Yan Sun

Spinal Cord and Brain Injury Research Group, Indiana University School of Medicine

Affiliated withIndiana University School of Medicine Fudan University National Clinical Research Center for Infectious Diseases

Research Area

Biography

Dr. Sun is a clinician-scientist with clinical specialty in glaucoma medical and surgical management, as well as cataract surgery. He practices at both Byers Eye Institute at Stanford as well as Palo Alto VA medical center. He is an NIH and VA funded investigator with the research focus on roles of inositol metabolism in eye development and disease. The current research interests in his lab include the elucidation of the mechanisms in cilia-mediated signaling in glaucoma and retinal degeneration.

JoVE Journal Publications

ArticleTotal : 5	Year
Publication title Cited by 11	2017
Publication title Cited by 7	2022
Publication title
Publication title Cited by 1	2025
Publication title	2026

Other Publications

Article	Year
Repertoire of human antibodies against the polysaccharide capsule of Streptococcus pneumoniae serotype 6B. Infection and immunity\| PubMed ID: 10024557	1999
Differential effects of hypothalamic IGF-I on gonadotropin releasing hormone neuronal activation during steroid-induced LH surges in young and middle-aged female rats. Endocrinology\| PubMed ID: 21914776	2011
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nature genetics\| PubMed ID: 22267201	2012
Peripubertal vitamin D(3) deficiency delays puberty and disrupts the estrous cycle in adult female mice. Biology of reproduction\| PubMed ID: 22572998	2012
Intracerebroventricular infusion of vasoactive intestinal Peptide rescues the luteinizing hormone surge in middle-aged female rats. Frontiers in endocrinology\| PubMed ID: 22654857	2012
Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. The Journal of clinical investigation\| PubMed ID: 22684109	2012
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nature genetics\| PubMed ID: 23583978	2013
Genome-wide association of body fat distribution in african ancestry populations suggests new Loci. PLoS genetics\| PubMed ID: 23966867	2013
Agouti-related peptide plays a critical role in leptin's effects on female puberty and reproduction. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 24169048	2013
Insulin-like growth factor-I regulates LH release by modulation of kisspeptin and NMDA-mediated neurotransmission in young and middle-aged female rats. Endocrinology\| PubMed ID: 24617524	2014
Vasoactive intestinal peptide modulation of the steroid-induced LH surge involves kisspeptin signaling in young but not in middle-aged female rats. Endocrinology\| PubMed ID: 24654782	2014
mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC). PloS one\| PubMed ID: 26042770	2015
Maternal Vitamin D Deficiency Programs Reproductive Dysfunction in Female Mice Offspring Through Adverse Effects on the Neuroendocrine Axis. Endocrinology\| PubMed ID: 26741195	2016
The mTOR Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System Injury. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 28626016	2017
Polymorphisms in the vitamin D receptor gene are associated with reduced rate of sputum culture conversion in multidrug-resistant tuberculosis patients in South Africa. PloS one\| PubMed ID: 28700743	2017
Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry. American journal of human genetics\| PubMed ID: 33713608	2021
Independent transcriptomic and proteomic regulation by type I and II protein arginine methyltransferases. iScience\| PubMed ID: 34505004	2021
High throughput and low bias DNA methylation and hydroxymethylation analysis by direct injection mass spectrometry. Analytica chimica acta\| PubMed ID: 34538324	2021
Genotype-specific features reduce the susceptibility of South American yellow fever virus strains to vaccine-induced antibodies. Cell host & microbe\| PubMed ID: 34998466	2022
DNA methylation and hydroxymethylation analysis using a high throughput and low bias direct injection mass spectrometry platform. MethodsX\| PubMed ID: 35004218	2021
Synthesis and Characterization of Transition-State Analogue Inhibitors against Human DNA Methyltransferase 1. Journal of medicinal chemistry\| PubMed ID: 35324190	2022
Macrophages use apoptotic cell-derived methionine and DNMT3A during efferocytosis to promote tissue resolution. Nature metabolism\| PubMed ID: 35361955	2022
Prediction of recurrence risk in early breast cancer using human epidermal growth factor 2 and cyclin A2. Chinese medical journal\| PubMed ID: 20193482	2010
ZNF804A variants confer risk for heroin addiction and affect decision making and gray matter volume in heroin abusers. Addiction biology\| PubMed ID: 25708696	2016
Disrupted white matter structural connectivity in heroin abusers. Addiction biology\| PubMed ID: 26177615	2017
Anti-RAGE antibody attenuates isoflurane-induced cognitive dysfunction in aged rats. Behavioural brain research\| PubMed ID: 28115220	2017
Utility of 360° Real-time Endoanal Sonography for Evaluation of Perianal Fistulas. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine\| PubMed ID: 28708274	2018
Senescence as a novel mechanism involved in β-adrenergic receptor mediated cardiac hypertrophy. PloS one\| PubMed ID: 28783759	2017
Perception of Stigma and Its Associated Factors Among Patients With Major Depressive Disorder: A Multicenter Survey From an Asian Population. Frontiers in psychiatry\| PubMed ID: 31156476	2019
Ultrasound-Guided Biopsy of Pleural-Based Pulmonary Lesions by Injection of Contrast-Enhancing Drugs. Frontiers in pharmacology\| PubMed ID: 31551773	2019
Bubble-Manipulated Local Drug Release from a Smart Thermosensitive Cerasome for Dual-Mode Imaging Guided Tumor Chemo-Photothermal Therapy. Theranostics\| PubMed ID: 31754386	2019
Targeted Biopsy With Reduced Number of Cores: Optimal Sampling Scheme in Patients Undergoing Magnetic Resonance Imaging/Transrectal Ultrasound Fusion Prostate Biopsy. Ultrasound in medicine & biology\| PubMed ID: 32107089	2020
Target Biopsy and Core Number in Prostate Biopsy. Ultrasound in medicine & biology\| PubMed ID: 33261911	2021
Breast Imaging Reporting and Data System Classification for Central-Type Intra-Ductal Papillary Masses: Current Problems and Evaluation of Modified Parameters. Ultrasound in medicine & biology\| PubMed ID: 33455809	2021
Percutaneous Sonazoid-enhanced ultrasonography combined with in vitro verification for detection and characterization of sentinel lymph nodes in early breast cancer. European radiology\| PubMed ID: 33502555	2021
Dose escalation and expansion (phase Ia/Ib) study of GLS-010, a recombinant fully human antiprogrammed death-1 monoclonal antibody for advanced solid tumors or lymphoma. European journal of cancer (Oxford, England : 1990)\| PubMed ID: 33691262	2021
Comparative study of two contrast agents for intraoperative identification of sentinel lymph nodes in patients with early breast cancer. Gland surgery\| PubMed ID: 34164308	2021
Genotype-phenotype correlations in a chinese population with familial amyotrophic lateral sclerosis. Neurological research\| PubMed ID: 34431456	2022
Epidemiology and factors predicting survival of amyotrophic lateral sclerosis in a large Chinese cohort. Chinese medical journal\| PubMed ID: 34483254	2021
EZH2 Inhibitors Suppress Colorectal Cancer by Regulating Macrophage Polarization in the Tumor Microenvironment. Frontiers in immunology\| PubMed ID: 35432300	2022
Factors Influencing the Sample Adequacy of Ultrasound-Guided Fine-Needle Aspiration from Solid Thyroid Nodules for Liquid-Based Cytology: A Demographic, Sonographic, and Technical Perspectiv... Medicina (Kaunas, Lithuania)\| PubMed ID: 36422179	2022
Learning curve in ultrasound-guided vacuum-assisted excision of breast lesions for surgeons and ultrasound physicians. Quantitative imaging in medicine and surgery\| PubMed ID: 36915354	2023
Integrative analysis of DNA methylomes reveals novel cell-free biomarkers in lung adenocarcinoma. Frontiers in genetics\| PubMed ID: 37396036	2023
Targeting LTA4H facilitates the reshaping of the immune microenvironment mediated by CCL5 and sensitizes ovarian cancer to Cisplatin. Science China. Life sciences\| PubMed ID: 38300441	2024
EZH2 Inhibition Enhances PD-L1 Protein Stability Through USP22-Mediated Deubiquitination in Colorectal Cancer. Advanced science (Weinheim, Baden-Wurttemberg, Germany)\| PubMed ID: 38520088	2024
Transcriptomic analysis identified novel biomarker in invasive placenta accreta spectrum. Placenta\| PubMed ID: 39549433	2024
Methylation and its role in the disposition of tanshinol, a cardiovascular carboxylic catechol from Salvia miltiorrhiza roots (Danshen). Acta pharmacologica Sinica\| PubMed ID: 25891082	2015
Pharmacokinetics and disposition of monoterpene glycosides derived from Paeonia lactiflora roots (Chishao) after intravenous dosing of antiseptic XueBiJing injection in human subjects and ra... Acta pharmacologica Sinica\| PubMed ID: 26838074	2016
Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies. Cancer cell\| PubMed ID: 32860752	2020
Predicting bleeding risk in a Chinese immune thrombocytopenia (ITP) population: development and assessment of a new predictive nomogram. Scientific reports\| PubMed ID: 32948823	2020
[Apoptosis of Endothelial Cells Induced by Anti-Platelet Integrin β3 Antibody]. Zhongguo shi yan xue ye xue za zhi\| PubMed ID: 33812432	2021
[Expression of MicroRNAs in Peripheral Blood of Patients with Primary Immune Thrombocytopenia and Its Correlation with the Imbalance of Th1/Th2 Cell]. Zhongguo shi yan xue ye xue za zhi\| PubMed ID: 34627442	2021
Natural Language Processing Algorithms for Normalizing Expressions of Synonymous Symptoms in Traditional Chinese Medicine. Evidence-based complementary and alternative medicine : eCAM\| PubMed ID: 34671408	2021
Mechanism and Molecular Targets of Ejiao Siwu Decoction for Treating Primary Immune Thrombocytopenia Based on High-Performance Liquid Chromatograph, Network Pharmacology, Molecular Docking a... Frontiers in medicine\| PubMed ID: 35911404	2022
The Construction of ITP Diagnostic Modeling Based on the Expressions of Hub Genes Associated with M1 Polarization of Macrophages. Journal of inflammation research\| PubMed ID: 36274827	2022
Wide local excision for Merkel cell carcinoma of the lower extremity: A case report. Experimental and therapeutic medicine\| PubMed ID: 36277148	2022
The efficiency and safety of Shengxuening tablet on treating and preventing iron deficiency anemia: A systematic review and meta-analysis. Frontiers in pharmacology\| PubMed ID: 36408243	2022
TET2 Mutation May Be More Valuable in Predicting Thrombosis in ET Patients Compared to PV Patients: A Preliminary Report. Journal of clinical medicine\| PubMed ID: 36431092	2022
Coagulation status and determinants of possible aspirin resistance in patients with essential thrombocythemia. Frontiers in medicine\| PubMed ID: 36606056	2022
Halo-pelvic traction in the treatment of severe scoliosis: a meta-analysis. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society\| PubMed ID: 36622456	2023
Spinal Manual Therapy for Adolescent Idiopathic Scoliosis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. BioMed research international\| PubMed ID: 36644168	2023
Proteomic-Based Platelet Activation-Associated Protein SELP May Be a Novel Biomarker for Coagulation and Prognostic in Essential Thrombocythemia. Journal of clinical medicine\| PubMed ID: 36769725	2023
IGHG1 promotes malignant progression in breast cancer cells through the regulation of AKT and VEGF signaling. Biomolecules & biomedicine\| PubMed ID: 36883223	2023
Posterior hybrid surgery for atlantoaxial dislocation coexisting with multilevel cervical spondylotic myelopathy. Frontiers in surgery\| PubMed ID: 37334204	2023
Incidence of Thrombosis at Different Sites During the Follow-Up Period in Essential Thrombocythemia: A Systematic Review and Meta-Analysis. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis\| PubMed ID: 37350087	2023
Therapeutic Efficacy and Safety of Percutaneous Curved Vertebroplasty in Osteoporotic Vertebral Compression Fractures: A Systematic Review and Meta-Analysis. Orthopaedic surgery\| PubMed ID: 37497571	2023
Activated PRKCD-mediated neutrophil extracellular traps pathway may be the prothrombotic mechanism of neutrophils in polycythemia vera patients based on clinical retrospective analysis and b... International immunopharmacology\| PubMed ID: 38128308	2024
Adult Type II Choledochal Cyst. The American journal of gastroenterology\| PubMed ID: 38299615	2024
Efficacy and safety of Chinese herbal medicine in treating postcholecystectomy diarrhea: A systematic review and meta-analysis. Medicine\| PubMed ID: 38701312	2024
Integrated RNA sequencing and biochemical studies reveal endoplasmic reticulum stress and autophagy dysregulation contribute to Tri (2-Ethylhexyl) phosphate (TEHP)-induced cell injury in Ser... Environmental pollution (Barking, Essex : 1987)\| PubMed ID: 39029862	2024
Comparative efficacy and hematologic safety of different dosages of JAK inhibitors in the treatment of myelofibrosis: a network meta-analysis. Frontiers in oncology\| PubMed ID: 39281381	2024
Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing. Science China. Life sciences\| PubMed ID: 39470923	2025
[Analysis of Genes Related to Platelet Activation in Essential Thrombocythemia Based on Transcriptomics]. Zhongguo shi yan xue ye xue za zhi\| PubMed ID: 39743270	2024
EasyMetagenome: A user-friendly and flexible pipeline for shotgun metagenomic analysis in microbiome research. iMeta\| PubMed ID: 40027489	2025
A simplified stent-bridging pancreaticogastrostomy during pancreaticoduodenectomy: How I do it. Langenbeck's archives of surgery\| PubMed ID: 40380980	2025
Case Report: Upper extremity fibro-adipose vascular anomaly. Frontiers in surgery\| PubMed ID: 40989492	2025
[Research on prediction of fracture reduction fixator therapy based on multimodal multi-label method]. Zhongguo gu shang = China journal of orthopaedics and traumatology\| PubMed ID: 41340307	2025
Isolated right hepatic duct dilation - Type VI of Mirizzi syndrome? Surgery open science\| PubMed ID: 41438001	2025
Effects of different prehabilitation programs on the major abdominal surgery population: a systematic review and network meta-analysis. Frontiers in medicine\| PubMed ID: 41613317	2025
Fibroblast growth enhancement and antibiotic-free disinfection microneedles with self-powered electrical stimulations. Nanoscale\| PubMed ID: 41705503	2026
Effect of acupuncture pretreatment on clinical pregnancy rate in women with diminished ovarian reserve undergoing IVF-ET: study protocol for a multicenter randomized controlled trial. Frontiers in endocrinology\| PubMed ID: 41727691	2026