Stephen R. Holdsworth

Department of Medicine, Monash University

Affiliated withMonash University Monash Health Monash Health

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 18	2017
Publication title Cited by 5	2020

Other Publications

Article	Year
The requirement for granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor in leukocyte-mediated immune glomerular injury. Journal of the American Society of Nephrology : JASN\| PubMed ID: 11805162	2002
IFN-gamma production by intrinsic renal cells and bone marrow-derived cells is required for full expression of crescentic glomerulonephritis in mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 11937574	2002
Adaptive immunity to nontypeable Haemophilus influenzae. American journal of respiratory and critical care medicine\| PubMed ID: 12433671	2003
Laboratory assessment of immune function in renal transplant patients. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 12686675	2003
Plasminogen activator inhibitor-1 is a significant determinant of renal injury in experimental crescentic glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 12761249	2003
T cells in glomerulonephritis. Springer seminars in immunopathology\| PubMed ID: 12778334	2003
Intrinsic renal cells are the major source of tumor necrosis factor contributing to renal injury in murine crescentic glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 12819238	2003
Intrinsic renal cell expression of CD40 directs Th1 effectors inducing experimental crescentic glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 14569091	2003
The role of flow cytometric ANCA detection in screening for acute pauci-immune crescentic glomerulonephritis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 14736960	2004
Contributions of IL-1beta and IL-1alpha to crescentic glomerulonephritis in mice. Journal of the American Society of Nephrology : JASN\| PubMed ID: 15034093	2004
Leukocyte-derived interleukin-1beta interacts with renal interleukin-1 receptor I to promote renal tumor necrosis factor and glomerular injury in murine crescentic glomerulonephritis. The American journal of pathology\| PubMed ID: 15161633	2004
Ex vivo lymphocyte proliferative function is severely inhibited in renal transplant patients on mycophenolate mofetil treatment. Transplant immunology\| PubMed ID: 15203129	2004
An IL-12-independent role for CD40-CD154 in mediating effector responses: studies in cell-mediated glomerulonephritis and dermal delayed-type hypersensitivity. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15210767	2004
Experimental autoimmune anti-glomerular basement membrane glomerulonephritis: a protective role for IFN-gamma. Journal of the American Society of Nephrology : JASN\| PubMed ID: 15213264	2004
Fibrin independent proinflammatory effects of tissue factor in experimental crescentic glomerulonephritis. Kidney international\| PubMed ID: 15253718	2004
Endogenous IL-13 limits humoral responses and injury in experimental glomerulonephritis but does not regulate Th1 cell-mediated crescentic glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 15339986	2004
Experimental autoimmune Goodpasture's disease: a pathogenetic role for both effector cells and antibody in injury. Kidney international\| PubMed ID: 15673304	2005
IL-12p40 and IL-18 in crescentic glomerulonephritis: IL-12p40 is the key Th1-defining cytokine chain, whereas IL-18 promotes local inflammation and leukocyte recruitment. Journal of the American Society of Nephrology : JASN\| PubMed ID: 15888563	2005
Glomerular expression of CD80 and CD86 is required for leukocyte accumulation and injury in crescentic glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 15944341	2005
CD80 and CD86 costimulatory molecules regulate crescentic glomerulonephritis by different mechanisms. Kidney international\| PubMed ID: 16014035	2005
Leukocyte phenotype and function predicts infection risk in renal transplant recipients. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 16030032	2005
Granulocyte macrophage colony-stimulating factor expression by both renal parenchymal and immune cells mediates murine crescentic glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 16033860	2005
A pathogenetic role for mast cells in experimental crescentic glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 16319187	2006
The isolation and purification of biologically active recombinant and native autoantigens for the study of autoimmune disease. Journal of immunological methods\| PubMed ID: 16388818	2006
Inducible co-stimulatory molecule ligand is protective during the induction and effector phases of crescentic glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 16540559	2006
T cells in crescentic glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 16624930	2006
Characterisation of the onset and presenting clinical features of adult bronchiectasis. Respiratory medicine\| PubMed ID: 16650970	2006
Anti-neutrophil cytoplasmic antibodies and effector CD4+ cells play nonredundant roles in anti-myeloperoxidase crescentic glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 16769746	2006
CD100 enhances dendritic cell and CD4+ cell activation leading to pathogenetic humoral responses and immune complex glomerulonephritis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16920982	2006
Outcome in adult bronchiectasis. COPD\| PubMed ID: 17136958	2005
Endogenous myeloperoxidase promotes neutrophil-mediated renal injury, but attenuates T cell immunity inducing crescentic glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 17267745	2007
Microbiologic follow-up study in adult bronchiectasis. Respiratory medicine\| PubMed ID: 17467966	2007
Cytokines in glomerulonephritis. Seminars in nephrology\| PubMed ID: 17533006	2007
Leukocytes in glomerular injury. Seminars in immunopathology\| PubMed ID: 17938927	2007
Intrarenal antigens activate CD4+ cells via co-stimulatory signals from dendritic cells. Journal of the American Society of Nephrology : JASN\| PubMed ID: 18184859	2008
Distinct in vivo roles of CD80 and CD86 in the effector T-cell responses inducing antigen-induced arthritis. Immunology\| PubMed ID: 18217945	2008
T-bet deficiency attenuates renal injury in experimental crescentic glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 18235099	2008
Advances in the pathogenesis of Goodpasture's disease: from epitopes to autoantibodies to effector T cells. Journal of autoimmunity\| PubMed ID: 18502098	2008
Role of mast cells in progressive renal diseases. Journal of the American Society of Nephrology : JASN\| PubMed ID: 18776124	2008
IL-23, not IL-12, directs autoimmunity to the Goodpasture antigen. Journal of the American Society of Nephrology : JASN\| PubMed ID: 19357249	2009
Phenotypes of adult bronchiectasis: onset of productive cough in childhood and adulthood. COPD\| PubMed ID: 19378226	2009
IL-1RI deficiency ameliorates early experimental renal interstitial fibrosis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 19465557	2009
Endogenous CD100 promotes glomerular injury and macrophage recruitment in experimental crescentic glomerulonephritis. Immunology\| PubMed ID: 19689741	2009
Atorvastatin enhances humoral immune responses but does not alter renal injury in experimental crescentic glomerulonephritis. Nephrology (Carlton, Vic.)\| PubMed ID: 19796023	2009
Th1 and Th17 cells induce proliferative glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 19820122	2009
Th17 cells promote autoimmune anti-myeloperoxidase glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 20299361	2010
Review: T helper 17 cells: their role in glomerulonephritis. Nephrology (Carlton, Vic.)\| PubMed ID: 20649870	2010
Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis. Kidney international\| PubMed ID: 20844472	2010
Toll-like receptor 9 enhances nephritogenic immunity and glomerular leukocyte recruitment, exacerbating experimental crescentic glomerulonephritis. The American journal of pathology\| PubMed ID: 20847283	2010
Lung diffusing capacity in adult bronchiectasis: a longitudinal study. Respiratory care\| PubMed ID: 21122177	2010
The Th17-defining transcription factor RORγt promotes glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 21183590	2011
Toll-like receptor 2 induces Th17 myeloperoxidase autoimmunity while Toll-like receptor 9 drives Th1 autoimmunity in murine vasculitis. Arthritis and rheumatism\| PubMed ID: 21190299	2011
Endogenous foxp3(+) T-regulatory cells suppress anti-glomerular basement membrane nephritis. Kidney international\| PubMed ID: 21248715	2011
The IL-27 receptor has biphasic effects in crescentic glomerulonephritis mediated through Th1 responses. The American journal of pathology\| PubMed ID: 21281790	2011
The emergence of TH17 cells as effectors of renal injury. Journal of the American Society of Nephrology : JASN\| PubMed ID: 21289213	2011
Interleukin-17A promotes early but attenuates established disease in crescentic glomerulonephritis in mice. The American journal of pathology\| PubMed ID: 21741931	2011
Tim-1 promotes cisplatin nephrotoxicity. American journal of physiology. Renal physiology\| PubMed ID: 21835770	2011
Mast cells mediate acute kidney injury through the production of TNF. Journal of the American Society of Nephrology : JASN\| PubMed ID: 22021718	2011
Renal dendritic cells adopt a pro-inflammatory phenotype in obstructive uropathy to activate T cells but do not directly contribute to fibrosis. The American journal of pathology\| PubMed ID: 22079432	2012
Endogenous Tim-1 (Kim-1) promotes T-cell responses and cell-mediated injury in experimental crescentic glomerulonephritis. Kidney international\| PubMed ID: 22205357	2012
Mast cell activation and degranulation promotes renal fibrosis in experimental unilateral ureteric obstruction. Kidney international\| PubMed ID: 22673890	2012
The immunodominant myeloperoxidase T-cell epitope induces local cell-mediated injury in antimyeloperoxidase glomerulonephritis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22955884	2012
Mast cells contribute to peripheral tolerance and attenuate autoimmune vasculitis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 23138486	2012
Lung T-cell responses to nontypeable Haemophilus influenzae in patients with chronic obstructive pulmonary disease. The Journal of allergy and clinical immunology\| PubMed ID: 23142009	2012
Chest pain and exacerbations of bronchiectasis. International journal of general medicine\| PubMed ID: 23271921	2012
Thymic deletion and regulatory T cells prevent antimyeloperoxidase GN. Journal of the American Society of Nephrology : JASN\| PubMed ID: 23393320	2013
The HLA-DRB1*15:01-restricted Goodpasture's T cell epitope induces GN. Journal of the American Society of Nephrology : JASN\| PubMed ID: 23411782	2013
Reply: To PMID 23142009. The Journal of allergy and clinical immunology\| PubMed ID: 23453686	2013
Neutrophil myeloperoxidase regulates T-cell-driven tissue inflammation in mice by inhibiting dendritic cell function. Blood\| PubMed ID: 23509155	2013
Myeloperoxidase (MPO)-specific CD4+ T cells contribute to MPO-anti-neutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis. Cellular immunology\| PubMed ID: 23665205	2013
MicroRNA-155 a new therapeutic target in crescentic GN. Journal of the American Society of Nephrology : JASN\| PubMed ID: 24158984	2013
Histopathologic and clinical predictors of kidney outcomes in ANCA-associated vasculitis. American journal of kidney diseases : the official journal of the National Kidney Foundation\| PubMed ID: 24183110	2014
Innate IL-17A-producing leukocytes promote acute kidney injury via inflammasome and Toll-like receptor activation. The American journal of pathology\| PubMed ID: 24631024	2014
Endogenous myeloperoxidase is a mediator of joint inflammation and damage in experimental arthritis. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 24757143	2014
FcγRIIB regulates T-cell autoreactivity, ANCA production, and neutrophil activation to suppress anti-myeloperoxidase glomerulonephritis. Kidney international\| PubMed ID: 24869670	2014
Glomerulonephritis Induced by Heterologous Anti-GBM Globulin as a Planted Foreign Antigen. Current protocols in immunology\| PubMed ID: 25081909	2014
T cell mediated autoimmune glomerular disease in mice. Current protocols in immunology\| PubMed ID: 25367126	2014
Mouse models of anti-neutrophil cytoplasmic antibody-associated vasculitis. Current pharmaceutical design\| PubMed ID: 25777754	2015
Suppression of Autoimmunity and Renal Disease in Pristane-Induced Lupus by Myeloperoxidase. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 25777776	2015
Nontypeable Haemophilus influenzae induces sustained lung oxidative stress and protease expression. PloS one\| PubMed ID: 25793977	2015
FMS-like tyrosine kinase 3 ligand treatment does not ameliorate experimental rapidly progressive glomerulonephritis. PloS one\| PubMed ID: 25849330	2015
Cytokines: Names and Numbers You Should Care About. Clinical journal of the American Society of Nephrology : CJASN\| PubMed ID: 25941193	2015
Programmed death 1 and its ligands do not limit experimental foreign antigen-induced immune complex glomerulonephritis. Nephrology (Carlton, Vic.)\| PubMed ID: 26043977	2015
Myeloperoxidase Peptide-Based Nasal Tolerance in Experimental ANCA-Associated GN. Journal of the American Society of Nephrology : JASN\| PubMed ID: 26047792	2016
Endogenous Toll-Like Receptor 9 Regulates AKI by Promoting Regulatory T Cell Recruitment. Journal of the American Society of Nephrology : JASN\| PubMed ID: 26116356	2016
Renal participation of myeloperoxidase in antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis. Kidney international\| PubMed ID: 26176828	2015
Regulatory T cells in immune-mediated renal disease. Nephrology (Carlton, Vic.)\| PubMed ID: 26206106	2016
Mast Cell Stabilization Ameliorates Autoimmune Anti-Myeloperoxidase Glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 26374606	2016
The lung immune response to bacteria in chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine\| PubMed ID: 26426789	2015
Targeting IL-17 and IL-23 in Immune Mediated Renal Disease. Current medicinal chemistry\| PubMed ID: 26521930	2015
Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of Myeloperoxidase. Journal of immunology research\| PubMed ID: 26904693	2016
Biologics for the treatment of autoimmune renal diseases. Nature reviews. Nephrology\| PubMed ID: 26949177	2016
The NLRP3 inflammasome in kidney disease and autoimmunity. Nephrology (Carlton, Vic.)\| PubMed ID: 27011059	2016
CD8+ T Cells Effect Glomerular Injury in Experimental Anti-Myeloperoxidase GN. Journal of the American Society of Nephrology : JASN\| PubMed ID: 27288012	2017
Activated Renal Dendritic Cells Cross Present Intrarenal Antigens After Ischemia-Reperfusion Injury. Transplantation\| PubMed ID: 27495751	2017
Induced regulatory T cells are phenotypically unstable and do not protect mice from rapidly progressive glomerulonephritis. Immunology\| PubMed ID: 27606831	2017
Interleukin-17RA Promotes Humoral Responses and Glomerular Injury in Experimental Rapidly Progressive Glomerulonephritis. Nephron\| PubMed ID: 27941331	2017
T cell receptor assessment in autoimmune disease requires access to the most adjacent immunologically active organ. Journal of autoimmunity\| PubMed ID: 28318808	2017
Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells. Nature\| PubMed ID: 28467828	2017
ANCA-Associated Vasculitis: Pathogenesis, Models, and Preclinical Testing. Seminars in nephrology\| PubMed ID: 28863790	2017
Deoxyribonuclease 1 reduces pathogenic effects of cigarette smoke exposure in the lung. Scientific reports\| PubMed ID: 28935869	2017