Scott A. Weed

Department of Neurobiology and Anatomy, Mary Babb Randolph Cancer Center, West Virginia University

Affiliated withMary Babb Randolph Cancer Center, West Virginia University West Virginia University West Virginia University

Research Area

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 15	2011
Publication title Cited by 74	2012
Publication title Cited by 6	2015

Other Publications

Article	Year
Dynamin2 and cortactin regulate actin assembly and filament organization. Current biology : CB\| PubMed ID: 12419186	2002
Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion. Current biology : CB\| PubMed ID: 12620186	2003
MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts. The EMBO journal\| PubMed ID: 12839996	2003
Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton. Molecular biology of the cell\| PubMed ID: 12925758	2003
Rac2D57N, a dominant inhibitory Rac2 mutant that inhibits p38 kinase signaling and prevents surface ruffling in bone-marrow-derived macrophages. Journal of cell science\| PubMed ID: 14676277	2004
Characterization of an ankyrin repeat-containing Shank2 isoform (Shank2E) in liver epithelial cells. The Biochemical journal\| PubMed ID: 14977424	2004
Cortactin is necessary for E-cadherin-mediated contact formation and actin reorganization. The Journal of cell biology\| PubMed ID: 15024035	2004
Actin depolymerization-induced tyrosine phosphorylation of cortactin: the role of Fer kinase. The Biochemical journal\| PubMed ID: 15030313	2004
Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells. The Journal of cell biology\| PubMed ID: 15263018	2004
Protein kinase Calpha activates c-Src and induces podosome formation via AFAP-110. Molecular and cellular biology\| PubMed ID: 15314167	2004
Cortactin overexpression regulates actin-related protein 2/3 complex activity, motility, and invasion in carcinomas with chromosome 11q13 amplification. Cancer research\| PubMed ID: 16912177	2006
Overexpression of cyclin D1 and cortactin is primarily independent of gene amplification in salivary gland adenoid cystic carcinoma. Oral oncology\| PubMed ID: 17113340	2007
PI3K activation is required for PMA-directed activation of cSrc by AFAP-110. American journal of physiology. Cell physiology\| PubMed ID: 17360811	2007
Actin cytoskeletal mediators of motility and invasion amplified and overexpressed in head and neck cancer. Clinical & experimental metastasis\| PubMed ID: 18324357	2008
Phosphorylation of AFAP-110 affects podosome lifespan in A7r5 cells. Journal of cell science\| PubMed ID: 18577577	2008
Cortactin branches out: roles in regulating protrusive actin dynamics. Cell motility and the cytoskeleton\| PubMed ID: 18615630	2008
Cortactin is a functional target of E-cadherin-activated Src family kinases in MCF7 epithelial monolayers. The Journal of biological chemistry\| PubMed ID: 19457864	2009
Saracatinib Impairs Head and Neck Squamous Cell Carcinoma Invasion by Disrupting Invadopodia Function. Journal of cancer science & therapy\| PubMed ID: 20505783	2009
Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturation. Journal of cell science\| PubMed ID: 20980387	2010
Cortactin phosphorylated by ERK1/2 localizes to sites of dynamic actin regulation and is required for carcinoma lamellipodia persistence. PloS one\| PubMed ID: 21079800	2010
Revisiting the ERK/Src cortactin switch. Communicative & integrative biology\| PubMed ID: 21655441	2011
Further insights into cortactin conformational regulation. Bioarchitecture\| PubMed ID: 21866257	2011
Effects of Tobacco Smoking and Nicotine on Cancer Treatment. Pharmacotherapy\| PubMed ID: 22887142	2012
Cortactin is a substrate of activated Cdc42-associated kinase 1 (ACK1) during ligand-induced epidermal growth factor receptor downregulation. PloS one\| PubMed ID: 22952966	2012
Effects of tobacco smoking and nicotine on cancer treatment. Pharmacotherapy\| PubMed ID: 23033231	2012
Src binds cortactin through an SH2 domain cystine-mediated linkage. Journal of cell science\| PubMed ID: 23097045	2012
Phosphorylation of the alternative mRNA splicing factor 45 (SPF45) by Clk1 regulates its splice site utilization, cell migration and invasion. Nucleic acids research\| PubMed ID: 23519612	2013
Metastatic MTLn3 and non-metastatic MTC adenocarcinoma cells can be differentiated by Pseudomonas aeruginosa. Biology open\| PubMed ID: 24143275	2013
NEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasis. Molecular cancer research : MCR\| PubMed ID: 24202705	2014
Recently identified biomarkers that promote lymph node metastasis in head and neck squamous cell carcinoma. Cancers\| PubMed ID: 24212639	2011
NEDD9 regulates actin dynamics through cortactin deacetylation in an AURKA/HDAC6-dependent manner. Molecular cancer research : MCR\| PubMed ID: 24574519	2014
Use of high frequency ultrasound to monitor cervical lymph node alterations in mice. PloS one\| PubMed ID: 24955984	2014
Tumor and stromal-based contributions to head and neck squamous cell carcinoma invasion. Cancers\| PubMed ID: 25734659	2015