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Chapters
- 00:05Title
- 01:14Infrarenal Aortic Clamping
- 03:59Closure of Laparotomy and Postoperative Assessment
- 04:58Aortic Dissection and Staining
- 05:40Results: Efficiency of Endothelial Denudation and Reproducibility and Denudation Injury
- 07:28Conclusion
Understanding the cellular and molecular mechanisms of re-endothelialization following arterial denudation injury is of paramount importance in preventing thrombosis and restenosis of arteries. Here we describe a protocol for reproducible arterial denudation injury of the infrarenal abdominal aorta. The procedure was developed to investigate the underlying mechanisms that regulate endothelial regeneration using mouse models.
Tags
Arterial DenudationAortic ClampingMurine ModelVascular BiologyEndothelial RegenerationEndothelial Cell ProgenitorsVascular InjuryRe-endothelializationThrombotic EventsStent DeploymentCoronary Artery DiseasePeripheral Vascular DiseaseSurgical ProcedureAnesthesiaAbdominal IncisionIntestine RetractionRetroperitoneal DissectionAortic Exposure
