Hubert Schorle

Department of Developmental Pathology, Bonn Medical School, Institute of Pathology

Affiliated withBonn Medical School, Institute of Pathology Institute of Pathology, University of Bonn Medical School

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 32	2010
Publication title Cited by 3	2016

Other Publications

Article	Year
A subtractive gene expression screen suggests a role of transcription factor AP-2 alpha in control of proliferation and differentiation. The Journal of biological chemistry\| PubMed ID: 11741941	2002
Conditional inactivation of transcription factor AP-2gamma by using the Cre/loxP recombination system. Genesis (New York, N.Y. : 2000)\| PubMed ID: 11857798	2002
Transcription factor gene AP-2 gamma essential for early murine development. Molecular and cellular biology\| PubMed ID: 11940672	2002
Exencephaly in a subset of animals heterozygous for AP-2alpha mutation. Teratology\| PubMed ID: 11967920	2002
Mutation of the SBF2 gene, encoding a novel member of the myotubularin family, in Charcot-Marie-Tooth neuropathy type 4B2/11p15. Human molecular genetics\| PubMed ID: 12554688	2003
Terminal renal failure in mice lacking transcription factor AP-2 beta. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 12695560	2003
Dynamic expression of KrÃ¼ppel-like factor 4 (Klf4), a target of transcription factor AP-2alpha during murine mid-embryogenesis. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology\| PubMed ID: 12845703	2003
Cloning, expression and characterization of the murine Efemp1, a gene mutated in Doyne-Honeycomb retinal dystrophy. Gene expression patterns : GEP\| PubMed ID: 12915309	2003
Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5. The EMBO journal\| PubMed ID: 14517256	2003
Transcription factor AP-2gamma stimulates proliferation and apoptosis and impairs differentiation in a transgenic model. Molecular cancer research : MCR\| PubMed ID: 14573793	2003
Starvation response in mouse liver shows strong correlation with life-span-prolonging processes. Physiological genomics\| PubMed ID: 14762175	2004
Cell type-specific conditional regulation of the c-myc proto-oncogene by combining Cre/loxP recombination and tamoxifen-mediated activation. Genesis (New York, N.Y. : 2000)\| PubMed ID: 15048812	2004
Distinct spatial expression patterns of AP-2alpha and AP-2gamma in non-neoplastic human breast and breast cancer. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 15467710	2005
Towards dissecting the complexity of the AP-1 (activator protein 1) family. Advances in experimental medicine and biology\| PubMed ID: 15503467	2004
Transcription factor AP-2gamma, a novel marker of gonocytes and seminomatous germ cell tumors. International journal of cancer. Journal international du cancer\| PubMed ID: 15700319	2005
Dual role of AP-2gamma in ErbB-2-induced mammary tumorigenesis. Breast cancer research and treatment\| PubMed ID: 15830141	2005
A mouse model for cystic biliary dysgenesis in autosomal recessive polycystic kidney disease (ARPKD). Hepatology (Baltimore, Md.)\| PubMed ID: 15830394	2005
Mice transgenic for NPM-ALK develop non-Hodgkin lymphomas. Anticancer research\| PubMed ID: 16101126	2005
Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16109770	2005
Spatial expression of germ cell markers during maturation of human fetal male gonads: an immunohistochemical study. Human reproduction (Oxford, England)\| PubMed ID: 16210381	2006
The AP-2 family of transcription factors. Genome biology\| PubMed ID: 16420676	2005
Establishment and controlled differentiation of neural crest stem cell lines using conditional transgenesis. Differentiation; research in biological diversity\| PubMed ID: 17381545	2007
Deficiency in the LIM-only protein Fhl2 impairs skin wound healing. The Journal of cell biology\| PubMed ID: 17420295	2007
Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo. Molecular and cellular biology\| PubMed ID: 17452457	2007
Enhanced purification of cell-permeant Cre and germline transmission after transduction into mouse embryonic stem cells. Genesis (New York, N.Y. : 2000)\| PubMed ID: 17661398	2007
Gene expression profiling identifies new biological markers of neoplastic germ cells. Anticancer research\| PubMed ID: 17970049	2007
Lactogenic differentiation of HC11 cells is not accompanied by downregulation of AP-2 transcription factor genes. BMC research notes\| PubMed ID: 18710545	2008
Expression of BLIMP1/PRMT5 and concurrent histone H2A/H4 arginine 3 dimethylation in fetal germ cells, CIS/IGCNU and germ cell tumors. BMC developmental biology\| PubMed ID: 18992153	2008
Sustained platelet-derived growth factor receptor alpha signaling in osteoblasts results in craniosynostosis by overactivating the phospholipase C-gamma pathway. Molecular and cellular biology\| PubMed ID: 19047372	2009
Autochthonous liver tumors induce systemic T cell tolerance associated with T cell receptor down-modulation. Hepatology (Baltimore, Md.)\| PubMed ID: 19105207	2009
An activating mutation in the PDGF receptor alpha results in embryonic lethality caused by malformation of the vascular system. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 19334281	2009
Loss of connexin43-mediated gap junctional coupling in the mesenchyme of limb buds leads to altered expression of morphogens in mice. Human molecular genetics\| PubMed ID: 19439426	2009
AP-2alpha regulates migration of GN-11 neurons via a specific genetic programme involving the Axl receptor tyrosine kinase. BMC biology\| PubMed ID: 19463168	2009
AP2gamma regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex. Nature neuroscience\| PubMed ID: 19749747	2009
Critical function of AP-2 gamma/TCFAP2C in mouse embryonic germ cell maintenance. Biology of reproduction\| PubMed ID: 19776388	2010
Loss of transcription factor AP-2gamma/TFAP2C impairs branching morphogenesis of the murine mammary gland. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 20131354	2010
The transcription factor TCFAP2C/AP-2gamma cooperates with CDX2 to maintain trophectoderm formation. Molecular and cellular biology\| PubMed ID: 20404091	2010
Interference with activator protein-2 transcription factors leads to induction of apoptosis and an increase in chemo- and radiation-sensitivity in breast cancer cells. BMC cancer\| PubMed ID: 20459791	2010
NANOG promoter methylation and expression correlation during normal and malignant human germ cell development. Epigenetics : official journal of the DNA Methylation Society\| PubMed ID: 20930529	2011
Lineage conversion of murine extraembryonic trophoblast stem cells to pluripotent stem cells. Molecular and cellular biology\| PubMed ID: 21300784	2011
Transgenic overexpression of Tcfap2c/AP-2gamma results in liver failure and intestinal dysplasia. PloS one\| PubMed ID: 21779369	2011
Lactogenic differentiation of HC11 cells is not accompanied by downregulation of AP-2 transcription factor genes. BMC research notes\| PubMed ID: 21906301	2011
The seminoma cell line TCam-2 is sensitive to HDAC inhibitor depsipeptide but tolerates various other chemotherapeutic drugs and loss of NANOG expression. Genes, chromosomes & cancer\| PubMed ID: 21987446	2011
PDGF signalling controls age-dependent proliferation in pancreatic Î²-cells. Nature\| PubMed ID: 21993628	2011
Establishment of a versatile seminoma model indicates cellular plasticity of germ cell tumor cells. Genes, chromosomes & cancer\| PubMed ID: 22489004	2012
The role of transcription factor Tcfap2c/TFAP2C in trophectoderm development. Reproductive biomedicine online\| PubMed ID: 22560121	2012
Connexin 31 (GJB3) deficiency in mouse trophoblast stem cells alters giant cell differentiation and leads to loss of oxygen sensing. Biology of reproduction\| PubMed ID: 22623621	2012
Valproic acid confers functional pluripotency to human amniotic fluid stem cells in a transgene-free approach. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 22760542	2012
Fetuin-B, a liver-derived plasma protein is essential for fertilization. Developmental cell\| PubMed ID: 23562279	2013
Transcription factor TFAP2C regulates major programs required for murine fetal germ cell maintenance and haploinsufficiency predisposes to teratomas in male mice. PloS one\| PubMed ID: 23967156	2013
Analysis of TET expression/activity and 5mC oxidation during normal and malignant germ cell development. PloS one\| PubMed ID: 24386123	2013
Derivation and maintenance of murine trophoblast stem cells under defined conditions. Stem cell reports\| PubMed ID: 24527396	2014
Reference gene validation for RT-qPCR, a note on different available software packages. PloS one\| PubMed ID: 25825906	2015
Injury-induced decline of intrinsic regenerative ability revealed by quantitative proteomics. Neuron\| PubMed ID: 25937169	2015
Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71. Scientific reports\| PubMed ID: 26057209	2015
Reduced Gene Dosage of Tfap2c Impairs Trophoblast Lineage Differentiation and Alters Maternal Blood Spaces in the Mouse Placenta. Biology of reproduction\| PubMed ID: 26063869	2015
BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma. PLoS genetics\| PubMed ID: 26226633	2015
Direct Induction of Trophoblast Stem Cells from Murine Fibroblasts. Cell stem cell\| PubMed ID: 26412560	2015
Tpbpa-Cre-mediated deletion of TFAP2C leads to deregulation of Cdkn1a, Akt1 and the ERK pathway, causing placental growth arrest. Development (Cambridge, England)\| PubMed ID: 26811378	2016
SOX2 is essential for in vivo reprogramming of seminoma-like TCam-2 cells to an embryonal carcinoma-like fate. Oncotarget\| PubMed ID: 27283990	2016