M. Luisa Iruela-Arispe

Department of Molecular, University of California, Los Angeles

Affiliated withUniversity of California, Los Angeles UCLA

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 5	2016
Publication title Cited by 15	2018

Other Publications

Article	Year
Expression of ADAMTS1 during murine development. Mechanisms of development\| PubMed ID: 12049787	2002
ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors. Biochemical and biophysical research communications\| PubMed ID: 12054629	2002
Opposing functions of the Ets factors NERF and ELF-1 during chicken blood vessel development. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 12117724	2002
Visualization of advanced human prostate cancer lesions in living mice by a targeted gene transfer vector and optical imaging. Nature medicine\| PubMed ID: 12134144	2002
Selective binding of lectins to embryonic chicken vasculature. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society\| PubMed ID: 12704207	2003
ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165. The Journal of biological chemistry\| PubMed ID: 12716911	2003
ADAMTS1: a matrix metalloprotease with angioinhibitory properties. Annals of the New York Academy of Sciences\| PubMed ID: 12814950	2003
Myc-driven murine prostate cancer shares molecular features with human prostate tumors. Cancer cell\| PubMed ID: 14522256	2003
Alpha4beta1 integrin mediates selective endothelial cell responses to thrombospondins 1 and 2 in vitro and modulates angiogenesis in vivo. Circulation research\| PubMed ID: 14699013	2004
Thrombospondin modules and angiogenesis. The international journal of biochemistry & cell biology\| PubMed ID: 15094121	2004
Whence thrombospondin? Cancer biology & therapy\| PubMed ID: 15107618	2004
Notch signaling in vascular morphogenesis. Current opinion in hematology\| PubMed ID: 15314528	2004
ADAMTS1 proteinase is up-regulated in wounded skin and regulates migration of fibroblasts and endothelial cells. The Journal of biological chemistry\| PubMed ID: 15843381	2005
Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors. The Journal of cell biology\| PubMed ID: 15911882	2005
Enhanced inhibition of murine tumor and human breast tumor xenografts using targeted delivery of an antibody-endostatin fusion protein. Molecular cancer therapeutics\| PubMed ID: 15956253	2005
Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1. The Journal of biological chemistry\| PubMed ID: 16061471	2005
VE-Cadherin-Cre-recombinase transgenic mouse: a tool for lineage analysis and gene deletion in endothelial cells. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 16450386	2006
The ever-elusive endothelial progenitor cell: identities, functions and clinical implications. Pediatric research\| PubMed ID: 16549545	2006
Proteolytic cleavage of versican during cardiac cushion morphogenesis. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 16691565	2006
Generation of a mouse for conditional excision of progesterone receptor. Genesis (New York, N.Y. : 2000)\| PubMed ID: 16868919	2006
When it comes to blocking lymphatics, it is all a question of time. The American journal of pathology\| PubMed ID: 16877337	2006
My O'Myeloid, a tale of two lineages. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16924095	2006
VE-cadherin-CreERT2 transgenic mouse: a model for inducible recombination in the endothelium. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 17072878	2006
ADAMTS1 mediates the release of antiangiogenic polypeptides from TSP1 and 2. The EMBO journal\| PubMed ID: 17082774	2006
Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensor. Molecular and cellular biology\| PubMed ID: 17145776	2007
Notch expression patterns in the retina: An eye on receptor-ligand distribution during angiogenesis. Gene expression patterns : GEP\| PubMed ID: 17161657	2007
Modulation of protein delivery from modular polymer scaffolds. Biomaterials\| PubMed ID: 17184836	2007
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature\| PubMed ID: 17259973	2007
Notch signaling in blood vessels: who is talking to whom about what? Circulation research\| PubMed ID: 17556669	2007
Autocrine VEGF signaling is required for vascular homeostasis. Cell\| PubMed ID: 17719546	2007
Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis. Developmental cell\| PubMed ID: 18267097	2008
Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation. Nature\| PubMed ID: 18463637	2008
Cleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion. The international journal of biochemistry & cell biology\| PubMed ID: 18775505	2009
Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18779589	2008
Regulation of thrombospondin1 by extracellular proteases. Current drug targets\| PubMed ID: 18855620	2008
Fate tracing reveals the endothelial origin of hematopoietic stem cells. Cell stem cell\| PubMed ID: 19041779	2008
Cellular and molecular mechanisms of vascular lumen formation. Developmental cell\| PubMed ID: 19217424	2009
Conditional Cre/LoxP strategies for the study of hematopoietic stem cell formation. Blood cells, molecules & diseases\| PubMed ID: 19250847	2009
The phosphorylation of vascular endothelial growth factor receptor-2 (VEGFR-2) by engineered surfaces with electrostatically or covalently immobilized VEGF. Biomaterials\| PubMed ID: 19540581	2009
Time to cut the cord: placental HSCs grow up. Cell stem cell\| PubMed ID: 19796613	2009
Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy. Blood\| PubMed ID: 20008303	2010
Variable inhibition of thrombospondin 1 against liver and lung metastases through differential activation of metalloproteinase ADAMTS1. Cancer research\| PubMed ID: 20103648	2010
Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism. Developmental cell\| PubMed ID: 20152176	2010
Extracellular matrix, inflammation, and the angiogenic response. Cardiovascular research\| PubMed ID: 20154066	2010
Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells. The Journal of cell biology\| PubMed ID: 20176926	2010
Signaling circuitry in vascular morphogenesis. Current opinion in hematology\| PubMed ID: 20216211	2010
The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling. Developmental cell\| PubMed ID: 20627076	2010
Endothelial alpha3beta1-integrin represses pathological angiogenesis and sustains endothelial-VEGF. The American journal of pathology\| PubMed ID: 20639457	2010
Vascular remodeling of the vitelline artery initiates extravascular emergence of hematopoietic clusters. Blood\| PubMed ID: 20699440	2010
When Cre-mediated recombination in mice does not result in protein loss. Genetics\| PubMed ID: 20813881	2010
Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome. Development (Cambridge, England)\| PubMed ID: 21062863	2010
LUMENating blood vessels. Developmental cell\| PubMed ID: 21497753	2011
VEGF internalization is not required for VEGFR-2 phosphorylation in bioengineered surfaces with covalently linked VEGF. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 21826315	2011
Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane. Blood\| PubMed ID: 22134168	2012
Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 22183742	2012
An essential requirement for Î²1 integrin in the assembly of extracellular matrix proteins within the vascular wall. Developmental biology\| PubMed ID: 22331032	2012
CCN2/connective tissue growth factor is essential for pericyte adhesion and endothelial basement membrane formation during angiogenesis. PloS one\| PubMed ID: 22363445	2012
Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling. Developmental cell\| PubMed ID: 22387002	2012
Recent advances in vascular development. Current opinion in hematology\| PubMed ID: 22406825	2012
ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1. Nature medicine\| PubMed ID: 22581286	2012
Molecular mechanisms of tumor angiogenesis. Genes & cancer\| PubMed ID: 22866200	2011
Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages. Blood\| PubMed ID: 22919031	2012
Selective decline of synaptic protein levels in the frontal cortex of female mice deficient in the extracellular metalloproteinase ADAMTS1. PloS one\| PubMed ID: 23071766	2012
Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome. Development (Cambridge, England)\| PubMed ID: 23095891	2012
Real-time maps of fluid flow fields in porous biomaterials. Biomaterials\| PubMed ID: 23245922	2013
Cellular and molecular regulation of vascular permeability. Thrombosis and haemostasis\| PubMed ID: 23389236	2013
Testosterone levels influence mouse fetal Leydig cell progenitors through notch signaling. Biology of reproduction\| PubMed ID: 23467742	2013
Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models. Development (Cambridge, England)\| PubMed ID: 23533173	2013
Reciprocal interactions between endothelial cells and macrophages in angiogenic vascular niches. Experimental cell research\| PubMed ID: 23542777	2013
Notch1 regulates angio-supportive bone marrow-derived cells in mice: relevance to chemoresistance. Blood\| PubMed ID: 23690447	2013
Progesterone receptor signaling in the microenvironment of endometrial cancer influences its response to hormonal therapy. Cancer research\| PubMed ID: 23744837	2013
Selective suppression of endothelial cytokine production by progesterone receptor. Vascular pharmacology\| PubMed ID: 23747964	2013
Tubulogenesis. Development (Cambridge, England)\| PubMed ID: 23821032	2013
β1-integrin is essential for vasoregulation and smooth muscle survival in vivo. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 23887637	2013
The mouse retina in 3D: quantification of vascular growth and remodeling. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 24136100	2013
Sox17 is indispensable for acquisition and maintenance of arterial identity. Nature communications\| PubMed ID: 24153254	2013
A ligand-independent VEGFR2 signaling pathway limits angiogenic responses in diabetes. Science signaling\| PubMed ID: 24399295	2014
Hybrid photopatterned enzymatic reaction (HyPER) for in situ cell manipulation. Chembiochem : a European journal of chemical biology\| PubMed ID: 24399784	2014
Progesterone receptor in the vascular endothelium triggers physiological uterine permeability preimplantation. Cell\| PubMed ID: 24485460	2014
Local acting Sticky-trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye. EMBO molecular medicine\| PubMed ID: 24705878	2014
The chicken chorioallantoic membrane model in biology, medicine and bioengineering. Angiogenesis\| PubMed ID: 25138280	2014
Podosome rosettes precede vascular sprouts in tumour angiogenesis. Nature cell biology\| PubMed ID: 25271481	2014
Canonical and noncanonical vascular endothelial growth factor pathways: new developments in biology and signal transduction. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 25278287	2015
Stealing VEGF from thy neighbor. Cell\| PubMed ID: 25417099	2014
Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells. Developmental cell\| PubMed ID: 25535917	2014
Blockade of specific NOTCH ligands: a new promising approach in cancer therapy. Cancer discovery\| PubMed ID: 25656896	2015
ADAMTS proteases in vascular biology. Matrix biology : journal of the International Society for Matrix Biology\| PubMed ID: 25698314	2015
State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization: A Scientific Statement From the American Heart Association. Circulation research\| PubMed ID: 25931450	2015
Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy. Journal of cell science\| PubMed ID: 25956888	2015
Healing arterial ulcers: Endothelial lining regeneration upon vascular denudation injury. Vascular pharmacology\| PubMed ID: 26093336	2015
Macrophage Blockade Using CSF1R Inhibitors Reverses the Vascular Leakage Underlying Malignant Ascites in Late-Stage Epithelial Ovarian Cancer. Cancer research\| PubMed ID: 26471360	2015
Endothelial RhoGEFs: A systematic analysis of their expression profiles in VEGF-stimulated and tumor endothelial cells. Vascular pharmacology\| PubMed ID: 26471833	2015
Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis. The Journal of experimental medicine\| PubMed ID: 26552708	2015
Cross-talk between signaling and metabolism in the vasculature. Vascular pharmacology\| PubMed ID: 27291139	2016
Notch, lipids, and endothelial cells. Current opinion in lipidology\| PubMed ID: 27454451	2016
Perivascular Macrophages Limit Permeability. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 27634833	2016
Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy. JCI insight\| PubMed ID: 27699251	2016
Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-β and cholesterol 25-hydroxylase in jejunum. Journal of lipid research\| PubMed ID: 28592401	2017
NOTCH1 is a mechanosensor in adult arteries. Nature communications\| PubMed ID: 29158473	2017
A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis. Cell reports\| PubMed ID: 29386109	2018
Analysis of cardiomyocyte clonal expansion during mouse heart development and injury. Nature communications\| PubMed ID: 29467410	2018
NOTCH regulation of the endothelial cell phenotype. Current opinion in hematology\| PubMed ID: 29547401	2018
A multi-step transcriptional cascade underlies vascular regeneration in vivo. Scientific reports\| PubMed ID: 29615716	2018
Metastasis of Circulating Tumor Cells: Speed Matters. Developmental cell\| PubMed ID: 29634934	2018
Vav3-induced cytoskeletal dynamics contribute to heterotypic properties of endothelial barriers. The Journal of cell biology\| PubMed ID: 29858212	2018
Treating the Intestine with Oral ApoA-I Mimetic Tg6F Reduces Tumor Burden in Mouse Models of Metastatic Lung Cancer. Scientific reports\| PubMed ID: 29899427	2018