Ian A. Blair

Centers for Cancer Pharmacology and Excellence in Environmental Toxicology, University of Pennsylvania

Affiliated withUniversity of Pennsylvania University of Pennsylvania

Research Area

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 6	2011
Publication title Cited by 32	2013
Publication title Cited by 7	2016

Other Publications

Article	Year
A validated liquid chromatography/tandem mass spectrometry assay for cis-amminedichloro(2-methylpyridine)platinum(II) in human plasma ultrafiltrate. Analytical chemistry\| PubMed ID: 11838680	2002
4,5-Epoxy-2(E)-decenal-induced formation of 1,N(6)-etheno-2'-deoxyadenosine and 1,N(2)-etheno-2'-deoxyguanosine adducts. Chemical research in toxicology\| PubMed ID: 11896675	2002
Activation of polycyclic aromatic hydrocarbon trans-dihydrodiol proximate carcinogens by human aldo-keto reductase (AKR1C) enzymes and their functional overexpression in human lung carcinoma... The Journal of biological chemistry\| PubMed ID: 11978787	2002
Analysis of anticancer drugs and their metabolites by mass spectrometry. Current drug metabolism\| PubMed ID: 12369893	2002
A human melanoma xenograft in a nude rat responds to isolated limb perfusion with TNF plus melphalan. Surgery\| PubMed ID: 12717360	2003
Characterization of 2'-deoxycytidine adducts derived from 4-oxo-2-nonenal, a novel lipid peroxidation product. Chemical research in toxicology\| PubMed ID: 12870892	2003
A novel lipid hydroperoxide-derived cyclic covalent modification to histone H4. The Journal of biological chemistry\| PubMed ID: 12930824	2003
Targeted lipidomics using electron capture atmospheric pressure chemical ionization mass spectrometry. Rapid communications in mass spectrometry : RCM\| PubMed ID: 14515314	2003
Reciprocal DNA topoisomerase II cleavage events at 5'-TATTA-3' sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint... Oncogene\| PubMed ID: 14627986	2003
A novel lipid hydroperoxide-derived modification to arginine. Chemical research in toxicology\| PubMed ID: 14680374	2003
Plasma etoposide catechol increases in pediatric patients undergoing multiple-day chemotherapy with etoposide. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 15131033	2004
Kinetics and regulation of cytochrome P450-mediated etoposide metabolism. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 15319341	2004
Viniferin formation by COX-1: evidence for radical intermediates during co-oxidation of resveratrol. Journal of natural products\| PubMed ID: 15679314	2005
Liquid chromatography/mass spectrometry analysis of bifunctional electrophiles and DNA adducts from vitamin C mediated decomposition of 15-hydroperoxyeicosatetraenoic acid. Rapid communications in mass spectrometry : RCM\| PubMed ID: 15723435	2005
Analysis of FeII-mediated decomposition of a linoleic acid-derived lipid hydroperoxide by liquid chromatography/mass spectrometry. Journal of mass spectrometry : JMS\| PubMed ID: 15739161	2005
Dioxododecenoic acid: a lipid hydroperoxide-derived bifunctional electrophile responsible for etheno DNA adduct formation. Chemical research in toxicology\| PubMed ID: 15777096	2005
Unexpected formation of etheno-2'-deoxyguanosine adducts from 5(S)-hydroperoxyeicosatetraenoic acid: evidence for a bis-hydroperoxide intermediate. Chemical research in toxicology\| PubMed ID: 15777099	2005
Novel lipid hydroperoxide-derived hemoglobin histidine adducts as biomarkers of oxidative stress. Journal of mass spectrometry : JMS\| PubMed ID: 15827957	2005
DNA topoisomerase II in therapy-related acute promyelocytic leukemia. The New England journal of medicine\| PubMed ID: 15829534	2005
4-Hydroperoxy-2-nonenal-induced formation of 1,N2-etheno-2'-deoxyguanosine adducts. Chemical research in toxicology\| PubMed ID: 15833039	2005
Cyclooxygenase-2-mediated DNA damage. The Journal of biological chemistry\| PubMed ID: 15964853	2005
Targeted chiral lipidomics analysis. Prostaglandins & other lipid mediators\| PubMed ID: 16099399	2005
Interaction with phospholipids modulates alpha-synuclein nitration and lipid-protein adduct formation. The Biochemical journal\| PubMed ID: 16146428	2006
Effect of immunoaffinity depletion of human serum during proteomic investigations. Journal of proteome research\| PubMed ID: 16212426	2005
Characterization of proteins in human pancreatic cancer serum using differential gel electrophoresis and tandem mass spectrometry. Journal of proteome research\| PubMed ID: 16212428	2005
Induction of endothelial cell apoptosis by lipid hydroperoxide-derived bifunctional electrophiles. Free radical biology & medicine\| PubMed ID: 16214032	2005
Analysis of protein expression during oxidative stress in breast epithelial cells using a stable isotope labeled proteome internal standard. Journal of proteome research\| PubMed ID: 16335945	2005
Competing roles of aldo-keto reductase 1A1 and cytochrome P4501B1 in benzo[a]pyrene-7,8-diol activation in human bronchoalveolar H358 cells: role of AKRs in P4501B1 induction. Chemical research in toxicology\| PubMed ID: 16411658	2006
Endogenous lipid hydroperoxide-mediated DNA-adduct formation in min mice. The Journal of biological chemistry\| PubMed ID: 16449227	2006
Mild folate deficiency induces a proatherosclerotic phenotype in endothelial cells. Atherosclerosis\| PubMed ID: 16469322	2006
Liquid chromatography/tandem mass spectrometry characterization of oxidized amyloid beta peptides as potential biomarkers of Alzheimer's disease. Rapid communications in mass spectrometry : RCM\| PubMed ID: 16470704	2006
Quantification of benzo[a]pyrene diol epoxide DNA-adducts by stable isotope dilution liquid chromatography/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM\| PubMed ID: 16557497	2006
Characterization of a lipid hydroperoxide-derived RNA adduct in rat intestinal epithelial cells. Chemical research in toxicology\| PubMed ID: 16780360	2006
Translesion DNA Synthesis across the heptanone--etheno-2'-deoxycytidine adduct in cells. Chemical research in toxicology\| PubMed ID: 16918247	2006
基于蛋白质组学的策略以确定生物标志物和白血病的&#x836... Journal of proteome research\| PubMed ID: 17022645	2006
Analysis of phosphorylation sites on focal adhesion kinase using nanospray liquid chromatography/multiple reaction monitoring mass spectrometry. Rapid communications in mass spectrometry : RCM\| PubMed ID: 17117420	2006
Quantitative analysis of amyloid beta peptides in cerebrospinal fluid of Alzheimer's disease patients by immunoaffinity purification and stable isotope dilution liquid chromatography/negativ... Rapid communications in mass spectrometry : RCM\| PubMed ID: 17117458	2006
Quantification of intracellular homocysteine by stable isotope dilution liquid chromatography/tandem mass spectrometry. Biomedical chromatography : BMC\| PubMed ID: 17121413	2007
Convenient and efficient syntheses of 4-hydroxy-2(E)-nonenal and 4-oxo-2(E)-nonenal. Lipids\| PubMed ID: 17152925	2006
EBP, a program for protein identification using multiple tandem mass spectrometry datasets. Molecular & cellular proteomics : MCP\| PubMed ID: 17164401	2007
Endogenous glutathione adducts. Current drug metabolism\| PubMed ID: 17168687	2006
Characterization of an etoposide-glutathione conjugate derived from metabolic activation by human cytochrome p450. Current drug metabolism\| PubMed ID: 17168690	2006
LC/ESI/MS analysis of saturated and unsaturated fatty acids in rat intestinal epithelial cells. Current drug metabolism\| PubMed ID: 17168692	2006
Aldo-keto reductase- and cytochrome P450-dependent formation of benzo[a]pyrene-derived DNA adducts in human bronchoalveolar cells. Chemical research in toxicology\| PubMed ID: 17295519	2007
A novel 4-oxo-2(E)-nonenal-derived endogenous thiadiazabicyclo glutathione adduct formed during cellular oxidative stress. Chemical research in toxicology\| PubMed ID: 17550273	2007
Metabolism of benzo[a]pyrene in human bronchoalveolar H358 cells using liquid chromatography-mass spectrometry. Chemical research in toxicology\| PubMed ID: 17702526	2007
Cyclooxygenase-2-mediated metabolism of arachidonic acid to 15-oxo-eicosatetraenoic acid by rat intestinal epithelial cells. Chemical research in toxicology\| PubMed ID: 17910482	2007
Targeted chiral lipidomics analysis by liquid chromatography electron capture atmospheric pressure chemical ionization mass spectrometry (LC-ECAPCI/MS). Methods in enzymology\| PubMed ID: 17954234	2007
Strategies for synthesis of adducts of omicron-quinone metabolites of carcinogenic polycyclic aromatic hydrocarbons with 2'-deoxyribonucleosides. The Journal of organic chemistry\| PubMed ID: 18181642	2008
Analysis of the zebrafish proteome during embryonic development. Molecular & cellular proteomics : MCP\| PubMed ID: 18212345	2008
Determination of cellular redox status by stable isotope dilution liquid chromatography/mass spectrometry analysis of glutathione and glutathione disulfide. Rapid communications in mass spectrometry : RCM\| PubMed ID: 18215009	2008
Fjord-region benzo[g]chrysene-11,12-dihydrodiol and benzo[c]phenanthrene-3,4-dihydrodiol as substrates for rat liver dihydrodiol dehydrogenase (AKR1C9): structural basis for stereochemical p... Chemical research in toxicology\| PubMed ID: 18251511	2008
Synthesis of dibenzo[def,p]chrysene, its active metabolites, and their 13C-labeled analogues. Organic letters\| PubMed ID: 18284245	2008
DNA adducts with lipid peroxidation products. The Journal of biological chemistry\| PubMed ID: 18285329	2008
Evidence for the aldo-keto reductase pathway of polycyclic aromatic trans-dihydrodiol activation in human lung A549 cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18474869	2008
The pattern of p53 mutations caused by PAH o-quinones is driven by 8-oxo-dGuo formation while the spectrum of mutations is determined by biological selection for dominance. Chemical research in toxicology\| PubMed ID: 18489080	2008
Quantification of key red blood cell folates from subjects with defined MTHFR 677C>T genotypes using stable isotope dilution liquid chromatography/mass spectrometry. Rapid communications in mass spectrometry : RCM\| PubMed ID: 18634122	2008
Genetic and biochemical determinants of serum concentrations of monocyte chemoattractant protein-1, a potential neural tube defect risk factor. Birth defects research. Part A, Clinical and molecular teratology\| PubMed ID: 18937353	2008
Two distinct translesion synthesis pathways across a lipid peroxidation-derived DNA adduct in mammalian cells. The Journal of biological chemistry\| PubMed ID: 18981176	2009
Quantification of focal adhesion kinase activation loop phosphorylation as a biomarker of Src activity. Molecular pharmacology\| PubMed ID: 19098120	2009
Synthesis of phenol and quinone metabolites of benzo[a]pyrene, a carcinogenic component of tobacco smoke implicated in lung cancer. The Journal of organic chemistry\| PubMed ID: 19132942	2009
The up-regulation of monocyte chemoattractant protein-1 (MCP-1) in Ea.hy 926 endothelial cells under long-term low folate stress is mediated by the p38 MAPK pathway. Atherosclerosis\| PubMed ID: 19152916	2009
Stable isotope dilution multidimensional liquid chromatography-tandem mass spectrometry for pancreatic cancer serum biomarker discovery. Journal of proteome research\| PubMed ID: 19199705	2009
TNFalpha-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish S-adenosylhomocysteine hydrolase. Development (Cambridge, England)\| PubMed ID: 19201949	2009
Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolis... The Journal of biological chemistry\| PubMed ID: 19218247	2009
Identification and quantification of preterm birth biomarkers in human cervicovaginal fluid by liquid chromatography/tandem mass spectrometry. Journal of proteome research\| PubMed ID: 19271751	2009
Analysis of 7,8-dihydro-8-oxo-2'-deoxyguanosine in cellular DNA during oxidative stress. Chemical research in toxicology\| PubMed ID: 19309085	2009
Overexpression of human 15(S)-lipoxygenase-1 in RAW macrophages leads to increased cholesterol mobilization and reverse cholesterol transport. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 19325142	2009
Absolute quantification of phosphorylation on the kinase activation loop of cellular focal adhesion kinase by stable isotope dilution liquid chromatography/mass spectrometry. Analytical chemistry\| PubMed ID: 19354260	2009
The post-synaptic density of human postmortem brain tissues: an experimental study paradigm for neuropsychiatric illnesses. PloS one\| PubMed ID: 19370153	2009
5-Lipoxygenase-mediated endogenous DNA damage. The Journal of biological chemistry\| PubMed ID: 19390118	2009
Folate and homocysteine phenotypes: Comparative findings using research and clinical laboratory data. Clinical biochemistry\| PubMed ID: 19427846	2009
15(S)-Lipoxygenase-1 associates with neutral lipid droplets in macrophage foam cells: evidence of lipid droplet metabolism. Journal of lipid research\| PubMed ID: 19528634	2009
15-oxo-Eicosatetraenoic acid, a metabolite of macrophage 15-hydroxyprostaglandin dehydrogenase that inhibits endothelial cell proliferation. Molecular pharmacology\| PubMed ID: 19535459	2009
A 4-oxo-2(E)-nonenal-derived glutathione adduct from 15-lipoxygenase-1-mediated oxidation of cytosolic and esterified arachidonic acid. Free radical biology & medicine\| PubMed ID: 19576981	2009
Targeted chiral lipidomics analysis of bioactive eicosanoid lipids in cellular systems. BMB reports\| PubMed ID: 19643036	2009
Aryl hydrocarbon receptor facilitates DNA strand breaks and 8-oxo-2'-deoxyguanosine formation by the aldo-keto reductase product benzo[a]pyrene-7,8-dione. The Journal of biological chemistry\| PubMed ID: 19726680	2009
Differential secreted proteome approach in murine model for candidate biomarker discovery in colon cancer. Journal of proteome research\| PubMed ID: 19769411	2009
12/15-lipoxygenase-dependent myeloid production of interleukin-12 is essential for resistance to chronic toxoplasmosis. Infection and immunity\| PubMed ID: 19822654	2009
Secondhand smoke inhibits both Cl- and K+ conductances in normal human bronchial epithelial cells. Respiratory research\| PubMed ID: 19943936	2009
Analysis of endogenous glutathione-adducts and their metabolites. Biomedical chromatography : BMC\| PubMed ID: 20017120	2010
Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer. The Journal of steroid biochemistry and molecular biology\| PubMed ID: 20036328	2010
Liquid chromatography-mass spectrometry (LC-MS) of steroid hormone metabolites and its applications. The Journal of steroid biochemistry and molecular biology\| PubMed ID: 20083198	2010
Analysis of estrogens in serum and plasma from postmenopausal women: past present, and future. Steroids\| PubMed ID: 20109478	2010
A 13-Oxo-9,10-epoxytridecenoate phospholipid analogue of the genotoxic 4,5-epoxy-2E-decenal: detection in vivo, chemical synthesis, and adduction with DNA. Chemical research in toxicology\| PubMed ID: 20131875	2010
Stable-isotope dilution LCâ€“MS for quantitative biomarker analysis. Bioanalysis\| PubMed ID: 20352077	2010
Hematopoietic stem cell function requires 12/15-lipoxygenase-dependent fatty acid metabolism. Blood\| PubMed ID: 20357242	2010
20-HETE mediates ozone-induced, neutrophil-independent airway hyper-responsiveness in mice. PloS one\| PubMed ID: 20422032	2010
Genetic and lifestyle variables associated with homocysteine concentrations and the distribution of folate derivatives in healthy premenopausal women. Birth defects research. Part A, Clinical and molecular teratology\| PubMed ID: 20544798	2010
Interferon regulatory factor-8-driven myeloid differentiation is regulated by 12/15-lipoxygenase-mediated redox signaling. Experimental hematology\| PubMed ID: 20647030	2010
Deciphering the human platelet sheddome. Blood\| PubMed ID: 20962327	2011
Analysis of epoxyeicosatrienoic acids by chiral liquid chromatography/electron capture atmospheric pressure chemical ionization mass spectrometry using [13C]-analog internal standards. Rapid communications in mass spectrometry : RCM\| PubMed ID: 20972997	2010
Regulation of benzo[a]pyrene-mediated DNA- and glutathione-adduct formation by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human lung cells. Chemical research in toxicology\| PubMed ID: 21028851	2011
Thermal stability of bimatoprost, latanoprost, and travoprost under simulated daily use. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics\| PubMed ID: 21117945	2011
A new liquid chromatography/mass spectrometry method for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in urine. Rapid communications in mass spectrometry : RCM\| PubMed ID: 21154658	2011
Prediction of postoperative recurrence-free survival in non-small cell lung cancer by using an internationally validated gene expression model. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 21242119	2011
Stable isotope labeling by essential nutrients in cell culture for preparation of labeled coenzyme A and its thioesters. Analytical chemistry\| PubMed ID: 21268609	2011
CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (Â±)-14,15-epoxyeicosatrienoic aci... The Journal of biological chemistry\| PubMed ID: 21402692	2011
Nicotine exposure and metabolizer phenotypes from analysis of urinary nicotine and its 15 metabolites by LC-MS. Bioanalysis\| PubMed ID: 21452992	2011
Liquid chromatography/mass spectrometry of pre-ionized Girard P derivatives for quantifying estrone and its metabolites in serum from postmenopausal women. Rapid communications in mass spectrometry : RCM\| PubMed ID: 21488127	2011
Analysis of the human pancreatic stellate cell secreted proteome. Pancreas\| PubMed ID: 21499210	2011
Stereospecific reduction of 5Î²-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and pro... The Biochemical journal\| PubMed ID: 21521174	2011
Detoxication of structurally diverse polycyclic aromatic hydrocarbon (PAH) o-quinones by human recombinant catechol-O-methyltransferase (COMT) via O-methylation of PAH catechols. The Journal of biological chemistry\| PubMed ID: 21622560	2011
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature\| PubMed ID: 21734707	2011
11-Oxoeicosatetraenoic acid is a cyclooxygenase-2/15-hydroxyprostaglandin dehydrogenase-derived antiproliferative eicosanoid. Chemical research in toxicology\| PubMed ID: 21916491	2011
Rotenone-mediated changes in intracellular coenzyme A thioester levels: implications for mitochondrial dysfunction. Chemical research in toxicology\| PubMed ID: 21950265	2011
Quantitation of benzo[a]pyrene metabolic profiles in human bronchoalveolar (H358) cells by stable isotope dilution liquid chromatography-atmospheric pressure chemical ionization mass spectro... Chemical research in toxicology\| PubMed ID: 21962213	2011
Multidrug resistance protein (MRP) 4 attenuates benzo[a]pyrene-mediated DNA-adduct formation in human bronchoalveolar H358 cells. Toxicology letters\| PubMed ID: 22155354	2012
SILEC: a protocol for generating and using isotopically labeled coenzyme A mass spectrometry standards. Nature protocols\| PubMed ID: 22157971	2012
Relative Quantification of Serum Proteins from Pancreatic Ductal Adenocarcinoma Patients by Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry. Journal of proteome research\| PubMed ID: 22264027	2012