321	2018
Inter-homologue repair in fertilized human eggs? Nature\| PubMed ID: 30089924	2018
Pancreatic Beta Cell Differentiation From Human Pluripotent Stem Cells. Current protocols in human genetics\| PubMed ID: 30192441	2018
β Cell Replacement after Gene Editing of a Neonatal Diabetes-Causing Mutation at the Insulin Locus. Stem cell reports\| PubMed ID: 30503261	2018
Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells. Cell metabolism\| PubMed ID: 30581122	2019
NanoMod: a computational tool to detect DNA modifications using Nanopore long-read sequencing data. BMC genomics\| PubMed ID: 30712508	2019
Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development. JCI insight\| PubMed ID: 30728336	2019
Transgenic substitution with Greater Amberjack Seriola dumerili fish insulin 2 in NOD mice reduces beta cell immunogenicity. Scientific reports\| PubMed ID: 30899071	2019
Induction of α cell-restricted Gc in dedifferentiating β cells contributes to stress-induced β-cell dysfunction. JCI insight\| PubMed ID: 31120862	2019
Stimulation of CRISPR-mediated homology-directed repair by an engineered RAD18 variant. Nature communications\| PubMed ID: 31363085	2019
Distinct Imprinting Signatures and Biased Differentiation of Human Androgenetic and Parthenogenetic Embryonic Stem Cells. Cell stem cell\| PubMed ID: 31491396	2019
Murine Perinatal β-Cell Proliferation and the Differentiation of Human Stem Cell-Derived Insulin-Expressing Cells Require NEUROD1. Diabetes\| PubMed ID: 31519700	2019
Physiological consequences of transient hyperleptinemia during discrete developmental periods on body weight in mice. Science translational medicine\| PubMed ID: 31894105	2020
GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration. Science translational medicine\| PubMed ID: 32051230	2020
How Safe Are Universal Pluripotent Stem Cells? Cell stem cell\| PubMed ID: 32142661	2020
Efficient SNP editing in haploid human pluripotent stem cells. Journal of assisted reproduction and genetics\| PubMed ID: 32162131	2020
Lessons Learned from Somatic Cell Nuclear Transfer. International journal of molecular sciences\| PubMed ID: 32230814	2020
Pluripotent stem cells with low differentiation potential contain incompletely reprogrammed DNA replication. The Journal of cell biology\| PubMed ID: 32673399	2020
Detection of base analogs incorporated during DNA replication by nanopore sequencing. Nucleic acids research\| PubMed ID: 32710620	2020
How Safe Are Universal Pluripotent Stem Cells? Cell stem cell\| PubMed ID: 32763183	2020
Allele-Specific Chromosome Removal after Cas9 Cleavage in Human Embryos. Cell\| PubMed ID: 33125898	2020
Reduced replication fork speed promotes pancreatic endocrine differentiation and controls graft size. JCI insight\| PubMed ID: 33529174	2021
Bardet-Biedl syndrome proteins regulate intracellular signaling and neuronal function in patient-specific iPSC-derived neurons. The Journal of clinical investigation\| PubMed ID: 33630762	2021
Heritable human genome editing: Research progress, ethical considerations, and hurdles to clinical practice. Cell\| PubMed ID: 33740453	2021
The genetic architecture of DNA replication timing in human pluripotent stem cells. Nature communications\| PubMed ID: 34799581	2021
Delayed DNA replication in haploid human embryonic stem cells. Genome research\| PubMed ID: 34810218	2021
Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes. Frontiers in endocrinology\| PubMed ID: 34858326	2021
Comprehensive analysis of DNA replication timing across 184 cell lines suggests a role for MCM10 in replication timing regulation. Human molecular genetics\| PubMed ID: 35394024	2022
Replication stress impairs chromosome segregation and preimplantation development in human embryos. Cell\| PubMed ID: 35858625	2022
Reduced calcium levels and accumulation of abnormal insulin granules in stem cell models of HNF1A deficiency. Communications biology\| PubMed ID: 35918471	2022
ZnT8 Loss of Function Mutation Increases Resistance of Human Embryonic Stem Cell-Derived Beta Cells to Apoptosis in Low Zinc Condition. Cells\| PubMed ID: 36980244	2023
Replication stress in mammalian embryo development, differentiation, and reprogramming. Trends in cell biology\| PubMed ID: 37202286	2023
Incomplete Reprogramming of DNA Replication Timing in Induced Pluripotent Stem Cells. bioRxiv : the preprint server for biology\| PubMed ID: 37398435	2023
Permanent Neonatal diabetes-causing Insulin mutations have dominant negative effects on beta cell identity. bioRxiv : the preprint server for biology\| PubMed ID: 37745320	2023
Incomplete reprogramming of DNA replication timing in induced pluripotent stem cells. Cell reports\| PubMed ID: 38194345	2024
DNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragility. bioRxiv : the preprint server for biology\| PubMed ID: 38234839	2023
Permanent neonatal diabetes-causing insulin mutations have dominant negative effects on beta cell identity. Molecular metabolism\| PubMed ID: 38237895	2024