Kevin D. Costa

Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai

Affiliated withIcahn School of Medicine at Mount Sinai Icahn School of Medicine at Mount Sinai

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 16	2016
Publication title Cited by 2	2023

Other Publications

Article	Year
Direct hydrogel encapsulation of pluripotent stem cells enables ontomimetic differentiation and growth of engineered human heart tissues. Biomaterials\| PubMed ID: 26826618	2016
Biomedical model fitting and error analysis. Science signaling\| PubMed ID: 21954296	2011
Myocyte-depleted engineered cardiac tissues support therapeutic potential of mesenchymal stem cells. Tissue engineering. Part A\| PubMed ID: 22500611	2012
Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform. Chemical communications (Cambridge, England)\| PubMed ID: 23877789	2013
Shear stress triggers insertion of voltage-gated potassium channels from intracellular compartments in atrial myocytes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24065831	2013
Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 24174427	2014
Abnormal muscle mechanosignaling triggers cardiomyopathy in mice with Marfan syndrome. The Journal of clinical investigation\| PubMed ID: 24531548	2014
Stem cell factor gene transfer improves cardiac function after myocardial infarction in swine. Circulation. Heart failure\| PubMed ID: 25342737	2015
Phospholamban as a crucial determinant of the inotropic response of human pluripotent stem cell-derived ventricular cardiomyocytes and engineered 3-dimensional tissue constructs. Circulation. Arrhythmia and electrophysiology\| PubMed ID: 25504561	2015
Physical developmental cues for the maturation of human pluripotent stem cell-derived cardiomyocytes. Stem cell research & therapy\| PubMed ID: 25688759	2014
An Evolving Understanding of the Genetic Causes of Abdominal Aortic Aneurysm Disease. Surgical technology international\| PubMed ID: 26055010	2015
An update on the etiology of abdominal aortic aneurysms: implications for future diagnostic testing. Expert review of cardiovascular therapy\| PubMed ID: 26401919	2015
Myocardial Delivery of Lipidoid Nanoparticle Carrying modRNA Induces Rapid and Transient Expression. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 26471463	2016
Human Engineered Cardiac Tissues Created Using Induced Pluripotent Stem Cells Reveal Functional Characteristics of BRAF-Mediated Hypertrophic Cardiomyopathy. PloS one\| PubMed ID: 26784941	2016
Mechanostimulation Promotes Nuclear and Epigenetic Changes in Oligodendrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 26791211	2016
Decellularized Scaffold Hydrogel Materials for MI Treatment: Could "The Matrix" Really Be the Future? Journal of the American College of Cardiology\| PubMed ID: 26940930	2016
Losartan Attenuates Degradation of Aorta and Lung Tissue Micromechanics in a Mouse Model of Severe Marfan Syndrome. Annals of biomedical engineering\| PubMed ID: 27090893	2016
Genomic correction of familial cardiomyopathy in human engineered cardiac tissues. European heart journal\| PubMed ID: 27450564	2016
Modeling Electrophysiological Coupling and Fusion between Human Mesenchymal Stem Cells and Cardiomyocytes. PLoS computational biology\| PubMed ID: 27454812	2016
Lipidoid mRNA Nanoparticles for Myocardial Delivery in Rodents. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 27910047	2017
Inhibition of SRF/myocardin reduces aortic stiffness by targeting vascular smooth muscle cell stiffening in hypertension. Cardiovascular research\| PubMed ID: 28003268	2017
Experimental and Computational Insight Into Human Mesenchymal Stem Cell Paracrine Signaling and Heterocellular Coupling Effects on Cardiac Contractility and Arrhythmogenicity. Circulation research\| PubMed ID: 28642329	2017
CXCR4 and CXCR7 play distinct roles in cardiac lineage specification and pharmacologic β-adrenergic response. Stem cell research\| PubMed ID: 28711757	2017
Machine Learning of Human Pluripotent Stem Cell-Derived Engineered Cardiac Tissue Contractility for Automated Drug Classification. Stem cell reports\| PubMed ID: 29033305	2017
Coronary capillary blood flow in a rat model of congestive heart failure. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 29051335	2018
Rho Kinase Regulates Aortic Vascular Smooth Muscle Cell Stiffness Via Actin/SRF/Myocardin in Hypertension. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology\| PubMed ID: 29169155	2017
Physiologic, Pathologic, and Therapeutic Paracrine Modulation of Cardiac Excitation-Contraction Coupling. Circulation research\| PubMed ID: 29301848	2018
Exosomal microRNA-21-5p Mediates Mesenchymal Stem Cell Paracrine Effects on Human Cardiac Tissue Contractility. Circulation research\| PubMed ID: 29449318	2018
Bioengineering an electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells. Biomaterials\| PubMed ID: 29459321	2018
Functional and transcriptomic insights into pathogenesis of R9C phospholamban mutation using human induced pluripotent stem cell-derived cardiomyocytes. Journal of molecular and cellular cardiology\| PubMed ID: 29752948	2018
Dehomogenized Elastic Properties of Heterogeneous Layered Materials in AFM Indentation Experiments. Biophysical journal\| PubMed ID: 29874620	2018
An Introduction to Computational Modeling of Cardiac Electrophysiology and Arrhythmogenicity. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 29987808	2018
Cardiac Tissue Engineering Models of Inherited and Acquired Cardiomyopathies. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 29987817	2018
Human Cardiac Ventricular-Like Organoid Chambers and Tissue Strips From Pluripotent Stem Cells as a Two-Tiered Assay for Inotropic Responses. Clinical pharmacology and therapeutics\| PubMed ID: 30723889	2019
Modulation of chromatin remodeling proteins SMYD1 and SMARCD1 promotes contractile function of human pluripotent stem cell-derived ventricular cardiomyocyte in 3D-engineered cardiac tissues. Scientific reports\| PubMed ID: 31097748	2019
3D Printing a Mechanically-Tunable Acrylate Resin on a Commercial DLP-SLA Printer. Additive manufacturing\| PubMed ID: 31106119	2018
Sarco/endoplasmic reticulum Ca-ATPase is a more effective calcium remover than sodium-calcium exchanger in human embryonic stem cell-derived cardiomyocytes. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 31347915	2019
Adult human cardiac stem cell supplementation effectively increases contractile function and maturation in human engineered cardiac tissues. Stem cell research & therapy\| PubMed ID: 31801634	2019
Combinatorial Treatment of Human Cardiac Engineered Tissues With Biomimetic Cues Induces Functional Maturation as Revealed by Optical Mapping of Action Potentials and Calcium Transients. Frontiers in physiology\| PubMed ID: 32226389	2020
High-resolution integrated piezoresistive sensors for microfluidic monitoring. Lab on a chip\| PubMed ID: 33300516	2021
Adverse effects of hydroxychloroquine and azithromycin on contractility and arrhythmogenicity revealed by human engineered cardiac tissues. Journal of molecular and cellular cardiology\| PubMed ID: 33373642	2021
Cell Therapy Model Restores Failing Human Myocyte Electrophysiology and Calcium Cycling in Fibrotic Myocardium. Frontiers in physiology\| PubMed ID: 35046835	2021
Gene editing reverses arrhythmia susceptibility in humanized PLN-R14del mice: modelling a European cardiomyopathy with global impact. Cardiovascular research\| PubMed ID: 35191471	2022
Generation of human induced pluripotent stem cell (iPSC) lines derived from five patients carrying the pathogenic phospholamban-R14del (PLN-R14del) variant and three non-carrier family membe... Stem cell research\| PubMed ID: 35247838	2022
Age and Blood Pressure Contribute to Aortic Cell and Tissue Stiffness Through Distinct Mechanisms. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 35766034	2022
Computational design of custom therapeutic cells to correct failing human cardiomyocytes. Frontiers in systems biology\| PubMed ID: 36743445	2023
Single-cell RNA sequencing reveals maturation trajectory in human pluripotent stem cell-derived cardiomyocytes in engineered tissues. iScience\| PubMed ID: 36950112	2023