Yongxin Zhao

Yongxin Zhao

Department of Biological Sciences, Carnegie Mellon University

Affiliated withCarnegie Mellon University

Research Area

Biography

Yongxin (Leon) Zhao is an assistant professor in the Department of Biological Sciences at Carnegie Mellon University in Pittsburgh, Pennsylvania. He received his B.Sc. in Chemistry at Sun Yat-sen University, China. He then joined the Department of Chemistry at University of Alberta, Canada, in 2009. Under the guidance of Professors Robert E. Campbell and D. Jed Harrison, Leon worked on the development of novel directed evolution approaches for improved optogenetic calcium ion and voltage indicators for his doctoral projects. He developed the neuronal imaging tools, GECO and QuasAr families, which have been distributed to and used by hundreds of research groups worldwide. After earning his Ph.D. in 2014, Leon went on and joined Professor Ed Boyden’s lab as a postdoctoral associate at MIT Media lab. In the Boyden lab, he developed a transformative imaging approach, termed Expansion Pathology, for visualization of biomolecules in clinical samples with nanoscale precision using only conventional light microscopes. In the fall of 2017, Leon started his Biophotonics Engineering lab in the Department of Biological Sciences at Carnegie Mellon University.

Leon is a recipient of the National Institutes of Health (NIH) Director’s New Innovator Award. His lab focuses on developing transformative nanoscale imaging techniques that will allow researchers to see precise “biomolecule maps” in pathology samples. These maps will allow for the comprehensive analysis of complex diseases, such as cancer, infection and immune diseases.

JoVE Journal Publications

ArticleTotal : 2
Year
Nanoscopic Imaging of Human Tissue Sections via Physical and Isotropic Expansion
Publication title

Cited by 5

2019
2023

Other Publications

Article
Year
Inverse-response Ca indicators for optogenetic visualization of neuronal inhibition.

Scientific reports| PubMed ID: 30082904

2018
2018
2019
Basics of Expansion Microscopy.

Current protocols in cytometry| PubMed ID: 31763769

2019
2020
Nanoscale imaging of E. coli cells by expansion microscopy.

Discoveries (Craiova, Romania)| PubMed ID: 32309616

2019
Nanoscale Imaging of Synaptic Connections with Expansion Microscopy.

Discoveries (Craiova, Romania)| PubMed ID: 32309619

2019
2020
2021
2022
Super-Resolution Vibrational Imaging Using Expansion Stimulated Raman Scattering Microscopy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)| PubMed ID: 35521971

2022
2022
2023
2023
Imaging pathology goes nanoscale with a low-cost strategy.

Nature nanotechnology| PubMed ID: 37037894

2023
A New Expansion Microscopy Method Optimized for Microbiology.

Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada| PubMed ID: 37613535

2023
11-fold Expansion Microscopy with Universal Molecular Retention Using Magnify.

Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada| PubMed ID: 37613623

2023
MicroMagnify: A Multiplexed Expansion Microscopy Method for Pathogens and Infected Tissues.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)| PubMed ID: 37658522

2023