Dihua Yu

Department of Molecular and Cellular Oncology, The Univeristy of Texas M. D. Anderson Cancer Center

Affiliated withThe Univeristy of Texas M. D. Anderson Cancer Center The University of Texas MD Anderson Cancer Center

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 84	2011
Publication title Cited by 32	2017

Other Publications

Article	Year
Early placenta insulin-like growth factor (pro-EPIL) is overexpressed and secreted by c-erbB-2-positive cells with high invasion potential. Cancer research\| PubMed ID: 11861376	2002
Combined anti-fetal liver kinase 1 monoclonal antibody and continuous low-dose doxorubicin inhibits angiogenesis and growth of human soft tissue sarcoma xenografts by induction of endothelia... Cancer research\| PubMed ID: 11929822	2002
Phosphorylation on tyrosine-15 of p34(Cdc2) by ErbB2 inhibits p34(Cdc2) activation and is involved in resistance to taxol-induced apoptosis. Molecular cell\| PubMed ID: 12049736	2002
ErbB2 overexpression correlates with increased expression of vascular endothelial growth factors A, C, and D in human breast carcinoma. Cancer\| PubMed ID: 12115372	2002
Characterization of 11 human sarcoma cell strains: evaluation of cytogenetics, tumorigenicity, metastasis, and production of angiogenic factors. Cancer\| PubMed ID: 12237927	2002
Enhanced sensitization to taxol-induced apoptosis by herceptin pretreatment in ErbB2-overexpressing breast cancer cells. Cancer research\| PubMed ID: 12384528	2002
ErbB2 overexpression in human breast carcinoma is correlated with p21Cip1 up-regulation and tyrosine-15 hyperphosphorylation of p34Cdc2: poor responsiveness to chemotherapy with cyclophosham... Cancer\| PubMed ID: 12973835	2003
Combined trastuzumab and paclitaxel treatment better inhibits ErbB-2-mediated angiogenesis in breast carcinoma through a more effective inhibition of Akt than either treatment alone. Cancer\| PubMed ID: 14508823	2003
Silibinin: a thorny therapeutic for EGF-R expressing tumors? Cancer biology & therapy\| PubMed ID: 14614321	2003
Liposomal mediated transfer of ErbB2 antisense DNA: coming of age in the war against cancer. Cancer biology & therapy\| PubMed ID: 14764991	2004
Lineage infidelity of MDA-MB-435 cells: expression of melanocyte proteins in a breast cancer cell line. Cancer research\| PubMed ID: 15150101	2004
PI3K: Missense Mutation Motivates Malignancy. Cancer biology & therapy\| PubMed ID: 15280668	2004
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer cell\| PubMed ID: 15324695	2004
Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 15501954	2004
Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis. Cancer cell\| PubMed ID: 15542430	2004
Transcriptional repression of protein kinase Calpha via Sp1 by wild type p53 is involved in inhibition of multidrug resistance 1 P-glycoprotein phosphorylation. The Journal of biological chemistry\| PubMed ID: 15563462	2005
Expression of receptor tyrosine kinases epidermal growth factor receptor and HER-2/neu in synovial sarcoma. Cancer\| PubMed ID: 15641030	2005
A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 15671549	2005
ErbB2 promotes Src synthesis and stability: novel mechanisms of Src activation that confer breast cancer metastasis. Cancer research\| PubMed ID: 15753384	2005
A knotty turnabout?: Akt1 as a metastasis suppressor. Cancer cell\| PubMed ID: 16338656	2005
Prostate tumor cells infected with a recombinant influenza virus expressing a truncated NS1 protein activate cytolytic CD8+ cells to recognize noninfected tumor cells. Journal of virology\| PubMed ID: 16352563	2006
Mechanisms of trastuzumab resistance and their clinical implications. Annals of the New York Academy of Sciences\| PubMed ID: 16382045	2005
ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of rapamycin/p70S6K leading to increased angiogenesis and spontaneous metastasis of hu... Cancer research\| PubMed ID: 16489002	2006
Synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest in HER2-overexpressing breast cancer cells. Molecular cancer therapeutics\| PubMed ID: 16505105	2006
Selective inhibition of ErbB2-overexpressing breast cancer in vivo by a novel TAT-based ErbB2-targeting signal transducers and activators of transcription 3-blocking peptide. Cancer research\| PubMed ID: 16585203	2006
Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer. Nature clinical practice. Oncology\| PubMed ID: 16683005	2006
Vascular endothelial growth factor overexpression by soft tissue sarcoma cells: implications for tumor growth, metastasis, and chemoresistance. Cancer research\| PubMed ID: 16951193	2006
Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKbeta overexpression in human breast cancers. International journal of oncology\| PubMed ID: 17016640	2006
Wild-type p53 inhibits nuclear factor-kappaB-induced matrix metalloproteinase-9 promoter activation: implications for soft tissue sarcoma growth and metastasis. Molecular cancer research : MCR\| PubMed ID: 17077165	2006
Adenoviral-Vector Based siRNA for Mutant K-ras as a Promising Tool for Lung Cancer Gene Therapy: A License to Kill. Cancer biology & therapy\| PubMed ID: 17224631	2006
Tumor progression and metastasis from genetic to microenvironmental determinants: a workshop of the tumor progression and metastasis NIH study section in honor of Dr. Martin L. Padarathsingh... Cancer biology & therapy\| PubMed ID: 17224636	2006
High prevalence of p53 exon 4 mutations in soft tissue sarcoma. Cancer\| PubMed ID: 17429838	2007
Rad51 overexpression contributes to chemoresistance in human soft tissue sarcoma cells: a role for p53/activator protein 2 transcriptional regulation. Molecular cancer therapeutics\| PubMed ID: 17513613	2007
Preclinical testing of clinically applicable strategies for overcoming trastuzumab resistance caused by PTEN deficiency. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 17908983	2007
Molecular mechanisms of erbB2-mediated breast cancer chemoresistance. Advances in experimental medicine and biology\| PubMed ID: 17993237	2007
Novel approaches for chemosensitization of breast cancer cells: the E1A story. Advances in experimental medicine and biology\| PubMed ID: 17993239	2007
Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers. Molecular carcinogenesis\| PubMed ID: 18176935	2008
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nature cell biology\| PubMed ID: 18204439	2008
14-3-3 zeta down-regulates p53 in mammary epithelial cells and confers luminal filling. Cancer research\| PubMed ID: 18339856	2008
Ph.D. Training in cancer biology. Cancer research\| PubMed ID: 19010881	2008
Mitotic deregulation by survivin in ErbB2-overexpressing breast cancer cells contributes to Taxol resistance. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19228734	2009
Oxygen sensor boosts growth factor signaling. Nature medicine\| PubMed ID: 19265822	2009
14-3-3zeta overexpression defines high risk for breast cancer recurrence and promotes cancer cell survival. Cancer research\| PubMed ID: 19318578	2009
14-3-3zeta/tau heterodimers regulate Slingshot activity in migrating keratinocytes. Biochemical and biophysical research communications\| PubMed ID: 19371722	2009
ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells. Molecular cancer research : MCR\| PubMed ID: 19372587	2009
Breast cancer metastasis: challenges and opportunities. Cancer research\| PubMed ID: 19470768	2009
14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition. Cancer cell\| PubMed ID: 19732720	2009
Upregulation of neutrophil gelatinase-associated lipocalin by ErbB2 through nuclear factor-kappaB activation. Cancer research\| PubMed ID: 19951994	2009
Molecular predictors of response to trastuzumab and lapatinib in breast cancer. Nature reviews. Clinical oncology\| PubMed ID: 20027191	2010
Invasive breast cancer development: "fatal accident" from malfunctions in both "motor" and "brake". Cell cycle (Georgetown, Tex.)\| PubMed ID: 20090417	2010
PI(3)king apart PTEN's role in cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 20622047	2010
PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer. The American journal of pathology\| PubMed ID: 20813970	2010
Activation of murine double minute 2 by Akt in mammary epithelium delays mammary involution and accelerates mammary tumorigenesis. Cancer research\| PubMed ID: 20841468	2010
Cancer cell stiffness: integrated roles of three-dimensional matrix stiffness and transforming potential. Biophysical journal\| PubMed ID: 20923638	2010
Tissue transglutaminase promotes drug resistance and invasion by inducing mesenchymal transition in mammary epithelial cells. PloS one\| PubMed ID: 20967228	2010
Activation of p21(CIP1/WAF1) in mammary epithelium accelerates mammary tumorigenesis and promotes lung metastasis. Biochemical and biophysical research communications\| PubMed ID: 21040707	2010
14-3-3Î¶ as a prognostic marker and therapeutic target for cancer. Expert opinion on therapeutic targets\| PubMed ID: 21058923	2010
Cytokine receptor CXCR4 mediates estrogen-independent tumorigenesis, metastasis, and resistance to endocrine therapy in human breast cancer. Cancer research\| PubMed ID: 21123450	2011
Protein microarray analysis of mammary epithelial cells from obese and nonobese women at high risk for breast cancer: feasibility data. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 21242333	2011
p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nature cell biology\| PubMed ID: 21336307	2011
Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways. Nature medicine\| PubMed ID: 21399647	2011
Cancer cell migration: integrated roles of matrix mechanics and transforming potential. PloS one\| PubMed ID: 21647371	2011
Pilot and feasibility study: prospective proteomic profiling of mammary epithelial cells from high-risk women provides evidence of activation of pro-survival pathways. Breast cancer research and treatment\| PubMed ID: 21647677	2011
Evidence that aberrant expression of tissue transglutaminase promotes stem cell characteristics in mammary epithelial cells. PloS one\| PubMed ID: 21687668	2011
Microenvironment determinants of brain metastasis. Cell & bioscience\| PubMed ID: 21711688	2011
Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpressing metastatic breast cancer who progressed on trastuzumab-based therapy. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 21730275	2011
BikDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment. Cancer cell\| PubMed ID: 21907925	2011
Nucleolin protein interacts with microprocessor complex to affect biogenesis of microRNAs 15a and 16. The Journal of biological chemistry\| PubMed ID: 22049078	2011
Targeting Src family kinases in anti-cancer therapies: turning promise into triumph. Trends in pharmacological sciences\| PubMed ID: 22153719	2011
Evidence that GTP-binding domain but not catalytic domain of transglutaminase 2 is essential for epithelial-to-mesenchymal transition in mammary epithelial cells. Breast cancer research : BCR\| PubMed ID: 22225906	2012
The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis. Cell\| PubMed ID: 22632973	2012
Growth factor signaling in metastasis: current understanding and future opportunities. Cancer metastasis reviews\| PubMed ID: 22706845	2012
Concomitant targeting of tumor cells and induction of T-cell response synergizes to effectively inhibit trastuzumab-resistant breast cancer. Cancer research\| PubMed ID: 22773664	2012
SRC family kinases as novel therapeutic targets to treat breast cancer brain metastases. Cancer research\| PubMed ID: 23913825	2013
Needle-based fluorescence endomicroscopy via structured illumination with a plastic, achromatic objective. Journal of biomedical optics\| PubMed ID: 24002190	2013
Inhibition of type I insulin-like growth factor receptor signaling attenuates the development of breast cancer brain metastasis. PloS one\| PubMed ID: 24039934	2013
14-3-3ζ orchestrates mammary tumor onset and progression via miR-221-mediated cell proliferation. Cancer research\| PubMed ID: 24197133	2014
Enhanced PI3K p110α signaling confers acquired lapatinib resistance that can be effectively reversed by a p110α-selective PI3K inhibitor. Molecular cancer therapeutics\| PubMed ID: 24249715	2014
Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors. Cell research\| PubMed ID: 24675532	2014
Definition of PKC-α, CDK6, and MET as therapeutic targets in triple-negative breast cancer. Cancer research\| PubMed ID: 24970481	2014
Cooperativity of oncogenic K-ras and downregulated p16/INK4A in human pancreatic tumorigenesis. PloS one\| PubMed ID: 25029561	2014
MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer. Science signaling\| PubMed ID: 25074979	2014
S6K1 promotes invasiveness of breast cancer cells in a model of metastasis of triple-negative breast cancer. American journal of translational research\| PubMed ID: 25075253	2014
HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer. Molecular oncology\| PubMed ID: 25435280	2015
Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines. Oncotarget\| PubMed ID: 25668816	2015
14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2. Cancer cell\| PubMed ID: 25670079	2015
PI3K-independent mTOR activation promotes lapatinib resistance and IAP expression that can be effectively reversed by mTOR and Hsp90 inhibition. Cancer biology & therapy\| PubMed ID: 25692408	2015
Neural Stem Cells Secreting Anti-HER2 Antibody Improve Survival in a Preclinical Model of HER2 Overexpressing Breast Cancer Brain Metastases. Stem cells (Dayton, Ohio)\| PubMed ID: 26260958	2015
Src Inhibition Blocks c-Myc Translation and Glucose Metabolism to Prevent the Development of Breast Cancer. Cancer research\| PubMed ID: 26383165	2015
Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature\| PubMed ID: 26479035	2015
Fluoxetine induces cytotoxic endoplasmic reticulum stress and autophagy in triple negative breast cancer. World journal of clinical oncology\| PubMed ID: 26677444	2015
Selective expression of constitutively active pro-apoptotic protein BikDD gene in primary mammary tumors inhibits tumor growth and reduces tumor initiating cells. American journal of cancer research\| PubMed ID: 26885451	2015
Upregulation of lactate dehydrogenase a by 14-3-3ζ leads to increased glycolysis critical for breast cancer initiation and progression. Oncotarget\| PubMed ID: 27150057	2016
Downregulation of GLUT4 contributes to effective intervention of estrogen receptor-negative/HER2-overexpressing early stage breast disease progression by lapatinib. American journal of cancer research\| PubMed ID: 27293993	2016
Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity. Nature communications\| PubMed ID: 27572267	2016
Deubiquitination and Stabilization of PD-L1 by CSN5. Cancer cell\| PubMed ID: 27866850	2016
Advances in decoding breast cancer brain metastasis. Cancer metastasis reviews\| PubMed ID: 27873078	2016
Brain metastasis: Unique challenges and open opportunities. Biochimica et biophysica acta\| PubMed ID: 27939792	2017