Fatah Kashanchi

Fatah Kashanchi

Laboratory of Molecular Virology, George Mason University

Affiliated withGeorge Mason University

Research Area

Biography

Dr. Kashanchi obtained his Ph.D. from Dr. Charles Wood, and trained under Dr. Susumu Tonegawa at MIT (Nobel Laureate 1987 for Physiology and Medicine). He is currently a Professor and Director at the George Mason University’s Laboratory of Molecular Virology. He has obtained more than $15.8 M in funding (NIH, DOD, DOE, and Keck) since his departure from NIH’s intramural program in 2000. He has published more than 218 peer-reviewed manuscripts (h index = 57) and served as an editorial board and reviewer for journals such as JBC, Retrovirology, J. Virol, Virology, NAR, 4 PLoS Journals, Cell, Molecular Cell, Nature Medicine, Nature communications, Scientific Report and Science Translational Medicine.

His lab focuses on understanding the mechanism of viral gene expression in human viruses and how the virus and the host control the dynamics of fundamental machineries needed for viral replication and/or host survival, including pathways that leads to transcription and chromatin remolding using in vitro reconstituted DNA/RNA elements. His lab has also contributed to general understanding of how these machineries are different in T-cells vs. myeloid cells. In recent years, his lab has additionally been focusing on exosomes secreted from HIV and HTLV infected cells, as well as 7 other RNA and DNA virus infections (through collaborations) and validation of data using in vitro functional analysis and humanized mouse models. Since 1999, Dr. Kashanchi has trained more than 23 postodcs, 29 Ph.D students and 57 MS and undergrad students. Many of these students have continued as postdocs, and obtained Tenure-track academic appointments. Finally, he is a regular NIH study section member and has served on 143 panels since 2000, where he chaired or co-chaired 17 panels.

JoVE Journal Publications

ArticleTotal : 1
Year
Purification of High Yield Extracellular Vesicle Preparations Away from Virus
Publication title

Cited by 13

2019

Other Publications

Article
Year
Human T-lymphotropic virus type 1 transcription and chromatin-remodeling complexes.

Journal of virology| PubMed ID: 20164218

2010
Inhibition of human immunodeficiency virus type-1 by cdk inhibitors.

AIDS research and therapy| PubMed ID: 20334651

2010
Absence of DICER in monocytes and its regulation by HIV-1.

The Journal of biological chemistry| PubMed ID: 20584909

2010
2010
2010
2010
microRNA machinery is an integral component of drug-induced transcription inhibition in HIV-1 infection.

Journal of RNAi and gene silencing : an international journal of RNA and gene targeting research| PubMed ID: 20628499

2010
2010
2011
Erratum to: microRNA machinery is an integral component of drug-induced transcription inhibition in HIV-1 infection.

Journal of RNAi and gene silencing : an international journal of RNA and gene targeting research| PubMed ID: 20963190

2010
2010
2010
Analysis of the roles of HIV-derived microRNAs.

Expert opinion on biological therapy| PubMed ID: 21133815

2011
Developments in antivirals against influenza, smallpox and hemorrhagic fever viruses.

Expert opinion on investigational drugs| PubMed ID: 21235430

2011
Secreted Bacillus anthracis proteases target the host fibrinolytic system.

FEMS immunology and medical microbiology| PubMed ID: 21395696

2011
2011
2011
2011
2011
Varying modulation of HIV-1 LTR activity by Baf complexes.

Journal of molecular biology| PubMed ID: 21699904

2011
2012
Humanized mouse models of HIV-1 latency.

Current HIV research| PubMed ID: 22211664

2011
2012
2012
2012
2012
2012
2012
2012
2012
2012
2012
Curcumin inhibits Rift Valley fever virus replication in human cells.

The Journal of biological chemistry| PubMed ID: 22847000

2012
2013
2012
Bacillus anthracis-derived nitric oxide induces protein S-nitrosylation contributing to macrophage death.

Biochemical and biophysical research communications| PubMed ID: 23178574

2013
2012
Effect of Mimetic CDK9 Inhibitors on HIV-1-Activated Transcription.

Journal of molecular biology| PubMed ID: 23247501

2013
Complex role of microRNAs in HTLV-1 infections.

Frontiers in genetics| PubMed ID: 23251140

2012
Retrovirus infected cells contain viral microRNAs.

Retrovirology| PubMed ID: 23391025

2013
2013
2013
2014
2014
2014
Repeated cocaine treatment enhances HIV-1 Tat-induced cortical excitability via over-activation of L-type calcium channels.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology| PubMed ID: 24567038

2014
Exosomes and their role in CNS viral infections.

Journal of neurovirology| PubMed ID: 24578033

2014
2014
2014
2012
2014
2014
2014
2015
2015
2015
2015
2015
2015
2016
2016
HIV-1 Nef blocks autophagy in human astrocytes.

Cell cycle (Georgetown, Tex.)| PubMed ID: 26697833

2015
2016
2016
Zika Virus: A New Animal Model for an Arbovirus.

PLoS neglected tropical diseases| PubMed ID: 27149628

2016
Exosomes in Viral Disease.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics| PubMed ID: 27324390

2016
Biodegradable Nanoparticles for Delivery of Therapeutics in CNS Infection.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology| PubMed ID: 27372507

2017
HIV Vpr controls CNS metabolism.

Cell cycle (Georgetown, Tex.)| PubMed ID: 27421087

2016
Ebola VP40 in Exosomes Can Cause Immune Cell Dysfunction.

Frontiers in microbiology| PubMed ID: 27872619

2016
The Role of Exosomal VP40 in Ebola Virus Disease.

DNA and cell biology| PubMed ID: 28177658

2017
2017
Isolation of Exosomes from HTLV-Infected Cells.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 28357662

2017
2017
2017
Exosomes from uninfected cells activate transcription of latent HIV-1.

The Journal of biological chemistry| PubMed ID: 28536264

2017
2017
2017
2017
Proceedings of the ISEV symposium on "HIV, NeuroAIDS, drug abuse & EVs".

Journal of extracellular vesicles| PubMed ID: 28800366

2017
2017
2017
2017
2018
2018
2018
Role of Exosomes in Human Retroviral Mediated Disorders.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology| PubMed ID: 29656370

2018
2018
2018
2018
Ebola Virus VP40 Modulates Cell Cycle and Biogenesis of Extracellular Vesicles.

The Journal of infectious diseases| PubMed ID: 30169850

2018
Removal of HIV DNA by CRISPR from Patient Blood Engrafts in Humanized Mice.

Molecular therapy. Nucleic acids| PubMed ID: 30195766

2018
2018
2018
Autophagy, EVs, and Infections: A Perfect Question for a Perfect Time.

Frontiers in cellular and infection microbiology| PubMed ID: 30406039

2018
2019
2019
2019
2019
Stem Cell Extracellular Vesicles and their Potential to Contribute to the Repair of Damaged CNS Cells.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology| PubMed ID: 31338754

2019
2019