Karen K. Hirschi

Departments of Medicine, Yale University School of Medicine

Affiliated withYale University School of Medicine University of Virginia University of Virginia School of Medicine

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 11	2016
Publication title Cited by 5	2021
Publication title Cited by 3	2021

Other Publications

Article	Year
Diverse roles of the vasculature within the neural stem cell niche. Regenerative medicine\| PubMed ID: 19903006	2009
Transforming growth factor-beta induction of smooth muscle cell phenotpye requires transcriptional and post-transcriptional control of serum response factor. The Journal of biological chemistry\| PubMed ID: 11741973	2002
Quaking is essential for blood vessel development. Genesis (New York, N.Y. : 2000)\| PubMed ID: 11892011	2002
Vascular assembly in natural and engineered tissues. Annals of the New York Academy of Sciences\| PubMed ID: 12081906	2002
Vascular assembly in engineered and natural tissues: breakout session summary. Annals of the New York Academy of Sciences\| PubMed ID: 12081911	2002
Distinct progenitor populations in skeletal muscle are bone marrow derived and exhibit different cell fates during vascular regeneration. The Journal of clinical investigation\| PubMed ID: 12511590	2003
The FAKs about blood vessel assembly. Circulation research\| PubMed ID: 12595334	2003
Phenotype and hematopoietic potential of side population cells throughout embryonic development. Blood\| PubMed ID: 12805065	2003
Gap junction communication mediates transforming growth factor-beta activation and endothelial-induced mural cell differentiation. Circulation research\| PubMed ID: 12919949	2003
Altered phenotype and reduced function of muscle-derived hematopoietic stem cells. Experimental hematology\| PubMed ID: 12962727	2003
Retinoic acid regulates endothelial cell proliferation during vasculogenesis. Development (Cambridge, England)\| PubMed ID: 14627725	2003
Ouabain- and marinobufagenin-induced proliferation of human umbilical vein smooth muscle cells and a rat vascular smooth muscle cell line, A7r5. Circulation\| PubMed ID: 14638550	2003
Primitive adult hematopoietic stem cells can function as osteoblast precursors. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14673088	2003
Smooth muscle stem cells. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology\| PubMed ID: 14699631	2004
Signaling hierarchy downstream of retinoic acid that independently regulates vascular remodeling and endothelial cell proliferation. Genes & development\| PubMed ID: 15175265	2004
Nutrient regulation of cell cycle progression. Annual review of nutrition\| PubMed ID: 15189127	2004
Retinoic acid slows progression and promotes apoptosis of spontaneous prostate cancer. The Prostate\| PubMed ID: 15305337	2004
Red light, green light: signals that control endothelial cell proliferation during embryonic vascular development. Cell cycle (Georgetown, Tex.)\| PubMed ID: 15611620	2004
Understanding abnormalities in vascular specification and remodeling. Pediatrics\| PubMed ID: 15995057	2005
Visceral endoderm function is regulated by quaking and required for vascular development. Genesis (New York, N.Y. : 2000)\| PubMed ID: 16470614	2006
Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3. The Journal of cell biology\| PubMed ID: 17030988	2006
Murine neonatal intravascular injections: modeling newborn disease. Journal of the American Association for Laboratory Animal Science : JAALAS\| PubMed ID: 17994673	2007
Injury mechanism dictates contribution of bone marrow-derived cells to murine hepatic vascular regeneration. Pediatric research\| PubMed ID: 18043513	2008
Assessing identity, phenotype, and fate of endothelial progenitor cells. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 18669889	2008
Cell signaling directing the formation and function of hemogenic endothelium during murine embryogenesis. Blood\| PubMed ID: 18684862	2008
Signaling hierarchy regulating human endothelial cell development. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 19213939	2009
A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines. BMC genetics\| PubMed ID: 19267930	2009
Embryonic vasculogenesis and hematopoietic specification. Organogenesis\| PubMed ID: 19337406	2008
Epimorphic regeneration approach to tissue replacement in adult mammals. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19966310	2010
Hemato-vascular origins of endothelial progenitor cells? Microvascular research\| PubMed ID: 20149806	2010
Vascular precursors: origin, regulation and function. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 20453165	2010
Vascular potential of human pluripotent stem cells. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 20453170	2010
Characterization of bacterial artificial chromosome transgenic mice expressing mCherry fluorescent protein substituted for the murine smooth muscle alpha-actin gene. Genesis (New York, N.Y. : 2000)\| PubMed ID: 20506352	2010
Quiescence and activation of stem and precursor cell populations in the subependymal zone of the mammalian brain are associated with distinct cellular and extracellular matrix signals. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20660259	2010
Endothelial cell migration during murine yolk sac vascular remodeling occurs by means of a Rac1 and FAK activation pathway in vivo. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 20737513	2010
Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity. Cell stem cell\| PubMed ID: 21040902	2010
Establishment and regulation of the HSC niche: Roles of osteoblastic and vascular compartments. Birth defects research. Part C, Embryo today : reviews\| PubMed ID: 21181885	2010
The role of quaking in mammalian embryonic development. Advances in experimental medicine and biology\| PubMed ID: 21189687	2010
Stem cell-derived vascular endothelial cells and their potential application in regenerative medicine. Cells, tissues, organs\| PubMed ID: 22005724	2012
Cardiovascular regenerative biology. Cells, tissues, organs\| PubMed ID: 22179179	2012
Hemogenic endothelium during development and beyond. Blood\| PubMed ID: 22415753	2012
Partial characterization of the Sox2+ cell population in an adult murine model of digit amputation. Tissue engineering. Part A\| PubMed ID: 22530556	2012
Vascular precursor cells. Genes & cancer\| PubMed ID: 22866199	2011
Vascular progenitor cell mobilization. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22890930	2012
Studying vascular progenitor cells in a neonatal mouse model. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22890936	2012
Connexin45 regulates endothelial-induced mesenchymal cell differentiation toward a mural cell phenotype. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 23220276	2013
A computational approach to detect gap junction plaques and associate them with cells in fluorescent images. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society\| PubMed ID: 23324867	2013
Regulation of endothelial cell differentiation and specification. Circulation research\| PubMed ID: 23620236	2013
Hemogenic endothelial cell specification requires c-Kit, Notch signaling, and p27-mediated cell-cycle control. Developmental cell\| PubMed ID: 24331925	2013
Induced pluripotent stem cells for regenerative medicine. Annual review of biomedical engineering\| PubMed ID: 24905879	2014
The magic touch: endothelial cells muscle-up adipose. Circulation research\| PubMed ID: 25301822	2014
Development of the fetal bone marrow niche and regulation of HSC quiescence and homing ability by emerging osteolineage cells. Cell reports\| PubMed ID: 25310984	2014
Bioactive poly(ethylene glycol) hydrogels to recapitulate the HSC niche and facilitate HSC expansion in culture. Biotechnology and bioengineering\| PubMed ID: 26497172	2016
Ionizing Particle Radiation as a Modulator of Endogenous Bone Marrow Cell Reprogramming: Implications for Hematological Cancers. Frontiers in oncology\| PubMed ID: 26528440	2015
Corrigendum: Ionizing Particle Radiation as a Modulator of Endogenous Bone Marrow Cell Reprogramming: Implications for Hematological Cancers. Frontiers in oncology\| PubMed ID: 26636037	2015
Specification and function of hemogenic endothelium during embryogenesis. Cellular and molecular life sciences : CMLS\| PubMed ID: 26849156	2016
Tet2-mediated clonal hematopoiesis in nonconditioned mice accelerates age-associated cardiac dysfunction. JCI insight\| PubMed ID: 32154790	2020
Single Cell Analysis in Vascular Biology. Frontiers in cardiovascular medicine\| PubMed ID: 32296715	2020
Isolation of Highly Purified and Viable Retinal Endothelial Cells. Journal of vascular research\| PubMed ID: 33022674	2021
Regulation of Hemogenic Endothelial Cell Development and Function. Annual review of physiology\| PubMed ID: 33035429	2021
Retinoic Acid Promotes Endothelial Cell Cycle Early G1 State to Enable Human Hemogenic Endothelial Cell Specification. Cell reports\| PubMed ID: 33264627	2020
The N-glycome regulates the endothelial-to-hematopoietic transition. Science (New York, N.Y.)\| PubMed ID: 33273096	2020
Tissue-Resident Macrophage Development and Function. Frontiers in cell and developmental biology\| PubMed ID: 33490082	2020
Vascular endothelial cell specification in health and disease. Angiogenesis\| PubMed ID: 33844116	2021
The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation. Journal of the American Heart Association\| PubMed ID: 34155901	2021
Understanding neural stem cell regulation and applying the insights to cell therapy for strokes. Regenerative medicine\| PubMed ID: 34498495	2021