Schahram Akbarian

Psychiatry, University of Massachusetts Medical School

Affiliated withUniversity of Massachusetts Medical School Icahn School of Medicine at Mount Sinai Icahn School of Medicine at Mount Sinai

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 16	2008
Publication title Cited by 136	2008
Publication title Cited by 6	2021

Other Publications

Article	Year
Neurotrophin-3 promotes cell death induced in cerebral ischemia, oxygen-glucose deprivation, and oxidative stress: possible involvement of oxygen free radicals. Neurobiology of disease\| PubMed ID: 11848682	2002
Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12019333	2002
Diseases of the mind and brain: Rett's syndrome. The American journal of psychiatry\| PubMed ID: 12091185	2002
Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia. Archives of general psychiatry\| PubMed ID: 12150646	2002
Diseases of the mind and brain: Rett's syndrome, part II. The American journal of psychiatry\| PubMed ID: 12153818	2002
Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12432090	2002
The neurobiology of Rett syndrome. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry\| PubMed ID: 12580340	2003
Clinical experts on Rett disorder. Pediatric rehabilitation\| PubMed ID: 12596822	2002
Dopamine D2-like antagonists induce chromatin remodeling in striatal neurons through cyclic AMP-protein kinase A and NMDA receptor signaling. Journal of neurochemistry\| PubMed ID: 15312167	2004
Histone methylation at gene promoters is associated with developmental regulation and region-specific expression of ionotropic and metabotropic glutamate receptors in human brain. Journal of neurochemistry\| PubMed ID: 15998284	2005
Chromatin alterations associated with down-regulated metabolic gene expression in the prefrontal cortex of subjects with schizophrenia. Archives of general psychiatry\| PubMed ID: 16061760	2005
Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice. Journal of neurobiology\| PubMed ID: 16408297	2006
Chromatin immunoprecipitation in postmortem brain. Journal of neuroscience methods\| PubMed ID: 16574239	2006
NT-3 facilitates hippocampal plasticity and learning and memory by regulating neurogenesis. Learning & memory (Cold Spring Harbor, N.Y.)\| PubMed ID: 16705139	2006
Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders. Brain research reviews\| PubMed ID: 16759710	2006
Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse. Biological psychiatry\| PubMed ID: 16945350	2007
The molecular pathology of Rett syndrome: synopsis and update. Neuromolecular medicine\| PubMed ID: 17028371	2006
GAD1 mRNA expression and DNA methylation in prefrontal cortex of subjects with schizophrenia. PloS one\| PubMed ID: 17726539	2007
DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. PloS one\| PubMed ID: 17878930	2007
Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17942719	2007
Drug-induced activation of dopamine D(1) receptor signaling and inhibition of class I/II histone deacetylase induce chromatin remodeling in reward circuitry and modulate cocaine-related beha... Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 18288092	2008
DNA methylation changes in schizophrenia and bipolar disorder. Epigenetics : official journal of the DNA Methylation Society\| PubMed ID: 18398310	2008
Isolation of neuronal chromatin from brain tissue. BMC neuroscience\| PubMed ID: 18442397	2008
A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex. Human molecular genetics\| PubMed ID: 18632683	2008
Epigenetic regulation in human brain-focus on histone lysine methylation. Biological psychiatry\| PubMed ID: 18814864	2009
Approaching the molecular pathology of suicide. Biological psychiatry\| PubMed ID: 18926170	2008
Epigenetics in the nervous system. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19005036	2008
Restoring GABAergic signaling and neuronal synchrony in schizophrenia. The American journal of psychiatry\| PubMed ID: 19047328	2008
Molecular determinants of dysregulated GABAergic gene expression in the prefrontal cortex of subjects with schizophrenia. Biological psychiatry\| PubMed ID: 19121517	2009
Cingulate white matter neurons in schizophrenia and bipolar disorder. Biological psychiatry\| PubMed ID: 19559403	2009
Cocaine-induced metabolic activation in cortico-limbic circuitry is increased after exposure to the histone deacetylase inhibitor, sodium butyrate. Neuroscience letters\| PubMed ID: 19638299	2009
The molecular pathology of schizophrenia--focus on histone and DNA modifications. Brain research bulletin\| PubMed ID: 19729053	2010
rAAV9--a human-derived adeno-associated virus vector for efficient transgene expression in mouse cingulate cortex. Cold Spring Harbor protocols\| PubMed ID: 20360371	2010
Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20421462	2010
A simple method for improving the specificity of anti-methyl histone antibodies. Epigenetics : official journal of the DNA Methylation Society\| PubMed ID: 20458167	2010
Setdb1 histone methyltransferase regulates mood-related behaviors and expression of the NMDA receptor subunit NR2B. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20505083	2010
Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice. The Journal of biological chemistry\| PubMed ID: 20592034	2010
RPP25 is developmentally regulated in prefrontal cortex and expressed at decreased levels in autism spectrum disorder. Autism research : official journal of the International Society for Autism Research\| PubMed ID: 20632321	2010
White matter neuron alterations in schizophrenia and related disorders. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience\| PubMed ID: 20691252	2011
Gender-Specific Reduction of Estrogen-Sensitive Small RNA, miR-30b, in Subjects With Schizophrenia. Schizophrenia bulletin\| PubMed ID: 20732949	2010
Setdb1-mediated histone H3K9 hypermethylation in neurons worsens the neurological phenotype of Mecp2-deficient mice. Neuropharmacology\| PubMed ID: 20869373	2011
Keep the 'phospho' on MAPK, be happy. Nature medicine\| PubMed ID: 21052065	2010
The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism. PloS one\| PubMed ID: 21209826	2010
Epigenetics of schizophrenia. Current topics in behavioral neurosciences\| PubMed ID: 21312415	2010
Balancing histone methylation activities in psychiatric disorders. Trends in molecular medicine\| PubMed ID: 21429800	2011
Advancing drug discovery for schizophrenia. Annals of the New York Academy of Sciences\| PubMed ID: 22032400	2011
Epigenetic Signatures of Autism: Trimethylated H3K4 Landscapes in Prefrontal Neurons. Archives of general psychiatry\| PubMed ID: 22065254	2011
Epigenetic and post-transcriptional dysregulation of gene expression in schizophrenia and related disease. Neurobiology of disease\| PubMed ID: 22182689	2011
The neuroepigenetics of suicide. The American journal of psychiatry\| PubMed ID: 23632831	2013
Chromatin-bound RNA and the neurobiology of psychiatric disease. Neuroscience\| PubMed ID: 23831425	2014
Conserved Chromosome 2q31 Conformations Are Associated with Transcriptional Regulation of GAD1 GABA Synthesis Enzyme and Altered in Prefrontal Cortex of Subjects with Schizophrenia. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23864674	2013
The Genome in Three Dimensions: A New Frontier in Human Brain Research. Biological psychiatry\| PubMed ID: 23958183	2013
Epigenetics and sex differences in the brain: A genome-wide comparison of histone-3 lysine-4 trimethylation (H3K4me3) in male and female mice. Experimental neurology\| PubMed ID: 25131640	2015
Regulation of histone H3K4 methylation in brain development and disease. Philosophical transactions of the Royal Society of London. Series B, Biological sciences\| PubMed ID: 25135975	2014
Analytical tools and current challenges in the modern era of neuroepigenomics. Nature neuroscience\| PubMed ID: 25349914	2014
Epigenetic mechanisms in schizophrenia. Dialogues in clinical neuroscience\| PubMed ID: 25364289	2014
The future of neuroepigenetics in the human brain. Progress in molecular biology and translational science\| PubMed ID: 25410546	2014
A role for noncoding variation in schizophrenia. Cell reports\| PubMed ID: 25453756	2014
Transcriptional regulation of GAD1 GABA synthesis gene in the prefrontal cortex of subjects with schizophrenia. Schizophrenia research\| PubMed ID: 25458568	2015
Conserved higher-order chromatin regulates NMDA receptor gene expression and cognition. Neuron\| PubMed ID: 25467983	2014
Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25834037	2015
Interneuron epigenomes during the critical period of cortical plasticity: Implications for schizophrenia. Neurobiology of learning and memory\| PubMed ID: 25849095	2015
Cognition and mood-related behaviors in L3mbtl1 null mutant mice. PloS one\| PubMed ID: 25849281	2015
miR-10b-5p expression in Huntington's disease brain relates to age of onset and the extent of striatal involvement. BMC medical genomics\| PubMed ID: 25889241	2015
Quantifying polymorphism and divergence from epigenetic data: a framework for inferring the action of selection. Frontiers in genetics\| PubMed ID: 26074949	2015
Critical Role of Histone Turnover in Neuronal Transcription and Plasticity. Neuron\| PubMed ID: 26139371	2015
Chemogenetic Inactivation of Dorsal Anterior Cingulate Cortex Neurons Disrupts Attentional Behavior in Mouse. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 26224620	2016
DNA methylation levels of α-synuclein intron 1 in the aging brain. Neurobiology of aging\| PubMed ID: 26422361	2015
Epigenetic Basis of Mental Illness. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry\| PubMed ID: 26450593	2016
Pharmacological modulation of astrocytes and the role of cell type-specific histone modifications for the treatment of mood disorders. Current opinion in pharmacology\| PubMed ID: 26515273	2016
CHRNA7 and CHRFAM7A: psychosis and smoking? Blame the neighbors! The American journal of psychiatry\| PubMed ID: 26575444	2015
The PsychENCODE project. Nature neuroscience\| PubMed ID: 26605881	2015
Prefrontal Cortex and Social Cognition in Mouse and Man. Frontiers in psychology\| PubMed ID: 26635701	2015
RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression. PloS one\| PubMed ID: 26636579	2015
Back to the past in schizophrenia genomics. Nature neuroscience\| PubMed ID: 26713739	2016
NeuN+ neuronal nuclei in non-human primate prefrontal cortex and subcortical white matter after clozapine exposure. Schizophrenia research\| PubMed ID: 26776227	2016
Understanding the genetic liability to schizophrenia through the neuroepigenome. Schizophrenia research\| PubMed ID: 26827128	2016
Practical Guidelines for High-Resolution Epigenomic Profiling of Nucleosomal Histones in Postmortem Human Brain Tissue. Biological psychiatry\| PubMed ID: 27113501	2017
DNA Methylation Signatures of Early Childhood Malnutrition Associated With Impairments in Attention and Cognition. Biological psychiatry\| PubMed ID: 27184921	2016
Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research. Biological psychiatry\| PubMed ID: 27346079	2016
Insulin-like Growth Factor 1 for Healthy Spines and Healthy Minds? Biological psychiatry\| PubMed ID: 27468627	2016
Neuronal Deletion of Kmt2a/Mll1 Histone Methyltransferase in Ventral Striatum is Associated with Defective Spike-Timing-Dependent Striatal Synaptic Plasticity, Altered Response to Dopaminerg... Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 27485686	2016
Longitudinal assessment of neuronal 3D genomes in mouse prefrontal cortex. Nature communications\| PubMed ID: 27597321	2016
Disruption of an Evolutionarily Novel Synaptic Expression Pattern in Autism. PLoS biology\| PubMed ID: 27685936	2016
Spatial genome organization and cognition. Nature reviews. Neuroscience\| PubMed ID: 27708356	2016
MEF2C transcription factor is associated with the genetic and epigenetic risk architecture of schizophrenia and improves cognition in mice. Molecular psychiatry\| PubMed ID: 28115742	2018
Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network. Science (New York, N.Y.)\| PubMed ID: 28450582	2017
Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice. Nature communications\| PubMed ID: 28485378	2017
Cocaine-Induced Chromatin Modifications Associate With Increased Expression and Three-Dimensional Looping of Auts2. Biological psychiatry\| PubMed ID: 28577753	2017
The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain. Nature genetics\| PubMed ID: 28671686	2017
The epigenomics of schizophrenia, in the mouse. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics\| PubMed ID: 28699694	2017
Evaluating Synthetic Activation and Repression of Neuropsychiatric-Related Genes in hiPSC-Derived NPCs, Neurons, and Astrocytes. Stem cell reports\| PubMed ID: 28757163	2017
Antipsychotic-induced Hdac2 transcription via NF-κB leads to synaptic and cognitive side effects. Nature neuroscience\| PubMed ID: 28783139	2017
Allele-specific expression in a family quartet with autism reveals mono-to-biallelic switch and novel transcriptional processes of autism susceptibility genes. Scientific reports\| PubMed ID: 29523860	2018
Modeling Neuropsychiatric and Neurodegenerative Diseases With Induced Pluripotent Stem Cells. Frontiers in pediatrics\| PubMed ID: 29666786	2018
Landscape of Conditional eQTL in Dorsolateral Prefrontal Cortex and Co-localization with Schizophrenia GWAS. American journal of human genetics\| PubMed ID: 29805045	2018
Activity-Induced Regulation of Synaptic Strength through the Chromatin Reader L3mbtl1. Cell reports\| PubMed ID: 29898393	2018
Chromosomal Conformations and Epigenomic Regulation in Schizophrenia. Progress in molecular biology and translational science\| PubMed ID: 29933951	2018
Cell-specific histone modification maps in the human frontal lobe link schizophrenia risk to the neuronal epigenome. Nature neuroscience\| PubMed ID: 30038276	2018
Evaluation of chromatin accessibility in prefrontal cortex of individuals with schizophrenia. Nature communications\| PubMed ID: 30087329	2018
Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders. Molecular psychiatry\| PubMed ID: 30089790	2018
Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk. Science (New York, N.Y.)\| PubMed ID: 30545851	2018
Comprehensive functional genomic resource and integrative model for the human brain. Science (New York, N.Y.)\| PubMed ID: 30545857	2018
Epigenetic-genetic chromatin footprinting identifies novel and subject-specific genes active in prefrontal cortex neurons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 30970224	2019
Spatial genome exploration in the context of cognitive and neurological disease. Current opinion in neurobiology\| PubMed ID: 31255842	2019
Metabolome signature of autism in the human prefrontal cortex. Communications biology\| PubMed ID: 31263778	2019
CRISPR-based functional evaluation of schizophrenia risk variants. Schizophrenia research\| PubMed ID: 31277978	2020
In vivo epigenetic editing of Sema6a promoter reverses transcallosal dysconnectivity caused by C11orf46/Arl14ep risk gene. Nature communications\| PubMed ID: 31511512	2019
CommonMind Consortium provides transcriptomic and epigenomic data for Schizophrenia and Bipolar Disorder. Scientific data\| PubMed ID: 31551426	2019
Chromatin profiling of cortical neurons identifies individual epigenetic signatures in schizophrenia. Translational psychiatry\| PubMed ID: 31624234	2019
Special volume: The genomics and epigenomics of schizophrenia. Schizophrenia research\| PubMed ID: 31813801	2020
Use of the epigenetic toolbox to contextualize common variants associated with schizophrenia risk . Dialogues in clinical neuroscience\| PubMed ID: 31949408	2019
A chromosomal connectome for psychiatric and metabolic risk variants in adult dopaminergic neurons. Genome medicine\| PubMed ID: 32075678	2020
Prefrontal parvalbumin interneurons require juvenile social experience to establish adult social behavior. Nature communications\| PubMed ID: 32081848	2020
A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles. Nature neuroscience\| PubMed ID: 32152537	2020
Investigation of Schizophrenia with Human Induced Pluripotent Stem Cells. Advances in neurobiology\| PubMed ID: 32578147	2020
Epigenetic Clocks in Schizophrenia: Promising Biomarkers, Foggy Clockwork. Biological psychiatry\| PubMed ID: 32674842	2020
Genotype-phenotype correlation at codon 1740 of SETD2. American journal of medical genetics. Part A\| PubMed ID: 32710489	2020
A prefrontal-paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice. Nature neuroscience\| PubMed ID: 32868932	2020
Common genetic variation in humans impacts susceptibility to SARS-CoV-2 infection. bioRxiv : the preprint server for biology\| PubMed ID: 32995783	2020
Parsing the Functional Impact of Noncoding Genetic Variants in the Brain Epigenome. Biological psychiatry\| PubMed ID: 33131715	2021
Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection. Stem cell reports\| PubMed ID: 33636110	2021
Comprehensive identification of somatic nucleotide variants in human brain tissue. Genome biology\| PubMed ID: 33781308	2021