Juanita L. Merchant

Department of Internal Medicine-Gastroenterology, University of Michigan

Affiliated withUniversity of Michigan University of Arizona College of Medicine The University of Michigan

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 21	2018
Publication title Cited by 10	2019

Other Publications

Article	Year
An OmpA-like protein from Acinetobacter spp. stimulates gastrin and interleukin-8 promoters. Infection and immunity\| PubMed ID: 10816525	2000
ZBP-89 promotes growth arrest through stabilization of p53. Molecular and cellular biology\| PubMed ID: 11416144	2001
VacA pores as portable portals for urea. The Journal of clinical investigation\| PubMed ID: 11560948	2001
Genetic or chemical hypochlorhydria is associated with inflammation that modulates parietal and G-cell populations in mice. Gastroenterology\| PubMed ID: 11781287	2002
A model for integrative study of human gastric acid secretion. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 12433865	2003
Regulation of epithelial cell growth by ZBP-89: potential relevance in pancreatic cancer. International journal of gastrointestinal cancer\| PubMed ID: 12622418	2002
Mutation of p53 in recurrent hepatocellular carcinoma and its association with the expression of ZBP-89. The American journal of pathology\| PubMed ID: 12759240	2003
Acinetobacter lwoffii infection and gastritis. Microbes and infection\| PubMed ID: 12787741	2003
ZBP-89 mediates butyrate regulation of gene expression. The Journal of nutrition\| PubMed ID: 12840224	2003
Treatment of Helicobacter gastritis with IL-4 requires somatostatin. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14555768	2003
Transcription factor ZBP-89 is required for STAT1 constitutive expression. Nucleic acids research\| PubMed ID: 14654702	2003
Inflammation and cancer III. Somatostatin and the innate immune system. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 15068961	2004
Kinetic profiles of p300 occupancy in vivo predict common features of promoter structure and coactivator recruitment. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15286281	2004
Helicobacter-induced intestinal metaplasia in the stomach correlates with Elk-1 and serum response factor induction of villin. The Journal of biological chemistry\| PubMed ID: 15576363	2005
The Epstein-Barr virus protein BMRF1 activates gastrin transcription. Journal of virology\| PubMed ID: 15613302	2005
Modulating the cytokine response to treat Helicobacter gastritis. Biochemical pharmacology\| PubMed ID: 15652228	2005
Regulation and function of the sonic hedgehog signal transduction pathway in isolated gastric parietal cells. The Journal of biological chemistry\| PubMed ID: 15691835	2005
Chronic gastritis in the hypochlorhydric gastrin-deficient mouse progresses to adenocarcinoma. Oncogene\| PubMed ID: 15735748	2005
Interferon gamma induction of gastric mucous neck cell hypertrophy. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 15765119	2005
Inflammation, atrophy, gastric cancer: connecting the molecular dots. Gastroenterology\| PubMed ID: 16143144	2005
Helicobacter pylori outer membrane protein 18 (Hp1125) induces dendritic cell maturation and function. Helicobacter\| PubMed ID: 16181353	2005
Somatostatin inhibits dendritic cell responsiveness to Helicobacter pylori. Regulatory peptides\| PubMed ID: 16375983	2006
Parietal cell hyperstimulation and autoimmune gastritis in cholera toxin transgenic mice. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 16399875	2006
Helicobacter pylori-secreted factors inhibit dendritic cell IL-12 secretion: a mechanism of ineffective host defense. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 16469828	2006
An isoform of ZBP-89 predisposes the colon to colitis. Nucleic acids research\| PubMed ID: 16517939	2006
Inhibition of growth hormone receptor gene expression by saturated fatty acids: role of Kruppel-like zinc finger factor, ZBP-89. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 16825291	2006
P53 mutants suppress ZBP-89 function. Anticancer research\| PubMed ID: 16827139	2006
Recruitment of ataxia-telangiectasia mutated to the p21(waf1) promoter by ZBP-89 plays a role in mucosal protection. Gastroenterology\| PubMed ID: 16952553	2006
Intestinal overexpression of ZNF148 suppresses ApcMin/+ neoplasia. Mammalian genome : official journal of the International Mammalian Genome Society\| PubMed ID: 17019648	2006
Tales from the crypts: regulatory peptides and cytokines in gastrointestinal homeostasis and disease. The Journal of clinical investigation\| PubMed ID: 17200701	2007
ATM phosphorylates ZBP-89 at Ser202 to potentiate p21waf1 induction by butyrate. Biochemical and biophysical research communications\| PubMed ID: 17560543	2007
H pylori infection causes chronic pancreatitis in Mongolian gerbils. World journal of gastroenterology\| PubMed ID: 17663507	2007
Reduced pepsin A processing of sonic hedgehog in parietal cells precedes gastric atrophy and transformation. The Journal of biological chemistry\| PubMed ID: 17872943	2007
Sumoylation-dependent control of homotypic and heterotypic synergy by the Kruppel-type zinc finger protein ZBP-89. The Journal of biological chemistry\| PubMed ID: 17940278	2007
A role for CITED2, a CBP/p300 interacting protein, in colon cancer cell invasion. FEBS letters\| PubMed ID: 18054336	2007
Prospective identification of a multilineage progenitor in murine stomach epithelium. Gastroenterology\| PubMed ID: 18054570	2007
What lurks beneath: IL-11, via Stat3, promotes inflammation-associated gastric tumorigenesis. The Journal of clinical investigation\| PubMed ID: 18431518	2008
Regulated expression of the human gastrin gene in mice. Regulatory peptides\| PubMed ID: 18456349	2008
Hip1r is expressed in gastric parietal cells and is required for tubulovesicle formation and cell survival in mice. The Journal of clinical investigation\| PubMed ID: 18535670	2008
Somatostatin stimulates menin gene expression by inhibiting protein kinase A. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 18755809	2008
Induction of follistatin precedes gastric transformation in gastrin deficient mice. Biochemical and biophysical research communications\| PubMed ID: 18804092	2008
Sonic hedgehog in gastric physiology and neoplastic transformation: friend or foe? Current opinion in endocrinology, diabetes, and obesity\| PubMed ID: 19104239	2009
ZBP-89 reduces the cell death threshold in hepatocellular carcinoma cells by increasing caspase-6 and S phase cell cycle arrest. Cancer letters\| PubMed ID: 19362768	2009
Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning. Gastroenterology\| PubMed ID: 19445942	2009
Interleukin-1beta promotes gastric atrophy through suppression of Sonic Hedgehog. Gastroenterology\| PubMed ID: 19883649	2010
Underrepresentation of underrepresented minorities in academic medicine: the need to enhance the pipeline and the pipe. Gastroenterology\| PubMed ID: 19944787	2010
Hedgehog is an anti-inflammatory epithelial signal for the intestinal lamina propria. Gastroenterology\| PubMed ID: 20206176	2010
Hedgehog signaling and gastrointestinal cancer. Biochimica et biophysica acta\| PubMed ID: 20307590	2010
Intracellular calcium release and protein kinase C activation stimulate sonic hedgehog gene expression during gastric acid secretion. Gastroenterology\| PubMed ID: 20816837	2010
Bone morphogenetic protein signaling regulates gastric epithelial cell development and proliferation in mice. Gastroenterology\| PubMed ID: 20826155	2010
ZBP-89 enhances Bak expression and causes apoptosis in hepatocellular carcinoma cells. Biochimica et biophysica acta\| PubMed ID: 20850481	2011
Hedgehog signaling in gastric physiology and cancer. Progress in molecular biology and translational science\| PubMed ID: 21075343	2010
Helicobacter pylori induction of the gastrin promoter through GC-rich DNA elements. Helicobacter\| PubMed ID: 21083750	2010
Histamine 3 receptor activation mediates inhibition of acid secretion during Helicobacter-induced gastritis. World journal of gastrointestinal pathophysiology\| PubMed ID: 21607157	2010
Gastric tuft cells express DCLK1 and are expanded in hyperplasia. Histochemistry and cell biology\| PubMed ID: 21688022	2011
Menin and JunD regulate gastrin gene expression through proximal DNA elements. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 21852362	2011
Hedgehog signalling in gut development, physiology and cancer. The Journal of physiology\| PubMed ID: 22144577	2012
Interaction between ZBP-89 and p53 mutants and its contribution to effects of HDACi on hepatocellular carcinoma. Cell cycle (Georgetown, Tex.)\| PubMed ID: 22214764	2012
The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature\| PubMed ID: 22327296	2012
Plasma Shh levels reduced in pancreatic cancer patients. Pancreas\| PubMed ID: 22513293	2012
A high-fat diet regulates gastrin and acid secretion through primary cilia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 22516298	2012
IFNγ contributes to the development of gastric epithelial cell metaplasia in Huntingtin interacting protein 1 related (Hip1r)-deficient mice. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 22525425	2012
Conditional deletion of menin results in antral G cell hyperplasia and hypergastrinemia. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 22766853	2012
Transgenic expression of interferon-γ in mouse stomach leads to inflammation, metaplasia, and dysplasia. The American journal of pathology\| PubMed ID: 23036899	2012
Butyrate increases IL-23 production by stimulated dendritic cells. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 23086919	2012
Inflammation and Gli2 suppress gastrin gene expression in a murine model of antral hyperplasia. PloS one\| PubMed ID: 23110168	2012
ZBP-89 regulates expression of tryptophan hydroxylase I and mucosal defense against Salmonella typhimurium in mice. Gastroenterology\| PubMed ID: 23395646	2013
Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets. PloS one\| PubMed ID: 23520544	2013
Dual oxidases control release of hydrogen peroxide by the gastric epithelium to prevent Helicobacter felis infection and inflammation in mice. Gastroenterology\| PubMed ID: 23860501	2013
Epigenetic upregulation of Bak by ZBP-89 inhibits the growth of hepatocellular carcinoma. Biochimica et biophysica acta\| PubMed ID: 23954442	2013
Inhibition of Hedgehog signaling in the gastrointestinal tract: targeting the cancer microenvironment. Cancer treatment reviews\| PubMed ID: 24007940	2014
Identification of a functional TPH1 polymorphism associated with irritable bowel syndrome bowel habit subtypes. The American journal of gastroenterology\| PubMed ID: 24060757	2013
Stress hematopoiesis is regulated by the Krüppel-like transcription factor ZBP-89. Stem cells (Dayton, Ohio)\| PubMed ID: 24549639	2014
Increased Expression of DUOX2 Is an Epithelial Response to Mucosal Dysbiosis Required for Immune Homeostasis in Mouse Intestine. Gastroenterology\| PubMed ID: 26261005	2015
Invasive mouse gastric adenocarcinomas arising from Lgr5+ stem cells are dependent on crosstalk between the Hedgehog/GLI2 and mTOR pathways. Oncotarget\| PubMed ID: 26859571	2016
Deletion of and induces hypergastrinemia and gastric carcinoids. Gut\| PubMed ID: 26860771	2017
SCHLAFEN 5 expression correlates with intestinal metaplasia that progresses to gastric cancer. Journal of gastroenterology\| PubMed ID: 27032393	2017
Schlafen 4-expressing myeloid-derived suppressor cells are induced during murine gastric metaplasia. The Journal of clinical investigation\| PubMed ID: 27427984	2016
Recapitulating Human Gastric Cancer Pathogenesis: Experimental Models of Gastric Cancer. Advances in experimental medicine and biology\| PubMed ID: 27573785	2016
Transcription Factor ZBP-89 Drives a Feedforward Loop of β-Catenin Expression in Colorectal Cancer. Cancer research\| PubMed ID: 27758879	2016
NF-κB mediated transcription of DARPP-32 prevents -induced cell death. Gut\| PubMed ID: 27789656	2017
Weight gain in mice on a high caloric diet and chronically treated with omeprazole depends on sex and genetic background. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 27810953	2017
Hedgehog Signaling Links Chronic Inflammation to Gastric Cancer Precursor Lesions. Cellular and molecular gastroenterology and hepatology\| PubMed ID: 28275687	2017
Gastric Acid Secretion from Parietal Cells Is Mediated by a Ca Efflux Channel in the Tubulovesicle. Developmental cell\| PubMed ID: 28486130	2017
A Summary of the 2016 James W. Freston Conference of the American Gastroenterological Association: Intestinal Metaplasia in the Esophagus and Stomach: Origins, Differences, Similarities and ... Gastroenterology\| PubMed ID: 28583825	2017
Pathophysiology of Gastric NETs: Role of Gastrin and Menin. Current gastroenterology reports\| PubMed ID: 28608155	2017
Gastrin Induces Nuclear Export and Proteasome Degradation of Menin in Enteric Glial Cells. Gastroenterology\| PubMed ID: 28859856	2017
ZBP-89 function in colonic stem cells and during butyrate-induced senescence. Oncotarget\| PubMed ID: 29212231	2017
Indian Hedgehog Suppresses Intestinal Inflammation. Cellular and molecular gastroenterology and hepatology\| PubMed ID: 29276751	2018
Parietal Cell Death by Cytokines. Cellular and molecular gastroenterology and hepatology\| PubMed ID: 29713663	2018
Mature Enteroendocrine Cells Contributes to Basal and Pathological Stem Cell Dynamics in the Small Intestine. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 29848020	2018