John S. Condeelis

Department of Anatomy & Structural Biology, Albert Einstein College of Medicine

Affiliated withAlbert Einstein College of Medicine Montefiore Medical Center Albert Einstein College of Medicine/Montefiore Medical Center

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 4	Year
Publication title Cited by 25	2016
Publication title Cited by 32	2016
Publication title Cited by 20	2019
Publication title	2023

Other Publications

Article	Year
A new strategy for caging proteins regulated by kinases. Journal of the American Chemical Society\| PubMed ID: 11890784	2002
Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling. Cancer research\| PubMed ID: 12414658	2002
GFP expression in the mammary gland for imaging of mammary tumor cells in transgenic mice. Cancer research\| PubMed ID: 12499251	2002
Gene expression analysis on small numbers of invasive cells collected by chemotaxis from primary mammary tumors of the mouse. BMC biotechnology\| PubMed ID: 12914671	2003
Cofilin promotes actin polymerization and defines the direction of cell motility. Science (New York, N.Y.)\| PubMed ID: 15118165	2004
Over-expression of the p110beta but not p110alpha isoform of PI 3-kinase inhibits motility in breast cancer cells. Cell motility and the cytoskeleton\| PubMed ID: 15468162	2004
Breast cancer cells isolated by chemotaxis from primary tumors show increased survival and resistance to chemotherapy. Cancer research\| PubMed ID: 15520165	2004
Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors. Cancer research\| PubMed ID: 15574765	2004
Tumor cells caught in the act of invading: their strategy for enhanced cell motility. Trends in cell biology\| PubMed ID: 15752977	2005
Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop. Cancer research\| PubMed ID: 15958574	2005
The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors. The Journal of cell biology\| PubMed ID: 16651380	2006
Initiation of cofilin activity in response to EGF is uncoupled from cofilin phosphorylation and dephosphorylation in carcinoma cells. Journal of cell science\| PubMed ID: 16803871	2006
ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo. Current biology : CB\| PubMed ID: 16890527	2006
Molecular cloning of hMena (ENAH) and its splice variant hMena+11a: epidermal growth factor increases their expression and stimulates hMena+11a phosphorylation in breast cancer cell lines. Cancer research\| PubMed ID: 17363586	2007
Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors. Cancer research\| PubMed ID: 17440055	2007
The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migration. Journal of cell science\| PubMed ID: 17698922	2007
Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells. Journal of cell science\| PubMed ID: 17855387	2007
ZBP1 enhances cell polarity and reduces chemotaxis. Journal of cell science\| PubMed ID: 17878234	2007
EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells. The Journal of cell biology\| PubMed ID: 18086920	2007
RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells. Experimental cell research\| PubMed ID: 18316075	2008
Mechanisms and cellular roles of local protein synthesis in mammalian cells. Current opinion in cell biology\| PubMed ID: 18378131	2008
Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo. Clinical & experimental metastasis\| PubMed ID: 18985426	2009
A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis. Developmental cell\| PubMed ID: 19081071	2008
Tumor microenvironment of metastasis in human breast carcinoma: a potential prognostic marker linked to hematogenous dissemination. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19318480	2009
Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase. Cancer research\| PubMed ID: 19903845	2009
Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor. Cancer research\| PubMed ID: 19934330	2009
Gene expression analysis of macrophages that facilitate tumor invasion supports a role for Wnt-signaling in mediating their activity in primary mammary tumors. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20018620	2010
AACR special conference on epithelial-mesenchymal transition and cancer progression and treatment. Cancer research\| PubMed ID: 20823151	2010
A new chemotaxis device for cell migration studies. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 20938544	2010
Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors. Breast cancer research : BCR\| PubMed ID: 21108830	2010
Imaging real-time gene expression in Mammalian cells with single-transcript resolution. CSH protocols\| PubMed ID: 21356977	2007
Imaging real-time gene expression in living yeast. CSH protocols\| PubMed ID: 21356978	2007
Imaging real-time gene expression in living systems with single-transcript resolution: image analysis of single mRNA transcripts. CSH protocols\| PubMed ID: 21356979	2007
Imaging Real-Time Gene Expression in Living Systems with Single-Transcript Resolution: Single mRNA Particle Tracking with ImageJ-Based Analysis. CSH protocols\| PubMed ID: 21356980	2007
Imaging real-time gene expression in living systems with single-transcript resolution: construct design and imaging system setup. CSH protocols\| PubMed ID: 21356986	2007
Mena invasive (Mena(INV)) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM. Clinical & experimental metastasis\| PubMed ID: 21484349	2011
Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer. Journal of cell science\| PubMed ID: 21670198	2011
Chemotaxis in cancer. Nature reviews. Cancer\| PubMed ID: 21779009	2011
A photoswitchable orange-to-far-red fluorescent protein, PSmOrange. Nature methods\| PubMed ID: 21804536	2011
An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype. PLoS genetics\| PubMed ID: 21876675	2011
Opposing roles of CXCR4 and CXCR7 in breast cancer metastasis. Breast cancer research : BCR\| PubMed ID: 22152016	2011
Correlated Immunohistochemical and Cytological Assays for the Prediction of Hematogenous Dissemination of Breast Cancer. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society\| PubMed ID: 22215635	2012
Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22869695	2012
A FRET-facilitated photoswitching using an orange fluorescent protein with the fast photoconversion kinetics. Journal of the American Chemical Society\| PubMed ID: 22900938	2012
Quantitative assessment of invasive mena isoforms (Menacalc) as an independent prognostic marker in breast cancer. Breast cancer research : BCR\| PubMed ID: 22971274	2012
Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients. Breast cancer research : BCR\| PubMed ID: 23113900	2012
Dysregulation of PAD4-mediated citrullination of nuclear GSK3β activates TGF-β signaling and induces epithelial-to-mesenchymal transition in breast cancer cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23818587	2013
Wiskott-Aldrich syndrome protein regulates leukocyte-dependent breast cancer metastasis. Cell reports\| PubMed ID: 23911287	2013
Filamin A interacting protein 1-like inhibits WNT signaling and MMP expression to suppress cancer cell invasion and metastasis. International journal of cancer\| PubMed ID: 24327474	2014
Reconstitution of in vivo macrophage-tumor cell pairing and streaming motility on one-dimensional micro-patterned substrates. Intravital\| PubMed ID: 24634804	2012
Spatial regulation of tumor cell protrusions by RhoC. Cell adhesion & migration\| PubMed ID: 24642482	2014
Invadopodia in context. Cell adhesion & migration\| PubMed ID: 24713806	2014
Tumor microenvironment of metastasis and risk of distant metastasis of breast cancer. Journal of the National Cancer Institute\| PubMed ID: 24895374	2014
Metastatic cells: moving onco-targets. Oncotarget\| PubMed ID: 24907202	2014
An in vitro one-dimensional assay to study growth factor-regulated tumor cell-macrophage interaction. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 24908299	2014
Intravital multiphoton imaging reveals multicellular streaming as a crucial component of in vivo cell migration in human breast tumors. Intravital\| PubMed ID: 25013744	2013
Development path and current status of the NANIVID: a new device for cancer cell studies. Journal of micro/nanolithography, MEMS, and MOEMS : JM3\| PubMed ID: 25419258	2012
Invasive breast carcinoma cells from patients exhibit MenaINV- and macrophage-dependent transendothelial migration. Science signaling\| PubMed ID: 25429076	2014
Menacalc, a quantitative method of metastasis assessment, as a prognostic marker for axillary node-negative breast cancer. BMC cancer\| PubMed ID: 26112005	2015
Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA. Cancer discovery\| PubMed ID: 26269515	2015
PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena. Molecular biology of the cell\| PubMed ID: 26337385	2015
Characterization of the expression of the pro-metastatic Mena(INV) isoform during breast tumor progression. Clinical & experimental metastasis\| PubMed ID: 26680363	2016
3-D individual cell based computational modeling of tumor cell-macrophage paracrine signaling mediated by EGF and CSF-1 gradients. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 26686751	2016
GPCR Signaling Mediates Tumor Metastasis via PI3Kβ. Cancer research\| PubMed ID: 27013201	2016
Signatures of breast cancer metastasis at a glance. Journal of cell science\| PubMed ID: 27084578	2016
Black race and distant recurrence after neoadjuvant or adjuvant chemotherapy in breast cancer. Clinical & experimental metastasis\| PubMed ID: 30136072	2018
Validation of an Automated Quantitative Digital Pathology Approach for Scoring TMEM, a Prognostic Biomarker for Metastasis. Cancers\| PubMed ID: 32244564	2020
Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells. Nature communications\| PubMed ID: 35110548	2022
Combining TMEM Doorway Score and Mena Score Improves the Prediction of Distant Recurrence Risk in HR+/HER2- Breast Cancer Patients. Cancers\| PubMed ID: 35565297	2022
Racial disparity in distant recurrence-free survival in patients with localized breast cancer: A pooled analysis of National Surgical Adjuvant Breast and Bowel Project trials. Cancer\| PubMed ID: 35578919	2022
Assessment of MRI to estimate metastatic dissemination risk and prometastatic effects of chemotherapy. NPJ breast cancer\| PubMed ID: 36056005	2022
Interleukin 4 Controls the Pro-Tumoral Role of Macrophages in Mammary Cancer Pulmonary Metastasis in Mice. Cancers\| PubMed ID: 36077870	2022
Intravital imaging to study cancer progression and metastasis. Nature reviews. Cancer\| PubMed ID: 36385560	2023
Cooperative NF-κB and Notch1 signaling promotes macrophage-mediated MenaINV expression in breast cancer. Breast cancer research : BCR\| PubMed ID: 37024946	2023
Macrophages Promote Tumor Cell Extravasation across an Endothelial Barrier through Thin Membranous Connections. Cancers\| PubMed ID: 37046751	2023
Racial disparity in tumor microenvironment and distant recurrence in residual breast cancer after neoadjuvant chemotherapy. NPJ breast cancer\| PubMed ID: 37311792	2023