Maiken Nedergaard

Center for Translational Neuromedicine, University of Copenhagen

Affiliated withUniversity of Copenhagen University of Rochester Medical Center

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 134	2018
Publication title Cited by 26	2019

Other Publications

Article	Year
P2X7 receptor inhibition improves recovery after spinal cord injury. Nature medicine\| PubMed ID: 15258577	2004
Role of glial cells in cerebral ischemia. Glia\| PubMed ID: 15846807	2005
An astrocytic basis of epilepsy. Nature medicine\| PubMed ID: 16116433	2005
Receptor-mediated glutamate release from volume sensitive channels in astrocytes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16254051	2005
Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo. Nature neuroscience\| PubMed ID: 16699507	2006
Astrocytic complexity distinguishes the human brain. Trends in neurosciences\| PubMed ID: 16938356	2006
Imaging of cortical astrocytes using 2-photon laser scanning microscopy in the intact mouse brain. Advanced drug delivery reviews\| PubMed ID: 17045697	2006
Purinergic signaling regulates neural progenitor cell expansion and neurogenesis. Developmental biology\| PubMed ID: 17188262	2007
Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease. Annals of the New York Academy of Sciences\| PubMed ID: 17413008	2007
Cortical spreading depression causes and coincides with tissue hypoxia. Nature neuroscience\| PubMed ID: 17468748	2007
Resolving vesicle fusion from lysis to monitor calcium-triggered lysosomal exocytosis in astrocytes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17715060	2007
The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17989291	2007
Loss of astrocytic domain organization in the epileptic brain. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18367594	2008
Connexin 43 hemichannels are permeable to ATP. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18448647	2008
Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse. Cell stem cell\| PubMed ID: 18522848	2008
Astrocytic calcium signaling: mechanism and implications for functional brain imaging. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 18839089	2009
Astrocytes and ischemic injury. Stroke\| PubMed ID: 19064795	2009
Physiological and pathological functions of P2X7 receptor in the spinal cord. Purinergic signalling\| PubMed ID: 19205927	2009
Uniquely hominid features of adult human astrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19279265	2009
Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19666625	2009
Glial calcium and diseases of the nervous system. Cell calcium\| PubMed ID: 20045186	2010
Calcium dyshomeostasis and pathological calcium signalling in neurological diseases. Cell calcium\| PubMed ID: 20079921	2010
Adrenoceptors in brain: cellular gene expression and effects on astrocytic metabolism and [Ca(2+)]i. Neurochemistry international\| PubMed ID: 20380860	2010
Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture. Nature neuroscience\| PubMed ID: 20512135	2010
Sulforhodamine 101 induces long-term potentiation of intrinsic excitability and synaptic efficacy in hippocampal CA1 pyramidal neurons. Neuroscience\| PubMed ID: 20600669	2010
Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 20859293	2011
Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21187412	2011
Cultured astrocytes do not release adenosine during hypoxic conditions. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 21989480	2012
Heterogeneity of astrocytic form and function. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22144298	2012
Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22399755	2012
Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22421436	2012
Alexander disease. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22496548	2012
The locus coeruleus-norepinephrine network optimizes coupling of cerebral blood volume with oxygen demand. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 22872230	2012
A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Science translational medicine\| PubMed ID: 22896675	2012
Molecular scaffolds underpinning macroglial polarization: an analysis of retinal Müller cells and brain astrocytes in mouse. Glia\| PubMed ID: 22987438	2012
General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortex. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23112168	2012
Glial progenitor cell-based treatment and modeling of neurological disease. Science (New York, N.Y.)\| PubMed ID: 23112326	2012
Cognitive deficits and delayed neuronal loss in a mouse model of multiple microinfarcts. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23238711	2012
Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. The Journal of clinical investigation\| PubMed ID: 23434588	2013
'Hit & Run' model of closed-skull traumatic brain injury (TBI) reveals complex patterns of post-traumatic AQP4 dysregulation. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 23443171	2013
Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice. Cell stem cell\| PubMed ID: 23472873	2013
In vivo NADH fluorescence imaging indicates effect of aquaporin-4 deletion on oxygen microdistribution in cortical spreading depression. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 23611872	2013
Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer. Journal of translational medicine\| PubMed ID: 23635358	2013
Is there a cerebral lymphatic system? Stroke\| PubMed ID: 23709744	2013
Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntington's disease. Cell stem cell\| PubMed ID: 23746982	2013
Neuroscience. Garbage truck of the brain. Science (New York, N.Y.)\| PubMed ID: 23812703	2013
Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain. Scientific reports\| PubMed ID: 24002448	2013
Sleep drives metabolite clearance from the adult brain. Science (New York, N.Y.)\| PubMed ID: 24136970	2013
α1-Adrenergic receptors mediate coordinated Ca2+ signaling of cortical astrocytes in awake, behaving mice. Cell calcium\| PubMed ID: 24138901	2013
Photolysis of caged Ca2+ but not receptor-mediated Ca2+ signaling triggers astrocytic glutamate release. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 24174673	2013
Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 24227727	2013
White matter astrocytes in health and disease. Neuroscience\| PubMed ID: 24231735	2014
Rapid manifestation of reactive astrogliosis in acute hippocampal brain slices. Glia\| PubMed ID: 24272704	2014
P2X receptors in neuroglia. Wiley interdisciplinary reviews. Membrane transport and signaling\| PubMed ID: 24349942	2012
Contributions of the Na⁺/K⁺-ATPase, NKCC1, and Kir4.1 to hippocampal K⁺ clearance and volume responses. Glia\| PubMed ID: 24482245	2014
A novel technique for morphometric quantification of subarachnoid hemorrhage-induced microglia activation. Journal of neuroscience methods\| PubMed ID: 24735531	2014
The spectrum of neurobehavioral sequelae after repetitive mild traumatic brain injury: a novel mouse model of chronic traumatic encephalopathy. Journal of neurotrauma\| PubMed ID: 24766454	2014
Effects of traumatic brain injury on reactive astrogliosis and seizures in mouse models of Alexander disease. Brain research\| PubMed ID: 25069089	2014
Fine-tuning the central nervous system: microglial modelling of cells and synapses. Philosophical transactions of the Royal Society of London. Series B, Biological sciences\| PubMed ID: 25225087	2014
Drowning stars: reassessing the role of astrocytes in brain edema. Trends in neurosciences\| PubMed ID: 25236348	2014
Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25471560	2014
How do astrocytes participate in neural plasticity? Cold Spring Harbor perspectives in biology\| PubMed ID: 25502516	2014
Vascular contributions to cognitive impairment and dementia including Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 25510382	2015
Biomarkers of traumatic injury are transported from brain to blood via the glymphatic system. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25589747	2015
The pathophysiology underlying repetitive mild traumatic brain injury in a novel mouse model of chronic traumatic encephalopathy. Surgical neurology international\| PubMed ID: 25593768	2014
Modern cerebrospinal fluid flow research and Heinrich Quincke's seminal 1872 article on the distribution of cinnabar in freely moving animals. The Journal of comparative neurology\| PubMed ID: 25684428	2015
Why have we not yet developed a simple blood test for TBI? Expert review of neurotherapeutics\| PubMed ID: 25821902	2015
Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism. Nature communications\| PubMed ID: 25904018	2015
The Glymphatic System: A Beginner's Guide. Neurochemical research\| PubMed ID: 25947369	2015
Filtering the muddied waters of brain edema. Trends in neurosciences\| PubMed ID: 26008121	2015
Modeling cognition and disease using human glial chimeric mice. Glia\| PubMed ID: 26010831	2015
A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 26311768	2015
Implications of the discovery of brain lymphatic pathways. The Lancet. Neurology\| PubMed ID: 26376966	2015
Cerebral microcirculatory failure after subarachnoid hemorrhage is reversed by hyaluronidase. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 26661183	2016
Ultra-fast magnetic resonance encephalography of physiological brain activity - Glymphatic pulsation mechanisms? Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 26690495	2016
Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26755608	2016
Changes in the composition of brain interstitial ions control the sleep-wake cycle. Science (New York, N.Y.)\| PubMed ID: 27126038	2016
Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease. Neurobiology of disease\| PubMed ID: 27234656	2016
Human glia can both induce and rescue aspects of disease phenotype in Huntington disease. Nature communications\| PubMed ID: 27273432	2016
Impairment of the glymphatic system after diabetes. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 27306755	2017
The homeostatic astroglia emerges from evolutionary specialization of neural cells. Philosophical transactions of the Royal Society of London. Series B, Biological sciences\| PubMed ID: 27377722	2016
Sulforhodamine 101, a widely used astrocyte marker, can induce cortical seizure-like activity at concentrations commonly used. Scientific reports\| PubMed ID: 27457281	2016
Glymphatic clearance controls state-dependent changes in brain lactate concentration. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 27481936	2017
Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation. Neuron\| PubMed ID: 27499087	2016
A Novel Model of Transient Occlusion of the Middle Cerebral Artery in Awake Mice. Journal of nature and science\| PubMed ID: 27774515	2016
Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation. Molecular neurodegeneration\| PubMed ID: 27931262	2016
Erratum to: Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation. Molecular neurodegeneration\| PubMed ID: 28081701	2017
Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 28188218	2017
Does Global Astrocytic Calcium Signaling Participate in Awake Brain State Transitions and Neuronal Circuit Function? Neurochemical research\| PubMed ID: 28210958	2017
Cerebrospinal Fluid Clearance in Alzheimer Disease Measured with Dynamic PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 28302766	2017
SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 28336567	2017
Quantitative Gd-DOTA uptake from cerebrospinal fluid into rat brain using 3D VFA-SPGR at 9.4T. Magnetic resonance in medicine\| PubMed ID: 28627037	2018
Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia. Cell stem cell\| PubMed ID: 28736215	2017
Perivascular spaces, glymphatic dysfunction, and small vessel disease. Clinical science (London, England : 1979)\| PubMed ID: 28798076	2017
Do Evolutionary Changes in Astrocytes Contribute to the Computational Power of the Hominid Brain? Neurochemical research\| PubMed ID: 28822066	2017
Understanding the functions and relationships of the glymphatic system and meningeal lymphatics. The Journal of clinical investigation\| PubMed ID: 28862640	2017
Brain energetics during the sleep-wake cycle. Current opinion in neurobiology\| PubMed ID: 29024871	2017
Voluntary running enhances glymphatic influx in awake behaving, young mice. Neuroscience letters\| PubMed ID: 29079431	2018
The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future. Annual review of pathology\| PubMed ID: 29195051	2018
Physiology of Astroglia. Physiological reviews\| PubMed ID: 29351512	2018
Fluorescent Ca indicators directly inhibit the Na,K-ATPase and disrupt cellular functions. Science signaling\| PubMed ID: 29382785	2018
Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function. Scientific reports\| PubMed ID: 29396480	2018
Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology. Clinical science (London, England : 1979)\| PubMed ID: 29712883	2018
Understanding the role of the perivascular space in cerebral small vessel disease. Cardiovascular research\| PubMed ID: 29726891	2018
Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain. JCI insight\| PubMed ID: 30333324	2018
The glymphatic pathway in neurological disorders. The Lancet. Neurology\| PubMed ID: 30353860	2018
Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension. Nature communications\| PubMed ID: 30451853	2018
Aquaporin-4-dependent glymphatic solute transport in the rodent brain. eLife\| PubMed ID: 30561329	2018
Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia. Science advances\| PubMed ID: 30820460	2019
Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 31067483	2019
Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 31097598	2019
When the air hits your brain: decreased arterial pulsatility after craniectomy leading to impaired glymphatic flow. Journal of neurosurgery\| PubMed ID: 31100725	2019
Oxygen tension-mediated erythrocyte membrane interactions regulate cerebral capillary hyperemia. Science advances\| PubMed ID: 31149638	2019
Impaired Glymphatic Transport in Spontaneously Hypertensive Rats. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 31209176	2019
Hydraulic resistance of periarterial spaces in the brain. Fluids and barriers of the CNS\| PubMed ID: 31217012	2019
Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling. Cell reports\| PubMed ID: 31242417	2019
Cellular Control of Brain Capillary Blood Flow: In Vivo Imaging Veritas. Trends in neurosciences\| PubMed ID: 31255380	2019
Astrocytic connexin 43 potentiates myelin injury in ischemic white matter disease. Theranostics\| PubMed ID: 31285774	2019