James R. Sellers

Laboratory of Molecular Physiology, National Institutes of Health

Affiliated withNational Institutes of Health

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 22	2019
Publication title Cited by 4	2021

Other Publications

Article	Year
A myosin III from Limulus eyes is a clock-regulated phosphoprotein. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 9614231	1998
Analysis of the regulatory phosphorylation site in Acanthamoeba myosin IC by using site-directed mutagenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 9860946	1998
Myosin-I nomenclature. The Journal of cell biology\| PubMed ID: 11724811	2001
Identification of an organelle receptor for myosin-Va. Nature cell biology\| PubMed ID: 11887186	2002
Rab27a is an essential component of melanosome receptor for myosin Va. Molecular biology of the cell\| PubMed ID: 12006666	2002
Mutations in human nonmuscle myosin IIA found in patients with May-Hegglin anomaly and Fechtner syndrome result in impaired enzymatic function. The Journal of biological chemistry\| PubMed ID: 12237319	2002
The prepower stroke conformation of myosin V. The Journal of cell biology\| PubMed ID: 12499355	2002
Kinetic mechanism of non-muscle myosin IIB: functional adaptations for tension generation and maintenance. The Journal of biological chemistry\| PubMed ID: 12704189	2003
Neck length and processivity of myosin V. The Journal of biological chemistry\| PubMed ID: 12740393	2003
Utility of genetic screening in hypertrophic cardiomyopathy: prevalence and significance of novel and double (homozygous and heterozygous) beta-myosin mutations. Genetic testing\| PubMed ID: 12820698	2003
Functional divergence of human cytoplasmic myosin II: kinetic characterization of the non-muscle IIA isoform. The Journal of biological chemistry\| PubMed ID: 12847096	2003
Regulated conformation of myosin V. The Journal of biological chemistry\| PubMed ID: 14634000	2004
Trifluoperazine inhibits the MgATPase activity and in vitro motility of conventional and unconventional myosins. Journal of muscle research and cell motility\| PubMed ID: 14870973	2003
Two-headed binding of the unphosphorylated nonmuscle heavy meromyosin.ADP complex to actin. Biochemistry\| PubMed ID: 15065866	2004
Mechanism of blebbistatin inhibition of myosin II. The Journal of biological chemistry\| PubMed ID: 15205456	2004
Nanometer localization of single green fluorescent proteins: evidence that myosin V walks hand-over-hand via telemark configuration. Biophysical journal\| PubMed ID: 15345556	2004
Specificity of blebbistatin, an inhibitor of myosin II. Journal of muscle research and cell motility\| PubMed ID: 15548862	2004
Fifty years of contractility research post sliding filament hypothesis. Journal of muscle research and cell motility\| PubMed ID: 15630612	2004
Blebbistatin, a myosin II inhibitor, is photoinactivated by blue light. Biochemistry\| PubMed ID: 15641783	2005
Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia. Nature cell biology\| PubMed ID: 15654330	2005
Mechanism of action of myosin X, a membrane-associated molecular motor. The Journal of biological chemistry\| PubMed ID: 15705568	2005
Disease-associated mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C. The Journal of biological chemistry\| PubMed ID: 15845534	2005
Myosin V from Drosophila reveals diversity of motor mechanisms within the myosin V family. The Journal of biological chemistry\| PubMed ID: 15980429	2005
Myosin VIIB from Drosophila is a high duty ratio motor. The Journal of biological chemistry\| PubMed ID: 16055438	2005
Step-size is determined by neck length in myosin V. Biochemistry\| PubMed ID: 16331980	2005
Walking with myosin V. Current opinion in cell biology\| PubMed ID: 16378722	2006
Dimerized Drosophila myosin VIIa: a processive motor. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16585515	2006
The cargo-binding domain regulates structure and activity of myosin 5. Nature\| PubMed ID: 16838021	2006
In vitro reconstitution of a transport complex containing Rab27a, melanophilin and myosin Va. FEBS letters\| PubMed ID: 17045265	2006
Loop 2 of limulus myosin III is phosphorylated by protein kinase A and autophosphorylation. Biochemistry\| PubMed ID: 17367164	2007
Diversity of structural behavior in vertebrate conventional myosins complexed with actin. Journal of molecular biology\| PubMed ID: 17433365	2007
Myo4p is a monomeric myosin with motility uniquely adapted to transport mRNA. The Journal of cell biology\| PubMed ID: 17893244	2007
The B2 alternatively spliced isoform of nonmuscle myosin II-B lacks actin-activated MgATPase activity and in vitro motility. Biochemical and biophysical research communications\| PubMed ID: 18060863	2008
Calcium and cargoes as regulators of myosin 5a activity. Biochemical and biophysical research communications\| PubMed ID: 18060865	2008
Mutation spectrum of MYO7A and evaluation of a novel nonsyndromic deafness DFNB2 allele with residual function. Human mutation\| PubMed ID: 18181211	2008
Folding and regulation in myosins II and V. Journal of muscle research and cell motility\| PubMed ID: 18427938	2007
The small molecule tool (S)-(-)-blebbistatin: novel insights of relevance to myosin inhibitor design. Organic & biomolecular chemistry\| PubMed ID: 18528569	2008
Switch 1 mutation S217A converts myosin V into a low duty ratio motor. The Journal of biological chemistry\| PubMed ID: 19008235	2009
An alternatively spliced isoform of non-muscle myosin II-C is not regulated by myosin light chain phosphorylation. The Journal of biological chemistry\| PubMed ID: 19240025	2009
A FERM domain autoregulates Drosophila myosin 7a activity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19255446	2009
Extensibility of the extended tail domain of processive and nonprocessive myosin V molecules. Biophysical journal\| PubMed ID: 20006949	2009
Influence of lever structure on myosin 5a walking. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20133809	2010
Direct observation of the myosin-Va power stroke and its reversal. Nature structural & molecular biology\| PubMed ID: 20418880	2010
Nonmuscle myosin IIA with a GFP fused to the N-terminus of the regulatory light chain is regulated normally. Journal of muscle research and cell motility\| PubMed ID: 20711642	2010
Myosin VI and its binding partner optineurin are involved in secretory vesicle fusion at the plasma membrane. Molecular biology of the cell\| PubMed ID: 21148290	2011
The kinetic mechanism of mouse myosin VIIA. The Journal of biological chemistry\| PubMed ID: 21212272	2011
Drosophila melanogaster myosin-18 represents a highly divergent motor with actin tethering properties. The Journal of biological chemistry\| PubMed ID: 21498886	2011
Light-triggered myosin activation for probing dynamic cellular processes. Angewandte Chemie (International ed. in English)\| PubMed ID: 21542072	2011
Dynein struts its stuff. Nature structural & molecular biology\| PubMed ID: 21642959	2011
Nucleotide pyrophosphatase employs a P-loop-like motif to enhance catalytic power and NDP/NTP discrimination. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21831832	2011
Myosin motor proteins are involved in the final stages of the secretory pathways. Biochemical Society transactions\| PubMed ID: 21936774	2011
Regulation of myosin 5a and myosin 7a. Biochemical Society transactions\| PubMed ID: 21936778	2011
Walking to work: roles for class V myosins as cargo transporters. Nature reviews. Molecular cell biology\| PubMed ID: 22146746	2011
Nonmuscle myosin II exerts tension but does not translocate actin in vertebrate cytokinesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22393000	2012
Dynamic exchange of myosin VI on endocytic structures. The Journal of biological chemistry\| PubMed ID: 22992744	2012
Kinetic characterization of nonmuscle myosin IIb at the single molecule level. The Journal of biological chemistry\| PubMed ID: 23148220	2013
Mammalian myosin-18A, a highly divergent myosin. The Journal of biological chemistry\| PubMed ID: 23382379	2013
Myosin regulatory light chain (RLC) phosphorylation change as a modulator of cardiac muscle contraction in disease. The Journal of biological chemistry\| PubMed ID: 23530050	2013
Loss of actomyosin regulation in distal arthrogryposis myopathy due to mutant myosin binding protein-C slow. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 23657818	2013
Kinetic characterization of the ATPase and actin-activated ATPase activities of Acanthamoeba castellanii myosin-2. The Journal of biological chemistry\| PubMed ID: 23897814	2013
Actin structure-dependent stepping of myosin 5a and 10 during processive movement. PloS one\| PubMed ID: 24069366	2013
Characterization of three full-length human nonmuscle myosin II paralogs. The Journal of biological chemistry\| PubMed ID: 24072716	2013
To understand muscle you must take it apart. Frontiers in physiology\| PubMed ID: 24653704	2014
Myosin-10 produces its power-stroke in two phases and moves processively along a single actin filament under low load. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24753602	2014
Regulation of nonmuscle myosin II by tropomyosin. Biochemistry\| PubMed ID: 24873380	2014
Use of fluorescent techniques to study the in vitro movement of myosins. Experientia supplementum (2012)\| PubMed ID: 25095996	2014
Chaperone-enhanced purification of unconventional myosin 15, a molecular motor specialized for stereocilia protein trafficking. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25114250	2014
Kinetic characterization of the sole nonmuscle myosin-2 from the model organism Drosophila melanogaster. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 25636739	2015
Four things to know about myosin light chains as reporters for non-muscle myosin-2 dynamics in live cells. Cytoskeleton (Hoboken, N.J.)\| PubMed ID: 25712372	2015
Structural dynamics of myosin 5 during processive motion revealed by interferometric scattering microscopy. eLife\| PubMed ID: 25748137	2015
Myosin 18A coassembles with nonmuscle myosin 2 to form mixed bipolar filaments. Current biology : CB\| PubMed ID: 25754640	2015
Myosin light chains: Teaching old dogs new tricks. Bioarchitecture\| PubMed ID: 26155737	2014
Various Themes of Myosin Regulation. Journal of molecular biology\| PubMed ID: 26827725	2016
The Arf GTPase-activating Protein, ASAP1, Binds Nonmuscle Myosin 2A to Control Remodeling of the Actomyosin Network. The Journal of biological chemistry\| PubMed ID: 26893376	2016
Kinetic Adaptations of Myosins for Their Diverse Cellular Functions. Traffic (Copenhagen, Denmark)\| PubMed ID: 26929436	2016
Mechanisms and Functional Diversity of Macromolecular Remodeling by ATP-Dependent Motors. Journal of molecular biology\| PubMed ID: 27113061	2016
Mammalian Nonmuscle Myosin II Binds to Anionic Phospholipids with Concomitant Dissociation of the Regulatory Light Chain. The Journal of biological chemistry\| PubMed ID: 27697842	2016
Local pulsatile contractions are an intrinsic property of the myosin 2A motor in the cortical cytoskeleton of adherent cells. Molecular biology of the cell\| PubMed ID: 27881665	2017
non-muscle myosin II motor activity determines the rate of tissue folding. eLife\| PubMed ID: 28035903	2016
Re-evaluating the roles of myosin 18Aα and F-actin in determining Golgi morphology. Cytoskeleton (Hoboken, N.J.)\| PubMed ID: 28329908	2017
Effect of ATP and regulatory light-chain phosphorylation on the polymerization of mammalian nonmuscle myosin II. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28739905	2017
Kinetic signatures of myosin-5B, the motor involved in microvillus inclusion disease. The Journal of biological chemistry\| PubMed ID: 28882893	2017
Mechanistic insights into the active site and allosteric communication pathways in human nonmuscle myosin-2C. eLife\| PubMed ID: 29256864	2017
Bipolar filaments of human nonmuscle myosin 2-A and 2-B have distinct motile and mechanical properties. eLife\| PubMed ID: 29419377	2018
Dissecting myosin-5B mechanosensitivity and calcium regulation at the single molecule level. Nature communications\| PubMed ID: 30030431	2018
Multiple S100 protein isoforms and C-terminal phosphorylation contribute to the paralog-selective regulation of nonmuscle myosin 2 filaments. The Journal of biological chemistry\| PubMed ID: 30087119	2018
Nonmuscle myosin-2 isoforms. Current biology : CB\| PubMed ID: 31014482	2019
Remarkable Rigidity of the Single α-Helical Domain of Myosin-VI As Revealed by NMR Spectroscopy. Journal of the American Chemical Society\| PubMed ID: 31117653	2019
Perfringolysin O-Induced Plasma Membrane Pores Trigger Actomyosin Remodeling and Endoplasmic Reticulum Redistribution. Toxins\| PubMed ID: 31319618	2019
Competition between kinesin-1 and myosin-V defines posterior determination. eLife\| PubMed ID: 32057294	2020
Megakaryocyte migration defects due to nonmuscle myosin IIA mutations underlie thrombocytopenia in MYH9-related disease. Blood\| PubMed ID: 32315395	2020
How Myosin 5 Walks Deduced from Single-Molecule Biophysical Approaches. Advances in experimental medicine and biology\| PubMed ID: 32451859	2020
Tyrosine Phosphorylation of the Myosin Regulatory Light Chain Controls Non-muscle Myosin II Assembly and Function in Migrating Cells. Current biology : CB\| PubMed ID: 32502416	2020
The ATPase mechanism of myosin 15, the molecular motor mutated in DFNB3 human deafness. The Journal of biological chemistry\| PubMed ID: 33372036	2020
The ATPase mechanism of myosin 15, the molecular motor mutated in DFNB3 human deafness. The Journal of biological chemistry\| PubMed ID: 33428946	2021
A binding protein regulates myosin-7a dimerization and actin bundle assembly. Nature communications\| PubMed ID: 33495456	2021