Jianjie Ma

Department of Physiology and Biophysics, Robert Wood Johnson Medical School

Affiliated withRobert Wood Johnson Medical School UMDNJ-Robert Wood Johnson Medical School The Ohio State University Wexner Medical Center

Research Area

Biography

Jianjie Ma has not added Biography.
If you are Jianjie Ma and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 5	Year
Publication title Cited by 17	2011
Publication title Cited by 53	2012
Publication title Cited by 15	2014
Publication title	2022
Publication title Cited by 8	2021

Other Publications

Article	Year
Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals. Cell research\| PubMed ID: 21556035	2011
Store-operated Ca(2+) entry (SOCE) contributes to normal skeletal muscle contractility in young but not in aged skeletal muscle. Aging\| PubMed ID: 21666285	2011
Stimulatory and Inhibitory Functions of the R Domain on CFTR Chloride Channel. News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society\| PubMed ID: 11390899	2000
The transmembrane segment of ryanodine receptor contains an intracellular membrane retention signal for Ca(2+) release channel. The Journal of biological chemistry\| PubMed ID: 11779857	2002
A short segment of the R domain of cystic fibrosis transmembrane conductance regulator contains channel stimulatory and inhibitory activities that are separable by sequence modification. The Journal of biological chemistry\| PubMed ID: 11950844	2002
Dysfunction of store-operated calcium channel in muscle cells lacking mg29. Nature cell biology\| PubMed ID: 11988740	2002
Identification of a dantrolene-binding sequence on the skeletal muscle ryanodine receptor. The Journal of biological chemistry\| PubMed ID: 12167662	2002
Ca(2+)-dependent interaction between FKBP12 and calcineurin regulates activity of the Ca(2+) release channel in skeletal muscle. Biophysical journal\| PubMed ID: 12414688	2002
A retrograde signal from calsequestrin for the regulation of store-operated Ca2+ entry in skeletal muscle. The Journal of biological chemistry\| PubMed ID: 12419813	2003
Junctional membrane structure and store operated calcium entry in muscle cells. Frontiers in bioscience : a journal and virtual library\| PubMed ID: 12456355	2003
Targeting of protein kinase A by muscle A kinase-anchoring protein (mAKAP) regulates phosphorylation and function of the skeletal muscle ryanodine receptor. The Journal of biological chemistry\| PubMed ID: 12709444	2003
Retrograde activation of store-operated calcium channel. Cell calcium\| PubMed ID: 12765683	2003
Intermolecular interaction between R domains of cystic fibrosis transmembrane conductance regulator. American journal of respiratory cell and molecular biology\| PubMed ID: 12933354	2004
Negatively charged amino acids within the intraluminal loop of ryanodine receptor are involved in the interaction with triadin. The Journal of biological chemistry\| PubMed ID: 14638677	2004
Co-expression of MG29 and ryanodine receptor leads to apoptotic cell death: effect mediated by intracellular Ca2+ release. The Journal of biological chemistry\| PubMed ID: 15039443	2004
Membrane topology and membrane retention of the ryanodine receptor calcium release channel. Cell biochemistry and biophysics\| PubMed ID: 15054223	2004
Nuclear translocation of cytochrome c during apoptosis. The Journal of biological chemistry\| PubMed ID: 15073175	2004
The role of glycine residues in the function of human organic anion transporter 4. Molecular pharmacology\| PubMed ID: 15102942	2004
Calcium-dependent facilitation and graded deactivation of store-operated calcium entry in fetal skeletal muscle. Biophysical journal\| PubMed ID: 15240463	2004
Mutational analysis of histidine residues in human organic anion transporter 4 (hOAT4). The Biochemical journal\| PubMed ID: 15291761	2004
The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4. Molecular pharmacology\| PubMed ID: 15576633	2005
Probing a putative dantrolene-binding site on the cardiac ryanodine receptor. The Biochemical journal\| PubMed ID: 15656791	2005
A rapid and efficient PCR-based mutagenesis method applicable to cell physiology study. American journal of physiology. Cell physiology\| PubMed ID: 15659713	2005
Uncontrolled calcium sparks act as a dystrophic signal for mammalian skeletal muscle. Nature cell biology\| PubMed ID: 15834406	2005
Enhanced resistance to fatigue and altered calcium handling properties of sarcalumenin knockout mice. Physiological genomics\| PubMed ID: 15998745	2005
Inhibition of intestinal tumorigenesis in Apcmin/+ mice by (-)-epigallocatechin-3-gallate, the major catechin in green tea. Cancer research\| PubMed ID: 16288056	2005
Uncoupling store-operated Ca2+ entry and altered Ca2+ release from sarcoplasmic reticulum through silencing of junctophilin genes. Biophysical journal\| PubMed ID: 16565048	2006
The presenilin-2 loop peptide perturbs intracellular Ca2+ homeostasis and accelerates apoptosis. The Journal of biological chemistry\| PubMed ID: 16603547	2006
Butylated hydroxyanisole regulates ARE-mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells. Molecular carcinogenesis\| PubMed ID: 16739127	2006
Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2. Molecular cancer therapeutics\| PubMed ID: 16928811	2006
Muscle aging is associated with compromised Ca2+ spark signaling and segregated intracellular Ca2+ release. The Journal of cell biology\| PubMed ID: 16943181	2006
Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor. The Journal of biological chemistry\| PubMed ID: 16945924	2006
Determination of the external loops and the cellular orientation of the N- and the C-termini of the human organic anion transporter hOAT1. The Biochemical journal\| PubMed ID: 17014423	2007
Conformation-dependent stability of junctophilin 1 (JP1) and ryanodine receptor type 1 (RyR1) channel complex is mediated by their hyper-reactive thiols. The Journal of biological chemistry\| PubMed ID: 17237236	2007
Systemic ablation of RyR3 alters Ca2+ spark signaling in adult skeletal muscle. Cell calcium\| PubMed ID: 17412417	2007
Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans. Journal of molecular and cellular cardiology\| PubMed ID: 17509612	2007
TRIC channels are essential for Ca2+ handling in intracellular stores. Nature\| PubMed ID: 17611541	2007
The tail-anchoring domain of Bfl1 and HCCS1 targets mitochondrial membrane permeability to induce apoptosis. Journal of cell science\| PubMed ID: 17666431	2007
Immuno-proteomic approach to excitation--contraction coupling in skeletal and cardiac muscle: molecular insights revealed by the mitsugumins. Cell calcium\| PubMed ID: 18061662	2008
Overexpression of Bax induces down-regulation of store-operated calcium entry in prostate cancer cells. Journal of cellular physiology\| PubMed ID: 18247359	2008
Altered Ca2+ sparks in aging skeletal and cardiac muscle. Ageing research reviews\| PubMed ID: 18272434	2008
Compromised store-operated Ca2+ entry in aged skeletal muscle. Aging cell\| PubMed ID: 18505477	2008
Genetic evidence for functional role of ryanodine receptor 1 in pulmonary artery smooth muscle cells. PflÃ¼gers Archiv : European journal of physiology\| PubMed ID: 18663468	2009
Organic anion transporter OAT1 undergoes constitutive and protein kinase C-regulated trafficking through a dynamin- and clathrin-dependent pathway. The Journal of biological chemistry\| PubMed ID: 18818201	2008
Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells. American journal of respiratory cell and molecular biology\| PubMed ID: 19011160	2009
MG53 regulates membrane budding and exocytosis in muscle cells. The Journal of biological chemistry\| PubMed ID: 19029292	2009
MG53 nucleates assembly of cell membrane repair machinery. Nature cell biology\| PubMed ID: 19043407	2009
The amino-terminal peptide of Bax perturbs intracellular Ca2+ homeostasis to enhance apoptosis in prostate cancer cells. American journal of physiology. Cell physiology\| PubMed ID: 19091958	2009
Mitsugumin 53-mediated maintenance of K+ currents in cardiac myocytes. Channels (Austin, Tex.)\| PubMed ID: 19202355	2009
Glutamate at position 227 of junctophilin-2 is involved in binding to TRPC3. Molecular and cellular biochemistry\| PubMed ID: 19277847	2009
Membrane repair defects in muscular dystrophy are linked to altered interaction between MG53, caveolin-3, and dysferlin. The Journal of biological chemistry\| PubMed ID: 19380584	2009
NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature\| PubMed ID: 19387438	2009
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels. PflÃ¼gers Archiv : European journal of physiology\| PubMed ID: 19475418	2009
Mitsugumin 53 (MG53) facilitates vesicle trafficking in striated muscle to contribute to cell membrane repair. Communicative & integrative biology\| PubMed ID: 19641737	2009
Calcium signaling via two-pore channels: local or global, that is the question. American journal of physiology. Cell physiology\| PubMed ID: 20018950	2010
Impaired interaction between skeletal ryanodine receptors in malignant hyperthermia. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 20023768	2009
S165F mutation of junctophilin 2 affects Ca2+ signalling in skeletal muscle. The Biochemical journal\| PubMed ID: 20095964	2010
TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP. FEBS letters\| PubMed ID: 20159015	2010
Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair. Circulation research\| PubMed ID: 20466981	2010
2-Methoxyoestradiol inhibits glucose transport in rodent skeletal muscle. Experimental physiology\| PubMed ID: 20472648	2010
MG53 constitutes a primary determinant of cardiac ischemic preconditioning. Circulation\| PubMed ID: 20516375	2010
Two-pore channels for integrative Ca signaling. Communicative & integrative biology\| PubMed ID: 20539775	2010
Bid agonist regulates murine hepatocyte proliferation by controlling endoplasmic reticulum calcium homeostasis. Hepatology (Baltimore, Md.)\| PubMed ID: 20578150	2010
Charade of the SR K+-channel: two ion-channels, TRIC-A and TRIC-B, masquerade as a single K+-channel. Biophysical journal\| PubMed ID: 20643059	2010
Increased store-operated Ca2+ entry in skeletal muscle with reduced calsequestrin-1 expression. Biophysical journal\| PubMed ID: 20816068	2010
Ca2+ overload and sarcoplasmic reticulum instability in tric-a null skeletal muscle. The Journal of biological chemistry\| PubMed ID: 20858894	2010
Impaired Orai1-mediated resting Ca2+ entry reduces the cytosolic [Ca2+] and sarcoplasmic reticulum Ca2+ loading in quiescent junctophilin 1 knock-out myotubes. The Journal of biological chemistry\| PubMed ID: 20937810	2010
An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic Î²-cell. Islets\| PubMed ID: 21099331	2010
Amphipathic tail-anchoring peptide and Bcl-2 homology domain-3 (BH3) peptides from Bcl-2 family proteins induce apoptosis through different mechanisms. The Journal of biological chemistry\| PubMed ID: 21189256	2011
Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling. Circulation. Heart failure\| PubMed ID: 21216834	2011
Cyclic adenosine diphosphate ribose activates ryanodine receptors, whereas NAADP activates two-pore domain channels. The Journal of biological chemistry\| PubMed ID: 21216967	2011
MG53 participates in ischaemic postconditioning through the RISK signalling pathway. Cardiovascular research\| PubMed ID: 21285295	2011
Polymerase transcriptase release factor (PTRF) anchors MG53 protein to cell injury site for initiation of membrane repair. The Journal of biological chemistry\| PubMed ID: 21343302	2011
Dysferlin, annexin A1, and mitsugumin 53 are upregulated in muscular dystrophy and localize to longitudinal tubules of the T-system with stretch. Journal of neuropathology and experimental neurology\| PubMed ID: 21412170	2011
tBHQ-induced HO-1 expression is mediated by calcium through regulation of Nrf2 binding to enhancer and polymerase II to promoter region of HO-1. Chemical research in toxicology\| PubMed ID: 21443188	2011
Ataxin-1 and Brother of ataxin-1 are components of the Notch signalling pathway. EMBO reports\| PubMed ID: 21475249	2011
A versatile single-plasmid system for tissue-specific and inducible control of gene expression in transgenic mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 21518849	2011
Redox-dependent oligomerization through a leucine zipper motif is essential for MG53-mediated cell membrane repair. American journal of physiology. Cell physiology\| PubMed ID: 21525429	2011
Molecular architecture of Ca2+ signaling control in muscle and heart cells. Channels (Austin, Tex.)\| PubMed ID: 21712647	2011
Mitochondrial calcium uptake regulates rapid calcium transients in skeletal muscle during excitation-contraction (E-C) coupling. The Journal of biological chemistry\| PubMed ID: 21795684	2011
Disrupted membrane structure and intracellular CaÂ²âº signaling in adult skeletal muscle with acute knockdown of Bin1. PloS one\| PubMed ID: 21984944	2011
Detection of calcium sparks in intact and permeabilized skeletal muscle fibers. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22130850	2012
Nonmuscle myosin IIA facilitates vesicle trafficking for MG53-mediated cell membrane repair. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 22253476	2012
Enhancing Muscle Membrane Repair by Gene Delivery of MG53 Ameliorates Muscular Dystrophy and Heart Failure in Î´-Sarcoglycan-deficient Hamsters. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 22314291	2012
Hypertrophy in skeletal myotubes induced by junctophilin-2 mutant, Y141H, involves an increase in store-operated Ca2+ entry via Orai1. The Journal of biological chemistry\| PubMed ID: 22389502	2012
Recombinant MG53 protein modulates therapeutic cell membrane repair in treatment of muscular dystrophy. Science translational medicine\| PubMed ID: 22723464	2012
Switch from ER-mitochondrial to SR-mitochondrial calcium coupling during muscle differentiation. Cell calcium\| PubMed ID: 22784666	2012
TRIM50 Protein Regulates Vesicular Trafficking for Acid Secretion in Gastric Parietal Cells. The Journal of biological chemistry\| PubMed ID: 22872646	2012
Mitsugumin 53 attenuates the activity of sarcoplasmic reticulum Ca(2+)-ATPase 1a (SERCA1a) in skeletal muscle. Biochemical and biophysical research communications\| PubMed ID: 23103543	2012
The Mesobuthus martensii genome reveals the molecular diversity of scorpion toxins. Cell & bioscience\| PubMed ID: 24383941	2014
The effect of recombinant human MG53 protein on tourniquet-induced ischemia reperfusion injury in rat muscle. Muscle & nerve\| PubMed ID: 24395153	2014
Store-operated Ca2+ entry in muscle physiology and diseases. BMB reports\| PubMed ID: 24411466	2014
Trimeric intracellular cation channels and sarcoplasmic/endoplasmic reticulum calcium homeostasis. Circulation research\| PubMed ID: 24526676	2014
Core-shell nanoparticle-based peptide therapeutics and combined hyperthermia for enhanced cancer cell apoptosis. ACS nano\| PubMed ID: 25133971	2014
Amphipathic tail-anchoring peptide is a promising therapeutic agent for prostate cancer treatment. Oncotarget\| PubMed ID: 25245280	2014
Cell membrane damage is involved in the impaired survival of bone marrow stem cells by oxidized low-density lipoprotein. Journal of cellular and molecular medicine\| PubMed ID: 25256620	2014
Organelle-specific subunit interactions of the vertebrate two-pore channel family. The Journal of biological chemistry\| PubMed ID: 25451935	2015
Lysosomal two-pore channel subtype 2 (TPC2) regulates skeletal muscle autophagic signaling. The Journal of biological chemistry\| PubMed ID: 25480788	2015
Open Sesame: treasure in store-operated calcium entry pathway for cancer therapy. Science China. Life sciences\| PubMed ID: 25481035	2015
Cardioprotection of recombinant human MG53 protein in a porcine model of ischemia and reperfusion injury. Journal of molecular and cellular cardiology\| PubMed ID: 25533937	2015
Dysfunction in the βII spectrin-dependent cytoskeleton underlies human arrhythmia. Circulation\| PubMed ID: 25632041	2015
Amelioration of ischemia-reperfusion-induced muscle injury by the recombinant human MG53 protein. Muscle & nerve\| PubMed ID: 25703692	2015
3D multifocus astigmatism and compressed sensing (3D MACS) based superresolution reconstruction. Biomedical optics express\| PubMed ID: 25798314	2015
Zinc Binding to MG53 Protein Facilitates Repair of Injury to Cell Membranes. The Journal of biological chemistry\| PubMed ID: 25869134	2015
Modulation of wound healing and scar formation by MG53 protein-mediated cell membrane repair. The Journal of biological chemistry\| PubMed ID: 26306047	2015
CRISPR-mediated Genome Editing Restores Dystrophin Expression and Function in mdx Mice. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 26449883	2016
Quantifying Drug-Induced Nanomechanics and Mechanical Effects to Single Cardiomyocytes for Optimal Drug Administration To Minimize Cardiotoxicity. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 26738425	2016
Autophagy, Innate Immunity and Tissue Repair in Acute Kidney Injury. International journal of molecular sciences\| PubMed ID: 27153058	2016
Dual function of MG53 in membrane repair and insulin signaling. BMB reports\| PubMed ID: 27174502	2016
Absence of physiological Ca transients is an initial trigger for mitochondrial dysfunction in skeletal muscle following denervation. Skeletal muscle\| PubMed ID: 28395670	2017
In Vivo Genome Editing Restores Dystrophin Expression and Cardiac Function in Dystrophic Mice. Circulation research\| PubMed ID: 28790199	2017
Irisin protects mitochondria function during pulmonary ischemia/reperfusion injury. Science translational medicine\| PubMed ID: 29187642	2017
Zinc in Wound Healing Modulation. Nutrients\| PubMed ID: 29295546	2017
Comparative analysis of FKBP family protein: evaluation, structure, and function in mammals and Drosophila melanogaster. BMC developmental biology\| PubMed ID: 29587629	2018
Quantum confined peptide assemblies with tunable visible to near-infrared spectral range. Nature communications\| PubMed ID: 30104564	2018
MG 53 Protein Protects Aortic Valve Interstitial Cells From Membrane Injury and Fibrocalcific Remodeling. Journal of the American Heart Association\| PubMed ID: 30741589	2019
MG53 promotes corneal wound healing and mitigates fibrotic remodeling in rodents. Communications biology\| PubMed ID: 30793049	2019
MG53 attenuates lipopolysaccharide-induced neurotoxicity and neuroinflammation via inhibiting TLR4/NF-κB pathway in vitro and in vivo. Progress in neuro-psychopharmacology & biological psychiatry\| PubMed ID: 31260721	2019
Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function. Nature communications\| PubMed ID: 31604915	2019
N-acetylcysteine prevents oxidized low-density lipoprotein-induced reduction of MG53 and enhances MG53 protective effect on bone marrow stem cells. Journal of cellular and molecular medicine\| PubMed ID: 31742908	2020
The TRIM protein Mitsugumin 53 enhances survival and therapeutic efficacy of stem cells in murine traumatic brain injury. Stem cell research & therapy\| PubMed ID: 31779687	2019
TRIC-A Channel Maintains Store Calcium Handling by Interacting With Type 2 Ryanodine Receptor in Cardiac Muscle. Circulation research\| PubMed ID: 31805819	2020
MG53 Does Not Manifest the Development of Diabetes in Mice. Diabetes\| PubMed ID: 32139593	2020
MG53 suppresses interferon-β and inflammation via regulation of ryanodine receptor-mediated intracellular calcium signaling. Nature communications\| PubMed ID: 32681036	2020
Peptidylarginine Deiminases 2 Mediates Caspase-1-Associated Lethality in Pseudomonas aeruginosa Pneumonia-Induced Sepsis. The Journal of infectious diseases\| PubMed ID: 32729925	2021
Recombinant MG53 Protein Protects Mice from Lethal Influenza Virus Infection. American journal of respiratory and critical care medicine\| PubMed ID: 33031705	2021
MG53, A Tissue Repair Protein with Broad Applications in Regenerative Medicine. Cells\| PubMed ID: 33440658	2021
TRIC-A regulates intracellular Ca homeostasis in cardiomyocytes. Pflugers Archiv : European journal of physiology\| PubMed ID: 33474637	2021
MG53 as a Novel Therapeutic Protein to Treat Acute Lung Injury. Military medicine\| PubMed ID: 33499468	2021
Muscle multiorgan crosstalk with MG53 as a myokine for tissue repair and regeneration. Current opinion in pharmacology\| PubMed ID: 34052525	2021
Efficient precise in vivo base editing in adult dystrophic mice. Nature communications\| PubMed ID: 34140489	2021
MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer. Molecular cancer\| PubMed ID: 34521423	2021
Correction to: The TRIM protein Mitsugumin 53 enhances survival and therapeutic efficacy of stem cells in murine traumatic brain injury. Stem cell research & therapy\| PubMed ID: 34593038	2021