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LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism
 

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism

Article doi: 10.3791/53941
April 4th, 2016

Summary April 4th, 2016

Here we show isolated human platelets can be used as an accessible ex vivo model to study metabolic adaptations in response to the complex I inhibitor rotenone. This approach employs isotopic tracing and relative quantification by liquid chromatography-mass spectrometry and can be applied to a variety of study designs.

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