Gene S. Tan

Department of Microbiology, Icahn School of Medicine at Mount Sinai

Affiliated withIcahn School of Medicine at Mount Sinai J. Craig Venter Institute Icahn School of Medicine at Mount Sinai

Research Area

Immunology and Infection

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 10	2017
Publication title Cited by 6	2018

Other Publications

Article	Year
Rabies virus nucleoprotein as a carrier for foreign antigens. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15197258	2004
Strong cellular and humoral anti-HIV Env immune responses induced by a heterologous rhabdoviral prime-boost approach. Virology\| PubMed ID: 15582655	2005
The application of reverse genetics technology in the study of rabies virus (RV) pathogenesis and for the development of novel RV vaccines. Journal of neurovirology\| PubMed ID: 15804964	2005
The dynein light chain 8 binding motif of rabies virus phosphoprotein promotes efficient viral transcription. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17438267	2007
PPEY motif within the rabies virus (RV) matrix protein is essential for efficient virion release and RV pathogenicity. Journal of virology\| PubMed ID: 18667490	2008
Immune modulating effect by a phosphoprotein-deleted rabies virus vaccine vector expressing two copies of the rabies virus glycoprotein gene. Vaccine\| PubMed ID: 18804506	2008
Intravenous inoculation of a bat-associated rabies virus causes lethal encephalopathy in mice through invasion of the brain via neurosecretory hypothalamic fibers. PLoS pathogens\| PubMed ID: 19543379	2009
Replication-deficient rabies virus-based vaccines are safe and immunogenic in mice and nonhuman primates. The Journal of infectious diseases\| PubMed ID: 19764884	2009
Attenuation of rabies virulence: takeover by the cytoplasmic domain of its envelope protein. Science signaling\| PubMed ID: 20086240	2010
Broadly protective monoclonal antibodies against H3 influenza viruses following sequential immunization with different hemagglutinins. PLoS pathogens\| PubMed ID: 20195520	2010
Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20956293	2010
Hemagglutinin stalk antibodies elicited by the 2009 pandemic influenza virus as a mechanism for the extinction of seasonal H1N1 viruses. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22308500	2012
Influenza viruses expressing chimeric hemagglutinins: globular head and stalk domains derived from different subtypes. Journal of virology\| PubMed ID: 22398287	2012
A pan-H1 anti-hemagglutinin monoclonal antibody with potent broad-spectrum efficacy in vivo. Journal of virology\| PubMed ID: 22491456	2012
Hemagglutinin Stalk-Reactive Antibodies Are Boosted following Sequential Infection with Seasonal and Pandemic H1N1 Influenza Virus in Mice. Journal of virology\| PubMed ID: 22787225	2012
A virus-like particle that elicits cross-reactive antibodies to the conserved stem of influenza virus hemagglutinin. Journal of virology\| PubMed ID: 22896619	2012
A carboxy-terminal trimerization domain stabilizes conformational epitopes on the stalk domain of soluble recombinant hemagglutinin substrates. PloS one\| PubMed ID: 22928001	2012
In vivo bioluminescent imaging of influenza a virus infection and characterization of novel cross-protective monoclonal antibodies. Journal of virology\| PubMed ID: 23698304	2013
Assessment of influenza virus hemagglutinin stalk-based immunity in ferrets. Journal of virology\| PubMed ID: 24403585	2014
Broadly neutralizing hemagglutinin stalk-specific antibodies require FcγR interactions for protection against influenza virus in vivo. Nature medicine\| PubMed ID: 24412922	2014
Divergent H7 immunogens offer protection from H7N9 virus challenge. Journal of virology\| PubMed ID: 24453375	2014
Characterization of a broadly neutralizing monoclonal antibody that targets the fusion domain of group 2 influenza A virus hemagglutinin. Journal of virology\| PubMed ID: 25210195	2014
Preexisting human antibodies neutralize recently emerged H7N9 influenza strains. The Journal of clinical investigation\| PubMed ID: 25689254	2015
Vaccination with adjuvanted recombinant neuraminidase induces broad heterologous, but not heterosubtypic, cross-protection against influenza virus infection in mice. mBio\| PubMed ID: 25759506	2015
Direct administration in the respiratory tract improves efficacy of broadly neutralizing anti-influenza virus monoclonal antibodies. Antimicrobial agents and chemotherapy\| PubMed ID: 25941218	2015
Vaccination with soluble headless hemagglutinin protects mice from challenge with divergent influenza viruses. Vaccine\| PubMed ID: 26026378	2015
Anti-HA Glycoforms Drive B Cell Affinity Selection and Determine Influenza Vaccine Efficacy. Cell\| PubMed ID: 26140596	2015
Hemagglutinin Stalk- and Neuraminidase-Specific Monoclonal Antibodies Protect against Lethal H10N8 Influenza Virus Infection in Mice. Journal of virology\| PubMed ID: 26512088	2015
Influenza A Viruses Expressing Intra- or Intergroup Chimeric Hemagglutinins. Journal of virology\| PubMed ID: 26764009	2016
Cryo-electron Microscopy Structures of Chimeric Hemagglutinin Displayed on a Universal Influenza Vaccine Candidate. mBio\| PubMed ID: 27006464	2016
Broadly-Reactive Neutralizing and Non-neutralizing Antibodies Directed against the H7 Influenza Virus Hemagglutinin Reveal Divergent Mechanisms of Protection. PLoS pathogens\| PubMed ID: 27081859	2016
Both Neutralizing and Non-Neutralizing Human H7N9 Influenza Vaccine-Induced Monoclonal Antibodies Confer Protection. Cell host & microbe\| PubMed ID: 27281570	2016
Optimal activation of Fc-mediated effector functions by influenza virus hemagglutinin antibodies requires two points of contact. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27647907	2016
Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27698132	2016
Broadly Neutralizing Hemagglutinin Stalk-Specific Antibodies Induce Potent Phagocytosis of Immune Complexes by Neutrophils in an Fc-Dependent Manner. mBio\| PubMed ID: 27703076	2016
Synthetic TLR4 and TLR7 ligands work additively via MyD88 to induce protective antiviral immunity in mice. Journal of virology\| PubMed ID: 28724768	2017
Broadly protective murine monoclonal antibodies against influenza B virus target highly conserved neuraminidase epitopes. Nature microbiology\| PubMed ID: 28827718	2017
Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice. Nature communications\| PubMed ID: 29018261	2017
Whole-Genome Sequences of Zika Virus FLR Strains after Passage in Vero or C6/36 Cells. Genome announcements\| PubMed ID: 29371358	2018