Renjie Chai

Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine

Affiliated withStanford University School of Medicine Southeast University

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 7	2011
Publication title Cited by 36	2019

Other Publications

Article	Year
Dynamic expression of Lgr5, a Wnt target gene, in the developing and mature mouse cochlea. Journal of the Association for Research in Otolaryngology : JARO\| PubMed ID: 21472479	2011
Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo. Development (Cambridge, England)\| PubMed ID: 24496619	2014
Ildr1b is essential for semicircular canal development, migration of the posterior lateral line primordium and hearing ability in zebrafish: implications for a role in the recessive hearing ... Human molecular genetics\| PubMed ID: 24990150	2014
In vivo overexpression of X-linked inhibitor of apoptosis protein protects against neomycin-induced hair cell loss in the apical turn of the cochlea during the ototoxic-sensitive period. Frontiers in cellular neuroscience\| PubMed ID: 25278835	2014
Combining use of captopril and losartan attenuates the progress of Streptococcus pneumoniae-induced tympanosclerosis through the suppression of TGF-β1 expression. PloS one\| PubMed ID: 25360706	2014
Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25535395	2015
MiRNA-320 in the human follicular fluid is associated with embryo quality in vivo and affects mouse embryonic development in vitro. Scientific reports\| PubMed ID: 25732513	2015
Lgr5+ cells regenerate hair cells via proliferation and direct transdifferentiation in damaged neonatal mouse utricle. Nature communications\| PubMed ID: 25849379	2015
LSD1 is Required for Hair Cell Regeneration in Zebrafish. Molecular neurobiology\| PubMed ID: 26008620	2016
Effects of local application of methylprednisolone delivered by the C/GP-hydrogel on the recovery of facial nerves. Acta oto-laryngologica\| PubMed ID: 26235110	2015
HDAC3 Is Required for Posterior Lateral Line Development in Zebrafish. Molecular neurobiology\| PubMed ID: 26395281	2016
Mutations in TUBB8 and Human Oocyte Meiotic Arrest. The New England journal of medicine\| PubMed ID: 26789871	2016
MicroRNA-10a/10b represses a novel target gene mib1 to regulate angiogenesis. Cardiovascular research\| PubMed ID: 26825552	2016
Histone deacetylase 1 is required for the development of the zebrafish inner ear. Scientific reports\| PubMed ID: 26832938	2016
Bmi1 Regulates the Proliferation of Cochlear Supporting Cells Via the Canonical Wnt Signaling Pathway. Molecular neurobiology\| PubMed ID: 26843109	2017
The Three-Dimensional Culture System with Matrigel and Neurotrophic Factors Preserves the Structure and Function of Spiral Ganglion Neuron In Vitro. Neural plasticity\| PubMed ID: 27057364	2016
Characterization of Lgr5+ progenitor cell transcriptomes in the apical and basal turns of the mouse cochlea. Oncotarget\| PubMed ID: 27070092	2016
Regeneration of hair cells in the mammalian vestibular system. Frontiers of medicine\| PubMed ID: 27189205	2016
The structural development of primary cultured hippocampal neurons on a graphene substrate. Colloids and surfaces. B, Biointerfaces\| PubMed ID: 27395037	2016
Reduced TRMU expression increases the sensitivity of hair-cell-like HEI-OC-1 cells to neomycin damage in vitro. Scientific reports\| PubMed ID: 27405449	2016
Co-regulation of the Notch and Wnt signaling pathways promotes supporting cell proliferation and hair cell regeneration in mouse utricles. Scientific reports\| PubMed ID: 27435629	2016
Spatiotemporal expression of Ezh2 in the developing mouse cochlear sensory epithelium. Frontiers of medicine\| PubMed ID: 27465826	2016
Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea. Frontiers of medicine\| PubMed ID: 27527363	2016
Extensive Supporting Cell Proliferation and Mitotic Hair Cell Generation by In Vivo Genetic Reprogramming in the Neonatal Mouse Cochlea. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 27535918	2016
Inhibition of ARC decreases the survival of HEI-OC-1 cells after neomycin damage in vitro. Oncotarget\| PubMed ID: 27556499	2016
Wnt activation followed by Notch inhibition promotes mitotic hair cell regeneration in the postnatal mouse cochlea. Oncotarget\| PubMed ID: 27564256	2016
Accelerating bioelectric functional development of neural stem cells by graphene coupling: Implications for neural interfacing with conductive materials. Biomaterials\| PubMed ID: 27566868	2016
MiR-182-5p protects inner ear hair cells from cisplatin-induced apoptosis by inhibiting FOXO3a. Cell death & disease\| PubMed ID: 27607577	2016
The somite-secreted factor Maeg promotes zebrafish embryonic angiogenesis. Oncotarget\| PubMed ID: 27780917	2016
c-Myb knockdown increases the neomycin-induced damage to hair-cell-like HEI-OC1 cells in vitro. Scientific reports\| PubMed ID: 28112219	2017
A Three-Dimensional Culture System with Matrigel Promotes Purified Spiral Ganglion Neuron Survival and Function In Vitro. Molecular neurobiology\| PubMed ID: 28283883	2018
Hearing Loss: Reestablish the Neural Plasticity in Regenerated Spiral Ganglion Neurons and Sensory Hair Cells. Neural plasticity\| PubMed ID: 28316840	2017
Targeting HSP90-HDAC6 Regulating Network Implicates Precision Treatment of Breast Cancer. International journal of biological sciences\| PubMed ID: 28529458	2017
An episomal vector-based CRISPR/Cas9 system for highly efficient gene knockout in human pluripotent stem cells. Scientific reports\| PubMed ID: 28539611	2017
Bone morphogenetic protein 4 promotes the survival and preserves the structure of flow-sorted Bhlhb5+ cochlear spiral ganglion neurons in vitro. Scientific reports\| PubMed ID: 28615657	2017
Inactivation of STAT3 Signaling Impairs Hair Cell Differentiation in the Developing Mouse Cochlea. Stem cell reports\| PubMed ID: 28669599	2017
Auditory Neuropathy after Damage to Cochlear Spiral Ganglion Neurons in Mice Resulting from Conditional Expression of Diphtheria Toxin Receptors. Scientific reports\| PubMed ID: 28743950	2017
Is Required for Zebrafish Posterior Lateral Line Development. Frontiers in molecular neuroscience\| PubMed ID: 28824372	2017
Insm1a Regulates Motor Neuron Development in Zebrafish. Frontiers in molecular neuroscience\| PubMed ID: 28894416	2017
Autophagy protects auditory hair cells against neomycin-induced damage. Autophagy\| PubMed ID: 28968134	2017
Loss of CIB2 Causes Profound Hearing Loss and Abolishes Mechanoelectrical Transduction in Mice. Frontiers in molecular neuroscience\| PubMed ID: 29255404	2017
Hedgehog Signaling Promotes the Proliferation and Subsequent Hair Cell Formation of Progenitor Cells in the Neonatal Mouse Cochlea. Frontiers in molecular neuroscience\| PubMed ID: 29311816	2017
Looking into the Future: Toward Advanced 3D Biomaterials for Stem-Cell-Based Regenerative Medicine. Advanced materials (Deerfield Beach, Fla.)\| PubMed ID: 29450919	2018
Wnt Signaling Activates TP53-Induced Glycolysis and Apoptosis Regulator and Protects Against Cisplatin-Induced Spiral Ganglion Neuron Damage in the Mouse Cochlea. Antioxidants & redox signaling\| PubMed ID: 29587485	2019
Characterization of Wnt and Notch-Responsive Lgr5+ Hair Cell Progenitors in the Striolar Region of the Neonatal Mouse Utricle. Frontiers in molecular neuroscience\| PubMed ID: 29760650	2018
Characterization of Lgr6+ Cells as an Enriched Population of Hair Cell Progenitors Compared to Lgr5+ Cells for Hair Cell Generation in the Neonatal Mouse Cochlea. Frontiers in molecular neuroscience\| PubMed ID: 29867341	2018
Meclofenamic Acid Reduces Reactive Oxygen Species Accumulation and Apoptosis, Inhibits Excessive Autophagy, and Protects Hair Cell-Like HEI-OC1 Cells From Cisplatin-Induced Damage. Frontiers in cellular neuroscience\| PubMed ID: 29875633	2018
Real-Time Multimodal Bioimaging of Cancer Cells and Exosomes through Biosynthesized Iridium and Iron Nanoclusters. ACS applied materials & interfaces\| PubMed ID: 30011179	2018
Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration. Cell stem cell\| PubMed ID: 30122476	2018
Tuberous sclerosis complex-mediated mTORC1 overactivation promotes age-related hearing loss. The Journal of clinical investigation\| PubMed ID: 30247156	2018
Loss of ARHGEF6 Causes Hair Cell Stereocilia Deficits and Hearing Loss in Mice. Frontiers in molecular neuroscience\| PubMed ID: 30333726	2018
The role of FOXG1 in the postnatal development and survival of mouse cochlear hair cells. Neuropharmacology\| PubMed ID: 30336149	2019
Author Correction: An episomal vector-based CRISPR/Cas9 system for highly efficient gene knockout in human pluripotent stem cells. Scientific reports\| PubMed ID: 30538257	2018
Surgery-free video-oculography in mouse models: enabling quantitative and short-interval longitudinal assessment of vestibular function. Neuroscience letters\| PubMed ID: 30597229	2019
Designs of Biomaterials and Microenvironments for Neuroengineering. Neural plasticity\| PubMed ID: 30627148	2018
Hearing Loss: Reestablish the Neural Plasticity in Regenerated Spiral Ganglion Neurons and Sensory Hair Cells 2018. Neural plasticity\| PubMed ID: 30647730	2018
Transduction of Adeno-Associated Virus Vectors Targeting Hair Cells and Supporting Cells in the Neonatal Mouse Cochlea. Frontiers in cellular neuroscience\| PubMed ID: 30733670	2019
A cytoskeleton structure revealed by super-resolution fluorescence imaging in inner ear hair cells. Cell discovery\| PubMed ID: 30792888	2019
Novel compounds protect auditory hair cells against gentamycin-induced apoptosis by maintaining the expression level of H3K4me2. Drug delivery\| PubMed ID: 30799660	2018
Deletion of Limk1 and Limk2 in mice does not alter cochlear development or auditory function. Scientific reports\| PubMed ID: 30833597	2019
Hair Cell Regeneration. Advances in experimental medicine and biology\| PubMed ID: 30915698	2019
Protection of Hair Cells from Ototoxic Drug-Induced Hearing Loss. Advances in experimental medicine and biology\| PubMed ID: 30915699	2019
Critical role of spectrin in hearing development and deafness. Science advances\| PubMed ID: 31001589	2019
A humanized mouse model, demonstrating progressive hearing loss caused by MYO6 p.C442Y, is inherited in a semi-dominant pattern. Hearing research\| PubMed ID: 31103816	2019
Transcriptomic profiling of neural stem cell differentiation on graphene substrates. Colloids and surfaces. B, Biointerfaces\| PubMed ID: 31288132	2019
The application of graphene-based biomaterials in biomedicine. American journal of translational research\| PubMed ID: 31312342	2019
TeraVR empowers precise reconstruction of complete 3-D neuronal morphology in the whole brain. Nature communications\| PubMed ID: 31375678	2019
Structurally Tunable Reduced Graphene Oxide Substrate Maintains Mouse Embryonic Stem Cell Pluripotency. Advanced science (Weinheim, Baden-Wurttemberg, Germany)\| PubMed ID: 31380157	2019
AAV-ie enables safe and efficient gene transfer to inner ear cells. Nature communications\| PubMed ID: 31427575	2019
Frizzled-9+ Supporting Cells Are Progenitors for the Generation of Hair Cells in the Postnatal Mouse Cochlea. Frontiers in molecular neuroscience\| PubMed ID: 31427926	2019
Laminin-Coated Electrospun Regenerated Silk Fibroin Mats Promote Neural Progenitor Cell Proliferation, Differentiation, and Survival . Frontiers in bioengineering and biotechnology\| PubMed ID: 31448271	2019
Knockdown of Foxg1 in supporting cells increases the trans-differentiation of supporting cells into hair cells in the neonatal mouse cochlea. Cellular and molecular life sciences : CMLS\| PubMed ID: 31485717	2019
Stress-Induced Metabolic Disorder in Peripheral CD4 T Cells Leads to Anxiety-like Behavior. Cell\| PubMed ID: 31675497	2019