Jianjie Ma

Department of Physiology and Biophysics, Robert Wood Johnson Medical School

Affiliated withRobert Wood Johnson Medical School UMDNJ-Robert Wood Johnson Medical School The Ohio State University Wexner Medical Center

Research Area

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JoVE Journal Publications

ArticleTotal : 5	Year
Publication title Cited by 17	2011
Publication title Cited by 54	2012
Publication title Cited by 14	2014
Publication title	2022
Publication title Cited by 6	2021

Other Publications

Article	Year
Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals. Cell research\| PubMed ID: 21556035	2011
Store-operated Ca(2+) entry (SOCE) contributes to normal skeletal muscle contractility in young but not in aged skeletal muscle. Aging\| PubMed ID: 21666285	2011
Stimulatory and Inhibitory Functions of the R Domain on CFTR Chloride Channel. News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society\| PubMed ID: 11390899	2000
The transmembrane segment of ryanodine receptor contains an intracellular membrane retention signal for Ca(2+) release channel. The Journal of biological chemistry\| PubMed ID: 11779857	2002
A short segment of the R domain of cystic fibrosis transmembrane conductance regulator contains channel stimulatory and inhibitory activities that are separable by sequence modification. The Journal of biological chemistry\| PubMed ID: 11950844	2002
Dysfunction of store-operated calcium channel in muscle cells lacking mg29. Nature cell biology\| PubMed ID: 11988740	2002
Identification of a dantrolene-binding sequence on the skeletal muscle ryanodine receptor. The Journal of biological chemistry\| PubMed ID: 12167662	2002
Ca(2+)-dependent interaction between FKBP12 and calcineurin regulates activity of the Ca(2+) release channel in skeletal muscle. Biophysical journal\| PubMed ID: 12414688	2002
A retrograde signal from calsequestrin for the regulation of store-operated Ca2+ entry in skeletal muscle. The Journal of biological chemistry\| PubMed ID: 12419813	2003
Junctional membrane structure and store operated calcium entry in muscle cells. Frontiers in bioscience : a journal and virtual library\| PubMed ID: 12456355	2003
Targeting of protein kinase A by muscle A kinase-anchoring protein (mAKAP) regulates phosphorylation and function of the skeletal muscle ryanodine receptor. The Journal of biological chemistry\| PubMed ID: 12709444	2003
Retrograde activation of store-operated calcium channel. Cell calcium\| PubMed ID: 12765683	2003
Intermolecular interaction between R domains of cystic fibrosis transmembrane conductance regulator. American journal of respiratory cell and molecular biology\| PubMed ID: 12933354	2004
Negatively charged amino acids within the intraluminal loop of ryanodine receptor are involved in the interaction with triadin. The Journal of biological chemistry\| PubMed ID: 14638677	2004
Co-expression of MG29 and ryanodine receptor leads to apoptotic cell death: effect mediated by intracellular Ca2+ release. The Journal of biological chemistry\| PubMed ID: 15039443	2004
Membrane topology and membrane retention of the ryanodine receptor calcium release channel. Cell biochemistry and biophysics\| PubMed ID: 15054223	2004
Nuclear translocation of cytochrome c during apoptosis. The Journal of biological chemistry\| PubMed ID: 15073175	2004
The role of glycine residues in the function of human organic anion transporter 4. Molecular pharmacology\| PubMed ID: 15102942	2004
Calcium-dependent facilitation and graded deactivation of store-operated calcium entry in fetal skeletal muscle. Biophysical journal\| PubMed ID: 15240463	2004
Mutational analysis of histidine residues in human organic anion transporter 4 (hOAT4). The Biochemical journal\| PubMed ID: 15291761	2004
The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4. Molecular pharmacology\| PubMed ID: 15576633	2005
Probing a putative dantrolene-binding site on the cardiac ryanodine receptor. The Biochemical journal\| PubMed ID: 15656791	2005
A rapid and efficient PCR-based mutagenesis method applicable to cell physiology study. American journal of physiology. Cell physiology\| PubMed ID: 15659713	2005
Uncontrolled calcium sparks act as a dystrophic signal for mammalian skeletal muscle. Nature cell biology\| PubMed ID: 15834406	2005
Enhanced resistance to fatigue and altered calcium handling properties of sarcalumenin knockout mice. Physiological genomics\| PubMed ID: 15998745	2005
Inhibition of intestinal tumorigenesis in Apcmin/+ mice by (-)-epigallocatechin-3-gallate, the major catechin in green tea. Cancer research\| PubMed ID: 16288056	2005
Uncoupling store-operated Ca2+ entry and altered Ca2+ release from sarcoplasmic reticulum through silencing of junctophilin genes. Biophysical journal\| PubMed ID: 16565048	2006
The presenilin-2 loop peptide perturbs intracellular Ca2+ homeostasis and accelerates apoptosis. The Journal of biological chemistry\| PubMed ID: 16603547	2006
Butylated hydroxyanisole regulates ARE-mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells. Molecular carcinogenesis\| PubMed ID: 16739127	2006
Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2. Molecular cancer therapeutics\| PubMed ID: 16928811	2006
Muscle aging is associated with compromised Ca2+ spark signaling and segregated intracellular Ca2+ release. The Journal of cell biology\| PubMed ID: 16943181	2006
Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor. The Journal of biological chemistry\| PubMed ID: 16945924	2006
Determination of the external loops and the cellular orientation of the N- and the C-termini of the human organic anion transporter hOAT1. The Biochemical journal\| PubMed ID: 17014423	2007
Conformation-dependent stability of junctophilin 1 (JP1) and ryanodine receptor type 1 (RyR1) channel complex is mediated by their hyper-reactive thiols. The Journal of biological chemistry\| PubMed ID: 17237236	2007
Systemic ablation of RyR3 alters Ca2+ spark signaling in adult skeletal muscle. Cell calcium\| PubMed ID: 17412417	2007
Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans. Journal of molecular and cellular cardiology\| PubMed ID: 17509612	2007
TRIC channels are essential for Ca2+ handling in intracellular stores. Nature\| PubMed ID: 17611541	2007
The tail-anchoring domain of Bfl1 and HCCS1 targets mitochondrial membrane permeability to induce apoptosis. Journal of cell science\| PubMed ID: 17666431	2007
Immuno-proteomic approach to excitation--contraction coupling in skeletal and cardiac muscle: molecular insights revealed by the mitsugumins. Cell calcium\| PubMed ID: 18061662	2008
Overexpression of Bax induces down-regulation of store-operated calcium entry in prostate cancer cells. Journal of cellular physiology\| PubMed ID: 18247359	2008
Altered Ca2+ sparks in aging skeletal and cardiac muscle. Ageing research reviews\| PubMed ID: 18272434	2008
Compromised store-operated Ca2+ entry in aged skeletal muscle. Aging cell\| PubMed ID: 18505477	2008
Genetic evidence for functional role of ryanodine receptor 1 in pulmonary artery smooth muscle cells. PflÃ¼gers Archiv : European journal of physiology\| PubMed ID: 18663468	2009
Organic anion transporter OAT1 undergoes constitutive and protein kinase C-regulated trafficking through a dynamin- and clathrin-dependent pathway. The Journal of biological chemistry\| PubMed ID: 18818201	2008
Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells. American journal of respiratory cell and molecular biology\| PubMed ID: 19011160	2009
MG53 regulates membrane budding and exocytosis in muscle cells. The Journal of biological chemistry\| PubMed ID: 19029292	2009
MG53 nucleates assembly of cell membrane repair machinery. Nature cell biology\| PubMed ID: 19043407	2009
The amino-terminal peptide of Bax perturbs intracellular Ca2+ homeostasis to enhance apoptosis in prostate cancer cells. American journal of physiology. Cell physiology\| PubMed ID: 19091958	2009
Mitsugumin 53-mediated maintenance of K+ currents in cardiac myocytes. Channels (Austin, Tex.)\| PubMed ID: 19202355	2009
Glutamate at position 227 of junctophilin-2 is involved in binding to TRPC3. Molecular and cellular biochemistry\| PubMed ID: 19277847	2009
Membrane repair defects in muscular dystrophy are linked to altered interaction between MG53, caveolin-3, and dysferlin. The Journal of biological chemistry\| PubMed ID: 19380584	2009
NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature\| PubMed ID: 19387438	2009
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels. PflÃ¼gers Archiv : European journal of physiology\| PubMed ID: 19475418	2009
Mitsugumin 53 (MG53) facilitates vesicle trafficking in striated muscle to contribute to cell membrane repair. Communicative & integrative biology\| PubMed ID: 19641737	2009
Calcium signaling via two-pore channels: local or global, that is the question. American journal of physiology. Cell physiology\| PubMed ID: 20018950	2010
Impaired interaction between skeletal ryanodine receptors in malignant hyperthermia. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 20023768	2009
S165F mutation of junctophilin 2 affects Ca2+ signalling in skeletal muscle. The Biochemical journal\| PubMed ID: 20095964	2010
TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP. FEBS letters\| PubMed ID: 20159015	2010
Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair. Circulation research\| PubMed ID: 20466981	2010
2-Methoxyoestradiol inhibits glucose transport in rodent skeletal muscle. Experimental physiology\| PubMed ID: 20472648	2010
MG53 constitutes a primary determinant of cardiac ischemic preconditioning. Circulation\| PubMed ID: 20516375	2010
Two-pore channels for integrative Ca signaling. Communicative & integrative biology\| PubMed ID: 20539775	2010
Bid agonist regulates murine hepatocyte proliferation by controlling endoplasmic reticulum calcium homeostasis. Hepatology (Baltimore, Md.)\| PubMed ID: 20578150	2010
Charade of the SR K+-channel: two ion-channels, TRIC-A and TRIC-B, masquerade as a single K+-channel. Biophysical journal\| PubMed ID: 20643059	2010
Increased store-operated Ca2+ entry in skeletal muscle with reduced calsequestrin-1 expression. Biophysical journal\| PubMed ID: 20816068	2010
Ca2+ overload and sarcoplasmic reticulum instability in tric-a null skeletal muscle. The Journal of biological chemistry\| PubMed ID: 20858894	2010
Impaired Orai1-mediated resting Ca2+ entry reduces the cytosolic [Ca2+] and sarcoplasmic reticulum Ca2+ loading in quiescent junctophilin 1 knock-out myotubes. The Journal of biological chemistry\| PubMed ID: 20937810	2010
An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic Î²-cell. Islets\| PubMed ID: 21099331	2010
Amphipathic tail-anchoring peptide and Bcl-2 homology domain-3 (BH3) peptides from Bcl-2 family proteins induce apoptosis through different mechanisms. The Journal of biological chemistry\| PubMed ID: 21189256	2011
Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling. Circulation. Heart failure\| PubMed ID: 21216834	2011
Cyclic adenosine diphosphate ribose activates ryanodine receptors, whereas NAADP activates two-pore domain channels. The Journal of biological chemistry\| PubMed ID: 21216967	2011
MG53 participates in ischaemic postconditioning through the RISK signalling pathway. Cardiovascular research\| PubMed ID: 21285295	2011
Polymerase transcriptase release factor (PTRF) anchors MG53 protein to cell injury site for initiation of membrane repair. The Journal of biological chemistry\| PubMed ID: 21343302	2011
Dysferlin, annexin A1, and mitsugumin 53 are upregulated in muscular dystrophy and localize to longitudinal tubules of the T-system with stretch. Journal of neuropathology and experimental neurology\| PubMed ID: 21412170	2011
tBHQ-induced HO-1 expression is mediated by calcium through regulation of Nrf2 binding to enhancer and polymerase II to promoter region of HO-1. Chemical research in toxicology\| PubMed ID: 21443188	2011
Ataxin-1 and Brother of ataxin-1 are components of the Notch signalling pathway. EMBO reports\| PubMed ID: 21475249	2011
A versatile single-plasmid system for tissue-specific and inducible control of gene expression in transgenic mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 21518849	2011
Redox-dependent oligomerization through a leucine zipper motif is essential for MG53-mediated cell membrane repair. American journal of physiology. Cell physiology\| PubMed ID: 21525429	2011
Molecular architecture of Ca2+ signaling control in muscle and heart cells. Channels (Austin, Tex.)\| PubMed ID: 21712647	2011
Mitochondrial calcium uptake regulates rapid calcium transients in skeletal muscle during excitation-contraction (E-C) coupling. The Journal of biological chemistry\| PubMed ID: 21795684	2011
Disrupted membrane structure and intracellular CaÂ²âº signaling in adult skeletal muscle with acute knockdown of Bin1. PloS one\| PubMed ID: 21984944	2011
Detection of calcium sparks in intact and permeabilized skeletal muscle fibers. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22130850	2012
Nonmuscle myosin IIA facilitates vesicle trafficking for MG53-mediated cell membrane repair. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 22253476	2012
Enhancing Muscle Membrane Repair by Gene Delivery of MG53 Ameliorates Muscular Dystrophy and Heart Failure in Î´-Sarcoglycan-deficient Hamsters. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 22314291	2012
Hypertrophy in skeletal myotubes induced by junctophilin-2 mutant, Y141H, involves an increase in store-operated Ca2+ entry via Orai1. The Journal of biological chemistry\| PubMed ID: 22389502	2012
Recombinant MG53 protein modulates therapeutic cell membrane repair in treatment of muscular dystrophy. Science translational medicine\| PubMed ID: 22723464	2012
Switch from ER-mitochondrial to SR-mitochondrial calcium coupling during muscle differentiation. Cell calcium\| PubMed ID: 22784666	2012
TRIM50 Protein Regulates Vesicular Trafficking for Acid Secretion in Gastric Parietal Cells. The Journal of biological chemistry\| PubMed ID: 22872646	2012
Mitsugumin 53 attenuates the activity of sarcoplasmic reticulum Ca(2+)-ATPase 1a (SERCA1a) in skeletal muscle. Biochemical and biophysical research communications\| PubMed ID: 23103543	2012
The Mesobuthus martensii genome reveals the molecular diversity of scorpion toxins. Cell & bioscience\| PubMed ID: 24383941	2014
The effect of recombinant human MG53 protein on tourniquet-induced ischemia reperfusion injury in rat muscle. Muscle & nerve\| PubMed ID: 24395153	2014
Store-operated Ca2+ entry in muscle physiology and diseases. BMB reports\| PubMed ID: 24411466	2014
Trimeric intracellular cation channels and sarcoplasmic/endoplasmic reticulum calcium homeostasis. Circulation research\| PubMed ID: 24526676	2014
Core-shell nanoparticle-based peptide therapeutics and combined hyperthermia for enhanced cancer cell apoptosis. ACS nano\| PubMed ID: 25133971	2014
Amphipathic tail-anchoring peptide is a promising therapeutic agent for prostate cancer treatment. Oncotarget\| PubMed ID: 25245280	2014
Cell membrane damage is involved in the impaired survival of bone marrow stem cells by oxidized low-density lipoprotein. Journal of cellular and molecular medicine\| PubMed ID: 25256620	2014
Organelle-specific subunit interactions of the vertebrate two-pore channel family. The Journal of biological chemistry\| PubMed ID: 25451935	2015
Lysosomal two-pore channel subtype 2 (TPC2) regulates skeletal muscle autophagic signaling. The Journal of biological chemistry\| PubMed ID: 25480788	2015
Open Sesame: treasure in store-operated calcium entry pathway for cancer therapy. Science China. Life sciences\| PubMed ID: 25481035	2015
Cardioprotection of recombinant human MG53 protein in a porcine model of ischemia and reperfusion injury. Journal of molecular and cellular cardiology\| PubMed ID: 25533937	2015
Dysfunction in the βII spectrin-dependent cytoskeleton underlies human arrhythmia. Circulation\| PubMed ID: 25632041	2015
Amelioration of ischemia-reperfusion-induced muscle injury by the recombinant human MG53 protein. Muscle & nerve\| PubMed ID: 25703692	2015
3D multifocus astigmatism and compressed sensing (3D MACS) based superresolution reconstruction. Biomedical optics express\| PubMed ID: 25798314	2015
Zinc Binding to MG53 Protein Facilitates Repair of Injury to Cell Membranes. The Journal of biological chemistry\| PubMed ID: 25869134	2015
Modulation of wound healing and scar formation by MG53 protein-mediated cell membrane repair. The Journal of biological chemistry\| PubMed ID: 26306047	2015
CRISPR-mediated Genome Editing Restores Dystrophin Expression and Function in mdx Mice. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 26449883	2016
Quantifying Drug-Induced Nanomechanics and Mechanical Effects to Single Cardiomyocytes for Optimal Drug Administration To Minimize Cardiotoxicity. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 26738425	2016
Autophagy, Innate Immunity and Tissue Repair in Acute Kidney Injury. International journal of molecular sciences\| PubMed ID: 27153058	2016
Dual function of MG53 in membrane repair and insulin signaling. BMB reports\| PubMed ID: 27174502	2016
Absence of physiological Ca transients is an initial trigger for mitochondrial dysfunction in skeletal muscle following denervation. Skeletal muscle\| PubMed ID: 28395670	2017
In Vivo Genome Editing Restores Dystrophin Expression and Cardiac Function in Dystrophic Mice. Circulation research\| PubMed ID: 28790199	2017
Irisin protects mitochondria function during pulmonary ischemia/reperfusion injury. Science translational medicine\| PubMed ID: 29187642	2017
Zinc in Wound Healing Modulation. Nutrients\| PubMed ID: 29295546	2017
Comparative analysis of FKBP family protein: evaluation, structure, and function in mammals and Drosophila melanogaster. BMC developmental biology\| PubMed ID: 29587629	2018
Quantum confined peptide assemblies with tunable visible to near-infrared spectral range. Nature communications\| PubMed ID: 30104564	2018
MG 53 Protein Protects Aortic Valve Interstitial Cells From Membrane Injury and Fibrocalcific Remodeling. Journal of the American Heart Association\| PubMed ID: 30741589	2019
MG53 promotes corneal wound healing and mitigates fibrotic remodeling in rodents. Communications biology\| PubMed ID: 30793049	2019
MG53 attenuates lipopolysaccharide-induced neurotoxicity and neuroinflammation via inhibiting TLR4/NF-κB pathway in vitro and in vivo. Progress in neuro-psychopharmacology & biological psychiatry\| PubMed ID: 31260721	2019
Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function. Nature communications\| PubMed ID: 31604915	2019
N-acetylcysteine prevents oxidized low-density lipoprotein-induced reduction of MG53 and enhances MG53 protective effect on bone marrow stem cells. Journal of cellular and molecular medicine\| PubMed ID: 31742908	2020
The TRIM protein Mitsugumin 53 enhances survival and therapeutic efficacy of stem cells in murine traumatic brain injury. Stem cell research & therapy\| PubMed ID: 31779687	2019
TRIC-A Channel Maintains Store Calcium Handling by Interacting With Type 2 Ryanodine Receptor in Cardiac Muscle. Circulation research\| PubMed ID: 31805819	2020
MG53 Does Not Manifest the Development of Diabetes in Mice. Diabetes\| PubMed ID: 32139593	2020
MG53 suppresses interferon-β and inflammation via regulation of ryanodine receptor-mediated intracellular calcium signaling. Nature communications\| PubMed ID: 32681036	2020
Peptidylarginine Deiminases 2 Mediates Caspase-1-Associated Lethality in Pseudomonas aeruginosa Pneumonia-Induced Sepsis. The Journal of infectious diseases\| PubMed ID: 32729925	2021
Recombinant MG53 Protein Protects Mice from Lethal Influenza Virus Infection. American journal of respiratory and critical care medicine\| PubMed ID: 33031705	2021
MG53, A Tissue Repair Protein with Broad Applications in Regenerative Medicine. Cells\| PubMed ID: 33440658	2021
TRIC-A regulates intracellular Ca homeostasis in cardiomyocytes. Pflugers Archiv : European journal of physiology\| PubMed ID: 33474637	2021
MG53 as a Novel Therapeutic Protein to Treat Acute Lung Injury. Military medicine\| PubMed ID: 33499468	2021
Muscle multiorgan crosstalk with MG53 as a myokine for tissue repair and regeneration. Current opinion in pharmacology\| PubMed ID: 34052525	2021
Efficient precise in vivo base editing in adult dystrophic mice. Nature communications\| PubMed ID: 34140489	2021
MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer. Molecular cancer\| PubMed ID: 34521423	2021
Correction to: The TRIM protein Mitsugumin 53 enhances survival and therapeutic efficacy of stem cells in murine traumatic brain injury. Stem cell research & therapy\| PubMed ID: 34593038	2021