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Biology

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Neuronal Nuclei Isolation from Human Postmortem Brain Tissue
 

Neuronal Nuclei Isolation from Human Postmortem Brain Tissue

Article DOI: 10.3791/914
October 1st, 2008

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Summary October 1st, 2008

The cellular heterogeneity of brain tissue poses a significant limitation for the study of epigenetic markings in chromatin because most assays lack single cell resolution. Neurons typically are intermingled with glia and other non-neuronal cells. We provide a protocol to extract and collect neuronal nuclei from human brain.

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